Gene UBLCP1
UBLCP1
Classification
Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.
Protein domain
Protein domains of UBLCP1.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit phosphatase group/family/subfamily, which is helpful to understand the relationship between phosphatases. Transmembrane region is predicted by TMHMM 2.0. Visualized by pviz.
Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking. View complete domain list.
| Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
|---|---|---|---|---|---|---|---|---|---|
| Ubiquitin | UBLCP1.AA | UBQ | 3-77 | 29 | 5.1e-12 | 47.18 | SMART | 1-72 (72) | Show / Hide |
Range on Protein: 3-77 Range on HMM: 1-72/72 Sequence Identity: 29% (23 aa) LPIIVKWGGQ-EYSVTTLSEDD-TVLDLKQFLKTLTGVLPERQKLLGLKVKGKPAENDVKLGALKLKPNTKIMMMGT . | ||| .. .. .....| ||..||| . ..|. ||.|.|. .|| |.| |......|...|..|.. MQIFVKWQNGWKTFTFEVKPSDWTVSELKQHIEDKEGIPPEQQRLI---YQGK-LEDD-TLADYNIQPGSTIHLMVR |
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| Phosphatase | UBLCP1.AA | Subfamily.UBLCP1.PD | 136-300 | 78 | 4.7e-96 | 307.9 | In-house | 1-164 (165) | Show / Hide |
Range on Protein: 136-300 Range on HMM: 1-164/165 Sequence Identity: 78% (129 aa) GKKLLVLDVDYTLFDHRSCAETGVELMRPYLHEFLTSAYEDYDIVIWSATNMKWIEAKMKELGVSTNANYKITFMLDSAAMITVHTPRRGLIDVKPLGVI |||||||||||||.||||.||...||.||||.||||||||||||||||||.|||||.|.|||||..|.||||.|.|||.|||.|.||..|.|.||||||| gkkllvldvdytlldhrsvaedalelkrpyleefltsayedydiviwsatsmkwievklkelGvadnpnykiafvldstamikvttpkygvievkplgvi WGKFSEFySKKNTIMFDDIGRNFLMNPQNGLKIRPFMKAHLNRDKDKELLKLTQYLKEIAKLDDF |.|...| |.||||||||. |||||||.||||||||..|.|||||||||||||.||||||||.|| wkklkkf-sskntimfddlrrnflmnpknGlkirpfkeadlnrdkdkellkltkylkeiakledf |
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| Phosphatase | UBLCP1.AA | Family.FCP.PD | 137-300 | 28 | 3.7e-39 | 123.3 | In-house | 2-163 (164) | Show / Hide |
Range on Protein: 137-300 Range on HMM: 2-163/164 Sequence Identity: 28% (51 aa) KKLLVLDVDYTLFDH----------------RSCAETGVELMRPYLHEFLTSAYEDYDIVIWSATNMKWIEAKMKELGVStNANYKITFMLDSAAMItvh |||||||.|.||... ....|| ..||.|.|||....|.|.|||..|...|........|. . . ..| .. |. ... kklLVlDLdetLvhselkpknkpdfvvkveideleetvyvkkRPhldeFLekvselyeiviftastrkyadpvadiLDpe-kklfkkrllrdecvlv--- tprRGlIDVKPLGVIwGKfsefySKKNTIMFDDIGRNFLMNPQNGLKIRPFMKAHlnrdKDKELLKLTQYLKEIAKLDDF .| .||.|... |. .....|..|| ... .||.|..|...|.... ||.|||.|...|...|| .|. ---kg-nyvkdLskl-gr-----dlskviiiDdspdsyklnpdnaikvksfkedp----kDteLldLlpfleslakeedv |
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| Phosphatase | UBLCP1.AA | NIF | 138-301 | 22 | 5.3e-34 | 124.09 | Pfam | 1-189 (189) | Show / Hide |
Range on Protein: 138-301 Range on HMM: 1-189/189 Sequence Identity: 22% (46 aa) KLLVLDVDYTLFDHRSCA------------------ETGVEL-M-RPYLHEFLTSAYEDYDIVIWSATNMKWIEAKMKELGVSTNANYK-ITFMLDSAAM |.|||| |.|| ... .. ... . |||..||| .. ..|.||||.| .... .. .. . .| ... |.. . KTLVLDLDETLVHCN-PWWEPPNWHDFIVPIPFNGQNHQWYVYKPRPYCDEFLQHMSKYYEIVIWTASMKEYADPVIDYID------PKSKKYF-DGHHR I---TV-HT--PRRG--L-IDVKPLGVIWGKFSEFYSK---KNTIMFDDIGRNFLMNPQNGLKIRP-FMKAHLNR--DKD--KELLKLTQYL-KEIA-KL . . |. .|.| . .| | ..| | ...|..|. ... ..|.||..| | .. .| .. ..| .|||.| ..| ...| . LICWYREHCWLYRNGGNYYV-KKDLSILW------YNRWDLSRVIIVDNSPHSW-LQPDNGIPIPPYWYGYHDDDDSPDDFWNELLDLLPFLIEYLALQC -DDFL ||. LDDVR |
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| Phosphatase | UBLCP1.AA | CPDc | 136-278 | 17 | 6.7e-25 | 89.97 | SMART | 1-173 (173) | Show / Hide |
Range on Protein: 136-278
Range on HMM: 1-173/173
Sequence Identity: 17% (33 aa)
GKKLLVLDVDYTL-------------FDHRSCAETGVE---------------------------LMRPYLHEFLTSAYEDYDIVIWSATNMKWIEAKMK
.||.|||| |.|| ...||..| . . ..||..||||. ... |....... .... .
KKKTLVLDLDHTLVHSCMIPTLHHWMKYLRSFKEWTRRDFIWPQLKWFHMCMIVEIDGHPHQWYVKKRPHVHEFLKRCSKWYEMHVFTMGMRMYAD----
ELGVSTNANYKITFMLDSAA-MITVH-------TPRRGLIDVKP-LGVIWGKFSEFYSKKNTIMFDDIGRNFLMNPQNGLKIRPFMKAHLNR
.. |||. .. . . .| .||. | ... .. ...|. || . ....|.|...|.|. . ..
----------PVLDMLDPKRKYFIYRRLYRDHCVYHKGKTYVKDTLSLVNR-----CDLSMVIIIDDSPDSWPWHPENAIPIKPWFYFMHDT
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| Phosphatase | UBLCP1.AA | Group.HAD.PD | 137-298 | 20 | 3.3e-24 | 75.0 | In-house | 1-185 (190) | Show / Hide |
Range on Protein: 137-298 Range on HMM: 1-185/190 Sequence Identity: 20% (39 aa) KKLLVLDVDYTLF---------DHRSCAETGVELMR------------------------PYLHEFLTSAYEDYDIVIWSATNMKWIEAKMKELGVStNA |..||||.| .|. .|| . ..|.. |.|.|||....|.|..|...|..... . ... ..|. . kdtlvlDldgvlwlhgspepleglrskgkvlifltnnatksrlyllkrlallgflveevephldeflervgelyelvvftagtreyadpvvgavdvg-de NYKITFMLDSAAMITVhTPRRGLIDVKPLGVIWGKFSefyskkNTIMFDDIGRNFLM--NPQNGLKIRPFmkahLNRDKDKELLKLTQYLKEIAKLD . ... |. ... . . |.. . ||... . . .....|. ..| . ||.|.| | .| ... .|.|||.|. .|..|.. . afsyrklrdacvylkg-pgalllatnrdlgalvrdle------kvviidnkpsvfafecnpenalmigdf----iddildaellglipdlenidvrf |
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| Phosphatase | UBLCP1.AA | Subfamily.DULLARD.PD | 162-294 | 18 | 7.4e-07 | 17.9 | In-house | 51-165 (172) | Show / Hide |
Range on Protein: 162-294 Range on HMM: 51-165/172 Sequence Identity: 18% (24 aa) MRPYLHEFLTSAYEDYDIVIWSATNMKWIEAKMKELGVSTNANYKITFMLDSAAMITVHTPRRGLIdvkplgviwgkfseFYSKKNTIMFDDIGRNFLMN ||.. .||. . ||.||. |. .. .| . .| . . . . . . .| |. . ...|.|. .. .||. krPhvdlfldvvskWydlviftasmeeyaaavvdkldsgrgilkrryyrqhCtlesgkytkdlslv--------------sedlssviilDnspvayrkn PQNGLKIRPFMKAhlnrDKDKELLKLTQYLKEI |...|. ... .|..||.| .| . pdnaipikswisd----psdtallnllPfldal |
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| Phosphatase | UBLCP1.AA | Subfamily.SCP.PD | 162-299 | 19 | 2.4e-06 | 16.2 | In-house | 43-161 (163) | Show / Hide |
Range on Protein: 162-299 Range on HMM: 43-161/163 Sequence Identity: 19% (26 aa) MRPYLHEFLTSAYEDYDIVIWSATNMKWIEAKMKELGvsTNANYKITFMLDSAAMITVHTPRrglidvkplgviwgKFSEFY-SKKNTIMFDDIGRNFLM ||...|||. | ...|...|. |. . .. | .. .| .. .| . . . ..|.. |.... |.....|.|. krpfvdeflkkvgelfevvlftaslakyadpvadlld--kknvikarlfrescvfhkgnyvk--------------dlsrlGrdlkkvvivdnspasyif NPQNGLKIRPFmkahLNRDKDKELLKLTQYLKEIAKLDD . .. . .. .|.|||.| .|.|..| .| hpdnavpvesw----fddeedtelldllplleelskved |
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