Gene PHLPP1
PHLPP1
Classification
Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.
Protein domain
Protein domains of PHLPP1.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit phosphatase group/family/subfamily, which is helpful to understand the relationship between phosphatases. Transmembrane region is predicted by TMHMM 2.0. Visualized by pviz.
Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking. View complete domain list.
| Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
|---|---|---|---|---|---|---|---|---|---|
| PH | PHLPP1.AA | PH | 544-636 | 17 | 4.2e-07 | 28.28 | Pfam | 1-92 (92) | Show / Hide |
Range on Protein: 544-636 Range on HMM: 1-92/92 Sequence Identity: 17% (17 aa) NVRKGKMQLPV--NRWTRRQVILCGTCLIVSSVKDSLTGKMHVLPLIGGKVEEVKK--HQHCLAFSSSGPQSQTYYICFDTFTEYLRWLRQVSKVAS ...| . . . .| .| ..|...||. .. . ...|| . .|..|.. ..||. .. .. .|||..... | .|.. ..... VIKEGWLHKKGKRKSWKKRWFVLFNNCLYYYKDDK--YRPKGSIPLSDCQVTKVPDNKRPHCFQIRT-DR--RTYYFQAESEEEMNDWMQAIQSACR |
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| Phosphatase | PHLPP1.AA | Subfamily.PHLPP.PD | 1165-1420 | 69 | 1.1e-139 | 453.6 | In-house | 1-257 (257) | Show / Hide |
Range on Protein: 1165-1420 Range on HMM: 1-257/257 Sequence Identity: 69% (178 aa) GDASGAPAVWSHGYTEASGVKNKLCVAALSVNNFCDNREALYGVFDGDRNVEVPYLLQCTMSDILAEELQKTKNEEEYMVNTFIVMQRKLGTAGQKLGGA ||||.|.||.|||..||.|||||||||||.|.||..|.||.||..|||||.|.|.||||||.|.|.||.||.||||.|..|...|..||||.||||||.. gdaslasavfshGlseaaGvknklCvaalavenfaenveavyGlidGdrnselpsllqctmadvlkeevqkdkneevyianillvshrklGeaGqklGas AVLCHIKHDPVDPGGSFTLTSANVGKCQTVLCRNGKPLPLSRSYIMSCE-EELKRIKQHKAIITEDGKVNGVTESTRILGYTFLHPSVVPRPHVQSVLLT |.|..||.|.||...|||||.||||||..||.|||||||||..||.... |||||||..|||||||.|||||.|||||||||||.|.|.|.|||.||||| allirikedrvdiassftltaanvgkcklvlirnGkplplskvyileiddeelkrikeakaiitednkvnGviestrilGytflfPvvlPkphvrsvlLt PQDEFFILGSKGLWDSLSVEEAVEAVRNVPDALAAAKKLCTLAQSYGCHDSISAVVV .|||..|||.|.||..||..|||||||||.|.|.|||||..||||||..||.||.|| eqdEllilGnkalWevlsideaveavrnvedplvaAkklvdlaqsygaadsvsalvv |
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| Phosphatase | PHLPP1.AA | PP2Cc | 1165-1420 | 21 | 1.4e-60 | 208.5 | SMART | 1-338 (338) | Show / Hide |
Range on Protein: 1165-1420
Range on HMM: 1-338/338
Sequence Identity: 21% (78 aa)
GDASGAPAVWSHGY--TEASGVKNKLCVAALSVNNFCDNREALYGVFDGDRNVEVPYLLQCTMSDILAEELQKTKN------------------------
. .| .. |..|| .. |.. . | . .. ..||||| . |. .. . ..||||||. |
HS-MGYNSGWRYGYMESSMQGWRHPMEDAHVCRP--------FFGVFDGHGGHECAQYCRKHLHEHLAEELQFHKDDDYKENDEMQDEPEMWWRMWHDKW
---EEEYMVNTFIVMQRKLGTAGQKLGGAAVLCHIKHDPVDPGGSFTLTSANVGKCQTVLCRNGK----------PLPLSRSYIMSCEEELKRIKQHKA-
|... ..| | .. ||...|. . | |||| .. ||||||. ...|.. ..|.|..||.| .
FEDWEDALRKAFLRMDEEI--------CTAVVALIRGNK--------LYVANVGDSRAVLCRNGNDNWWGIRHYTAHQLTEDHKPDNEDERRRIEQAGGR
------IITEDG-----KVNGV---TESTRILGYTFLH------------------------PSVVPRPHVQSVLL------TPQDEFFILGSKGLWDSL
. ... .|||| . .| .|. .. | |.. |.|... | ||.|.|.||.. |||| .
VMPMHRQWVMNWNCDVWRVNGVPIPLAVSRAFGDHYYKWKEDEKIEWNRWYQMFDPRLPFKEPYVIAEPDVTHHELWQMTVPTPDDDFLILCCDGLWDVM
SVEEAVEAVRNVP---------------------------DALAAAKKLCTLAQSYGCHDSISAVVV
| .|.|. ||. |. .|||.|| .|. .| ....||
SNQEVVDIVRKCLRKWHHKPVKNQAQENAHMMRHRQKKHNDPMEAAKRLCDCAI----CDNMTVIVV
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| Phosphatase | PHLPP1.AA | Family.PPM.PD | 1173-1423 | 29 | 8e-47 | 149.6 | In-house | 14-287 (495) | Show / Hide |
Range on Protein: 1173-1423
Range on HMM: 14-287/495
Sequence Identity: 29% (84 aa)
VWSHGYTEASGVKNKLCVAALSVNNFCDN-REALYGVFDGDRNVEVPYLLQCTMSDILAEELQKT-------------KNEEEYMVNTFIVMQRKLGTAG
...|... .| ... | |.|. .| . .|.||||| |. . . .. .||...|.|. .. .| . ..| ....| . .
glrygvasmqgwrsemeDahvvvenlennedfslfgvfDGhgGaeaaefaakklhkilkkqlekkddeksstsaessaekvkealrkafleldeelseel
Q------KLGGAAVLCHIKHDPvdpggsftLTSANVGKCQTVLCRNGKPLPLSRSYIMSCEEELKRIKQHKAIIT-EDGKVNGVTESTRILGYTFLHP--
. | || ..|... | ||.| .. |||||||. .||. . . .|| .||.. .. .||.|||| . .| || .| .
neksagkdsGtTAvvvlirgkk--------lyvAnaGDsravLcrngkavelskdHkpenpeEreRIekagGkvvirdgrvnGvlavsRalGdfdlkkee
--SVVPRPHVQSVLLTPQ-DEFFILGSKGLWDSLSVEEAVEAVRNVP-----DALAAAKKLCTLAQSYGCHDSISAVVVQLS
.|.. |...|| ||.. |||..| | |||| || ||.|| ||. |. ..|..|. | ..|..| |...||.|.
qaivsaePditsvkltqeedeflvlasdGlWdvlsneevvelvretleekeedleeiaeeLvdealakgsrDNiTvlvvaly
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| Phosphatase | PHLPP1.AA | Group.PPM.PD | 1173-1423 | 28 | 4.5e-43 | 137.3 | In-house | 37-322 (459) | Show / Hide |
Range on Protein: 1173-1423 Range on HMM: 37-322/459 Sequence Identity: 28% (82 aa) VWSHGYTEASGVKNKLCVAALSVNNFCDNReALYGVFDGDRNVEVPYLLQCTMSDILAEELQKT-------------------KNEEEYMVNTFIVMQRK .. |... .| ... . .|.|| .| ...||||| |. . . ....||...|.| .. .. . ..|....| glrygvasmqgwrkemEDrhvivenfdnnd-sffgVfDGHgGaeaaefaakkLpkilkkqlkkkkdevskksaeasldnddrgekvkkalrsaflelded LGTAGQ-------KLGGAAVLCHIKhdpvdpGGsfTLTSANVGKCQTVLCRNGKPLPLSRSYIMSCEEELKRIKQHKAIITEDGKVNGVTESTRILGYTF . . | || ..|. |. .| ||.| .. |||||||. |||. . .|| .||.. .. ||.|||.. .| || | . lseeanekeepgkdsGtTAvvalin------gk--klyvANaGDSravLcrngkavplskdHkpenpeEreRIekagGsveidgRvnGilavsRalGdhd LHPS---VVPRPHVQSVLLTPQDEFFILGSKGLWDSLSVEEAVEAVRNVPDA---------LAAAKKLCTLAQSYGCH------DSISAVVVQLS | . |.|..| ||..|||..|.| ||||.|| ||.|| ||. . ..|..|. | . |. ||...||.|. lkkeeqmvsaePdvsvvklteedeflvlAsDGlWdvlsneevvefvretlekkkkelkkdleeiaerlvdealakgstgdgtscDNiTvivvtln |
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| Phosphatase | PHLPP1.AA | PP2C | 1286-1415 | 30 | 4.7e-28 | 102.66 | Pfam | 133-284 (284) | Show / Hide |
Range on Protein: 1286-1415 Range on HMM: 133-284/284 Sequence Identity: 30% (47 aa) ANVGKCQTVLCRNGKPL----PLSRSYIMSCEEELKRIKQHKAIITE--DGKVNGV-TESTRILGYTFLHP---------SVVPRPHVQ-SVLLTPQ-DE ||.| ...||||||.. .|.. |.|.| .||.| . ..|||| . .| .|.... | |.. |... .. .||. || ANCGDSRAVLCRNGNAHNWVHQLTYDHKPSNEDERRRIRQAGGWVMWWGFWRVNGVWLAVSRAFGDFHYKPNHTCFPKEQPVTAEPDITPEHKITPDHDE FFILGSKGLWDSLSVEEAVEAVRNVPD----ALAAAKKLCTLAQSYGCHDSI |.||.. |||| .| .|... || . .. |..||......||..|.| FLILACDGLWDVMSDQEVCDIVRQCRSDWNDPMEACEKLVDYCIAYGSEDNI |
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| Phosphatase | PHLPP1.AA | Subfamily.LRR-PP2C.PD | 1197-1422 | 33 | 4.4e-27 | 84.9 | In-house | 33-257 (257) | Show / Hide |
Range on Protein: 1197-1422 Range on HMM: 33-257/257 Sequence Identity: 33% (74 aa) NFCDN-REALYGVFDGDRNVEVPYLLQCTMSDILAEELQKTKN-EEEYMVNTFIVMQRKLGTAGQKLGGAAVLCHIKHDpvdpggsfTLTSANVGKCQTV .| |. | .| .||| . .. |||| |. . .... ... .. ... .. .| .|. | .||||| . ||| ..| || sfrdksdedyyalfdGhgGraaakfaseelykilaelldlnnanPlkslkkaykeistqiserpkfiGttaasvliied--------kvyianvGdsrvv LC-RNGKPLPLSRSYIMSCEEELKRIKQHKAIITED---GKVNGVTESTRILGYTFLHPSVVPRPHVQ-SVLLTPQDEFFILGSKGLWDSLSVEEAVEAV . | |.| |||.. . .. .||| .| || .||.| ||| |... |.. .|.|.|| |.|| .| ||||| | .. |. ||.|| lcqkdgtakrlsldhkPseeseekriselGGtvvstvvtsrvnGtlavsralGdsflePfvvpdPdlsqsleiskkdkflilacdGiwdlisdeeaveiv RNVPDALAAAKKLCTLAQSYGCHDSISAVVVQL || | | | || .|..| agisdpekaaeklrdlayssGstdnisvivikl |
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| Phosphatase | PHLPP1.AA | Subfamily.PPM1E.PD | 1201-1421 | 27 | 9.2e-24 | 73.9 | In-house | 45-268 (269) | Show / Hide |
Range on Protein: 1201-1421 Range on HMM: 45-268/269 Sequence Identity: 27% (63 aa) NREALYGVFDGDRNVEVPYLLQCTMSDILAEELQKTKNEEEYMVNTFIVMQRKLGTA----GQKLGGAAVLCHIKHDPvdpggsftLTSANVGKCQTVLC . .| ..|||| || . . . |... . ... .| . ..| .. ... . . | | || . |..| || .| |..|.|. keraffavfDGHgGveaakyaaahlhellvrqeklkedpaealkeafkltDerflqkaereklksGstavvvliekdq--------lyvaWlGDsqallv RNGKPLPLSRSYIMSCEEELKRIKQHKAIITEDG--KVNGVTESTRILGYTFLHPSVVPRPHVQSVLLTPQDEFFILGSKGLWDSLSVEEAVEAV----- |. . | . . . |.| |||.. .. | .|||| .| .| . |.| |. . | .| |. .... ||.. |||| . ||.|..| .. rkgeavqlmkpHkPeredEkkRieeagGlvvvigawRvnGvLsvsRaiGDvklkpyvsgeadvaeveldgsedylilacDGlwDvvneeevvklveefla RNVPDALAAAKKLCTLAQSYGCHDSISAVVVQ . | .||.|.. |.. | .| |..||| dgaedlsevakllveaakeagssDnitvvvvf |
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| Phosphatase | PHLPP1.AA | Subfamily.PPM1A.PD | 1202-1423 | 24 | 1.6e-18 | 56.8 | In-house | 40-279 (309) | Show / Hide |
Range on Protein: 1202-1423 Range on HMM: 40-279/309 Sequence Identity: 24% (58 aa) REALYGVFDGDRNVEVPYLLQCTMSDILAEE--------LQKTKNEEEYMVNTFIVMQRKLGTAG------QKLGGAAVLCHIKhdpvdpggSFTLTSAN ....|||| .| . .. ... || ..... .| . ..|. . |. . .| | || . ...| ||.| .||.||| dwsffavfDGHaGskvskycakhlleaileeeefkaskeksskekvkealrkgfLelDekirklvelskgedksGsTavvvlvs--------pkklylan VGKCQTVLCRNGKPLPLSRSYIMSCEEELKRIKQHKAIITEdGKVNGVTESTRILGYTFL---------HPSVVPRPHVQSVLLTPQDEFFILGSKGLWD | .. | ..| .||.. .. ..||| .| || . . |.| |.|... . .|||..| . |.|| .| ||..| |. cGDsRavlsrngkvvfateDHkpsdpkEkeRienAgGsvmi-kRvnGsLAvsRalGDydykekpekkateqlvspepevtvierdeedeflvlacDGiwD SLSVEEAVEAVRNV----PDALAAAKKLCTLAQSYGCHDSISAVVVQLS . |. ..|..| . . | .| .|...| |. vmsneevaefvksrlevtddleevanelldtcLekgsrDNmsvilvllp |
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| Phosphatase | PHLPP1.AA | Subfamily.PPM1G.PD | 1232-1392 | 28 | 3.5e-18 | 55.8 | In-house | 281-439 (482) | Show / Hide |
Range on Protein: 1232-1392 Range on HMM: 281-439/482 Sequence Identity: 28% (48 aa) ELQKTKNEEEYMVNTFIVMQrklGTAGQKLGGAAVLCHIKHDpvdpggsfTLTSANVGKCQTVLCRNGKPLPLSRSYIMSCEEELKRIKQHKAIITEDGK | .. ..|. .... .. . |. | || . .|.. .|. ||.| .||.|||| | || . |.||.||.. .|.||. eedeeeededelaedllgks---eepGkdsGttavvaLvkgk--------klivanaGDsRcvlsrnGkaldlsiDhkPeDeveleRiekaGGkvtldgR VNGVTESTRILGYTFLH-P--------SVVPRPHVQSVLLTPQDEFFILGSKGLWDSLSVEEAVEAVRNV ||| | || . . | .. .||..|||..| . |.|...| .| |. ||. vnGGLnlsRalGDhaYktneeLpaeeqmisalPDikklilteedeFlvlacDGiWnvmssqevvdFvrak |
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| Phosphatase | PHLPP1.AA | Subfamily.PPM1K.PD | 1207-1422 | 26 | 6.2e-18 | 54.8 | In-house | 41-264 (264) | Show / Hide |
Range on Protein: 1207-1422 Range on HMM: 41-264/264 Sequence Identity: 26% (60 aa) GVFDGDRNVEVPYLLQCTMSDILAEELQKTKNEEEYMVNTFIVMQRKLGTAGQKL-GGAAVLCHIKHDPVDP-GGSFTLTSANVGKCQTVLCRNGKPLPL .|||| . . |. . |.| |. || ... | ...|| . . | | | | |..| ...||||||. | avfdGhgGssaadfvhdkleeivrrllekekdleevlkqafeeldkklkrylefsvaeaellssGttatvsllrdGnelvlaslGdsrailcrnGkakkl SRSYIMSCEEELKRIKQHKAIITE----DGKVNGVTESTRILGYTFLHPS-VVPRPHVQSVLL-TPQDEFFILGSKGLWDSLSVEEAVEAVRNVPDALAA .. . . .|| .|||. .. .||.. || || | .. |. |. .|. . .| |..| . |.. .. .| . || | || tkdhdPerkeekerikaagGsvewnslgkplvnsrlamtrslGdldlkryGviatPetkslkvkhaadsflvlitdgisfvvnsqelcdlvrlchdpeea AKKLCTLAQSYGCHDSISAVVVQL . ... | ||..| .|||| | ahavteqalqygsednatavvvpl |
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| Phosphatase | PHLPP1.AA | Subfamily.PPM1L.PD | 1282-1422 | 36 | 4e-16 | 49.1 | In-house | 126-273 (273) | Show / Hide |
Range on Protein: 1282-1422 Range on HMM: 126-273/273 Sequence Identity: 36% (52 aa) TLTSANVGKCQTVLC-RNGKPLPLSRSYIMSCEEELKRIKQHKAIITEDG--KVNGVTESTRILGYTFLH--PSVVPRPHVQSVLLT-PQDEFFILGSKG |. |||| . ||. ..|| .||| . .| ||||. .|. .| .|.|| .| || |. |.. | . . |. ||.|| | ||||. dlivanvGdsrGvlydkrGkaiplsfdhkpqqvkerkrikkaGGfiafrGvwrvaGvlatsralGdyplkdknlviadpdiltfdlddhkpeflilasdG LWDSLSVEEAVEAVRN-VPDALAAAKKLCTLAQSYGCHDSISAVVVQL .| ||||. ... . . || | . |. | |. .||.| lwdtfsneeavrfikerlkepdfGakslvlesfkrGsvdnitvlvvkl |
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| Phosphatase | PHLPP1.AA | Subfamily.ILKAP.PD | 1202-1393 | 25 | 5.8e-16 | 48.5 | In-house | 46-252 (298) | Show / Hide |
Range on Protein: 1202-1393 Range on HMM: 46-252/298 Sequence Identity: 25% (53 aa) REALYGVFDGDRNVEVPYLLQCTMSDILAEELQKTK------NEEEYMVNTFIVMQRKLGTAGQ------KLGGAAVLCHIKHDpvdpggsfTLTSANVG | . |.|||| . ... .. . . |.| |.. . . .|..| ... . . | | || . . ..| .||.| ..||.| rvsyyavfDGhaGsrasefaaeklhkviveklpkedvsakdkeikkclvdafkktDeeflklaskakPvWkdGstavvvlvvdn--------vlyvanlG KCQTVLCRN---GK--------PLPLSRSYIMSCEEELKRIKQHKAIITeDGKVNGVTESTRILGY-TFLHPSVVPRPHVQSVLLTPQDEFFILGSKGLW . |. ...||. . . .|| |||.. .... ||.|.|| | | .| | . |. |.|. . ||..| |..| |||......|. DskavlaRakeegdkagestiasvlLskdHtpasyeerkriqkaGgvvr-dgRvlGvlevsRsiGDgrfkelgvistPdvkkceLtenDlfvvlaCDGLw DSLSVEEAVEAVRNVP |. . .| kvfeadevvkfilkvl |
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| Phosphatase | PHLPP1.AA | Subfamily.PPM1G2.PD | 1200-1392 | 28 | 3.1e-13 | 39.3 | In-house | 40-237 (275) | Show / Hide |
Range on Protein: 1200-1392
Range on HMM: 40-237/275
Sequence Identity: 28% (55 aa)
DNREALYGVFDGDRNVEVPYLLQCTMSDILAEELQK-TKNEEEYMVNTFIVMQRKLGTA----GQKLGGAAVLCHIKHDPvdpggsftLTSANVGKCQTV
|.. ||..|||| .| . ..|. . . |. . ..|. . ..| .. | || ||..| ||.| ..||. .|.
dkslalfavfDGhGGakvakyagkklikkiakkksfkegaleqilkdafletDeellkdeklkdesaGstavvvlikeek--------lyvanaGDsrav
LCRNGKPLPLSRSYIMSCEEELKRIKQHKAIItEDGKVNGVTESTRILG-YTFLHPS--------VVPRPHVQSVLLTPQDEFFILGSKGLWDSLSVEEA
||. . . |.| |||.. .. | ..|||. | || ..| . . | | ||...||| .| |.|| |. .| |. ||.
lsskgnvkalsfDhkPqeesekkriiaagGfv-elnrvngnLalsralgDfefkknvkkkpeeqivtavPDvlvkkldeddeflvLaCDGiWDvltnkev
VEAVRNV
vdlvrer
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| Phosphatase | PHLPP1.AA | Subfamily.PDP.PD | 1349-1393 | 41 | 1.2e-09 | 27.8 | In-house | 282-326 (409) | Show / Hide |
Range on Protein: 1349-1393 Range on HMM: 282-326/409 Sequence Identity: 41% (18 aa) PSVVPRPHVQSVLLTPQDEFFILGSKGLWDSLSVEEAVEAVRNVP | . .| |.| |...| |..|.. |||| || ||.|. | . PYltaePevtshklrendkFLvlatDGLwdllsneevvslVgehl |
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| Phosphatase | PHLPP1.AA | Subfamily.PPM1D.PD | 1351-1392 | 45 | 1.2e-07 | 21.1 | In-house | 228-270 (311) | Show / Hide |
Range on Protein: 1351-1392 Range on HMM: 228-270/311 Sequence Identity: 45% (19 aa) VVPRPHVQSVLLTPQDE-FFILGSKGLWDSLSVEEAVEAVRNV | | |.|. . |.|..| | ||.| |||. |. |.||. |.. vsPePdvkvrtldpneekfiilasDGlwnvltpedavsvveke |
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