CTDNEP1
Species: Human
Alias: NET56, HSA011916, CTDNEP1, DULLARD
External Links: COSMIC , Entrez Gene
Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Superfamily: HAD
Family: FCP
Subfamily: DULLARD
Protein domain

Protein domains of CTDNEP1.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit phosphatase group/family/subfamily, which is helpful to understand the relationship between phosphatases. Transmembrane region is predicted by TMHMM 2.0. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking. View complete domain list.

Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Phosphatase CTDNEP1.AA Subfamily.DULLARD.PD 60-231 75 3e-93 299.1 In-house 1-172 (172) Show / Hide
Range on Protein: 60-231
Range on HMM: 1-172/172
Sequence Identity: 75% (129 aa)

KRKILVLDLDETLIHSHHDGVLRPTVRPGTPPDFILKVVIDKHPVRFFVHKRPHVDFFLEVVSQWYELVVFTASMEIYGSAVADKLDNSRSILKRRYYRQ
|||.||||||||||||.||.| . ||..||.|||.|||.|...||.|.|.||||||.||.|||.||.||.||||||.|..||.||||..|.|||||||||
krktlvldldetlihsahdsvtkstvkegtapdfklkvlierepvlfyvykrPhvdlfldvvskWydlviftasmeeyaaavvdkldsgrgilkrryyrq

HCTLELGSYIKDLSVVHSDLSSIVILDNSPGAYRSHPDNAIPIKSWFSDPSDTALLNLLPMLDALRFTADVR
||||| |.|.||||.|..||||..|||||| |||..||||||||||.|||||||||||||.|||||||.|||
hCtlesgkytkdlslvsedlssviilDnspvayrknpdnaipikswisdpsdtallnllPfldalrftkdvr

Phosphatase CTDNEP1.AA CPDc 60-212 44 1.6e-78 268.07 SMART 1-173 (173) Show / Hide
Range on Protein: 60-212
Range on HMM: 1-173/173
Sequence Identity: 44% (77 aa)

KRKILVLDLDETLIHS------HHDGVLRPTVRPGTPPDFILK----------VVIDKHPVRFFVHKRPHVDFFLEVVSQWYELVVFTASMEIYGSAVAD
|.|.||||||.||.||      ||. . .... . |..||| .          |.|| ||. ..|.|||||. ||. .|.|||..|||..|..|...|.|
KKKTLVLDLDHTLVHSCMIPTLHHWMKYLRSFKEWTRRDFIWPQLKWFHMCMIVEIDGHPHQWYVKKRPHVHEFLKRCSKWYEMHVFTMGMRMYADPVLD

KLDNSR-SILKRRYYRQHCTLELGS-YIKD-LSVVH-SDLSSIVILDNSPGAYRSHPDNAIPIKSWFSDPSDT
.||  |  .. ||.||.||... |  |.|| ||.|. .|||...|.|.|| ... ||.||||||.||....||
MLDPKRKYFIYRRLYRDHCVYHKGKTYVKDTLSLVNRCDLSMVIIIDDSPDSWPWHPENAIPIKPWFYFMHDT

Phosphatase CTDNEP1.AA NIF 62-231 36 6.7e-74 256.62 Pfam 1-189 (189) Show / Hide
Range on Protein: 62-231
Range on HMM: 1-189/189
Sequence Identity: 36% (72 aa)

KILVLDLDETLIHSH--HDGVLRPTVRPGTPPDFILKVVIDKHPVRFFVHK-RPHVDFFLEVVSQWYELVVFTASMEIYGSAVADKLDNS-RSIL--KRR
|.|||||||||.|.   .. ..        ..|||...... ... ..|.| ||..| ||. .|..||.|..||||. |  .| |..|   . .   ..|
KTLVLDLDETLVHCNPWWEPPN--------WHDFIVPIPFNGQNHQWYVYKPRPYCDEFLQHMSKYYEIVIWTASMKEYADPVIDYIDPKSKKYFDGHHR

Y---YRQHCT-LELG-SY-I-KDLSVV--HS-DLSSIVILDNSPGAYRSHPDNAIPIKS-WFS-----D-PSD--TALLNLLPML-DALR-FT-ADVR
.   ||.||. .. | .| . ||||..   . |||...|.|||| ..  .|||.|||.. |..     | |.|  ..||.||| | ..|. .   |||
LICWYREHCWLYRNGGNYYVKKDLSILWYNRWDLSRVIIVDNSPHSW-LQPDNGIPIPPYWYGYHDDDDSPDDFWNELLDLLPFLIEYLALQCLDDVR

Phosphatase CTDNEP1.AA Family.FCP.PD 60-231 49 7.7e-62 197.1 In-house 1-164 (164) Show / Hide
Range on Protein: 60-231
Range on HMM: 1-164/164
Sequence Identity: 49% (85 aa)

KRKILVLDLDETLIHShhdgvlrpTVRPGTPPDFILKVVIDKHPVRFFVHKRPHVDFFLEVVSQWYELVVFTASMEIYGSAVADKLDNSRSILKRRYYRQ
|.|.|||||||||.||        ...| . |||..|| ||... ...|.||||.| ||| ||..||.|.||||.. | ..|||.||......|.|..|.
kkklLVlDLdetLvhs--------elkpknkpdfvvkveideleetvyvkkRPhldeFLekvselyeiviftastrkyadpvadiLDpekklfkkrllrd

HCTLELGSYIKDLSVVHSDLSSIVILDNSPGAYRSHPDNAIPIKSWFSDPSDTALLNLLPMLDALRFTADVR
.|.|. |.|.||||... |||...|.|.|| .|. .|||||..||...||.||.||.|||.|..|... |||
ecvlvkgnyvkdLsklgrdlskviiiDdspdsyklnpdnaikvksfkedpkDteLldLlpfleslakeedvr

Phosphatase CTDNEP1.AA Subfamily.SCP.PD 61-230 46 1.9e-56 179.2 In-house 2-162 (163) Show / Hide
Range on Protein: 61-230
Range on HMM: 2-162/163
Sequence Identity: 46% (79 aa)

RKILVLDLDETLIHShhdgvlrpTVRPGTPPDFILKVVIDKHPVRFFVHKRPHVDFFLEVVSQWYELVVFTASMEIYGSAVADKLDNSRSiLKRRYYRQH
.| |||||||||.||        ...| . .||.. | ||.   . .| |||.|| ||. |.. .|.|.||||.. |.. ||| ||...  .|| .|..|
kkclvldldetlvhs--------sfkpvenadfvvpveidgtvhqvyvlkrpfvdeflkkvgelfevvlftaslakyadpvadlldkknv-ikarlfres

CTLELGSYIKDLSVVHSDLSSIVILDNSPGAYRSHPDNAIPIKSWFSDPSDTALLNLLPMLDALRFTADV
    |.|.|||| .  ||...||.|||| .|  |||||.|..|||.|..|| ||.|||.|. |. . || 
cvfhkgnyvkdlsrlGrdlkkvvivdnspasyifhpdnavpveswfddeedtelldllplleelskvedv

Phosphatase CTDNEP1.AA Subfamily.HSPC129.PD 62-231 41 1.3e-44 140.8 In-house 3-164 (164) Show / Hide
Range on Protein: 62-231
Range on HMM: 3-164/164
Sequence Identity: 41% (69 aa)

KILVLDLDETLIHSHhdgvLRPTvrpgTPPDFILKVVIDKHPVRFFVHKRPHVDFFLEVVSQWYELVVFTASMEIYGSAVADKLDNSRSILKRRYYRQHC
|||||||||.|.     |..         . .||. ...  . .|. ||..  ||| ||. .|...|||| ..|   . | || .... | .|.||    
fslvldldetlvhcs----lakl----edatlsfkveyqdktyqvyvrlrpflreflervsklfevilftaskkvyadklldlldpekklvrhrlfrehc

TLELGSYIKDLSVVHSDLSSIVILDNSPGAYRSHPDNAIPIKSWFSDPSDTALLNLLPMLDALRFTADVR
|.||||||..  |||  .|.|||| |.    .| |||.|||.|  |. ||.|||.|..|  . |||    
vcvdgnyikdlsilGrdlsktiivdnspqafayqlenGipieswfadendsellkllpfleklaekedvr

Phosphatase CTDNEP1.AA Group.HAD.PD 61-231 29 2.4e-42 134.2 In-house 1-190 (190) Show / Hide
Range on Protein: 61-231
Range on HMM: 1-190/190
Sequence Identity: 29% (57 aa)

RKILVLDLDETLI-HSHHDGVLRPTVRPGTPPDFILkvviDKHPVRFFVHKR------------PHVDFFLEVVSQWYELVVFTASMEIYGSAVADKLDN
.. ||||||..|. |.....     .. . . ..      . .. |....||            ||.| ||| |...||||||||... | . |....| 
kdtlvlDldgvlwlhgspepleglrskgkvlifltn----natksrlyllkrlallgflveevephldeflervgelyelvvftagtreyadpvvgavdv

SRSILKRRYYRQHCTLELGSYIK------DLSVVHSDLSSIVILDNSPGAYRS--HPDNAIPIKSWFSDPSDTALLNLLPMLDAL--RFTADVR
 . ....|..|..|.   | . .      ||.....||...||.||.| ..    .|.||..|.....|..|..||.|.|.|...  ||. ||.
gdeafsyrklrdacvylkgpgalllatnrdlgalvrdlekvviidnkpsvfafecnpenalmigdfiddildaellglipdlenidvrfgkdvg

Phosphatase CTDNEP1.AA Subfamily.TIM50.PD 108-225 33 1.8e-29 91.7 In-house 26-142 (150) Show / Hide
Range on Protein: 108-225
Range on HMM: 26-142/150
Sequence Identity: 33% (39 aa)

VHKRPHVDFFLEVVSQWYELVVFTASMEIYGSAVADKLDNsRSILKRRYYRQHCTLELGSYIKDLSVVHSDLSSIVILDNSPGAYRSHPDNAIPIKSWFS
..||| ||.||| ... .|.||||..  .. . . ||||  ..... | .|.....  |. .|||| .  ||| ....|  . ... .|.||. .| |  
fkkrPgvdafleelaelfeivvftseqgltaaplidkldP-kqlimyrlfrdatkyvdGehvkdlsklnrdlskvivvdldkesvklqpenalalkkwkG

DPSDTALLNLLPMLDALR
.. |. ||.||..|  . 
naddrelldllaflktia

Phosphatase CTDNEP1.AA Subfamily.FCP1.PD 62-204 27 1.4e-20 63.1 In-house 3-142 (150) Show / Hide
Range on Protein: 62-204
Range on HMM: 3-142/150
Sequence Identity: 27% (40 aa)

KILVLDLDETLIHSHHDGVLrpTVRPgTPPDFILKVVIDKHPVRFFVHKRPHVDFFLEVVSQWYELVVFTASMEIYGSAVADKLDNSRSILKRRYYRQHC
.||.|||.||||. .|  .  .|.  .    | |  . ...  ..|..||..  ||| .|. ||| ..| .   | ...|  || .... ..|   .  .
lvLvvDlDqtlihttkdpti--evke-eklkdikkftlpeekevyyvklRpnlkeFleklsklyelhiytmgtraYaeqiakilDpekklFserilsrde

TLELGSYIKDLSVV-HSDLSSIVILDNSPGAYrSHPDNAIPIKS
|.  | .|.|. .  .. | .||.|.    . .. .| | .|. 
llnassktkklkklfptgdsmvviiDDredvW-nfaenlikvkp

Sequence
Name Sequence Type Origin Length Description Download
CTDNEP1.AA Protein None 244 None Fasta, JSON
CTDNEP1.NA RNA None 732 None Fasta, JSON
CTDNEP1.AA.PD_60-231 Protein Phosphatase Domain None 172 None Fasta, JSON