Gene CTDP1
CTDP1
Classification
Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.
Protein domain
Protein domains of CTDP1.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit phosphatase group/family/subfamily, which is helpful to understand the relationship between phosphatases. Transmembrane region is predicted by TMHMM 2.0. Visualized by pviz.
Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking. View complete domain list.
| Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
|---|---|---|---|---|---|---|---|---|---|
| Phosphatase | CTDP1.AA | CPDc | 181-327 | 31 | 1.1e-64 | 222.15 | SMART | 1-173 (173) | Show / Hide |
Range on Protein: 181-327 Range on HMM: 1-173/173 Sequence Identity: 31% (55 aa) RKLVLMVDLDQTLIHT-----------TEQHCQQMSNKGIFHFQLGRGEPM------------LHTRLRPHCKDFLEKIAKLYELHVFTFGSRLYAHTIA .|..|..|||.||.|. ............. ..||... .| ....|||...||....|.||.|||| |.| ||.... KKKTLVLDLDHTLVHSCMIPTLHHWMKYLRSFKEWTRRDFIWPQLKWF-HMCMIVEIDGHPHQWYVKKRPHVHEFLKRCSKWYEMHVFTMGMRMYADPVL GFLDPEKKLFSHRILSRDECIDPFSKTGN--LRNLFPC-GDSMVCIIDDREDVWKFAP-NLITVKKYVYFQGTG .|||..|.|..|.|.||.| . ..|| . . .|... .|||.||||..|.|.. | |.| .|.. ||.. . DMLDPKRKYFIYRRLYRDHCVYHKGKTYVKDTLSLVNRCDLSMVIIIDDSPDSWPWHPENAIPIKPWFYFMHDT |
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| Phosphatase | CTDP1.AA | Subfamily.FCP1.PD | 181-326 | 59 | 2.6e-67 | 214.8 | In-house | 1-149 (150) | Show / Hide |
Range on Protein: 181-326 Range on HMM: 1-149/150 Sequence Identity: 59% (88 aa) RKLVLMVDLDQTLIHTTEQ---HCQQMSNKGIFHFQLGRGEPMLHTRLRPHCKDFLEKIAKLYELHVFTFGSRLYAHTIAGFLDPEKKLFSHRILSRDEC |||||.|||||||||||.. .......|.| .|.| . . . ...|||..|.||||..||||||..|.|.| ||..|| .|||||||||.|||||||. rklvLvvDlDqtlihttkdptievkeeklkdikkftlpeekevyyvklRpnlkeFleklsklyelhiytmgtraYaeqiakilDpekklFserilsrdel IDPFSKTGNLRNLFPCGDSMVCIIDDREDVWKFAPNLITVKKYVYFQGT ....|||..|..|||.|||||.|||||||||.||.|||.||.|..|.|. lnassktkklkklfptgdsmvviiDDredvWnfaenlikvkpykfFkgv |
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| Phosphatase | CTDP1.AA | Family.FCP.PD | 181-321 | 38 | 7e-40 | 125.6 | In-house | 1-139 (164) | Show / Hide |
Range on Protein: 181-321 Range on HMM: 1-139/164 Sequence Identity: 38% (54 aa) RKLVLMVDLDQTLIHTteQHCQQMSNKGIFHFQLGRGEPMLHTRLRPHCKDFLEKIAKLYELHVFTFGSRLYAHTIAGFLDPEKKLFSHRILsRDECIDP .|..|..|||.||.|. .. .. ... ...... . | .... |||...||||...|||...||...| ||...| .||||||||..|.| ||||. kkklLVlDLdetLvhs--elkpknkpdfvvkveideleetvyvkkRPhldeFLekvselyeiviftastrkyadpvadiLDpekklfkkrll-rdecvlv FSKT-GNLRNLfPCGDSMVCIIDDREDVWKFAP-NLITVKKYV ... .|..| ....|.|.||||..|..|. | |.| ||.. kgnyvkdLskl-grdlskviiiDdspdsyklnpdnaikvksfk |
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| Phosphatase | CTDP1.AA | NIF | 183-328 | 24 | 2.2e-25 | 94.04 | Pfam | 1-164 (189) | Show / Hide |
Range on Protein: 183-328 Range on HMM: 1-164/189 Sequence Identity: 24% (42 aa) LVLMVDLDQTLIHTT--EQHCQQMSNKGIFHFQLGRGEP-MLHTRL-RPHCKDFLEKIAKLYELHVFTFGSRLYAHTIAGFLDPE-KKLF-SHRIL---S ..| ||| ||.|.. .. .. . |..... .|.. .... ||.|..||....|.||....| ... || . ..||. ||.| .|..| . KTLVLDLDETLVHCNPWWEPPN--WHDFIVPIPF-NGQNHQWYVYKPRPYCDEFLQHMSKYYEIVIWTASMKEYADPVIDYIDPKSKKYFDGHHRLICWY RDECI------DPFS-KTGNLRNLFPCG-D-SMVCIIDDREDVWKF-APNLITVKKYVYFQ-----G-TGD |..|. . | .|. |... | | | |.|.. ..| . |.| .. | .. . | REHCWLYRNGGNYYVKK--DLSILWYNRWDLSRVIIVDNSPHSW-LQPDNGIPIPPY-WYGYHDDDDSPDD |
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| Phosphatase | CTDP1.AA | Group.HAD.PD | 183-324 | 25 | 1.5e-24 | 76.1 | In-house | 2-165 (190) | Show / Hide |
Range on Protein: 183-324 Range on HMM: 2-165/190 Sequence Identity: 25% (42 aa) LVLMVDLDQTLI-HTTEQHCQQMSNKGIFHFQLGR--GEPMLHTRLR------------PHCKDFLEKIAKLYELHVFTFGSRLYAHTIAGFLDPEKKLF .|..|||..|. |.. .. ||.....| . . |. . | ||. |||.. .||||.|||.|.| ||....| .|.... || dtlvlDldgvlwlhgspepleglrskgkvlifltnnatksrlyllkrlallgflveevephldeflervgelyelvvftagtreyadpvvgavdvgdeaf SHRILSRDECIDPFsKTGNL-----RNLFPCGDSM-VCIIDDREDVWKF---APNLITVKKYVyFQ .|.| .. .. ....| ... | . |.|||.. .|..| .| . .... . syrklrdacvylkg-pgalllatnrdlgalvrdlekvviidnkpsvfafecnpenalmigdfi-dd |
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| Phosphatase | CTDP1.AA | Subfamily.HSPC129.PD | 183-278 | 36 | 2e-20 | 62.2 | In-house | 3-95 (164) | Show / Hide |
Range on Protein: 183-278 Range on HMM: 3-95/164 Sequence Identity: 36% (34 aa) LVLMVDLDQTLIHTTEQHCQQMSNKGIFHFQlgRGEPMLHTRLRPHCKDFLEKIAKLYELHVFTFGSRLYAHTIAGFLDPEKKLFSHRiLSRDECI |..|||.||.|.. .. .. . . . ..| . .. ||||. ..|||...||.|. .|| ..||. . .|||||||. ||| |. |. fslvldldetlvhcslakledatlsfkveyq--dktyqvyvrlrpflreflervsklfevilftaskkvyadklldlldpekklvrhr-lfrehcv |
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| Phosphatase | CTDP1.AA | Subfamily.DULLARD.PD | 183-321 | 26 | 3.2e-18 | 54.9 | In-house | 3-147 (172) | Show / Hide |
Range on Protein: 183-321 Range on HMM: 3-147/172 Sequence Identity: 26% (38 aa) LVLMVDLDQTLIHTTEQHCQQMSNKG----IFHFQLGR-G-EPMLHTRLRPHCKDFLEKIAKLYELHVFTFGSRLYAHTIAGFLDPEKKLFSHRILsRDE .|..|||.||||..... .. ..| |.... . ... |||. ||....| |.| .|| . . ||.... .|| .......| |..| ktlvldldetlihsahdsvtkstvkegtapdfklkvlierepvlfyvykrPhvdlfldvvskWydlviftasmeeyaaavvdkldsgrgilkrryy-rqh CIDPFSK-TGNLRNLFPcGDSMVCIIDDREDVW-KFAPNLITVKKYV . ..| | .| . . | |.|.|. . |.. | |..| .. Ctlesgkytkdlslvse-dlssviilDnspvayrknpdnaipikswi |
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| Phosphatase | CTDP1.AA | Subfamily.SCP.PD | 182-313 | 26 | 1.8e-15 | 45.9 | In-house | 2-129 (163) | Show / Hide |
Range on Protein: 182-313 Range on HMM: 2-129/163 Sequence Identity: 26% (35 aa) KLVLMVDLDQTLIHTTEQHCQQmsNKGIFHFQLGRGEPMLHTRLRPHCKDFLEKIAKLYELHVFTFGSRLYAHTIAGFLDPEKkLFSHRiLSRDECIdpF | |..|||.||.|.. . .. . .. .. . .. ||. ..||.|...|.|. .|| ||. .| .||... ...| | |..|. | kkclvldldetlvhssfkpven--adfvvpveidgtvhqvyvlkrpfvdeflkkvgelfevvlftaslakyadpvadlldkkn-vikar-lfrescv--f SKTGNLRNLFPCGDSM--VCIIDDREDVWKFAPN |. ...| | . | |.|. . | |. hkgnyvkdlsrlGrdlkkvvivdnspasyifhpd |
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| BRCT | CTDP1.AA | BRCT | 631-718 | 13 | 7.6e-10 | 39.95 | SMART | 1-93 (93) | Show / Hide |
Range on Protein: 631-718 Range on HMM: 1-93/93 Sequence Identity: 13% (13 aa) SKVLADVAIIFSGLHPTNFPIEKTREHYHATALGAKILTRLVLSPD--APDRATHLIAARAGTEKVLQ---------AQECGHLHVVNPDWLWSCLERW .|..... . ..| .... ... . . . . . . . ...||.|. .....|. . . . ....|.|||.| |...| MKPFKGCTFCITG-DDIEGNFD-M-RDELKEMIEMHGGKVT-SVSRKRC-PDTTHVIC-SPENPKYETWNRMMTKYMKAIAWGIWIVHPDWIWDCIKKW |
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| Phosphatase | CTDP1.AA | Subfamily.TIM50.PD | 223-320 | 29 | 1.1e-07 | 20.9 | In-house | 26-122 (150) | Show / Hide |
Range on Protein: 223-320 Range on HMM: 26-122/150 Sequence Identity: 29% (29 aa) TRLRPHCKDFLEKIAKLYELHVFTFGSRLYAHTIAGFLDPeKKLFSHRILSRDECIDPFSKTGNLRNLFPcGDSMVCIIDDREDVWKFAP-NLITVKKY .. || . |||..|.|.|. ||| . |.|. . ||| |.| ..|.. ... .| .| | | ..| .. |. || ...||. fkkrPgvdafleelaelfeivvftseqgltaaplidkldP-kqlimyrlfrdatkyvdGehvkdlsklnr-dlskvivvdldkesvklqpenalalkkw |
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| FCP1_C | CTDP1.AA | FCP1_C | 716-961 | 66 | 3.9e-175 | 592.92 | Pfam | 1-295 (295) | Show / Hide |
Range on Protein: 716-961
Range on HMM: 1-295/295
Sequence Identity: 66% (195 aa)
ERWDKVEEQLFPLRDDHTKAQRENSPAAFPDREGVPPTALFHPMPVLPKA-QPGPEVRIYDSNTGKLIRTGARGP-PAP------SSSLPIRQEPSSFRA
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ERWEKVEEQLFPLKDDYMKKQRDNSPAAFHDRHGVLQTRLFHPMPIHPKAAQPGPEVRIYDPVTGKLIRMGPQASAPAPYFHAPGPSSLPDHGEPSCFRA
VPPPQPQMFG--EELPDAQDGEQPGPSRRKRQPSMSETMPLYTLCKEDLESMDKEVDDILGEGSD-DSDSEKRRP----EEQEEEPQPRK---PGTRRER
|.|.|||||. ||.||.||.|||||||||||||||||||||||||||||||||||||||||||| ||||||..| ||||...|.|| ||.|||
VQPHQPQMFDDEEEAPDSQDDEQPGPSRRKRQPSMSETMPLYTLCKEDLESMDKEVDDILGEGSDNDSDSEKKKPPDNEEEQEQQQQQRKQQNPGERREQ
-----------------TLGAPASSERSAAGGRGPRGHKRKLNEE---------DAASE----SSRESSNEDE-GSSSEADEMAKALEAELNDLM
..|.|||||..|.||||||||||||| ||.|| ||.||||||| ||||||||||.||||||||.|
GPVEVKCRTSGPQALGLDERTPSSSERSNIGMRGPRGHKRKLNEEDEEEEEGRADAESEDSSDSSKESSNEDEEGSSSEADEMAAALEAELNDFM
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| BRCT | CTDP1.AA | BRCT | 660-715 | 24 | 4e-06 | 25.56 | Pfam | 30-84 (84) | Show / Hide |
Range on Protein: 660-715 Range on HMM: 30-84/84 Sequence Identity: 24% (15 aa) ATALGAKILTRLVLSPDAPDRATHLI--AARA---GTEK-VLQAQECGHLHVVNPDWLWSCL . ..|.|. ... .. ||.| . . .|.| ...|.| . ...|.|||.| |. IEKHGGKV------TDSVSKQTTHVIPWVGEPHCTRTKKFYWKAKEWN-IPIVHPDWIWDCI |
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