• Phosphatome.Net

Gene EYA4

EYA4
Species: Human
Alias: DFNA10, EYA4, CMD1J
External Links: COSMIC , Entrez Gene
Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Superfamily: HAD
Family: EYA
Subfamily: EYA
Protein domain

Protein domains of EYA4.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit phosphatase group/family/subfamily, which is helpful to understand the relationship between phosphatases. Transmembrane region is predicted by TMHMM 2.0. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking. View complete domain list.

Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Phosphatase EYA4.AA Family.EYA.PD 369-615 87 2.4e-158 512.5 In-house 1-247 (247) Show / Hide 
Range on Protein: 369-615
Range on HMM: 1-247/247
Sequence Identity: 87% (217 aa)

ERVFVWDLDETIIVFHSLLTGSYAQKYGKDPPMAVTLGLRMEEMIFNLADTHLFFNDLEECDQVHIDDVSSDDNGQDLSTYSFATDGFHAAASSANLCLP
|||||||||||||.||||||||||.|||||....|.|||||||||||||||||||||||||||||||||||||||||||||.||||||||||.||||||.
ervfvwdldetiiifhslltgsyaekygkdasssvalglrmeemifnladthlffndleecdqvhiddvssddngqdlstynfatdgfhaaatsanlcla

TGVRGGVDWMRKLAFRYRRVKELYNTYKNNVGGLLGPAKRDAWLQLRAEIEGLTDSWLTNALKSLSIISTRSNCINVLVTTTQLIPALAKVLLYSLGGAF
||||||||||||||||||.|||.||.||||||||||||||.|||||||||| |||||||.|||.||.||.||||.|||||||||.|||||||||.||| |
tgvrggvdwmrklafryrkvkeiynsyknnvggllgpakreawlqlraeiealtdswltlalkalslissrsncvnvlvtttqlvpalakvllyglggvf

PIENIYSATKIGKESCFERIMQRFGRKVVYVVIGDGVEEEQAAKKHN
||||||||||||||||||||..||||||.|||||||..||.||||.|
pieniysatkigkescferivarfgrkvtyvvigdgkdeetaakkln
Phosphatase EYA4.AA Subfamily.EYA.PD 369-615 87 2.4e-158 512.5 In-house 1-247 (247) Show / Hide 
Range on Protein: 369-615
Range on HMM: 1-247/247
Sequence Identity: 87% (217 aa)

ERVFVWDLDETIIVFHSLLTGSYAQKYGKDPPMAVTLGLRMEEMIFNLADTHLFFNDLEECDQVHIDDVSSDDNGQDLSTYSFATDGFHAAASSANLCLP
|||||||||||||.||||||||||.|||||....|.|||||||||||||||||||||||||||||||||||||||||||||.||||||||||.||||||.
ervfvwdldetiiifhslltgsyaekygkdasssvalglrmeemifnladthlffndleecdqvhiddvssddngqdlstynfatdgfhaaatsanlcla

TGVRGGVDWMRKLAFRYRRVKELYNTYKNNVGGLLGPAKRDAWLQLRAEIEGLTDSWLTNALKSLSIISTRSNCINVLVTTTQLIPALAKVLLYSLGGAF
||||||||||||||||||.|||.||.||||||||||||||.|||||||||| |||||||.|||.||.||.||||.|||||||||.|||||||||.||| |
tgvrggvdwmrklafryrkvkeiynsyknnvggllgpakreawlqlraeiealtdswltlalkalslissrsncvnvlvtttqlvpalakvllyglggvf

PIENIYSATKIGKESCFERIMQRFGRKVVYVVIGDGVEEEQAAKKHN
||||||||||||||||||||..||||||.|||||||..||.||||.|
pieniysatkigkescferivarfgrkvtyvvigdgkdeetaakkln
Phosphatase EYA4.AA Group.HAD.PD 370-596 19 2.7e-38 119.7 In-house 2-189 (190) Show / Hide 
Range on Protein: 370-596
Range on HMM: 2-189/190
Sequence Identity: 19% (43 aa)

RVFVWDLDETIIvfhslLTGSYAQKYGKDPPMAVTLGLRMeemifNLADTHLFFNDLEECDQVHIDDVSsddngqdlstysFATDGFHAAA---------
...|.|||....     |.||.....|.. .  | ..|..     | ....|.... ..........|.            ...|.|........ . ..
dtlvlDldgvlw-----lhgspepleglrskgkvlifltn-----natksrlyllkrlallgflveeve------------phldeflervgelyelvvf

SSANLCLPTGVRGGVDWMrKLAFRYRRVKELYNTYKNnVGGLLGPAKRdawlqlraeieglTDSWLTNALKSLSIISTRSNCINVLVtttqlipALAKVL
 |.|.||.. ..||.||.... .. .|. .|.||....|             ....|. .|....||...... ..... ...|..       |..|..|
tagtreyadpvvgavdvg-deafsyrklrdacvylkg-pgalllatnr-------------dlgalvrdlekvviidnkpsvfafec-------npenal

LYSLGgafpIENIYSATKIGKESCFERIMQRFGRKV
...|.....|.|..|||..|                
migdf----iddildaellglipdlenidvrfgkdv
Phosphatase EYA4.AA Hydrolase 369-615 10 1.8e-12 44.13 Pfam 1-167 (167) Show / Hide 
Range on Protein: 369-615
Range on HMM: 1-167/167
Sequence Identity: 10% (26 aa)

ERVFVWDLDETIIVF----HSLLTGSYAQKYGKDPPMAVTLGLRMEEMIF-NLADTHLFFNDLEECDQVHIDDVSSDDNGQDLSTYSFATDGFHAAASSA
 ...|.|.| |.. .    |   . . |..||. .|....  .  ... . . .|..  . ..                                     
IKAVVFDKDGTLTDGSEHPHAQAWVEAAREYGY-WPFEEVEYIWGRGI-GDRIIDWWRATDEHI------------------------------------

NLCLPTGVRGGVDWMRKLAFRYRRVKELYNTYKNNVGGLLGPAKRDAWLQLRAEIEGLTDSWLTNALKSLSIISTRSNCINVLVTTTQLIPALAKVLLYS
                                                   . ... . | ..  | . |  .  . ..  ...| .   .| |.. .. 
------------------------------------------------D-EYLGVIAD-DQPYPGAREALQALKRM-GIKVAMITNDNR-NAQAVLEHLG

LGGAFPIENIYSATKI---GKESCFERIMQRFGRKVV---YVVIGDGVEEEQAAKKHN
.. .| .  ... ..|    .  ..|...||.| |..   ....|||.   .......
IA-YFDHIIDSDDVGIVGKPHPEMYEKACQRLGVKPHECGCMMVGDGINDDPMLAQAG
Sequence
Name Sequence Type Origin Length Description Download
EYA4.AA Protein None 639 None Fasta, JSON
EYA4.NA RNA None 1917 None Fasta, JSON
EYA4.AA.PD_369-615 Protein Phosphatase Domain None 247 None Fasta, JSON