PGP
Species: Human
Alias: PGP
External Links: COSMIC , Entrez Gene
Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Superfamily: HAD
Family: NagD
Subfamily: PGP
Protein domain

Protein domains of PGP.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit phosphatase group/family/subfamily, which is helpful to understand the relationship between phosphatases. Transmembrane region is predicted by TMHMM 2.0. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking. View complete domain list.

Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Phosphatase PGP.AA Subfamily.PGP.PD 28-273 52 1.3e-98 317.5 In-house 1-243 (243) Show / Hide
Range on Protein: 28-273
Range on HMM: 1-243/243
Sequence Identity: 52% (130 aa)

VDTLLFDCDGVLWRGETAVPGAPEALRALRARGKRLGFITNNSSKTRAAYAEKLRRLGFGGPAgpgaSLEVFGTAYCTALYLRQRLAGAPAPKAYVLGSP
.||.|||||||||.||||.|||.|.|.||||.||.. |.||||.|||..|..|...|||.       . |.. .|...| ||.|. | ... |.|..|. 
fdtvlfDcdGVlWlgetaipgavevlnaLraagKkvlfvtNnstktreeylkkfkklgfkvlk----keeilssaavladylkqakakkekkkvyligee

ALAAELEAVGVASVGVGPEPLQGEGPGDWL-HAPLEPDVRAVVVGFDPHFSYMKLTKALRYLQQPGCLLVGTNMDNRLPLENGRFIAGTGCLVRAVEMAA
.|..|||..|..|.||||. |..|. ||.  .. ||.||.||||||| ||||.||.|||.|||.|..|.|.||.|..|||.....|.|||.||.|||.|.
glkeeleelgieslgvgpdkledeldgdlaekvklekdvgaVvvgfdehfsyvklakAlnylqnpdvlfvatneDetlplnpevvipgtGslvaavetas

QRQADIIGKPSRFIFDCVSQEYGINPERTVMVGDRLDTDILLGATCG
.|.. ..||||....|.. ....|.||||.|||||||||||.| .||
greplvvGKPskllldallekakidpertlmvGDrldtDilfgkncG

Phosphatase PGP.AA Family.NagD.PD 28-273 48 1.7e-92 297.6 In-house 1-239 (239) Show / Hide
Range on Protein: 28-273
Range on HMM: 1-239/239
Sequence Identity: 48% (119 aa)

VDTLLFDCDGVLWRGETAVPGAPEALRALRARGKRLGFITNNSSKTRAAYAEKLRRLGFGGpagpgASLEVFGTAYCTALYLRQRLAGAPAPKAYVLGSP
.||.|||||||||.||.|.|||.|||..||..||.. |.||||.|.|.....||..|||.         |.| .|...| ||..|   ... |.|..|..
idtvlfDcdGVLwlgekaipgavealnrLrqkgkkvlfvTNnstksreellkklqklgfkv-----seeeifssaaaaadylkkrkkkpfkkkvyligee

ALAAELEAVGVASVGVGPEPLQGEGPGDWlHAPLEPDVRAVVVGFDPHFSYMKLTKALRYLQQPGCLLVGTNMDNRLpLENGRFIAGTGCLVRAVEMAAQ
.|..|||..|..|.|.||. |..|. ||. .  ||.||.|||||.| ||||.||.||.||||.|..|...||.|..|  |....|.|.|..|.|.|.|..
glkeeleelgieslgtgpdkledeldgdl-evdlekdvgaVvvgadehfsyeklakAfryLqnpdvlfiatnedktl-kepevlipgaGsfvaaletatg

RQADIIGKPSRFIFDCVSQEYGINPERTVMVGDRLDTDILLGATCG
|.|...||||...|... ...|..||||||.||||.||||.. .||
realvvGKPskllfealleklgvdpertvmiGDrlntDilfaqkcG

Phosphatase PGP.AA Group.HAD.PD 98-279 32 7.7e-36 112.2 In-house 34-179 (190) Show / Hide
Range on Protein: 98-279
Range on HMM: 34-179/190
Sequence Identity: 32% (60 aa)

VFGTAYCTALYLRQRLAGAPAPKAYVLgsPALAAELEAVGVAsVGVGPEPlQGEGPGdwlhapLEPDVRAVVVGfDPHFSYMKLTKALRYLQQPGCLLVG
.. .|....|||..||| .   . .|   |.|.. ||.||   ... . . .|..        ..|.|.||.|| |..|||.||..|..||..||.||. 
ltnnatksrlyllkrlallgflveeve--phldeflervgel-yelvvft-agtrey------adpvvgavdvg-deafsyrklrdacvylkgpgallla

TNMdnrlplengrfiaGTGCLVRAVEMaaqrQADIIGKPSRFIFDCvsqeygiNPERTVMVGDRLdTDILLGATCGLKTILT
||.             ..|.|||..|.    .. |..|||.|.|.|       |||...|.||.. .|||  . .||   |.
tnr-------------dlgalvrdlek----vviidnkpsvfafec-------npenalmigdfi-ddildaellglipdle

Phosphatase PGP.AA Hydrolase 28-273 16 4e-21 73.76 Pfam 1-167 (167) Show / Hide
Range on Protein: 28-273
Range on HMM: 1-167/167
Sequence Identity: 16% (41 aa)

VDTLLFDCDGVLWRGETAVPGAPEALRALRARGKRLGFITNNSSKTRAAYAEKLRRLGFGGPAGPGASLEVFGTAYCTALYLRQRLAGAPAPKAYVLGSP
.....||.||.|..|  . | |    .|.|..|.           ......|.. . |. |       .........|....                  
IKAVVFDKDGTLTDG-SEHPHAQAWVEAAREYGY-----------WPFEEVEYIWGRGI-G-------DRIIDWWRATDEHI------------------

ALAAELEAVGVASVGVGPEPLQGEGPGDWLHAPLEPDVRAVVVGFDPHFSYMKLTKALRYLQQPGCLLVGTNMDNRLPLENGRFIAGTGCLVRAVEMAAQ
                                    | ... |..|    |    .||..|.. |. ..    ||| . .  . ..| . .. ... ...
------------------------------------D-EYLGVIAD-DQPYPGAREALQALKRMGIKVAMITNDNR-NAQAVLEHLGIA-YFDHIIDSDD

RQADIIGKPSRFIFDCVSQEYGINPERT--VMVGDRLDTDILLGATCG
.   |.|||.  ..  . |..|..|...  .||||.. .|. | .  |
VG--IVGKPHPEMYEKACQRLGVKPHECGCMMVGDGINDDPMLAQ-AG

Phosphatase PGP.AA Subfamily.LHPP.PD 166-270 33 1.3e-18 55.5 In-house 105-210 (213) Show / Hide
Range on Protein: 166-270
Range on HMM: 105-210/213
Sequence Identity: 33% (34 aa)

RAVVVGFDP-HFSYMKLTKALRYLQQPGC-LLVGTNMdNRLPLENGRFIAGTGCLVRAVEMAAQRQADIIGKPSRFIFDCVSQEYGINPERTVMVGDRLD
|||.|  | .|.| .|.|| | | .    .|.  .   .   ..   . ..|. |.|.| |.. .| ..||||.. |  . || |..||..||.|| .  
navviglapesfnyetlnkafrlllekkkkvLiaigk-gkyykrkdglaldvGafvkaLeyatdveaevvGkPsklfFesalqelgvdpeeavmiGDDvk

TDILLGA
|.     
dDvgGAq

Phosphatase PGP.AA Group.HAD.PD 29-86 48 4.4e-16 47.7 In-house 2-54 (190) Show / Hide
Range on Protein: 29-86
Range on HMM: 2-54/190
Sequence Identity: 48% (28 aa)

DTLLFDCDGVLWrgetaVPGAPEALRALRARGKRLGFITNNSSKTRAAYAEKLRRLGF
|||..|.|||||     ..|.||.|..|| .||.| |.|||..|.|. . ..|..|||
dtlvlDldgvlw-----lhgspepleglrskgkvlifltnnatksrlyllkrlallgf

Phosphatase PGP.AA Subfamily.LHPP.PD 29-86 39 2.3e-13 38.3 In-house 2-59 (213) Show / Hide
Range on Protein: 29-86
Range on HMM: 2-59/213
Sequence Identity: 39% (23 aa)

DTLLFDCDGVLWRGETAVPGAPEALRALRARGKRLGFITNNSSKTRAAYAEKLRRLGF
...| |  |||.  |.|.||. |||. |.. | .. |.||.. ..... .|.|.||||
kgvllDlsGvlyveeaaipgsveAlkrLkqsglkvrfvtnttkeskrelverLqrlgf

Sequence
Name Sequence Type Origin Length Description Download
PGP.AA Protein None 321 None Fasta, JSON
PGP.NA RNA None 963 None Fasta, JSON
PGP.AA.PD_28-273 Protein Phosphatase Domain None 246 None Fasta, JSON