Gene LHPP
LHPP
Classification
Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.
Protein domain
Protein domains of LHPP.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit phosphatase group/family/subfamily, which is helpful to understand the relationship between phosphatases. Transmembrane region is predicted by TMHMM 2.0. Visualized by pviz.
Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking. View complete domain list.
| Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
|---|---|---|---|---|---|---|---|---|---|
| Phosphatase | LHPP.AA | Subfamily.LHPP.PD | 11-227 | 58 | 9.60000000001e-103 | 330.4 | In-house | 1-213 (213) | Show / Hide |
Range on Protein: 11-227 Range on HMM: 1-213/213 Sequence Identity: 58% (126 aa) VRGVLLDISGVLYDSGAgggtAIAGSVEAVARLKRSRLKVRFCTNESQKSRAELVGQLQRLGFDISEQEVTAPAPAACQILKEQGLRPYLLIHDGVRSEF ..|||||.|||||.. | ||.|||||..|||.|.|||||.||....|..||| .||||||...|.||....|||.|.||.. |||.||..|..|..| ikgvllDlsGvlyveea----aipgsveAlkrLkqsglkvrfvtnttkeskrelverLqrlgfkveeeevftslpaarqllkkeklrpfllveddaredF DQIDTSNPNCVVIADAGESFSYQNMNNAFQVLMELEKPVLISLGKGRYYKETSGLMLDVGPYMKALEYACGIKAEVVGKPSPEFFKSALQAIGVEAHQAV ..|||..||.|||..| |||.|...|.||..|.| .|.|||..|||.|||...||.||||...||||||....||||||||..||.||||..||....|| egidtdspnavviglapesfnyetlnkafrlllekkkkvLiaigkgkyykrkdglaldvGafvkaLeyatdveaevvGkPsklfFesalqelgvdpeeav MIGDDIVGDVGGAQRCG |||||.. ||||||..| miGDDvkdDvgGAqkvG |
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| Phosphatase | LHPP.AA | Family.NagD.PD | 12-227 | 34 | 6.2e-71 | 227.0 | In-house | 2-239 (239) | Show / Hide |
Range on Protein: 12-227 Range on HMM: 2-239/239 Sequence Identity: 34% (84 aa) RGVLLDISGVLYDSGAgggtAIAGSVEAVARLKRSRLKVRFCTNESQKSRAELVGQLQRLGFDISEQEVTAPAPAACQILKEQGLRP-----YLLIHDGV ..||.|..|||. . . ||.|.|||. ||... ||.|.||.|.|||.||. .||.|||..||.|....|.||...||.. ..| ||....|. dtvlfDcdGVLwlgek----aipgavealnrLrqkgkkvlfvTNnstksreellkklqklgfkvseeeifssaaaaadylkkrkkkpfkkkvyligeegl RSEFDQ----------------------IDTSNPNCVVIADAGESFSYQNMNNAFQVLMeLEKPVLISLGKGRYYKETSGLMLDVGPYMKALEYACGIKA ..|... .|.......|...| |.|||.....||..|. ... .|........||...|....|....|||.|.| .| keeleelgieslgtgpdkledeldgdlevdlekdvgaVvvgadehfsyeklakAfryLq-npdvlfiatnedktlkepevlipgaGsfvaaletatgrea EVVGKPSPEFFKSALQAIGVEAHQAVMIGDDIVGDVGGAQRCG .||||||. .|...|...||. ...|||||.. |...||.|| lvvGKPskllfealleklgvdpertvmiGDrlntDilfaqkcG |
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| Phosphatase | LHPP.AA | Group.HAD.PD | 12-230 | 25 | 4.9e-27 | 83.4 | In-house | 2-176 (190) | Show / Hide |
Range on Protein: 12-230 Range on HMM: 2-176/190 Sequence Identity: 25% (53 aa) RGVLLDISGVLYdsgagggtaIAGSVEAVARLKRSRLKVRFCTNESQKSRAELVGQLQRLGFDISEQEvtapaPAACQILKEQGLRPYLLIHDGVRSEFd ....||..|||. . || |. . |.. ... |.||...|||..|.. |..|||...|.| |.... |. .| .. | .....|. dtlvlDldgvlw---------lhgspepleglrskgkvlifltnnatksrlyllkrlallgflveeve-----phldeflervgelyelvvftagtrey- qidtSNPNCVVIADAGESFSYQNMNNAFQVLMELEKPVLISLGkgryyketsglmlDVGPYMKALEyacgiKAEVVG-KPSPEFFKSalqaigvEAHQAV .|..... . | ||| ...|...| . .. |. |.| ..|| | ... ||| .|.. .|.||||.| |. ----adpvvgavdvgdeafsyrklrdacvylkgpgalllatnr-------------dlgalvrdle-----kvviidnkpsvfafec-------npenal MIGDDIvGDVGGAQRCGMRA .|...|.. migdfi-ddildaellglip |
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| Phosphatase | LHPP.AA | Subfamily.PGP.PD | 13-115 | 31 | 2.2e-18 | 54.7 | In-house | 3-107 (243) | Show / Hide |
Range on Protein: 13-115 Range on HMM: 3-107/243 Sequence Identity: 31% (34 aa) GVLLDISGVLYDsgagGGTAIAGSVEAVARLKRSRLKVRFCTNESQKSRAELVGQLQRLGFDISE-QEVTAPAPAACQILKE-----QGLRPYLLIHDGV ||.| |||. | ||| |.||.. .|.. || |.|| | |.|.|.. ....|||.... .|. .| .... ||. .. . ||. ..|.. tvlfDcdGVlWl----getaipgavevlnaLraagKkvlfvtNnstktreeylkkfkklgfkvlkkeeilssaavladylkqakakkekkkvyligeegl RSEFDQIDT .| .... keeleelgi |
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| Phosphatase | LHPP.AA | Hydrolase | 11-227 | 16 | 1.1e-16 | 58.56 | Pfam | 1-167 (167) | Show / Hide |
Range on Protein: 11-227
Range on HMM: 1-167/167
Sequence Identity: 16% (37 aa)
VRGVLLDISGVLYDSGAGGGTAIAGSVEAVARLKR--SRLKVRFCTNESQKS-RAELVGQLQRLGFDISEQEVTAPAPAACQILKEQGLRPYLLIHDGVR
.. |..|. |.|.|. . ..| ....||... .. |. .. . |.......... .
IKAVVFDKDGTLTDG---SEHPHAQAWVEAAREYGYWPFEEVEYIWGRGI-GDRIIDWWRATDEHI----------------------------------
SEFDQIDTSNPNCVVIADAGESFSYQNMNNAFQVLMELEKP---VLISLGKGRYYKETSGLMLDVGPYMKALEYACGIKAEVVGKPSPEFFKSALQAIGV
. . . . | . | ..| .| . | . . | . . .|... | ....... . .||||.|| .. |.|. ||
-------------D-EYLGVIAD-DQPYPGAREALQALKRMGIKVAMITNDNR-NAQAVLEHLGIA-YFDHIIDSDDVG--IVGKPHPEMYEKACQRLGV
EAHQA--VMIGDDIVGDVGGAQRCG
. |.. .|.||.| .|. .|| |
KPHECGCMMVGDGINDDPMLAQ-AG
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| Phosphatase | LHPP.AA | Subfamily.PGP.PD | 114-227 | 21 | 2.3e-16 | 48.1 | In-house | 130-243 (243) | Show / Hide |
Range on Protein: 114-227 Range on HMM: 130-243/243 Sequence Identity: 21% (25 aa) DTSNPNCVVIADAGESFSYQNMNNAFQVLMeLEKPVLISLGKGRYYK-ETSGLMLDVGPYMKALEYACGIKAEVVGKPSPEFFKSALQAIGVEAHQAVMI . .. |... | ||| . .| ..| .. .. . . .. . . . . |. ..|.| | | .. ||||||. ... |.. .......|.| klekdvgaVvvgfdehfsyvklakAlnylq-npdvlfvatneDetlplnpevvipgtGslvaavetasgreplvvGKPskllldallekakidpertlmv GDDIVGDVGGAQRCG | . |. ...|| GDrldtDilfgkncG |
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