Gene CTDSP2
CTDSP2
Species: Human
Alias: NSL-TP, NLTP, SCPX, DKFZp686C12188, SCP2, DKFZp686D11188
External Links:
COSMIC
,
Entrez Gene
Classification
Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.
Protein domain
Protein domains of SCP2.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit phosphatase group/family/subfamily, which is helpful to understand the relationship between phosphatases. Transmembrane region is predicted by TMHMM 2.0. Visualized by pviz.
Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking. View complete domain list.
| Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
|---|---|---|---|---|---|---|---|---|---|
| Phosphatase | SCP2.AA | CPDc | 100-243 | 42 | 2e-76 | 261.12 | SMART | 1-173 (173) | Show / Hide |
Range on Protein: 100-243 Range on HMM: 1-173/173 Sequence Identity: 42% (74 aa) GRICVVIDLDETLVHS--------------SFKPINNADFIVP----------IEIEGTTHQVYVLKRPYVDEFLRRMGELFECVLFTASLAKYADPVTD .. ..|.|||.||||| |||. ...|||.| .||.|..||.||.|||.|.||| |.....|...||... .||||| | KKKTLVLDLDHTLVHSCMIPTLHHWMKYLRSFKEWTRRDFIWPQLKWFHMCMIVEIDGHPHQWYVKKRPHVHEFLKRCSKWYEMHVFTMGMRMYADPVLD LLD-RC-GVFRARLFRESCVFHQGC-YVKD-LSRLGR-DLRKTLILDNSPASYIFHPENAVPVQSWFDDMADT .|| .....||.|..||.|.| |||| ||...| ||....|.|.||.|. .|||||.|. .||..| || MLDPKRKYFIYRRLYRDHCVYHKGKTYVKDTLSLVNRCDLSMVIIIDDSPDSWPWHPENAIPIKPWFYFMHDT |
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| Phosphatase | SCP2.AA | Subfamily.SCP.PD | 101-262 | 76 | 5.8e-94 | 301.3 | In-house | 2-163 (163) | Show / Hide |
Range on Protein: 101-262 Range on HMM: 2-163/163 Sequence Identity: 76% (124 aa) RICVVIDLDETLVHSSFKPINNADFIVPIEIEGTTHQVYVLKRPYVDEFLRRMGELFECVLFTASLAKYADPVTDLLDRCGVFRARLFRESCVFHQGCYV ..|.|.|||||||||||||..||||.||.||.||.|||||||||.|||||...|||||.||||||||||||||.||||...|..|||||||||||.|.|| kkclvldldetlvhssfkpvenadfvvpveidgtvhqvyvlkrpfvdeflkkvgelfevvlftaslakyadpvadlldkknvikarlfrescvfhkgnyv KDLSRLGRDLRKTLILDNSPASYIFHPENAVPVQSWFDDMADTELLNLIPIFEELSGAEDVY ||||||||||.|..|.|||||||||||.|||||.|||||. |||||.|.|..|||| .|||. kdlsrlGrdlkkvvivdnspasyifhpdnavpveswfddeedtelldllplleelskvedvl |
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| Phosphatase | SCP2.AA | NIF | 102-262 | 42 | 1.8e-79 | 275.11 | Pfam | 1-189 (189) | Show / Hide |
Range on Protein: 102-262 Range on HMM: 1-189/189 Sequence Identity: 42% (81 aa) ICVVIDLDETLVHSS--FKPINNADFIVPIEIEGTTHQVYVLK-RPYVDEFLRRMGELFECVLFTASLAKYADPVTDLLDR--CGVF--RARL---FRES ...|.||||||||.. ..| |. |||||| ..| .||.|| | |||.||||..| ...| |..|||. .||||| | .|. ..| . || .||. KTLVLDLDETLVHCNPWWEPPNWHDFIVPIPFNGQNHQWYVYKPRPYCDEFLQHMSKYYEIVIWTASMKEYADPVIDYIDPKSKKYFDGHHRLICWYREH CV-FHQG-CY-V-KDLSRL--GR-DLRKTLILDNSPASYIFHPENAVPVQS-WFD-----D-MAD--TELLNLIPIF-EELS-GA-EDVY |. . .| | | ||||.| .| ||....|.|||| |. ..|.|..|... |.. | | .|||.|.|.. |.|. .. .|| CWLYRNGGNYYVKKDLSILWYNRWDLSRVIIVDNSPHSW-LQPDNGIPIPPYWYGYHDDDDSPDDFWNELLDLLPFLIEYLALQCLDDVR |
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| Phosphatase | SCP2.AA | Family.FCP.PD | 101-261 | 54 | 2.5e-65 | 208.6 | In-house | 2-163 (164) | Show / Hide |
Range on Protein: 101-261 Range on HMM: 2-163/164 Sequence Identity: 54% (88 aa) RICVVIDLDETLVHSSFKPINNADFIVPIEIEGTTHQVYVLKRPYVDEFLRRMGELFECVLFTASLAKYADPVTDLLDR-CGVFRARLFRESCVFHQGCY ....|.|||||||||..|| |..||.|..||......|||.|||..||||....||.|.|.|||| .||||||.|.||. ..|..||.|..||...| | kklLVlDLdetLvhselkpknkpdfvvkveideleetvyvkkRPhldeFLekvselyeiviftastrkyadpvadiLDpekklfkkrllrdecvlvkgny VKDLSRLGRDLRKTLILDNSPASYIFHPENAVPVQSWFDDMADTELLNLIPIFEELSGAEDV |||||.||||| |..|.|.||.|| ..|.||..|.|...|. |||||.|.|..|.|. ||| vkdLsklgrdlskviiiDdspdsyklnpdnaikvksfkedpkDteLldLlpfleslakeedv |
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| Phosphatase | SCP2.AA | Subfamily.HSPC129.PD | 101-261 | 50 | 2.1e-56 | 179.3 | In-house | 2-163 (164) | Show / Hide |
Range on Protein: 101-261 Range on HMM: 2-163/164 Sequence Identity: 50% (82 aa) RICVVIDLDETLVHSSFKPINNADFIVPIEIEGTTHQVYVLKRPYVDEFLRRMGELFECVLFTASLAKYADPVTDLLDRC-GVFRARLFRESCVFHQGCY . ..|.||||||||.|......| . ..| . .|.|||| ||.. |||.|. .||| .||||| ||| . |||| .| ||||| || .| | efslvldldetlvhcslakledatlsfkveyqdktyqvyvrlrpflreflervsklfevilftaskkvyadklldlldpekklvrhrlfrehcvcvdgny VKDLSRLGRDLRKTLILDNSPASYIFHPENAVPVQSWFDDMADTELLNLIPIFEELSGAEDV .|||| ||||| ||.|.|||| .. . || .|..|||.| |.|||.|.|..|.| ||| ikdlsilGrdlsktiivdnspqafayqlenGipieswfadendsellkllpfleklaekedv |
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| Phosphatase | SCP2.AA | Subfamily.DULLARD.PD | 103-261 | 41 | 5e-51 | 161.9 | In-house | 4-171 (172) | Show / Hide |
Range on Protein: 103-261 Range on HMM: 4-171/172 Sequence Identity: 41% (70 aa) CVVIDLDETLVHS--------SFKPINNADFIVPIEIEGTTHQVYVLKRPYVDEFLRRMGELFECVLFTASLAKYADPVTDLLDR-CGVFRARLFRESCV .|.||||||.|| . |. . ||.. . || . ..|| |||.||.|| .. . .. |.||||. .||..|.| ||. |... |..|..|. tlvldldetlihsahdsvtkstvkegtapdfklkvlierepvlfyvykrPhvdlfldvvskWydlviftasmeeyaaavvdkldsgrgilkrryyrqhCt FHQGCYVKDLSRLGRDLRKTLILDNSPASYIFHPENAVPVQSWFDDMADTELLNLIPIFEELSGAEDV ..| |.|||| . || ...|||||| .| .|.||.|..||. | ||.||||.|... | ..|| lesgkytkdlslvsedlssviilDnspvayrknpdnaipikswisdpsdtallnllPfldalrftkdv |
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| Phosphatase | SCP2.AA | Group.HAD.PD | 103-256 | 36 | 3e-49 | 156.9 | In-house | 3-182 (190) | Show / Hide |
Range on Protein: 103-256 Range on HMM: 3-182/190 Sequence Identity: 36% (66 aa) CVVIDLDETLV-HSSFKPINNADFIVPIEIEGTT----HQVYVLKR------------PYVDEFLRRMGELFECVLFTASLAKYADPVTDLLDR-CGVFR ..|.|||..|. |.|..|...... .. .|. |. ...|.||| |..|||| |.|||.|.|.|||.. .||||| . .| ..|. tlvlDldgvlwlhgspepleglrskgkvlifltnnatksrlyllkrlallgflveevephldeflervgelyelvvftagtreyadpvvgavdvgdeafs ARLFRESCVFHQGCYVK------DLSRLGRDLRKTLILDNSPASYIF--HPENAVPVQSWFDDMADTELLNLIPIFEELS .|..|..||...|.... ||. |.||| |. |.||.|....| .||||... ...||. |.|||.||| .|... yrklrdacvylkgpgalllatnrdlgalvrdlekvviidnkpsvfafecnpenalmigdfiddildaellglipdlenid |
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| Phosphatase | SCP2.AA | Subfamily.TIM50.PD | 138-256 | 39 | 9e-31 | 96.1 | In-house | 24-142 (150) | Show / Hide |
Range on Protein: 138-256 Range on HMM: 24-142/150 Sequence Identity: 39% (46 aa) VYVLKRPYVDEFLRRMGELFECVLFTASLAKYADPVTDLLDRCGVFRARLFRESCVFHQGCYVKDLSRLGRDLRKTLILDNSPASYIFHPENAVPVQSWF . ||| || || ...|||| |.||.. . .| |. | || .. . ||||... . .| ||||| | |||.| ...| ..|. ..||||. .. | . wrfkkrPgvdafleelaelfeivvftseqgltaaplidkldPkqlimyrlfrdatkyvdGehvkdlsklnrdlskvivvdldkesvklqpenalalkkwk DDMADTELLNLIPIFEELS ..|.|||.|..... .. Gnaddrelldllaflktia |
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| Phosphatase | SCP2.AA | Subfamily.FCP1.PD | 102-223 | 24 | 1.1e-14 | 44.2 | In-house | 3-131 (150) | Show / Hide |
Range on Protein: 102-223 Range on HMM: 3-131/150 Sequence Identity: 24% (30 aa) ICVVIDLDETLVHSSFKPI-----NNADFIVPIEIEGTTHQVYVLKRPYVDEFLRRMGELFECVLFTASLAKYADPVTDLLDRCG-VFRARLFRESCVFH ...|.|||.||.|.. .|. .. | ... . . || .||.. |||... .|.| ..| . .||. .. .|| . .| |..... . lvLvvDlDqtlihttkdptievkeeklkdikkftlpeekevyyvklRpnlkeFleklsklyelhiytmgtraYaeqiakilDpekklFserilsrdelln QGCYVKDLSRL-GRDLRKTLILDNSPASY |.|..| .. .|.|. . . assktkklkklfptgdsmvviiDDredvW |
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