PHLPP1
Species: Human
Alias: PHLPP, PLEKHE1, PHLPP1, SCOP, MGC161555
External Links: COSMIC , Entrez Gene
Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Superfamily: PPM
Family: PPM
Subfamily: PHLPP
Protein domain

Protein domains of PHLPP1.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit phosphatase group/family/subfamily, which is helpful to understand the relationship between phosphatases. Transmembrane region is predicted by TMHMM 2.0. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking. View complete domain list.

Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
PH PHLPP1.AA PH 544-636 17 4.2e-07 28.28 Pfam 1-92 (92) Show / Hide
Range on Protein: 544-636
Range on HMM: 1-92/92
Sequence Identity: 17% (17 aa)

NVRKGKMQLPV--NRWTRRQVILCGTCLIVSSVKDSLTGKMHVLPLIGGKVEEVKK--HQHCLAFSSSGPQSQTYYICFDTFTEYLRWLRQVSKVAS
 ...| . . .   .| .| ..|...||.    ..    . ...|| . .|..|..  ..||.  .. ..  .|||.....  |  .|..  .....
VIKEGWLHKKGKRKSWKKRWFVLFNNCLYYYKDDK--YRPKGSIPLSDCQVTKVPDNKRPHCFQIRT-DR--RTYYFQAESEEEMNDWMQAIQSACR

Phosphatase PHLPP1.AA Subfamily.PHLPP.PD 1165-1420 69 1.1e-139 453.6 In-house 1-257 (257) Show / Hide
Range on Protein: 1165-1420
Range on HMM: 1-257/257
Sequence Identity: 69% (178 aa)

GDASGAPAVWSHGYTEASGVKNKLCVAALSVNNFCDNREALYGVFDGDRNVEVPYLLQCTMSDILAEELQKTKNEEEYMVNTFIVMQRKLGTAGQKLGGA
||||.|.||.|||..||.|||||||||||.|.||..|.||.||..|||||.|.|.||||||.|.|.||.||.||||.|..|...|..||||.||||||..
gdaslasavfshGlseaaGvknklCvaalavenfaenveavyGlidGdrnselpsllqctmadvlkeevqkdkneevyianillvshrklGeaGqklGas

AVLCHIKHDPVDPGGSFTLTSANVGKCQTVLCRNGKPLPLSRSYIMSCE-EELKRIKQHKAIITEDGKVNGVTESTRILGYTFLHPSVVPRPHVQSVLLT
|.|..||.|.||...|||||.||||||..||.|||||||||..||.... |||||||..|||||||.|||||.|||||||||||.|.|.|.|||.|||||
allirikedrvdiassftltaanvgkcklvlirnGkplplskvyileiddeelkrikeakaiitednkvnGviestrilGytflfPvvlPkphvrsvlLt

PQDEFFILGSKGLWDSLSVEEAVEAVRNVPDALAAAKKLCTLAQSYGCHDSISAVVV
.|||..|||.|.||..||..|||||||||.|.|.|||||..||||||..||.||.||
eqdEllilGnkalWevlsideaveavrnvedplvaAkklvdlaqsygaadsvsalvv

Phosphatase PHLPP1.AA PP2Cc 1165-1420 21 1.4e-60 208.5 SMART 1-338 (338) Show / Hide
Range on Protein: 1165-1420
Range on HMM: 1-338/338
Sequence Identity: 21% (78 aa)

GDASGAPAVWSHGY--TEASGVKNKLCVAALSVNNFCDNREALYGVFDGDRNVEVPYLLQCTMSDILAEELQKTKN------------------------
 . .| .. |..||  ..  |.. .   | . ..        ..|||||  . |.   ..  . ..||||||. |                         
HS-MGYNSGWRYGYMESSMQGWRHPMEDAHVCRP--------FFGVFDGHGGHECAQYCRKHLHEHLAEELQFHKDDDYKENDEMQDEPEMWWRMWHDKW

---EEEYMVNTFIVMQRKLGTAGQKLGGAAVLCHIKHDPVDPGGSFTLTSANVGKCQTVLCRNGK----------PLPLSRSYIMSCEEELKRIKQHKA-
    |... ..|  |  ..          ||...|. .         |  |||| .. ||||||.          ...|..    ..|.|..||.|  . 
FEDWEDALRKAFLRMDEEI--------CTAVVALIRGNK--------LYVANVGDSRAVLCRNGNDNWWGIRHYTAHQLTEDHKPDNEDERRRIEQAGGR

------IITEDG-----KVNGV---TESTRILGYTFLH------------------------PSVVPRPHVQSVLL------TPQDEFFILGSKGLWDSL
      .  ...     .||||    . .| .|. ..                         | |.. |.|... |      ||.|.|.||.. |||| .
VMPMHRQWVMNWNCDVWRVNGVPIPLAVSRAFGDHYYKWKEDEKIEWNRWYQMFDPRLPFKEPYVIAEPDVTHHELWQMTVPTPDDDFLILCCDGLWDVM

SVEEAVEAVRNVP---------------------------DALAAAKKLCTLAQSYGCHDSISAVVV
| .|.|. ||.                             |. .|||.|| .|.    .| ....||
SNQEVVDIVRKCLRKWHHKPVKNQAQENAHMMRHRQKKHNDPMEAAKRLCDCAI----CDNMTVIVV

Phosphatase PHLPP1.AA Family.PPM.PD 1173-1423 29 8e-47 149.6 In-house 14-287 (495) Show / Hide
Range on Protein: 1173-1423
Range on HMM: 14-287/495
Sequence Identity: 29% (84 aa)

VWSHGYTEASGVKNKLCVAALSVNNFCDN-REALYGVFDGDRNVEVPYLLQCTMSDILAEELQKT-------------KNEEEYMVNTFIVMQRKLGTAG
...|... .| ...   |   |.|. .| . .|.|||||    |.  . . .. .||...|.|.             .. .| . ..|  ....| .  .
glrygvasmqgwrsemeDahvvvenlennedfslfgvfDGhgGaeaaefaakklhkilkkqlekkddeksstsaessaekvkealrkafleldeelseel

Q------KLGGAAVLCHIKHDPvdpggsftLTSANVGKCQTVLCRNGKPLPLSRSYIMSCEEELKRIKQHKAIIT-EDGKVNGVTESTRILGYTFLHP--
      . |  || ..|...         |  ||.| .. |||||||. .||. .  . .|| .||..    .. .||.|||| . .| ||  .| .   
neksagkdsGtTAvvvlirgkk--------lyvAnaGDsravLcrngkavelskdHkpenpeEreRIekagGkvvirdgrvnGvlavsRalGdfdlkkee

--SVVPRPHVQSVLLTPQ-DEFFILGSKGLWDSLSVEEAVEAVRNVP-----DALAAAKKLCTLAQSYGCHDSISAVVVQLS
 .|.. |...|| ||.. |||..| | |||| || ||.|| ||.       |. ..|..|.  | ..|..| |...||.|. 
qaivsaePditsvkltqeedeflvlasdGlWdvlsneevvelvretleekeedleeiaeeLvdealakgsrDNiTvlvvaly

Phosphatase PHLPP1.AA Group.PPM.PD 1173-1423 28 4.5e-43 137.3 In-house 37-322 (459) Show / Hide
Range on Protein: 1173-1423
Range on HMM: 37-322/459
Sequence Identity: 28% (82 aa)

VWSHGYTEASGVKNKLCVAALSVNNFCDNReALYGVFDGDRNVEVPYLLQCTMSDILAEELQKT-------------------KNEEEYMVNTFIVMQRK
.. |... .| ...   .  .|.|| .|  ...|||||    |.  . . ....||...|.|                    .. .. . ..|....|  
glrygvasmqgwrkemEDrhvivenfdnnd-sffgVfDGHgGaeaaefaakkLpkilkkqlkkkkdevskksaeasldnddrgekvkkalrsaflelded

LGTAGQ-------KLGGAAVLCHIKhdpvdpGGsfTLTSANVGKCQTVLCRNGKPLPLSRSYIMSCEEELKRIKQHKAIITEDGKVNGVTESTRILGYTF
  .       . |  || ..|.      |.  .|  ||.| .. |||||||. |||.    . .|| .||..    .. ||.|||.. .| ||   |  .
lseeanekeepgkdsGtTAvvalin------gk--klyvANaGDSravLcrngkavplskdHkpenpeEreRIekagGsveidgRvnGilavsRalGdhd

LHPS---VVPRPHVQSVLLTPQDEFFILGSKGLWDSLSVEEAVEAVRNVPDA---------LAAAKKLCTLAQSYGCH------DSISAVVVQLS
   | . |.|..| ||..|||..|.| ||||.|| ||.|| ||.  .           ..|..|.  | . |.       ||...||.|.     
lkkeeqmvsaePdvsvvklteedeflvlAsDGlWdvlsneevvefvretlekkkkelkkdleeiaerlvdealakgstgdgtscDNiTvivvtln

Phosphatase PHLPP1.AA PP2C 1286-1415 30 4.7e-28 102.66 Pfam 133-284 (284) Show / Hide
Range on Protein: 1286-1415
Range on HMM: 133-284/284
Sequence Identity: 30% (47 aa)

ANVGKCQTVLCRNGKPL----PLSRSYIMSCEEELKRIKQHKAIITE--DGKVNGV-TESTRILGYTFLHP---------SVVPRPHVQ-SVLLTPQ-DE
||.| ...||||||..     .|..    |.|.| .||.|    .     ..||||  . .| .|.... |          |.. |... .. .||. ||
ANCGDSRAVLCRNGNAHNWVHQLTYDHKPSNEDERRRIRQAGGWVMWWGFWRVNGVWLAVSRAFGDFHYKPNHTCFPKEQPVTAEPDITPEHKITPDHDE

FFILGSKGLWDSLSVEEAVEAVRNVPD----ALAAAKKLCTLAQSYGCHDSI
|.||.. |||| .| .|... ||   .    .. |..||......||..|.|
FLILACDGLWDVMSDQEVCDIVRQCRSDWNDPMEACEKLVDYCIAYGSEDNI

Phosphatase PHLPP1.AA Subfamily.LRR-PP2C.PD 1197-1422 33 4.4e-27 84.9 In-house 33-257 (257) Show / Hide
Range on Protein: 1197-1422
Range on HMM: 33-257/257
Sequence Identity: 33% (74 aa)

NFCDN-REALYGVFDGDRNVEVPYLLQCTMSDILAEELQKTKN-EEEYMVNTFIVMQRKLGTAGQKLGGAAVLCHIKHDpvdpggsfTLTSANVGKCQTV
.| |.  | .| .|||    .       ..  |||| |.  .   .... ...  .. ...  .. .| .|.   | .|||||  . ||| ..|    ||
sfrdksdedyyalfdGhgGraaakfaseelykilaelldlnnanPlkslkkaykeistqiserpkfiGttaasvliied--------kvyianvGdsrvv

LC-RNGKPLPLSRSYIMSCEEELKRIKQHKAIITED---GKVNGVTESTRILGYTFLHPSVVPRPHVQ-SVLLTPQDEFFILGSKGLWDSLSVEEAVEAV
  .  | |.| |||..    . ..    .|||    .| || .||.| ||| |... |.. .|.|.||   |.|| .| ||||| | .. |.  ||.|| 
lcqkdgtakrlsldhkPseeseekriselGGtvvstvvtsrvnGtlavsralGdsflePfvvpdPdlsqsleiskkdkflilacdGiwdlisdeeaveiv

RNVPDALAAAKKLCTLAQSYGCHDSISAVVVQL
 || | |  | || .|..|              
agisdpekaaeklrdlayssGstdnisvivikl

Phosphatase PHLPP1.AA Subfamily.PPM1E.PD 1201-1421 27 9.2e-24 73.9 In-house 45-268 (269) Show / Hide
Range on Protein: 1201-1421
Range on HMM: 45-268/269
Sequence Identity: 27% (63 aa)

NREALYGVFDGDRNVEVPYLLQCTMSDILAEELQKTKNEEEYMVNTFIVMQRKLGTA----GQKLGGAAVLCHIKHDPvdpggsftLTSANVGKCQTVLC
. .| ..||||   ||  .  .  .   |... . ... .| . ..| .. ... .     . | |  || . |..|         || .|  |..|.|.
keraffavfDGHgGveaakyaaahlhellvrqeklkedpaealkeafkltDerflqkaereklksGstavvvliekdq--------lyvaWlGDsqallv

RNGKPLPLSRSYIMSCEEELKRIKQHKAIITEDG--KVNGVTESTRILGYTFLHPSVVPRPHVQSVLLTPQDEFFILGSKGLWDSLSVEEAVEAV-----
|. . | . .  . |.| |||..   ..   |  .||||   .| .| . |.| |.  . | .| |. .... ||.. |||| .  ||.|..|     ..
rkgeavqlmkpHkPeredEkkRieeagGlvvvigawRvnGvLsvsRaiGDvklkpyvsgeadvaeveldgsedylilacDGlwDvvneeevvklveefla

RNVPDALAAAKKLCTLAQSYGCHDSISAVVVQ
. |   .||.|.. |.. | .| |..|||   
dgaedlsevakllveaakeagssDnitvvvvf

Phosphatase PHLPP1.AA Subfamily.PPM1A.PD 1202-1423 24 1.6e-18 56.8 In-house 40-279 (309) Show / Hide
Range on Protein: 1202-1423
Range on HMM: 40-279/309
Sequence Identity: 24% (58 aa)

REALYGVFDGDRNVEVPYLLQCTMSDILAEE--------LQKTKNEEEYMVNTFIVMQRKLGTAG------QKLGGAAVLCHIKhdpvdpggSFTLTSAN
....||||    .|    . .. ... ||         ..... .| . ..|. .  |. .        .| |  || . ...|  ||.|   .||.|||
dwsffavfDGHaGskvskycakhlleaileeeefkaskeksskekvkealrkgfLelDekirklvelskgedksGsTavvvlvs--------pkklylan

VGKCQTVLCRNGKPLPLSRSYIMSCEEELKRIKQHKAIITEdGKVNGVTESTRILGYTFL---------HPSVVPRPHVQSVLLTPQDEFFILGSKGLWD
|    ..    | ..| .||..    ..  ..|||    .| ||  .          .  |.| |.|...  . .|||..| . |.|| .| ||..| |.
cGDsRavlsrngkvvfateDHkpsdpkEkeRienAgGsvmi-kRvnGsLAvsRalGDydykekpekkateqlvspepevtvierdeedeflvlacDGiwD

SLSVEEAVEAVRNV----PDALAAAKKLCTLAQSYGCHDSISAVVVQLS
.      |. ..|..|   . . | .| .|...| |.            
vmsneevaefvksrlevtddleevanelldtcLekgsrDNmsvilvllp

Phosphatase PHLPP1.AA Subfamily.PPM1G.PD 1232-1392 28 3.5e-18 55.8 In-house 281-439 (482) Show / Hide
Range on Protein: 1232-1392
Range on HMM: 281-439/482
Sequence Identity: 28% (48 aa)

ELQKTKNEEEYMVNTFIVMQrklGTAGQKLGGAAVLCHIKHDpvdpggsfTLTSANVGKCQTVLCRNGKPLPLSRSYIMSCEEELKRIKQHKAIITEDGK
| ..  ..|. .... .. .      |.  |  || . .|..        .|. ||.|   .||.|||| | ||  .    |.||.||..    .|.||.
eedeeeededelaedllgks---eepGkdsGttavvaLvkgk--------klivanaGDsRcvlsrnGkaldlsiDhkPeDeveleRiekaGGkvtldgR

VNGVTESTRILGYTFLH-P--------SVVPRPHVQSVLLTPQDEFFILGSKGLWDSLSVEEAVEAVRNV
|||     | ||  .             .   | ..  .||..|||..| . |.|...| .| |. ||. 
vnGGLnlsRalGDhaYktneeLpaeeqmisalPDikklilteedeFlvlacDGiWnvmssqevvdFvrak

Phosphatase PHLPP1.AA Subfamily.PPM1K.PD 1207-1422 26 6.2e-18 54.8 In-house 41-264 (264) Show / Hide
Range on Protein: 1207-1422
Range on HMM: 41-264/264
Sequence Identity: 26% (60 aa)

GVFDGDRNVEVPYLLQCTMSDILAEELQKTKNEEEYMVNTFIVMQRKLGTAGQKL-GGAAVLCHIKHDPVDP-GGSFTLTSANVGKCQTVLCRNGKPLPL
.||||   .         .  |. . |.| |. || ... |  ...||    . .   |  |       |        |  |..|  ...||||||.  |
avfdGhgGssaadfvhdkleeivrrllekekdleevlkqafeeldkklkrylefsvaeaellssGttatvsllrdGnelvlaslGdsrailcrnGkakkl

SRSYIMSCEEELKRIKQHKAIITE----DGKVNGVTESTRILGYTFLHPS-VVPRPHVQSVLL-TPQDEFFILGSKGLWDSLSVEEAVEAVRNVPDALAA
.. .  . .|| .|||.    ..       .||..   || ||   | .. |.  |. .|. .   .| |..| . |.. .. .|  . ||   |   ||
tkdhdPerkeekerikaagGsvewnslgkplvnsrlamtrslGdldlkryGviatPetkslkvkhaadsflvlitdgisfvvnsqelcdlvrlchdpeea

AKKLCTLAQSYGCHDSISAVVVQL
. ... |  ||..|  .|||| | 
ahavteqalqygsednatavvvpl

Phosphatase PHLPP1.AA Subfamily.PPM1L.PD 1282-1422 36 4e-16 49.1 In-house 126-273 (273) Show / Hide
Range on Protein: 1282-1422
Range on HMM: 126-273/273
Sequence Identity: 36% (52 aa)

TLTSANVGKCQTVLC-RNGKPLPLSRSYIMSCEEELKRIKQHKAIITEDG--KVNGVTESTRILGYTFLH--PSVVPRPHVQSVLLT-PQDEFFILGSKG
|. ||||  . ||. ..|| .|||  .     .| ||||.   .|. .|  .|.||   .| ||   |.    |.. | . .  |. ||.|| | ||||.
dlivanvGdsrGvlydkrGkaiplsfdhkpqqvkerkrikkaGGfiafrGvwrvaGvlatsralGdyplkdknlviadpdiltfdlddhkpeflilasdG

LWDSLSVEEAVEAVRN-VPDALAAAKKLCTLAQSYGCHDSISAVVVQL
.| ||||. ... . .    || |   .   |. | |. .||.|    
lwdtfsneeavrfikerlkepdfGakslvlesfkrGsvdnitvlvvkl

Phosphatase PHLPP1.AA Subfamily.ILKAP.PD 1202-1393 25 5.8e-16 48.5 In-house 46-252 (298) Show / Hide
Range on Protein: 1202-1393
Range on HMM: 46-252/298
Sequence Identity: 25% (53 aa)

REALYGVFDGDRNVEVPYLLQCTMSDILAEELQKTK------NEEEYMVNTFIVMQRKLGTAGQ------KLGGAAVLCHIKHDpvdpggsfTLTSANVG
| . |.||||    .   ... .. . . |.| |..      . .  .|..|    ... .  .      | |  || . .  ..| .||.|  ..||.|
rvsyyavfDGhaGsrasefaaeklhkviveklpkedvsakdkeikkclvdafkktDeeflklaskakPvWkdGstavvvlvvdn--------vlyvanlG

KCQTVLCRN---GK--------PLPLSRSYIMSCEEELKRIKQHKAIITeDGKVNGVTESTRILGY-TFLHPSVVPRPHVQSVLLTPQDEFFILGSKGLW
.   |.        ...||. .  . .|| |||..  .... ||.|.|| |  | .|   | .  |.  |.|. . ||..| |..|   |||......|.
DskavlaRakeegdkagestiasvlLskdHtpasyeerkriqkaGgvvr-dgRvlGvlevsRsiGDgrfkelgvistPdvkkceLtenDlfvvlaCDGLw

DSLSVEEAVEAVRNVP
|. . .|         
kvfeadevvkfilkvl

Phosphatase PHLPP1.AA Subfamily.PPM1G2.PD 1200-1392 28 3.1e-13 39.3 In-house 40-237 (275) Show / Hide
Range on Protein: 1200-1392
Range on HMM: 40-237/275
Sequence Identity: 28% (55 aa)

DNREALYGVFDGDRNVEVPYLLQCTMSDILAEELQK-TKNEEEYMVNTFIVMQRKLGTA----GQKLGGAAVLCHIKHDPvdpggsftLTSANVGKCQTV
|.. ||..||||    .|       .  ..|.  .    . |. . ..|. . ..|        .. |  ||   ||..|  ||.|  ..||. .|.   
dkslalfavfDGhGGakvakyagkklikkiakkksfkegaleqilkdafletDeellkdeklkdesaGstavvvlikeek--------lyvanaGDsrav

LCRNGKPLPLSRSYIMSCEEELKRIKQHKAIItEDGKVNGVTESTRILG-YTFLHPS--------VVPRPHVQSVLLTPQDEFFILGSKGLWDSLSVEEA
||. .  . |.| |||..   .. | ..|||.    | || ..| . .        |   | ||...||| .|   |.|| |. .| |. ||.       
lsskgnvkalsfDhkPqeesekkriiaagGfv-elnrvngnLalsralgDfefkknvkkkpeeqivtavPDvlvkkldeddeflvLaCDGiWDvltnkev

VEAVRNV
       
vdlvrer

Phosphatase PHLPP1.AA Subfamily.PDP.PD 1349-1393 41 1.2e-09 27.8 In-house 282-326 (409) Show / Hide
Range on Protein: 1349-1393
Range on HMM: 282-326/409
Sequence Identity: 41% (18 aa)

PSVVPRPHVQSVLLTPQDEFFILGSKGLWDSLSVEEAVEAVRNVP
| .  .| |.|  |...| |..|.. |||| || ||.|. | .  
PYltaePevtshklrendkFLvlatDGLwdllsneevvslVgehl

Phosphatase PHLPP1.AA Subfamily.PPM1D.PD 1351-1392 45 1.2e-07 21.1 In-house 228-270 (311) Show / Hide
Range on Protein: 1351-1392
Range on HMM: 228-270/311
Sequence Identity: 45% (19 aa)

VVPRPHVQSVLLTPQDE-FFILGSKGLWDSLSVEEAVEAVRNV
| | |.|. . |.|..| | ||.| |||. |. |.||. |.. 
vsPePdvkvrtldpneekfiilasDGlwnvltpedavsvveke

Sequence
Name Sequence Type Origin Length Description Download
PHLPP1.AA Protein None 1717 None Fasta, JSON
PHLPP1.NA RNA None 5151 None Fasta, JSON
PHLPP1.AA.PD_1165-1420 Protein Phosphatase Domain None 256 None Fasta, JSON