Gene CTDSPL
CTDSPL
Classification
Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.
Protein domain
Protein domains of CTDSPL.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit phosphatase group/family/subfamily, which is helpful to understand the relationship between phosphatases. Transmembrane region is predicted by TMHMM 2.0. Visualized by pviz.
Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking. View complete domain list.
| Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
|---|---|---|---|---|---|---|---|---|---|
| Phosphatase | CTDSPL.AA | CPDc | 105-248 | 46 | 3.5e-82 | 280.24 | SMART | 1-173 (173) | Show / Hide |
Range on Protein: 105-248 Range on HMM: 1-173/173 Sequence Identity: 46% (81 aa) GKKCVVIDLDETLVHS--------------SFKPISNADFIVP----------VEIDGTIHQVYVLKRPHVDEFLQRMGQLFECVLFTASLAKYADPVAD .||..|.|||.||||| |||. ...|||.| |||||..||.||.|||||.|||.|.....|...||... .|||||.| KKKTLVLDLDHTLVHSCMIPTLHHWMKYLRSFKEWTRRDFIWPQLKWFHMCMIVEIDGHPHQWYVKKRPHVHEFLKRCSKWYEMHVFTMGMRMYADPVLD LLD-RW-GVFRARLFRESCVFHRGN-YVKD-LSRLGR-ELSKVIIVDNSPASYIFHPENAVPVQSWFDDMTDT .|| . .....||.|..||.|.|. |||| ||...| .||.|||.|.||.|. .|||||.|. .||..| || MLDPKRKYFIYRRLYRDHCVYHKGKTYVKDTLSLVNRCDLSMVIIIDDSPDSWPWHPENAIPIKPWFYFMHDT |
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| Phosphatase | CTDSPL.AA | Subfamily.SCP.PD | 106-267 | 79 | 3.5e-97 | 311.8 | In-house | 2-163 (163) | Show / Hide |
Range on Protein: 106-267 Range on HMM: 2-163/163 Sequence Identity: 79% (129 aa) KKCVVIDLDETLVHSSFKPISNADFIVPVEIDGTIHQVYVLKRPHVDEFLQRMGQLFECVLFTASLAKYADPVADLLDRWGVFRARLFRESCVFHRGNYV |||.|.|||||||||||||..||||.||||||||.|||||||||.|||||...|.|||.|||||||||||||||||||...|..|||||||||||.|||| kkclvldldetlvhssfkpvenadfvvpveidgtvhqvyvlkrpfvdeflkkvgelfevvlftaslakyadpvadlldkknvikarlfrescvfhkgnyv KDLSRLGRELSKVIIVDNSPASYIFHPENAVPVQSWFDDMTDTELLDLIPFFEGLSREDDVY ||||||||.|.||.|||||||||||||.|||||.|||||..|||||||.|..| ||...||. kdlsrlGrdlkkvvivdnspasyifhpdnavpveswfddeedtelldllplleelskvedvl |
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| Phosphatase | CTDSPL.AA | NIF | 107-267 | 45 | 1.4e-80 | 278.77 | Pfam | 1-189 (189) | Show / Hide |
Range on Protein: 107-267 Range on HMM: 1-189/189 Sequence Identity: 45% (87 aa) KCVVIDLDETLVHSS--FKPISNADFIVPVEIDGTIHQVYVLK-RPHVDEFLQRMGQLFECVLFTASLAKYADPVADLLDR--WGVF--RARL---FRES |..|.||||||||.. ..| .. |||||. ..| .||.|| | ||..|||||.| ...| |..|||. .||||| | .|. ..| . || .||. KTLVLDLDETLVHCNPWWEPPNWHDFIVPIPFNGQNHQWYVYKPRPYCDEFLQHMSKYYEIVIWTASMKEYADPVIDYIDPKSKKYFDGHHRLICWYREH CV-FHRG-NY-V-KDLSRL--GR-ELSKVIIVDNSPASYIFHPENAVPVQS-WFD-----D-MTD--TELLDLIPFF-EGLS-RE-DDVY |. . .| || | ||||.| .| ||.|||||||| |. ..|.|..|... |.. | | .|||||.||. | |. .. ||| CWLYRNGGNYYVKKDLSILWYNRWDLSRVIIVDNSPHSW-LQPDNGIPIPPYWYGYHDDDDSPDDFWNELLDLLPFLIEYLALQCLDDVR |
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| Phosphatase | CTDSPL.AA | Family.FCP.PD | 106-266 | 59 | 3.7e-70 | 224.3 | In-house | 2-163 (164) | Show / Hide |
Range on Protein: 106-266 Range on HMM: 2-163/164 Sequence Identity: 59% (97 aa) KKCVVIDLDETLVHSSFKPISNADFIVPVEIDGTIHQVYVLKRPHVDEFLQRMGQLFECVLFTASLAKYADPVADLLDR-WGVFRARLFRESCVFHRGNY ||..|.|||||||||..|| ...||.|.||||.. ..|||.||||.||||.....|.|.|.|||| .||||||||.||. ...|..||.|..||...||| kklLVlDLdetLvhselkpknkpdfvvkveideleetvyvkkRPhldeFLekvselyeiviftastrkyadpvadiLDpekklfkkrllrdecvlvkgny VKDLSRLGRELSKVIIVDNSPASYIFHPENAVPVQSWFDDMTDTELLDLIPFFEGLSREDDV |||||.|||.||||||.|.||.|| ..|.||..|.|...|..|||||||.||.|.|..|.|| vkdLsklgrdlskviiiDdspdsyklnpdnaikvksfkedpkDteLldLlpfleslakeedv |
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| Phosphatase | CTDSPL.AA | Subfamily.HSPC129.PD | 107-266 | 52 | 8.4e-57 | 180.6 | In-house | 3-163 (164) | Show / Hide |
Range on Protein: 107-266 Range on HMM: 3-163/164 Sequence Identity: 52% (84 aa) KCVVIDLDETLVHSSFKPISNADFIVPVEIDGTIHQVYVLKRPHVDEFLQRMGQLFECVLFTASLAKYADPVADLLDRW-GVFRARLFRESCVFHRGNYV ..|.||||||||.|.... .| . .|| . ...|||| ||.. |||.|. .||| .||||| ||| . |||| .| ||||| || |||.| fslvldldetlvhcslakledatlsfkveyqdktyqvyvrlrpflreflervsklfevilftaskkvyadklldlldpekklvrhrlfrehcvcvdgnyi KDLSRLGRELSKVIIVDNSPASYIFHPENAVPVQSWFDDMTDTELLDLIPFFEGLSREDDV ||| |||.||| ||||||| .. . || .|..|||.| .|.|||.|.||.| | ...|| kdlsilGrdlsktiivdnspqafayqlenGipieswfadendsellkllpfleklaekedv |
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| Phosphatase | CTDSPL.AA | Group.HAD.PD | 106-263 | 37 | 2.2e-54 | 173.6 | In-house | 1-184 (190) | Show / Hide |
Range on Protein: 106-263 Range on HMM: 1-184/190 Sequence Identity: 37% (68 aa) KKCVVIDLDETLV-HSSFKPISNADFIVPVEIDGTI----HQVYVLKR------------PHVDEFLQRMGQLFECVLFTASLAKYADPVADLLDRW-GV |...|.|||..|. |.|..|...... ..|.|. |. ...|.||| ||.||||.|.|.|.|.|.|||.. .|||||.. .| ...| kdtlvlDldgvlwlhgspepleglrskgkvlifltnnatksrlyllkrlallgflveevephldeflervgelyelvvftagtreyadpvvgavdvgdea FRARLFRESCVFHRGNYVK------DLSRLGRELSKVIIVDNSPASYIF--HPENAVPVQSWFDDMTDTELLDLIPFFEGLSRE ..|..|..||...|.... ||. |.|.|.||.|.||.|....| .||||... ...||. |.|||.|||..| .. fsyrklrdacvylkgpgalllatnrdlgalvrdlekvviidnkpsvfafecnpenalmigdfiddildaellglipdlenidvr |
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| Phosphatase | CTDSPL.AA | Subfamily.DULLARD.PD | 106-266 | 43 | 7.2e-54 | 171.1 | In-house | 2-171 (172) | Show / Hide |
Range on Protein: 106-266 Range on HMM: 2-171/172 Sequence Identity: 43% (73 aa) KKCVVIDLDETLVHS--------SFKPISNADFIVPVEIDGTIHQVYVLKRPHVDEFLQRMGQLFECVLFTASLAKYADPVADLLDR-WGVFRARLFRES .| .|.||||||.|| . |. . ||.. | |. . ..|| ||||||.||... . .. |.||||. .||..|.| ||.|... |..|..|. rktlvldldetlihsahdsvtkstvkegtapdfklkvlierepvlfyvykrPhvdlfldvvskWydlviftasmeeyaaavvdkldsgrgilkrryyrqh CVFHRGNYVKDLSRLGRELSKVIIVDNSPASYIFHPENAVPVQSWFDDMTDTELLDLIPFFEGLSREDDV . |.|.|||| . .||.|||.|||| .| .|.||.|..||. | .||.||.|.||.. | .|| CtlesgkytkdlslvsedlssviilDnspvayrknpdnaipikswisdpsdtallnllPfldalrftkdv |
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| Phosphatase | CTDSPL.AA | Subfamily.TIM50.PD | 145-262 | 42 | 2.5e-34 | 107.7 | In-house | 26-143 (150) | Show / Hide |
Range on Protein: 145-262 Range on HMM: 26-143/150 Sequence Identity: 42% (50 aa) VLKRPHVDEFLQRMGQLFECVLFTASLAKYADPVADLLDRWGVFRARLFRESCVFHRGNYVKDLSRLGRELSKVIIVDNSPASYIFHPENAVPVQSWFDD . ||| || ||.....||| |.||.. . .| |. | || .. . ||||... . |. ||||| | |.|||||.|| ..|. ..||||. .. | . fkkrPgvdafleelaelfeivvftseqgltaaplidkldPkqlimyrlfrdatkyvdGehvkdlsklnrdlskvivvdldkesvklqpenalalkkwkGn MTDTELLDLIPFFEGLSR . |.|||||..|.. .. addrelldllaflktiat |
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| Phosphatase | CTDSPL.AA | Subfamily.FCP1.PD | 108-238 | 27 | 1.6e-16 | 50.1 | In-house | 4-140 (150) | Show / Hide |
Range on Protein: 108-238 Range on HMM: 4-140/150 Sequence Identity: 27% (37 aa) CVVIDLDETLVHSSFKPI-----SNADFIVPVEIDGTIHQVYVLKRPHVDEFLQRMGQLFECVLFTASLAKYADPVADLLDRW-GVFRARLFRESCVFHR ..|.|||.||.|.. .|. .. | .. . . || .||.. |||... .|.| ..| . .||. .| .|| .| |.... . .| vLvvDlDqtlihttkdptievkeeklkdikkftlpeekevyyvklRpnlkeFleklsklyelhiytmgtraYaeqiakilDpekklFserilsrdellna GNYVKDLSRL-GRELSKVIIVDNSPASYIFHpENAVPV .|..| .. | |.|.|. . . |. || . | ssktkklkklfptgdsmvviiDDredvWnfa-enlikv |
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