Gene PHLPP2
PHLPP2
Classification
Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.
Protein domain
Protein domains of PHLPP2.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit phosphatase group/family/subfamily, which is helpful to understand the relationship between phosphatases. Transmembrane region is predicted by TMHMM 2.0. Visualized by pviz.
Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking. View complete domain list.
| Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
|---|---|---|---|---|---|---|---|---|---|
| Phosphatase | PHLPP2.AA | Subfamily.PHLPP.PD | 775-1031 | 66 | 8.99999999999e-143 | 463.7 | In-house | 1-257 (257) | Show / Hide |
Range on Protein: 775-1031 Range on HMM: 1-257/257 Sequence Identity: 66% (171 aa) TDSTVTSTFWSHGLAEMAGQRNKLCVSALAMDSFAEGVGAVYGMFDGDRNEELPRLLQCTMADVLLEEVQQSTNDTVFMANTFLVSHRKLGMAGQKLGSS .|....|...||||.|.||..|||||.|||...|||.|.||||..|||||.|||.||||||||||.||||...|..|..||..||||||||.||||||.| gdaslasavfshGlseaaGvknklCvaalavenfaenveavyGlidGdrnselpsllqctmadvlkeevqkdkneevyianillvshrklGeaGqklGas ALLCYIRPDTADPASSFSLTVANVGTCQAVLCRGGKPVPLSKVFSLEQDPEEAQRVKDQKAIITEDNKVNGVTCCTRMLGCTYLYPWILPKPHISSTPLT |||..|..|..|.||||.||.||||.|..||.|.|||.|||||..||.|.||..|.|..|||||||||||||...||.||.|.|.|..|||||..|..|| allirikedrvdiassftltaanvgkcklvlirnGkplplskvyileiddeelkrikeakaiitednkvnGviestrilGytflfPvvlPkphvrsvlLt IQDELLILGNKALWEHLSYTEAVNAVRHVQDPLAAAKKLCTLAQSYGCQDNVGAMVV .||||||||||||||.||..|||.|||.|.|||.|||||..||||||..|.|.|.|| eqdEllilGnkalWevlsideaveavrnvedplvaAkklvdlaqsygaadsvsalvv |
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| Phosphatase | PHLPP2.AA | Family.PPM.PD | 780-1034 | 27 | 4.5e-42 | 133.8 | In-house | 11-287 (495) | Show / Hide |
Range on Protein: 780-1034 Range on HMM: 11-287/495 Sequence Identity: 27% (76 aa) TSTFWSHGLAEMAGQRNKLCVSALAMDSFAEGV-GAVYGMFDGDRNEELPRLLQCTMADVLLEEVQQST-------------NDTVFMANTFLVSHRKLG | ...| |.| |.|.. . ..... . . ...| ||| .| .. . .. ..|...... . . ..||...| ssnglrygvasmqgwrsemeDahvvvenlennedfslfgvfDGhgGaeaaefaakklhkilkkqlekkddeksstsaessaekvkealrkafleldeels MAG-Q-----KLGSSALLCYIRPDTadpassfsLTVANVGTCQAVLCRGGKPVPLSKVFSLEqDPEEAQRVKDQKAIIT-EDNKVNGVTCCTRMLGCTYL . . |..|. ..||... | |||.| ..||||| ||.|.||| . | .||| .|.... .. .|..||||.| || | . eelneksagkdsGtTAvvvlirgkk--------lyvAnaGDsravLcrngkavelskdHkpe-npeEreRIekagGkvvirdgrvnGvlavsRalGdfdl YP----WILPKPHISSTPLT-IQDELLILGNKALWEHLSYTEAVNAVRHVQ-----DPLAAAKKLCTLAQSYGCQDNVGAMVVYLN . ..|.|.|..|| .|| |.| ||. || |.|. || |. ..|..|. | ..|..||. ..|| |. kkeeqaivsaePditsvkltqeedeflvlasdGlWdvlsneevvelvretleekeedleeiaeeLvdealakgsrDNiTvlvvaly |
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| Phosphatase | PHLPP2.AA | Group.PPM.PD | 779-1034 | 26 | 3.3e-38 | 121.2 | In-house | 33-322 (459) | Show / Hide |
Range on Protein: 779-1034 Range on HMM: 33-322/459 Sequence Identity: 26% (75 aa) VTSTFWSHGLAEMAGQRNKLCVSALAMDSFAEGVgAVYGMFDGDRNEELPRLLQCTMADVLLEEVQQS-------------------TNDTVFMANTFLV .. | |.| |.|.. . ....| . ...| ||| .| .. . .. ..|...... . ...|| ...| gsgnglrygvasmqgwrkemEDrhvivenfdnnd-sffgVfDGHgGaeaaefaakkLpkilkkqlkkkkdevskksaeasldnddrgekvkkalrsafle SHRKLG-M------AGQKLGSSALLCYIRPDtadpassfSLTVANVGTCQAVLCRGGKPVPLSKVFSLEqDPEEAQRVKDQKAIITEDNKVNGVTCCTRM . .|.. |..|. ..|... | |||.| ..||||| ||.||||| . | .||| .|.... .. |..|||. .| || | ldedlseeanekeepgkdsGtTAvvalingk--------klyvANaGDSravLcrngkavplskdHkpe-npeEreRIekagGsveidgRvnGilavsRa LGCTYLYPW---ILPKPHISSTPLTIQDELLILGNKALWEHLSYTEAVNAVRHVQDP---------LAAAKKLCTLAQSYGCQ------DNVGAMVVYLN . . ..|..|. .|| .|| |.|. ||. || |.|. || . ..|..|. | . |..||. ..|| || lGdhdlkkeeqmvsaePdvsvvklteedeflvlAsDGlWdvlsneevvefvretlekkkkelkkdleeiaerlvdealakgstgdgtscDNiTvivvtln |
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| Phosphatase | PHLPP2.AA | PP2Cc | 775-1031 | 18 | 6.5e-37 | 129.87 | SMART | 1-338 (338) | Show / Hide |
Range on Protein: 775-1031
Range on HMM: 1-338/338
Sequence Identity: 18% (69 aa)
TDSTVTSTFWSHGL--AEMAGQRNKLCVSALAMDSFAEGVGAVYGMFDGDRNEELPRLLQCTMADVLLEEVQQSTNDTVF--------------------
.. . |..|. .| | | . . .. ..| ||| . | . .. . . |.||.|. . |
HS-MGYNSGWRYGYMESSMQGWRHPMEDAHVCRP--------FFGVFDGHGGHECAQYCRKHLHEHLAEELQFHKDDDYKENDEMQDEPEMWWRMWHDKW
-------MANTFLVSHRKLGMAGQKLGSSALLCYIRPDTADPASSFSLTVANVGTCQAVLCRGGK----------PVPLSKVFSLEQDPEEAQRVKDQKA
. ..|| . .. ..|....||... | ||||| ..|||||.|. ...|.. . ...|..|... .
FEDWEDALRKAFLRMDEEI--------CTAVVALIRGNK--------LYVANVGDSRAVLCRNGNDNWWGIRHYTAHQLTEDHKP-DNEDERRRIEQAGG
-------IITEDN-----KVNGV---TCCTRMLGCTYLY------------------------PWILPKPHISSTPL------TIQDELLILGNKALWEH
. ... .|||| . .| .| |. |.. . |..... | | .|..|||. ||..
RVMPMHRQWVMNWNCDVWRVNGVPIPLAVSRAFGDHYYKWKEDEKIEWNRWYQMFDPRLPFKEPYVIAEPDVTHHELWQMTVPTPDDDFLILCCDGLWDV
LSYTEAVNAVRH---------------------------VQDPLAAAKKLCTLAQSYGCQDNVGAMVV
.|. |.| || ..|| .|||.|| .|. .||. ..||
MSNQEVVDIVRKCLRKWHHKPVKNQAQENAHMMRHRQKKHNDPMEAAKRLCDCAI----CDNMTVIVV
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| Phosphatase | PHLPP2.AA | PP2C | 872-1026 | 27 | 1.6e-26 | 97.1 | Pfam | 115-284 (284) | Show / Hide |
Range on Protein: 872-1026
Range on HMM: 115-284/284
Sequence Identity: 27% (48 aa)
GSSALLCYIRPDTADPASSFSLTVANVGTCQAVLCRGGKPV----PLSKVFSLEQDPEEAQRVKDQKAIITE--DNKVNGV-TCCTRMLGCTYLYP----
|..|...|||... .| |||.|...|||||.|... .|.. . . ...|. |... . ..|||| .|..| ....|
GCTAVCAYIRNQKN------ILYVANCGDSRAVLCRNGNAHNWVHQLTYDHKPS-NEDERRRIRQAGGWVMWWGFWRVNGVWLAVSRAFGDFHYKPNHTC
-----WILPKPHIS-STPLTIQ-DELLILGNKALWEHLSYTEAVNAVRHVQD----PLAAAKKLCTLAQSYGCQDNV
.. . |.|. ....| . || |||.. ||...|. |.. || . |. |..||......||..||.
FPKEQPVTAEPDITPEHKITPDHDEFLILACDGLWDVMSDQEVCDIVRQCRSDWNDPMEACEKLVDYCIAYGSEDNI
|
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| Phosphatase | PHLPP2.AA | Subfamily.LRR-PP2C.PD | 784-1031 | 25 | 1.4e-25 | 79.8 | In-house | 10-255 (257) | Show / Hide |
Range on Protein: 784-1031
Range on HMM: 10-255/257
Sequence Identity: 25% (64 aa)
WSHGLAEMAGQRNKLCVSALAMDSFAEGVGA-VYGMFDGDRNEELPRLLQCTMADVLLEEVQQS-TNDTVFMANTFLVSHRKLGMAGQKLGSSALLCYIR
. | ..| |.|. . . . || .. . .| .||| .. . .. .| | .. .| . ... . ..... .|..| .| |
fkvgfsdmiGrrptmedelviyGsfrdksdedyyalfdGhgGraaakfaseelykilaelldlnnanPlkslkkaykeistqiserpkfiGttaasvlii
PDTadpassfsLTVANVGTCQAVLC-RGGKPVPLSKVFSlEQDPEEAQRVKDQKAIITED---NKVNGVTCCTRMLGCTYLYPWILPKPHIS-STPLTIQ
.|||| ..||| . | . || ....| .|... . .. .|||.| || ..| |...|.|..| | ...|. |||
edk--------vyianvGdsrvvlcqkdgtakrlsldhk-PseeseekriselGGtvvstvvtsrvnGtlavsralGdsflePfvvpdPdlsqsleiskk
DELLILGNKALWEHLSYTEAVNAVRHVQDPLAAAKKLCTLAQSYGCQDNVGAMVV
.|. .| |||. | ..|| ||.|| || | | .||. .|.
dkflilacdGiwdlisdeeaveivagisdpekaaeklrdlayssGstdnisvivi
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| Phosphatase | PHLPP2.AA | Subfamily.PPM1E.PD | 813-1033 | 24 | 3.6e-23 | 71.9 | In-house | 47-269 (269) | Show / Hide |
Range on Protein: 813-1033 Range on HMM: 47-269/269 Sequence Identity: 24% (56 aa) GAVYGMFDGDRNEELPRLLQCTMADVLLEEVQQSTNDTVFMANTFLVSHRKLGMA----GQKLGSSALLCYIRPDTadpassfsLTVANVGTCQAVLCRG |....||| | . . . .| .. .. .. . . ..| . ... . | || | . |. |. | ||.| ||.|.| |. raffavfDGHgGveaakyaaahlhellvrqeklkedpaealkeafkltDerflqkaereklksGstavvvliekdq--------lyvaWlGDsqallvrk GKPVPLSKVFSLEQdPEEAQRVKDQKAIIT--EDNKVNGVTCCTRMLGCTYLYPWILPKPHISSTPLTIQDELLILGNKALWEHLSYTEAVNAV-RHVQD | | | . |. ..|..|... .. . .|||| .| .| . | |.. .. .....|. ....|||.||... |.|..| ...|. geavqlmkpHkPer-edEkkRieeagGlvvvigawRvnGvLsvsRaiGDvklkpyvsgeadvaeveldgsedylilacDGlwDvvneeevvklveeflad P----LAAAKKLCTLAQSYGCQDNVGAMVVYL .||.|.. |.. | .||. ..||.| gaedlsevakllveaakeagssDnitvvvvfl |
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| Phosphatase | PHLPP2.AA | Subfamily.PPM1K.PD | 892-1032 | 30 | 2.2e-16 | 49.6 | In-house | 118-263 (264) | Show / Hide |
Range on Protein: 892-1032 Range on HMM: 118-263/264 Sequence Identity: 30% (43 aa) SLTVANVGTCQAVLCRGGKPVPLSKVFSLEqDPEEAQRVKDQKAIITE----DNKVNGVTCCTRMLGCTYLYPW-ILPKPHISSTPL-TIQDELLILGNK | .|..| .|.||| ||. |.| . | || .|.| .. .||.. . || || | .. .. .|. | ..| .|.| . elvlaslGdsrailcrnGkakkltkdhdPe-rkeekerikaagGsvewnslgkplvnsrlamtrslGdldlkryGviatPetkslkvkhaadsflvlitd ALWEHLSYTEAVNAVRHVQDPLAAAKKLCTLAQSYGCQDNVGAMVVY .. | . || .|| ||. ... | ||..||. |.|| gisfvvnsqelcdlvrlchdpeeaahavteqalqygsednatavvvp |
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| Phosphatase | PHLPP2.AA | Subfamily.PPM1L.PD | 891-1032 | 32 | 1.3e-14 | 44.1 | In-house | 125-272 (273) | Show / Hide |
Range on Protein: 891-1032 Range on HMM: 125-272/273 Sequence Identity: 32% (47 aa) FSLTVANVGTCQAVLCR-GGKPVPLSKVFSlEQDPEEAQRVKDQKAIITED--NKVNGVTCCTRMLGCTYLY--PWILPKPHISSTPLT-IQDELLILGN |.||||| . ||. || .||| |...| .|.|. .|. . .|.|| .| || | ....| | . |. |.||| ||. sdlivanvGdsrGvlydkrGkaiplsfdhk-pqqvkerkrikkaGGfiafrGvwrvaGvlatsralGdyplkdknlviadpdiltfdlddhkpeflilas KALWEHLSYTEAVNAV-RHVQDPLAAAKKLCTLAQSYGCQDNVGAMVVY .| |||. . ....| || | . |. ||. .|| dGlwdtfsneeavrfikerlkepdfGakslvlesfkrGsvdnitvlvvk |
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| Phosphatase | PHLPP2.AA | Subfamily.PPM1A.PD | 787-1033 | 22 | 2.6e-13 | 39.6 | In-house | 13-278 (309) | Show / Hide |
Range on Protein: 787-1033 Range on HMM: 13-278/309 Sequence Identity: 22% (59 aa) GLAEMAGQRNKLCVSALAMDSFAEGV--GAVYGMFDGDRNEELPRLLQCTMADVLLEE------VQQSTND--TVFMANTFLVSHR------KLGMAGQK ||..| | | .. . |. ...... . ...||| .. . . .. . .||| ..|... . ..||.| .| || | . . glssmqgwRvemEDahtavidlpsklkdwsffavfDGHaGskvskycakhlleaileeeefkaskeksskekvkealrkgfLelDekirklvelskgedk LGSSALLCYIRpdtadpasSFSLTVANVGTCQAVLCRGGKPVPLSKVFSlEQDPEEAQRVKDQKAIITEdNKVNGVTCCTRMLGCTYL---------YPW . .| .||.| |||.| || | .. ||.| .|... .. ..|||.| || . |.|.. .. . sGsTavvvlvs--------pkklylancGDsRavlsrngkvvfateDHk-psdpkEkeRienAgGsvmi-kRvnGsLAvsRalGDydykekpekkateql ILPKPHISSTPLTIQDELLILGNKALWEHLSYTEAVNAVRHV----QDPLAAAKKLCTLAQSYGCQDNVGAMVVYL .|| |.| .|. .| |... |.. .|. ..|..| . . | .||. ...| | vspepevtvierdeedeflvlacDGiwDvmsneevaefvksrlevtddleevanelldtcLekgsrDNmsvilvll |
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| Phosphatase | PHLPP2.AA | Subfamily.PPM1G.PD | 853-1004 | 28 | 7.3e-12 | 34.9 | In-house | 292-440 (482) | Show / Hide |
Range on Protein: 853-1004 Range on HMM: 292-440/482 Sequence Identity: 28% (45 aa) MANTFLVSHrklGMAGQKLGSSALLCYIRPDTadpassfsLTVANVGTCQAVLCRGGKPVPLSKVFSlEQDPEEAQRVKDQKAIITEDNKVNGVTCCTRM .|.. |.. |. |. |. . .. .. |.|||.| .||.| || . || .|..|..|.. .|.|.||| | | laedllgks---eepGkdsGttavvaLvkgkk--------livanaGDsRcvlsrnGkaldlsiDhk-PeDeveleRiekaGGkvtldgRvnGGLnlsRa LGC-TYLYPWILP--------KPHISSTPLTIQDELLILGNKALWEHLSYTEAVNAVRHVQ | .| || | | . || .|| |.| .| .| | |. ||. lGDhaYktneeLpaeeqmisalPDikklilteedeFlvlacDGiWnvmssqevvdFvrakl |
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| Phosphatase | PHLPP2.AA | Subfamily.ILKAP.PD | 893-1004 | 27 | 3.6e-10 | 29.3 | In-house | 131-252 (298) | Show / Hide |
Range on Protein: 893-1004 Range on HMM: 131-252/298 Sequence Identity: 27% (33 aa) LTVANVGTCQAVLCRG---G--------KPVPLSKVFSLEqDPEEAQRVKDQKAIITeDNKVNGVTCCTRMLGC-TYLYPWILPKPHISSTPLTIQDELL | |||.| .|||.| | ..|.||| . . || .|... .... |..|.|| | .| . . .|.... || .| .. lyvanlGDskavlaRakeegdkagestiasvlLskdHtpa-syeerkriqkaGgvvr-dgRvlGvlevsRsiGDgrfkelgvistPdvkkceLtenDlfv ILGNKALWEHLSYTEAVNAVRHVQ | ||. ... |.|. . .| vlaCDGLwkvfeadevvkfilkvl |
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| Phosphatase | PHLPP2.AA | Subfamily.PPM1G2.PD | 841-1003 | 24 | 4.7e-07 | 19.0 | In-house | 78-237 (275) | Show / Hide |
Range on Protein: 841-1003 Range on HMM: 78-237/275 Sequence Identity: 24% (42 aa) EEVQQSTNDTVFMANTFLVSHRKlgMAGQKLGSSALLCYIRPDTadpassfsLTVANVGTCQAVLCRGGKPVPLSKVFSlEQDPEEAQRVKDQKAIItED ....| .|.. .. |....| .. .. || |. |. . | |||.| .|||. |. || |. .|..|.... .. | galeqilkdafletDeellkdek--lkdesaGstavvvlikeek--------lyvanaGDsravlsskgnvkalsfDhk-PqeesekkriiaagGfv-el NKVNGVTCCTRMLGCT-YLYP--------WILPKPHISSTPLTIQDELLILGNKALWEHLSYTEAVNAVRHV |.|||. | || . . | . . |. .|| |.| .|. |. .| |. ||. nrvngnLalsralgDfefkknvkkkpeeqivtavPDvlvkkldeddeflvLaCDGiWDvltnkevvdlvrer |
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| Phosphatase | PHLPP2.AA | Subfamily.PDP.PD | 960-1004 | 32 | 6.4e-06 | 15.4 | In-house | 282-326 (409) | Show / Hide |
Range on Protein: 960-1004 Range on HMM: 282-326/409 Sequence Identity: 32% (14 aa) PWILPKPHISSTPLTIQDELLILGNKALWEHLSYTEAVNAVRHVQ |.. .| . | .|. .| |.|. ||. || |.|. | . PYltaePevtshklrendkFLvlatDGLwdllsneevvslVgehl |
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