• Phosphatome.Net

Gene CTDSPL2

CTDSPL2
Species: Human
Alias: HSPC058, HSPC129, CTDSPL2
External Links: COSMIC , Entrez Gene
Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Superfamily: HAD
Family: FCP
Subfamily: HSPC129
Protein domain

Protein domains of CTDSPL2.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit phosphatase group/family/subfamily, which is helpful to understand the relationship between phosphatases. Transmembrane region is predicted by TMHMM 2.0. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking. View complete domain list.

Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Phosphatase CTDSPL2.AA Subfamily.HSPC129.PD 286-450 81 8e-97 310.8 In-house 1-164 (164) Show / Hide 
Range on Protein: 286-450
Range on HMM: 1-164/164
Sequence Identity: 81% (135 aa)

PEFSLVLDLDETLVHCSLNELEDAALTFPVLFQDVIYQVYVRLRPFFREFLERMSQMYEIILFTASKKVYADKLLNILDPKKQLVRHRLFREHCVCVQGN
||||||||||||||||||..||||.|.|.| .||..||||||||||.||||||.|...|.|||||||||||||||..|||.|.||||||||||||||.||
pefslvldldetlvhcslakledatlsfkveyqdktyqvyvrlrpflreflervsklfevilftaskkvyadklldlldpekklvrhrlfrehcvcvdgn

YIKDLNILGRDLSKTIIIDNSPQAFAYQLSNGIPIESWFMDKNDNELLKLIPFLEKLVELnEDVR
|||||.|||||||||||.|||||||||||.|||||||||.|.||.|||||.||||||.|. ||||
yikdlsilGrdlsktiivdnspqafayqlenGipieswfadendsellkllpfleklaek-edvr
Phosphatase CTDSPL2.AA NIF 288-450 44 1.2e-81 282.33 Pfam 1-189 (189) Show / Hide 
Range on Protein: 288-450
Range on HMM: 1-189/189
Sequence Identity: 44% (85 aa)

FSLVLDLDETLVHCS--LNELEDAALTFPVLFQDVIYQVYVRL-RPFFREFLERMSQMYEIILFTASKKVYADKLLNILDPK-KQLV--RHRL---FREH
. ||||||||||||.   .. .    ..|. |.. ..|.||.. ||. .|||..||..|||...|||.|.|||......||| |...  .|||   .|||
KTLVLDLDETLVHCNPWWEPPNWHDFIVPIPFNGQNHQWYVYKPRPYCDEFLQHMSKYYEIVIWTASMKEYADPVIDYIDPKSKKYFDGHHRLICWYREH

CV-CVQG-NY-I-KDLNIL--GR-DLSKTIIIDNSPQAFAYQLSNGIPIES-WFM-----D-KND--NELLKLIPFL-EKLV-ELNEDVR
|. ...| || . |||.||  .| |||..||.||||... .| .|||||.. |.      | ..|  ||||.|.||| |.|. .  .|||
CWLYRNGGNYYVKKDLSILWYNRWDLSRVIIVDNSPHSW-LQPDNGIPIPPYWYGYHDDDDSPDDFWNELLDLLPFLIEYLALQCLDDVR
Phosphatase CTDSPL2.AA CPDc 286-430 36 9.3e-74 252.27 SMART 1-173 (173) Show / Hide 
Range on Protein: 286-430
Range on HMM: 1-173/173
Sequence Identity: 36% (64 aa)

PEFSLVLDLDETLVHC--------------SLNELEDAALTFP----------VLFQDVIYQVYVRLRPFFREFLERMSQMYEIILFTASKKVYADKLLN
. ..||||||.||||.              |..|   .  ..|          | ... ..|.||..||. .|||.|.|..||...||.....|||..|.
KKKTLVLDLDHTLVHSCMIPTLHHWMKYLRSFKEWTRRDFIWPQLKWFHMCMIVEIDGHPHQWYVKKRPHVHEFLKRCSKWYEMHVFTMGMRMYADPVLD

ILDPKK-QLVRHRLFREHCVCVQGN-YIKD-LNILGR-DLSKTIIIDNSPQAFAYQLSNGIPIESWFMDKNDN
.||||.  . ..||.|.|||...|. |.|| |....| |||..||||.||...... .|.|||..|| ...|.
MLDPKRKYFIYRRLYRDHCVYHKGKTYVKDTLSLVNRCDLSMVIIIDDSPDSWPWHPENAIPIKPWFYFMHDT
Phosphatase CTDSPL2.AA Subfamily.SCP.PD 289-446 49 2e-68 218.3 In-house 4-160 (163) Show / Hide 
Range on Protein: 289-446
Range on HMM: 4-160/163
Sequence Identity: 49% (78 aa)

SLVLDLDETLVHCSLNELEDAALTFPVLFQDVIYQVYVRLRPFFREFLERMSQMYEIILFTASKKVYADKLLNILDPKKqLVRHRLFREHCVCVQGNYIK
.|||||||||||.|.. .|.| ...|| ......||||  |||. |||.......|..||||| . |||.....||.|.  ...|||||.||..|||.||
clvldldetlvhssfkpvenadfvvpveidgtvhqvyvlkrpfvdeflkkvgelfevvlftaslakyadpvadlldkkn-vikarlfrescvfhkgnyvk

DLNILGRDLSKTIIIDNSPQAFAYQLSNGIPIESWFMDKNDNELLKLIPFLEKLVELN
|. |||||.|..|.||||......  |..|.|||| |..|.|||.|.|.||.| . . 
dlsrlGrdlkkvvivdnspasyifhpdnavpveswfddeedtelldllplleelskve
Phosphatase CTDSPL2.AA Family.FCP.PD 288-450 50 3e-62 198.6 In-house 3-164 (164) Show / Hide 
Range on Protein: 288-450
Range on HMM: 3-164/164
Sequence Identity: 50% (82 aa)

FSLVLDLDETLVHCSLNELEDAALTFPVLFQDVIYQVYVRLRPFFREFLERMSQMYEIILFTASKKVYADKLLNILDPKKQLVRHRLFREHCVCVQGNYI
|||||||||||..|.. ... ....| ....  .|||. ||...||||..|..|||..||||.. |||....||||.|.|...||.|..||.|.|||.||
klLVlDLdetLvhselkpknkpdfvvkveideleetvyvkkRPhldeFLekvselyeiviftastrkyadpvadiLDpekklfkkrllrdecvlvkgnyv

KDLNILGRDLSKTIIIDNSPQAFAYQLSNGIPIESWFMDKNDNELLKLIPFLEKLVELnEDVR
|..|||||||.||||.||...... .|.|...|.. |..|.|||.|.||||.| .  ||||  
kdLsklgrdlskviiiDdspdsyklnpdnaikvksfkedpkDteLldLlpfleslake-edvr
Phosphatase CTDSPL2.AA Subfamily.DULLARD.PD 289-450 39 7.8e-48 151.5 In-house 4-172 (172) Show / Hide 
Range on Protein: 289-450
Range on HMM: 4-172/172
Sequence Identity: 39% (66 aa)

SLVLDLDETLVHC--------SLNELEDAALTFPVLFQDVIYQVYVRLRPFFREFLERMSQMYEIILFTASKKVYADKLLNILDPKKQLVRHRLFREHCV
|||||||||.|         ...|     ... || ..   ..||  ||.  .||...|. |....|||| ..||..... ||  ......|..|.||. 
tlvldldetlihsahdsvtkstvkegtapdfklkvlierepvlfyvykrPhvdlfldvvskWydlviftasmeeyaaavvdkldsgrgilkrryyrqhCt

CVQGNYIKDLNILGRDLSKTIIIDNSPQAFAYQLSNGIPIESWFMDKNDNELLKLIPFLEKLvELNEDVR
 .|.|.||| ..  |||..||.||||.|.. .. |.|||.||..| .|..||.|.|||. |    .||| 
lesgkytkdlslvsedlssviilDnspvayrknpdnaipikswisdpsdtallnllPfldal-rftkdvr
Phosphatase CTDSPL2.AA Group.HAD.PD 289-444 34 2.4e-42 134.4 In-house 3-183 (190) Show / Hide 
Range on Protein: 289-444
Range on HMM: 3-183/190
Sequence Identity: 34% (61 aa)

SLVLDLDETLV-HCSLNELEDAALTFPVLFQDVI----YQVYVRLR------------PFFREFLERMSQMYEIILFTASKKVYADKLLNILDPKKQLVR
.||||||..|. |.| . || ..   .||... .     ..|.. |            |. .|||||....||...|||. . ||| .....|. ....|
tlvlDldgvlwlhgspepleglrskgkvlifltnnatksrlyllkrlallgflveevephldeflervgelyelvvftagtreyadpvvgavdvgdeafs

HRLFREHCVCVQGNYIK------DLNILGRDLSKTIIIDNSPQAFAY--QLSNGIPIESWFMDKNDNELLKLIPFLEKLVE
..|..||...|.. .      ||. |.|||.|..||||.|..||   . .|...|.... | .| |||.|||.||....  
yrklrdacvylkgpgalllatnrdlgalvrdlekvviidnkpsvfafecnpenalmigdfiddildaellglipdlenidv
Phosphatase CTDSPL2.AA Subfamily.TIM50.PD 326-450 38 7.1e-33 102.9 In-house 26-150 (150) Show / Hide 
Range on Protein: 326-450
Range on HMM: 26-150/150
Sequence Identity: 38% (48 aa)

VRLRPFFREFLERMSQMYEIILFTASKKVYADKLLNILDPkKQLVRHRLFREHCVCVQGNYIKDLNILGRDLSKTIIIDNSPQAFAYQLSNGIPIESWFM
.. ||.   |||......||..||... ..| .|.. ||| |||...||||...  |.|. .|||. | ||||| |..|  ....  | .|. .. |  .
fkkrPgvdafleelaelfeivvftseqgltaaplidkldP-kqlimyrlfrdatkyvdGehvkdlsklnrdlskvivvdldkesvklqpenalalkkwkG

DKNDNELLKLIPFLEKLVELN-EDVR
..|.|||.|..||..... . |||| 
naddrelldllaflktiatsevedvr
Phosphatase CTDSPL2.AA Subfamily.FCP1.PD 288-413 28 2.5e-22 68.9 In-house 3-134 (150) Show / Hide 
Range on Protein: 288-413
Range on HMM: 3-134/150
Sequence Identity: 28% (38 aa)

FSLVLDLDETLVHCSLN-ELEDAA------LTFPVlfQDVIYQVYVRLRPFFREFLERMSQMYEIILFTASKKVYADKLLNILDPKKQLVRHRLF-REHC
. ||.|||.||.|.. . ..|  .       .| .  .      ||.|||  .||||..|..||. ..| ... ||... .||||.|.|  .|.  |. .
lvLvvDlDqtlihttkdptievkeeklkdikkftl--peekevyyvklRpnlkeFleklsklyelhiytmgtraYaeqiakilDpekklFserilsrdel

VCVQGNYIKDLNILGRDLSKTIIIDNSPQAFAYQ
.  . .  |  ... .. |  .|||.  . . ..
lnassktkklkklfptgdsmvviiDDredvWnfa
Sequence
Name Sequence Type Origin Length Description Download
CTDSPL2.AA Protein None 466 None Fasta, JSON
CTDSPL2.NA RNA None 1398 None Fasta, JSON
CTDSPL2.AA.PD_286-450 Protein Phosphatase Domain None 165 None Fasta, JSON