PPM1A
Species: Human
Alias: PPM1A, PP2C-ALPHA, PP2Calpha, MGC9201, PP2CA, FLJ42306
External Links: COSMIC , Entrez Gene
Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Superfamily: PPM
Family: PPM
Subfamily: PPM1A
Protein domain

Protein domains of PPM1A.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit phosphatase group/family/subfamily, which is helpful to understand the relationship between phosphatases. Transmembrane region is predicted by TMHMM 2.0. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking. View complete domain list.

Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Phosphatase PPM1A.AA Group.PPM.PD 11-365 39 5.8e-119 387.8 In-house 27-395 (459) Show / Hide
Range on Protein: 11-365
Range on HMM: 27-395/459
Sequence Identity: 39% (147 aa)

EKHNAQGQGNGLRYGLSSMQGWRVEMEDAHTAVIGLPSGLeswSFFAVYDGHAGSQVAKYCCEHLLDHITNNQDFKGSAGAPSV-----------ENVKN
. .. .|.||||||| .|||||| ||||.|..|  . .     |||.|.|||.|...|... ..| ......  .| .  . .            |.||.
hlessagsgnglrygvasmqgwrkemEDrhvivenfdnnd---sffgVfDGHgGaeaaefaakkLpkilkkqlkkkkdevskksaeasldnddrgekvkk

GIRTGFLEIDEHMRVMSEKKH-GADRSGSTAVGVLISPQHTYFINCGDSRGLLCRNRKVHFFTQDHKPSNPLEKERIQNAGGSVMI-QRVNGSLAVSRAL
 .|..|||.|| .. ....|.   ..||.||| .||.... |. |.||||..|||| |..  ..||||.|| |.|||..|||||.| .||||.|||||||
alrsafleldedlseeanekeepgkdsGtTAvvalingkklyvANaGDSravLcrngkavplskdHkpenpeEreRIekagGsveidgRvnGilavsRal

GDFDYKCvhgkgpTEQLVSPEPEVHDIERSEEdDQFIILACDGIWDVMGNEELCDFVRSRLEV-----TDDLEKVCNEVVDTCLYKGSR------DNMSV
||.|.|       .||.||.||.|. .. .|| |.|..||.||.|||. |||...|||..||      . |||......||..| |||.||..||.....
Gdhdlkk------eeqmvsaePdvsvvkltee-deflvlAsDGlWdvlsneevvefvretlekkkkelkkdleeiaerlvdealakgstgdgtscDNiTv

ILICFPNAPKVSPEAVKKEAELDKYLECRVEEIIKKQGEGVPDLVHVMRTLASENIPSLPPGGELASKRNVIEAVYNRL
.|.... |.||||..|.. |...|.|...|.|. .   |... . |...  . .....|.......|..|..|      
ivvtlndamrrqleivkkeevleeelafmvaelteksgltallsvqlklldaqaeeeitsvqdglqvtdrngeiiyqgl

Phosphatase PPM1A.AA Subfamily.PPM1A.PD 13-322 68 2.4e-157 513.0 In-house 1-309 (309) Show / Hide
Range on Protein: 13-322
Range on HMM: 1-309/309
Sequence Identity: 68% (213 aa)

HNAQGQGNGLRYGLSSMQGWRVEMEDAHTAVIGLPSGLESWSFFAVYDGHAGSQVAKYCCEHLLDHITNNQDFKGSAGAPSVENVKNGIRTGFLEIDEHM
.|..|.||||||||||||||||||||||||||.|||.|..||||||.||||||.|.|||..|||..|.....||.|. ..|.|.||...|.||||.||..
eneegegnglryglssmqgwRvemEDahtavidlpsklkdwsffavfDGHaGskvskycakhlleaileeeefkaskeksskekvkealrkgfLelDeki

RVMSEKKHGADRSGSTAVGVLISPQHTYFINCGDSRGLLCRNRKVHFFTQDHKPSNPLEKERIQNAGGSVMIQRVNGSLAVSRALGDFDYKCVHGKGPTE
| ..|...|.|.||||||.||.||...|..||||||..|.||.||.| |.|||||.| |||||.||||||||.||||||||||||||.|||. . |..||
rklvelskgedksGsTavvvlvspkklylancGDsRavlsrngkvvfateDHkpsdpkEkeRienAgGsvmikRvnGsLAvsRalGDydykekpekkate

QLVSPEPEVHDIERSEEDDqFIILACDGIWDVMGNEELCDFVRSRLEVTDDLEKVCNEVVDTCLYKGSRDNMSVILICFPNAPKVSPEAVKKEAELDKYL
|||||||||. |||.|||. |..|||||||||| |||...||.||||||||||.|.||..|||| |||||||||||...|.||||| ||.|||.|||| |
qlvspepevtvierdeede-flvlacDGiwDvmsneevaefvksrlevtddleevanelldtcLekgsrDNmsvilvllpgapkvseeaikkekeldkel

ECRVEEIIKK
|..|||...|
eekveevlek

Phosphatase PPM1A.AA PP2C 22-284 41 2.4e-116 397.62 Pfam 1-284 (284) Show / Hide
Range on Protein: 22-284
Range on HMM: 1-284/284
Sequence Identity: 41% (121 aa)

LRYGLSSMQGWRVEMEDAHTAVIGLP---SGLESWSFFAVYDGHAGSQVAKYCCEHLL----DHITNNQDFKGS-AGAPSVENVKNGIRTGFLE--IDEH
..||...||||| .|||||..   .    || .||.||||.|||.|.|.||||..||     ... ....|... .     ..|....| .|||  .|..
WDYGFCRMQGWRHFMEDAHHCYPNMNCSSSGKDSWHFFAVFDGHGGHQAAKYCRKHLHKAMNTILKERKSFPEGNP-----KDVEQALRKSFLECDTDMM

MRV---MSEK-KHG-ADRSGSTAVGVLISPQH--TYFINCGDSRGLLCRNRKVH----FFTQDHKPSNPLEKERIQNAGGSVM---IQRVNGS-LAVSRA
..    ...  .|.  ..||.||| ..|..|.   |. ||||||..||||...|    . |.||||||..|..||..|||.||    .||||. ||||||
FYSAPWHEQNVMHWECWHSGCTAVCAYIRNQKNILYVANCGDSRAVLCRNGNAHNWVHQLTYDHKPSNEDERRRIRQAGGWVMWWGFWRVNGVWLAVSRA

LGDFDYKCVHGKGPTEQLVSPEPEVH-DIERSEEDDQFIILACDGIWDVMGNEELCDFVRSRLEVTDDLEKVCNEVVDTCLYKGSRDNM
.|||.||. |...|.||.|..||...  .......|.|.||||||.|||| ..|.||.||.... ..|....|...||.|. .||.||.
FGDFHYKPNHTCFPKEQPVTAEPDITPEHKITPDHDEFLILACDGLWDVMSDQEVCDIVRQCRSDWNDPMEACEKLVDYCIAYGSEDNI

Phosphatase PPM1A.AA Family.PPM.PD 12-363 37 3.6e-114 372.0 In-house 5-358 (495) Show / Hide
Range on Protein: 12-363
Range on HMM: 5-358/495
Sequence Identity: 37% (134 aa)

KHNAQGQGNGLRYGLSSMQGWRVEMEDAHTAVIGLPSGLeSWSFFAVYDGHAGSQVAKYCCEHLLDHITNNQDFKGSAGAP-----SVENVKNGIRTGFL
... ....|||||| .|||||| ||||||..| .| .   ..|.|.|.|||.|...|... ..| .........|...        | |.||. .|..||
arteasssnglrygvasmqgwrsemeDahvvvenlenne-dfslfgvfDGhgGaeaaefaakklhkilkkqlekkddeksstsaessaekvkealrkafl

EIDEHMRVMSEKKHGADRSGSTAVGVLISPQHTYFINCGDSRGLLCRNRKVHFFTQDHKPSNPLEKERIQNAGGSVMI--QRVNGSLAVSRALGDFDYKC
|.|| .. . ..|.  ..||.||| |||.... |. |.|||| .|||| |..  ..||||.|| |.|||..|||.|.|  .||||.|||||||||||.| 
eldeelseelneksagkdsGtTAvvvlirgkklyvAnaGDsravLcrngkavelskdHkpenpeEreRIekagGkvvirdgrvnGvlavsRalGdfdlkk

vhgkgpTEQL-VSPEPEVHDIERSEEDDQFIILACDGIWDVMGNEELCDFVRSRL-EVTDDLEKVCNEVVDTCLYKGSRDNMSVILICFPNAPKVSPEAV
      .||. ||.||... .. ..|.|.|..||.||.|||. |||....||..| | . |||....|.||..| ||||||..|.........|.. ..|
------eeqaivsaePditsvkltqeedeflvlasdGlWdvlsneevvelvretleekeedleeiaeeLvdealakgsrDNiTvlvvalyenikqqnrfv

KKEAELDKYLECRVEEIIKKQGEGVPDLVHVMRTLASENIPSLPPGGELASKRNVIEAVYN
... .|.. ............ | . . .. . . ....  | ....  ........ ..|
lnknslmtrrstfedttlrrlqeeispptgnlamvftdiksstflwelfpnamrtaikthn

Phosphatase PPM1A.AA PP2Cc 13-289 30 1.1e-108 368.3 SMART 1-338 (338) Show / Hide
Range on Protein: 13-289
Range on HMM: 1-338/338
Sequence Identity: 30% (113 aa)

HNAQGQGNGLRYGL--SSMQGWRVEMEDAHTAVIGLPSGLESWSFFAVYDGHAGSQVAKYCCEHLLDHITNNQDFKGSA-------------------GA
|.  |...|.|||.  |||||||..||||| ...          ||.|.|||.|...|.||..||..|. .. .|. .                    . 
HS-MGYNSGWRYGYMESSMQGWRHPMEDAHVCRP----------FFGVFDGHGGHECAQYCRKHLHEHLAEELQFHKDDDYKENDEMQDEPEMWWRMWHD

PSVENVKNGIRTGFLEIDEHMRVMSEKKHGADRSGSTAVGVLISPQHTYFINCGDSRGLLCRNRK----------VHFFTQDHKPSNPLEKERIQNAGG-
.. |.... .| .||..|| .              .||| .||.... |. |.||||  |||| .          .|. |.||||.|. |..||..||| 
KWFEDWEDALRKAFLRMDEEI--------------CTAVVALIRGNKLYVANVGDSRAVLCRNGNDNWWGIRHYTAHQLTEDHKPDNEDERRRIEQAGGR

-------SVMIQ-----RVNGS---LAVSRALGDFDYKCVH----------------GKGPTEQLVSPEPEVHDIERS-----EEDDQFIILACDGIWDV
        || .     ||||.   ||||||.||..||. .                 ....|..|..||.|...|..      .||.|.||.|||.|||
VMPMHRQWVMNWNCDVWRVNGVPIPLAVSRAFGDHYYKW-KEDEKIEWNRWYQMFDPRLPFKEPYVIAEPDVTHHELWQMTVPTPDDDFLILCCDGLWDV

MGNEELCDFVRSRL-----------------------EVTDDLEKVCNEVVDTCLYKGSRDNMSVILI
| |.|..|.||..|                       ... |.........| ..    .|||.||..
MSNQEVVDIVRKCLRKWHHKPVKNQAQENAHMMRHRQKKHNDPMEAAKRLCDCAI----CDNMTVIVV

Phosphatase PPM1A.AA Subfamily.PPM1G2.PD 16-289 41 3.3e-85 275.7 In-house 4-275 (275) Show / Hide
Range on Protein: 16-289
Range on HMM: 4-275/275
Sequence Identity: 41% (114 aa)

QGQGNGLRYGLSSMQGWRVEMEDAHTA---VIGLPSGlESWSFFAVYDGHAGSQVAKYCCEHLLDHITNNQDFKgsagapsVENVKNGIRTGFLEIDEHM
.|. . .. |.|||||.|..|||||.    .. ..   .| ..|||.||| |..||||. ..|   |.....||        ..... ...|||.||...
sganariavgvssmqGyrlnmeDahilenelleksdd-kslalfavfDGhGGakvakyagkklikkiakkksfk-------egaleqilkdafletDeel

RVMseKKHGADRSGSTAVGVLISPQHTYFINCGDSRGLLCRNRKVHFFTQDHKPSNPLEKERIQNAGGSVMIQRVNGSLAVSRALGDFDYKCVHGKGPTE
    .|   . .||||| |||. .. |  |.|||| .|. . .|. .. ||||..  ||.||..||| | ..||||.||.||||||| .|  . |.| ||
lkd--eklkdesaGstavvvlikeeklyvanaGDsravlsskgnvkalsfDhkPqeesekkriiaagGfvelnrvngnLalsralgDfefkknvkkkpee

QLVSPEPEVHDIERSeEDDQFIILACDGIWDVMGNEELCDFVRSRLEVTDDLEKVCNEVVDTCLYKGSR------DNMSVILI
.|  .|.|   ... ||| |..|||||||||. |.|..|.||.||    .|.....|..|.|| . |.|||.|...       
qivtavPDvlvkkld-eddeflvLaCDGiWDvltnkevvdlvrerlvsgakldeiieelldkclapdssntgvGcDnmtvviv

Phosphatase PPM1A.AA Subfamily.PPM1E.PD 27-289 34 4.7e-56 180.1 In-house 16-267 (269) Show / Hide
Range on Protein: 27-289
Range on HMM: 16-267/269
Sequence Identity: 34% (91 aa)

SSMQGWRVEMEDAHTAVIGLPSGL-----ESWSFFAVYDGHAGSQVAKYCCEHLLDHITNNQDFKGSAGapsvenvkNGIRTGFLEIDEHMRVMSEKKhg
.... |  ||| | |.  | . .     .  .||||.|||.|.. |||  .||  .. .....| ..         . .. .| ..||...|..  . .|
aavknkrrkmEDrhvaledlnelfelkdekeraffavfDGHgGveaakyaaahlhellvrqeklkedpa--------ealkeafkltDerflqkaere--

ADRSGSTAVGVLISPQHTYFINCGDSRGLLCRNRKVHFFTQDHKPSNPLEKERIQNAGGSVMI---QRVNGSLAVSRALGDFDYKcvhgkgpteQLVSPE
||||| |||. .. |    |||..||.|....  ... |||... ||.||..||| |.     ||||.|.||||.||..|         . || |..| .
klksGstavvvliekdqlyvaWlGDsqallvrkgeavqlmkpHkPeredEkkRieeagGlvvvigawRvnGvLsvsRaiGDvklk---------pyvsge

PEVHDIERsEEDDQFIILACDGIWDVMGNEELCDFVRSRLEVTD-DLEKVCNEVVDTCLYKGSRDNMSVILI
.|  .......||||||.|||. .||... |.. |. .  ||..| ...|..   .||.||..|...     
advaevel-dgsedylilacDGlwDvvneeevvklveefladgaedlsevakllveaakeagssDnitvvvv

Phosphatase PPM1A.AA PP2C_C 285-364 71 4.5e-54 180.68 Pfam 1-82 (82) Show / Hide
Range on Protein: 285-364
Range on HMM: 1-82/82
Sequence Identity: 71% (59 aa)

SVILICFPNAPKVSPEAVKKEAELDKYLECRVEEIIKK--QGEGVPDLVHVMRTLASENIPSLPPGGELASKRNVIEAVYNR
|.|.||||.|||||.||||||||||||||.||||||.|    ...|||.|||..||||.|| ||||| |.|||..||||||.
SIIIICFPGAPKVSEEAVKKEAELDKYLEQRVEEIIEKMHSEHEYPDLLHVMKCLASEDIPNLPPGGGLHSKRSCIEAVYNQ

Phosphatase PPM1A.AA Subfamily.LRR-PP2C.PD 17-289 34 5.1e-51 163.6 In-house 5-255 (257) Show / Hide
Range on Protein: 17-289
Range on HMM: 5-255/257
Sequence Identity: 34% (92 aa)

GQGNGLRYGLSSMQGWRVEMEDAHTaVIGLPSGLESWSFFAVYDGHAGSQVAKYCCEHLLDHITNNQDFKGSagaPSVENVKNgirtGFLEIDEHMrvmS
.... .. | | | | |  |||  . . |   . .   ..|..|||.|.. ||...|.|   ...  | . .   . .. .|.. ||.  .   ||.   
sdssrfkvgfsdmiGrrptmedelv-iyGsfrdksdedyyalfdGhgGraaakfaseelykilaelldlnna---nPlkslkk----aykeistqi---s

EKKhgaDRSGSTAVGVLISPQHTYFINCGDSRGLLC-RNRKVHFFTQDHKPSNPLEKERIQNAGGSVMIQ----RVNGSLAVSRALGDFdYkcvhgkgpT
  . |.||. |||  ...|  | |||| .|| ..   .  . |||||.. |..||...|| |. .    |||| |||||||||  .         |  | 
erp---kfiGttaasvliiedkvyianvGdsrvvlcqkdgtakrlsldhkPseeseekriselGGtvvstvvtsrvnGtlavsralGds-f--------l

EQLVSPEPEVHDIERSEEDDQFIILACDGIWDVMGNEELCDFVRSrlevTDDLEKVCNEVVDTCLYKGSRDNMSVILI
|.|....  .  ..|.|.|||||||||.. .|| .. | .      | || .... |.|| ||.|||.|         
ePfvvpdPdlsqsleiskkdkflilacdGiwdlisdeeaveivag----isdpekaaeklrdlayssGstdnisvivi

Phosphatase PPM1A.AA Subfamily.PPM1G.PD 117-290 40 1.1e-48 156.8 In-house 300-481 (482) Show / Hide
Range on Protein: 117-290
Range on HMM: 300-481/482
Sequence Identity: 40% (74 aa)

EKKHGADrSGSTAVGVLISPQHTYFINCGDSRGLLCRNRKVHFFTQDHKPSNPLEKERIQNAGGSVM-IQRVNGSLAVSRALGDFDYKCVHGKGPTEQLV
. . | | ||.|||  |.  .. .  | ||||  |.|| |   .  |||| .. |.|||..||| |    |||| | .||||||  ||  ... ||..| 
seepGkd-sGttavvaLvkgkklivanaGDsRcvlsrnGkaldlsiDhkPeDeveleRiekaGGkvtldgRvnGGLnlsRalGDhaYktneeLpaeeqmi

SPEPEVHDIeRSEEDDQFIILACDGIWDVMGNEELCDFVRSRLEVT---DDLEKVCNEVVDTCLYKGS------RDNMSVILIC
 |...      |.|.|..|||||||.||  .|  ||||..|. .     | ..|.|..|.|| .         |||.|...   
salPDikkl-ilteedeFlvlacDGiWnvmssqevvdFvraklkeseeskklseiceeLlDaCLapdtsgDGtGCDnmtvvivq

Phosphatase PPM1A.AA Subfamily.ILKAP.PD 25-288 31 2.2e-47 151.9 In-house 12-297 (298) Show / Hide
Range on Protein: 25-288
Range on HMM: 12-297/298
Sequence Identity: 31% (92 aa)

GLSSMQGWRVEMEDAHTAVIGLP-------SGLESWSFFAVYDGHAGSQVAKYCCEHLLDHITNNQDfKGSAGAPSvENVKNGIRTGFLEIDEHMRVMSE
. .. .| | ||||||. .  |        | . . |..||.||||||. .... |.| ..| ..   | .  |   ...|  ..  | .||..  ...|
afaerkGereemeDahvilndldeqtrkekskvsrvsyyavfDGhaGsrasefaaeklhkviveklp-kedvsakd-keikkclvdafkktDeeflklas

KKHGADRSGSTAVGVLISPQHTYFINCGDSRGLLCRNRKV-----------HFFTQDHKPSNPLEKERIQNAGGSVMIQRVNGSLAVSRALGDFDYKCVH
.. . ..||||| ||.  .  |  | |||. .|.|...               ..||.|..  |..|||.|||.|.  ||.|.|.|||..||  .| .  
kakPvWkdGstavvvlvvdnvlyvanlGDskavlaRakeegdkagestiasvlLskdHtpasyeerkriqkaGgvvrdgRvlGvlevsRsiGDgrfkelg

gkgpteqlVSPEPEVHDIERSEEdDQFIILACDGIWDVMGNEELCDFVRSRLEVTDD---------------LEKVCNEVVDTCLYKGSRDNMSVIL
       |. .|.|. .| .|. |.|..|||||.|.|. ..|  .|. . ||  ||               .| .|. .    . .|| ||..|.| 
--------vistPdvkkceLten-DlfvvlaCDGLwkvfeadevvkfilkvlededdrkikqeegksaeevrfevacerlAseavkrgssDnvtvll

Phosphatase PPM1A.AA Subfamily.PPM1L.PD 28-291 32 1.5e-42 136.1 In-house 18-273 (273) Show / Hide
Range on Protein: 28-291
Range on HMM: 18-273/273
Sequence Identity: 32% (84 aa)

SMQGWRVEMEDAHTAVIGLPSGLEsWSFFAVYDGHAGSQVAKYCCEHLLDHITNNQ-DFKGSAGAPSVENVKNGIRTGFLEIDEHMrvMSEKKHGADRSG
|..| | .|||  .   ..  . .  |||||.||| |   |... . | . | |.  ... .       | .. .    | .||..  . .|.  | .|.
svlGrrprmedrfeieediknktg-esffavfdGhGGefaaefakdvlvkaiknklieldadkentvpinfsklltdeilsvdekl--lekakraediaG

STAVGVLISPQHTYFINCGDSRGLLCRNRKV-HFFTQDHKPSNPLEKERIQNAGGSVMI---QRVNGSLAVSRALGDFDYKcvhgkgpTEQLVSPEPEVH
||.  |.. ..    | |||||.|. .|     .. |||| .. |. ||..||| . .    ||.| ||.||||||.  |..|| ..|..  ..  . . 
ttalialvqesdlivanvGdsrGvlydkrGkaiplsfdhkpqqvkerkrikkaGGfiafrGvwrvaGvlatsralGdyplk-------dknlviadpdil

DIERSEEDDQFIILACDGIWDVMGNEELCDFVRSRLEVTDDLEKvcnEVVDTCLYKGSRDNMSVILICF
.|.|||.||.|| . ||| . |.. ||.  |   |    .|  . ..|| ||..|... .         
tfdlddhkpeflilasdGlwdtfsneeavrfikerlkepdfGak---slvlesfkrGsvdnitvlvvkl

Phosphatase PPM1A.AA Subfamily.PPM1K.PD 24-290 31 7.3e-42 133.5 In-house 12-263 (264) Show / Hide
Range on Protein: 24-290
Range on HMM: 12-263/264
Sequence Identity: 31% (85 aa)

YGLSSMQGWRVEMEDAHTaVIGLPsglESWSFFAVYDGHAGSQVAKYCCEHLLDHITNNQDfkgsagapSVENVKNGIRTGFLEIDEHMRVMSEKK---H
|  |..| | | ||  . .  |    .   .|||.|||.||  | .. ..|  .. .  .          ..... .   |.|.|....| .   .    
vGkdsliGkraenedrfk-lkeld---pdllyfavfdGhgGssaadfvhdkleeivrrlle--------kekdleevlkqafeeldkklkrylefsvaea

GADRSGSTAVGVLISP-QHTYFINCGDSRGLLCRNRKVHFFTQDHKPSNPLEKERIQNAGGSVMI-----QRVNGSLAVSRALGDFDYKCVhGkgpteql
||.||  .|.   ..    . |||| .|||| | . .|.||.|..  |||||..|||||        .||. ||..|.|||.| |   |       |  .
ellssGttatvsllrdGnelvlaslGdsrailcrnGkakkltkdhdPerkeekerikaagGsvewnslgkplvnsrlamtrslGdldlkry-G-------

VSPEPEVHDIERSEEDDQFIILACDGIWDVMGNEELCDFVRsrleVTDDLEKVCNEVVDTCLYKGSRDNMSVILIC
|| . .. . ..| |..|  ||| .|. ..||||.||    .  | |.  . |... |  || || .....     
viatPetkslkvkhaadsflvlitdgisfvvnsqelcdlvr----lchdpeeaahavteqalqygsednatavvvp

Phosphatase PPM1A.AA Subfamily.PPM1D.PD 26-185 33 7.6e-31 97.6 In-house 12-180 (311) Show / Hide
Range on Protein: 26-185
Range on HMM: 12-180/311
Sequence Identity: 33% (56 aa)

LSSMQGWRVEMEDAHTAVI-GLPSG-LESWSFFAVYDGHAGSQVAKYCCEHLLDHITNNQDFkgsaGAPSVENVKNGIRTGFLEIDEHMRVMSE----KK
.. || |  |||  . |.   .|.  . ..|.||.||| | . ||.  |||.  |.....|     . . |.| . || .||.. | |..    .|.|  
seadqGgrkymeDvvaivlereesaeeaeaafvavfDGHGGkeAakfarehlwsvikkqkkf----lssepedvleAireaflatheamkkklaeWpktk

HG-ADRSGSTAVGVLISPQHTYFINCGDSRGLLCRNRK------VHFFTQDHKPSNPLEKERIQNAGGSVMIQ
  .|.||  |.|  .. |  . |||. .|  . .       .  |.||||..| |||||...||.|...    
sgllstaGttasvviirreklyvahvGDsgivlgvkepkekklrakeltkdHkPespeEkerieelGGevaak

Phosphatase PPM1A.AA Subfamily.PPM1G.PD 17-113 39 3e-25 79.4 In-house 5-91 (482) Show / Hide
Range on Protein: 17-113
Range on HMM: 5-91/482
Sequence Identity: 39% (38 aa)

GQGNGLRYGLSSMQGWRVEMEDAHTAVIGLPsglESWSFFAVYDGHAGSQVAKYCCEHLLDHITNNQDFKGsagapsvENVKNGIRTGFLEIDEHMR
.. . | || |.||||||.|||||.... |    | .|.||||||| |. ||||| ..| | ..... .|        ..|.....  ||..|....
esneelsygasamqGWRvsmeDahncildld---edtslfavyDGhGGkevakycakklPdllkeskayke-------gdvekaleeaflkvDkkll

Phosphatase PPM1A.AA Subfamily.PDP.PD 96-270 26 3.7e-19 59.4 In-house 126-338 (409) Show / Hide
Range on Protein: 96-270
Range on HMM: 126-338/409
Sequence Identity: 26% (56 aa)

NVKNGIRTGFLEIDEHMR--VM--------SEKKHGADRSGSTAVGVLISPQHTYFINCGDSRGLLCRNRKVH-----FFTQDHKPSNPLEKERIQNAG-
.|.. ....||..|. ..   .        .|.   .  ||..|. .||.... .  | ||.| .|.....        ...|.  .|. | |||...  
kveealkkaFlrlDkdislealkkleekvleeavlkvalsGacallaliegtelhvAntGDcravlgvqeeegsweavkLskdqtadneeEveRikkeHP

--GS---VMIQRVNGSLAVSRALGDFDYKC---VHGKG----PTEQLVSP-----------EPEVHDIeRSEEDDQFIILACDGIWDVMGNEELCDFVRS
   |   .. .|. |.|| .|| ||. ||    .. |     . .. | |           ||||    . .|.|.|..|| ||.||.. |||  . |  
geesktvirngRlLgeLaPlRAFGdvryKwskelqkkvlekllevkvvepkdyktPPYltaePevtsh-klrendkFLvlatDGLwdllsneevvslVge

RLEVTDDLEKVCNE
 |. ... .|| .|
hlakkknkakvaae

Phosphatase PPM1A.AA Subfamily.PPM1D.PD 191-287 33 2e-14 43.7 In-house 207-309 (311) Show / Hide
Range on Protein: 191-287
Range on HMM: 207-309/311
Sequence Identity: 33% (36 aa)

LAVSRALGDF-DYKCVHGkgptEQLVSPEPEVHDIERSEEDDQFIILACDGIWDVMGNEELCDFVRSRLEVTDDL----EKVCNEVVDTCLYKGSR----
|||.|.|||.  |.   |    | .|||||.| . ..  ....||||| ||.|.|.  |.  ..|..  |..       ..| . .|.. |. ..     
LavaRslGDlWsynaksg----eyvvsPePdvkvrtldpneekfiilasDGlwnvltpedavsvvekeeekkelkeeqsrsvakalvkealqrwrskklr

-DNMSVI
||.||| 
aDnvsvi

Phosphatase PPM1A.AA Subfamily.TAB1.PD 124-273 24 1.3e-13 40.7 In-house 136-305 (336) Show / Hide
Range on Protein: 124-273
Range on HMM: 136-305/336
Sequence Identity: 24% (40 aa)

RSGSTAVGVLISPQHTYFINCGDSRGLLCRNR----KVHFFTQDHKPSNPLEKERIQNAG---GSVMIQRVNGSLAVSRALGDFDYKCVHGK-----GPT
. |.||| .||  .. | .|.|||| .|...     ||.   .||   |. | .|... |   . .  ... ||    |..||.  |  .... .  .|.
sgGttavvalilnnkLyvaNvGdsrAilvesekdgikvkQLsvdHnvdNedElkRlkdLGldieqikqnkrlgskeaTRsiGdykikkgykevdvlssAk

EQLVSPEPEVHDIERSEEDDQFIILACDGIWDVMG--------NEELCDFVRSRLEVTDDLEKVCNEVVD
..     ..  .|..|  ||. . .         . .|  .| ...|.  .|..| ..|||         
gePiiatPdingpkdindlegfllLmSdGlykalieltnpptadvslallviqeaeksatlddvaqavvd

Phosphatase PPM1A.AA Subfamily.PPM1H.PD 185-265 35 5.2e-13 38.7 In-house 277-360 (402) Show / Hide
Range on Protein: 185-265
Range on HMM: 277-360/402
Sequence Identity: 35% (30 aa)

QRVNGSLAVSRALGDFDYKCVHGKGPTEQLVSPEPEVH--DIER-SEEDDQFIILACDGIWDVMGNEELCDFVRSRLEVTDDLE
.|. . ..|.| ||| . | |. .     ..||.|||.  |..  ....|. .||| ||.|||. |||    ||. |. .|. .
aRllatigvtRGlGDheLkvvdtnlsikPfLspvPevrvldltqvesleDdvlilatDGLWdvlsneevaeivrevlskvdsed

Phosphatase PPM1A.AA Subfamily.PPM1H.PD 97-177 29 1.2e-10 30.9 In-house 138-214 (402) Show / Hide
Range on Protein: 97-177
Range on HMM: 138-214/402
Sequence Identity: 29% (24 aa)

VKNGIRTGFLEIDEHMRvmSEKKHGADRSGSTAVGVLISPQHTYFINCGDSRGLLCRNRKVHFFTQDHKPSNplEKERIQN
|.  . . |||.|| ..   |...  .. | ||. .|.  .  |  | |||| .|.|..... . .|. |    |..|.|.
viGalesaflemDeqia--rereayrikGGCtalvalvllgklYvanaGDsRailvrkdeiiplsadftPet--eRqRlqe

Phosphatase PPM1A.AA Subfamily.PHLPP.PD 143-257 26 2.7e-08 23.4 In-house 123-229 (257) Show / Hide
Range on Protein: 143-257
Range on HMM: 123-229/257
Sequence Identity: 26% (30 aa)

NCGDSRGLLCRNRK-VHFFTQDHKPSNPLEKERIQNAGGSVMI-QRVNGSLAVSRALGDFdykCVHgkgPteqLVSPEPEVHDIERSEeDDQFIILACDG
| |. .  |.|| | . .        .. | .||..| . .   ..||| .. .| || .    ..   |    | |.|.|...  .| .|..||  ...
nvgkcklvlirnGkplplskvyileiddeelkrikeakaiitednkvnGviestrilGyt---flf---P---vvlPkphvrsvlLte-qdEllilGnka

IWDVMGNEELCDFVRSR
|.|.  .|. . ||   
lWevlsideaveavrnv

Sequence
Name Sequence Type Origin Length Description Download
PPM1A.AA Protein None 382 None Fasta, JSON
PPM1A.NA RNA None 1146 None Fasta, JSON
PPM1A.AA.PD_13-364 Protein Phosphatase Domain None 352 None Fasta, JSON