Gene CTDNEP1
CTDNEP1
Classification
Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.
Protein domain
Protein domains of CTDNEP1.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit phosphatase group/family/subfamily, which is helpful to understand the relationship between phosphatases. Transmembrane region is predicted by TMHMM 2.0. Visualized by pviz.
Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking. View complete domain list.
| Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
|---|---|---|---|---|---|---|---|---|---|
| Phosphatase | CTDNEP1.AA | Subfamily.DULLARD.PD | 60-231 | 75 | 3e-93 | 299.1 | In-house | 1-172 (172) | Show / Hide |
Range on Protein: 60-231 Range on HMM: 1-172/172 Sequence Identity: 75% (129 aa) KRKILVLDLDETLIHSHHDGVLRPTVRPGTPPDFILKVVIDKHPVRFFVHKRPHVDFFLEVVSQWYELVVFTASMEIYGSAVADKLDNSRSILKRRYYRQ |||.||||||||||||.||.| . ||..||.|||.|||.|...||.|.|.||||||.||.|||.||.||.||||||.|..||.||||..|.||||||||| krktlvldldetlihsahdsvtkstvkegtapdfklkvlierepvlfyvykrPhvdlfldvvskWydlviftasmeeyaaavvdkldsgrgilkrryyrq HCTLELGSYIKDLSVVHSDLSSIVILDNSPGAYRSHPDNAIPIKSWFSDPSDTALLNLLPMLDALRFTADVR ||||| |.|.||||.|..||||..|||||| |||..||||||||||.|||||||||||||.|||||||.||| hCtlesgkytkdlslvsedlssviilDnspvayrknpdnaipikswisdpsdtallnllPfldalrftkdvr |
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| Phosphatase | CTDNEP1.AA | CPDc | 60-212 | 44 | 1.6e-78 | 268.07 | SMART | 1-173 (173) | Show / Hide |
Range on Protein: 60-212 Range on HMM: 1-173/173 Sequence Identity: 44% (77 aa) KRKILVLDLDETLIHS------HHDGVLRPTVRPGTPPDFILK----------VVIDKHPVRFFVHKRPHVDFFLEVVSQWYELVVFTASMEIYGSAVAD |.|.||||||.||.|| ||. . .... . |..||| . |.|| ||. ..|.|||||. ||. .|.|||..|||..|..|...|.| KKKTLVLDLDHTLVHSCMIPTLHHWMKYLRSFKEWTRRDFIWPQLKWFHMCMIVEIDGHPHQWYVKKRPHVHEFLKRCSKWYEMHVFTMGMRMYADPVLD KLDNSR-SILKRRYYRQHCTLELGS-YIKD-LSVVH-SDLSSIVILDNSPGAYRSHPDNAIPIKSWFSDPSDT .|| | .. ||.||.||... | |.|| ||.|. .|||...|.|.|| ... ||.||||||.||....|| MLDPKRKYFIYRRLYRDHCVYHKGKTYVKDTLSLVNRCDLSMVIIIDDSPDSWPWHPENAIPIKPWFYFMHDT |
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| Phosphatase | CTDNEP1.AA | NIF | 62-231 | 36 | 6.7e-74 | 256.62 | Pfam | 1-189 (189) | Show / Hide |
Range on Protein: 62-231 Range on HMM: 1-189/189 Sequence Identity: 36% (72 aa) KILVLDLDETLIHSH--HDGVLRPTVRPGTPPDFILKVVIDKHPVRFFVHK-RPHVDFFLEVVSQWYELVVFTASMEIYGSAVADKLDNS-RSIL--KRR |.|||||||||.|. .. .. ..|||...... ... ..|.| ||..| ||. .|..||.|..||||. | .| |..| . . ..| KTLVLDLDETLVHCNPWWEPPN--------WHDFIVPIPFNGQNHQWYVYKPRPYCDEFLQHMSKYYEIVIWTASMKEYADPVIDYIDPKSKKYFDGHHR Y---YRQHCT-LELG-SY-I-KDLSVV--HS-DLSSIVILDNSPGAYRSHPDNAIPIKS-WFS-----D-PSD--TALLNLLPML-DALR-FT-ADVR . ||.||. .. | .| . ||||.. . |||...|.|||| .. .|||.|||.. |.. | |.| ..||.||| | ..|. . ||| LICWYREHCWLYRNGGNYYVKKDLSILWYNRWDLSRVIIVDNSPHSW-LQPDNGIPIPPYWYGYHDDDDSPDDFWNELLDLLPFLIEYLALQCLDDVR |
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| Phosphatase | CTDNEP1.AA | Family.FCP.PD | 60-231 | 49 | 7.7e-62 | 197.1 | In-house | 1-164 (164) | Show / Hide |
Range on Protein: 60-231 Range on HMM: 1-164/164 Sequence Identity: 49% (85 aa) KRKILVLDLDETLIHShhdgvlrpTVRPGTPPDFILKVVIDKHPVRFFVHKRPHVDFFLEVVSQWYELVVFTASMEIYGSAVADKLDNSRSILKRRYYRQ |.|.|||||||||.|| ...| . |||..|| ||... ...|.||||.| ||| ||..||.|.||||.. | ..|||.||......|.|..|. kkklLVlDLdetLvhs--------elkpknkpdfvvkveideleetvyvkkRPhldeFLekvselyeiviftastrkyadpvadiLDpekklfkkrllrd HCTLELGSYIKDLSVVHSDLSSIVILDNSPGAYRSHPDNAIPIKSWFSDPSDTALLNLLPMLDALRFTADVR .|.|. |.|.||||... |||...|.|.|| .|. .|||||..||...||.||.||.|||.|..|... ||| ecvlvkgnyvkdLsklgrdlskviiiDdspdsyklnpdnaikvksfkedpkDteLldLlpfleslakeedvr |
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| Phosphatase | CTDNEP1.AA | Subfamily.SCP.PD | 61-230 | 46 | 1.9e-56 | 179.2 | In-house | 2-162 (163) | Show / Hide |
Range on Protein: 61-230
Range on HMM: 2-162/163
Sequence Identity: 46% (79 aa)
RKILVLDLDETLIHShhdgvlrpTVRPGTPPDFILKVVIDKHPVRFFVHKRPHVDFFLEVVSQWYELVVFTASMEIYGSAVADKLDNSRSiLKRRYYRQH
.| |||||||||.|| ...| . .||.. | ||. . .| |||.|| ||. |.. .|.|.||||.. |.. ||| ||... .|| .|..|
kkclvldldetlvhs--------sfkpvenadfvvpveidgtvhqvyvlkrpfvdeflkkvgelfevvlftaslakyadpvadlldkknv-ikarlfres
CTLELGSYIKDLSVVHSDLSSIVILDNSPGAYRSHPDNAIPIKSWFSDPSDTALLNLLPMLDALRFTADV
|.|.|||| . ||...||.|||| .| |||||.|..|||.|..|| ||.|||.|. |. . ||
cvfhkgnyvkdlsrlGrdlkkvvivdnspasyifhpdnavpveswfddeedtelldllplleelskvedv
|
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| Phosphatase | CTDNEP1.AA | Subfamily.HSPC129.PD | 62-231 | 41 | 1.3e-44 | 140.8 | In-house | 3-164 (164) | Show / Hide |
Range on Protein: 62-231 Range on HMM: 3-164/164 Sequence Identity: 41% (69 aa) KILVLDLDETLIHSHhdgvLRPTvrpgTPPDFILKVVIDKHPVRFFVHKRPHVDFFLEVVSQWYELVVFTASMEIYGSAVADKLDNSRSILKRRYYRQHC |||||||||.|. |.. . .||. ... . .|. ||.. ||| ||. .|...|||| ..| . | || .... | .|.|| fslvldldetlvhcs----lakl----edatlsfkveyqdktyqvyvrlrpflreflervsklfevilftaskkvyadklldlldpekklvrhrlfrehc TLELGSYIKDLSVVHSDLSSIVILDNSPGAYRSHPDNAIPIKSWFSDPSDTALLNLLPMLDALRFTADVR |.||||||.. ||| .|.|||| |. .| |||.|||.| |. ||.|||.|..| . ||| vcvdgnyikdlsilGrdlsktiivdnspqafayqlenGipieswfadendsellkllpfleklaekedvr |
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| Phosphatase | CTDNEP1.AA | Group.HAD.PD | 61-231 | 29 | 2.4e-42 | 134.2 | In-house | 1-190 (190) | Show / Hide |
Range on Protein: 61-231 Range on HMM: 1-190/190 Sequence Identity: 29% (57 aa) RKILVLDLDETLI-HSHHDGVLRPTVRPGTPPDFILkvviDKHPVRFFVHKR------------PHVDFFLEVVSQWYELVVFTASMEIYGSAVADKLDN .. ||||||..|. |..... .. . . .. . .. |....|| ||.| ||| |...||||||||... | . |....| kdtlvlDldgvlwlhgspepleglrskgkvlifltn----natksrlyllkrlallgflveevephldeflervgelyelvvftagtreyadpvvgavdv SRSILKRRYYRQHCTLELGSYIK------DLSVVHSDLSSIVILDNSPGAYRS--HPDNAIPIKSWFSDPSDTALLNLLPMLDAL--RFTADVR . ....|..|..|. | . . ||.....||...||.||.| .. .|.||..|.....|..|..||.|.|.|... ||. ||. gdeafsyrklrdacvylkgpgalllatnrdlgalvrdlekvviidnkpsvfafecnpenalmigdfiddildaellglipdlenidvrfgkdvg |
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| Phosphatase | CTDNEP1.AA | Subfamily.TIM50.PD | 108-225 | 33 | 1.8e-29 | 91.7 | In-house | 26-142 (150) | Show / Hide |
Range on Protein: 108-225 Range on HMM: 26-142/150 Sequence Identity: 33% (39 aa) VHKRPHVDFFLEVVSQWYELVVFTASMEIYGSAVADKLDNsRSILKRRYYRQHCTLELGSYIKDLSVVHSDLSSIVILDNSPGAYRSHPDNAIPIKSWFS ..||| ||.||| ... .|.||||.. .. . . |||| ..... | .|..... |. .|||| . ||| ....| . ... .|.||. .| | fkkrPgvdafleelaelfeivvftseqgltaaplidkldP-kqlimyrlfrdatkyvdGehvkdlsklnrdlskvivvdldkesvklqpenalalkkwkG DPSDTALLNLLPMLDALR .. |. ||.||..| . naddrelldllaflktia |
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| Phosphatase | CTDNEP1.AA | Subfamily.FCP1.PD | 62-204 | 27 | 1.4e-20 | 63.1 | In-house | 3-142 (150) | Show / Hide |
Range on Protein: 62-204 Range on HMM: 3-142/150 Sequence Identity: 27% (40 aa) KILVLDLDETLIHSHHDGVLrpTVRPgTPPDFILKVVIDKHPVRFFVHKRPHVDFFLEVVSQWYELVVFTASMEIYGSAVADKLDNSRSILKRRYYRQHC .||.|||.||||. .| . .|. . | | . ... ..|..||.. ||| .|. ||| ..| . | ...| || .... ..| . . lvLvvDlDqtlihttkdpti--evke-eklkdikkftlpeekevyyvklRpnlkeFleklsklyelhiytmgtraYaeqiakilDpekklFserilsrde TLELGSYIKDLSVV-HSDLSSIVILDNSPGAYrSHPDNAIPIKS |. | .|.|. . .. | .||.|. . .. .| | .|. llnassktkklkklfptgdsmvviiDDredvW-nfaenlikvkp |
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Sequence
| Name | Sequence Type | Origin | Length | Description | Download |
|---|---|---|---|---|---|
| CTDNEP1.AA | Protein | None | 244 | None | Fasta, JSON |
| CTDNEP1.NA | RNA | None | 732 | None | Fasta, JSON |
| CTDNEP1.AA.PD_60-231 | Protein Phosphatase Domain | None | 172 | None | Fasta, JSON |