Gene PPM1A
PPM1A
Species: Human
Alias: PPM1A, PP2C-ALPHA, PP2Calpha, MGC9201, PP2CA, FLJ42306
External Links:
COSMIC
,
Entrez Gene
Classification
Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.
Protein domain
Protein domains of PPM1A.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit phosphatase group/family/subfamily, which is helpful to understand the relationship between phosphatases. Transmembrane region is predicted by TMHMM 2.0. Visualized by pviz.
Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking. View complete domain list.
| Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
|---|---|---|---|---|---|---|---|---|---|
| Phosphatase | PPM1A.AA | Group.PPM.PD | 11-365 | 39 | 5.8e-119 | 387.8 | In-house | 27-395 (459) | Show / Hide |
Range on Protein: 11-365 Range on HMM: 27-395/459 Sequence Identity: 39% (147 aa) EKHNAQGQGNGLRYGLSSMQGWRVEMEDAHTAVIGLPSGLeswSFFAVYDGHAGSQVAKYCCEHLLDHITNNQDFKGSAGAPSV-----------ENVKN . .. .|.||||||| .|||||| ||||.|..| . . |||.|.|||.|...|... ..| ...... .| . . . |.||. hlessagsgnglrygvasmqgwrkemEDrhvivenfdnnd---sffgVfDGHgGaeaaefaakkLpkilkkqlkkkkdevskksaeasldnddrgekvkk GIRTGFLEIDEHMRVMSEKKH-GADRSGSTAVGVLISPQHTYFINCGDSRGLLCRNRKVHFFTQDHKPSNPLEKERIQNAGGSVMI-QRVNGSLAVSRAL .|..|||.|| .. ....|. ..||.||| .||.... |. |.||||..|||| |.. ..||||.|| |.|||..|||||.| .||||.||||||| alrsafleldedlseeanekeepgkdsGtTAvvalingkklyvANaGDSravLcrngkavplskdHkpenpeEreRIekagGsveidgRvnGilavsRal GDFDYKCvhgkgpTEQLVSPEPEVHDIERSEEdDQFIILACDGIWDVMGNEELCDFVRSRLEV-----TDDLEKVCNEVVDTCLYKGSR------DNMSV ||.|.| .||.||.||.|. .. .|| |.|..||.||.|||. |||...|||..|| . |||......||..| |||.||..||..... Gdhdlkk------eeqmvsaePdvsvvkltee-deflvlAsDGlWdvlsneevvefvretlekkkkelkkdleeiaerlvdealakgstgdgtscDNiTv ILICFPNAPKVSPEAVKKEAELDKYLECRVEEIIKKQGEGVPDLVHVMRTLASENIPSLPPGGELASKRNVIEAVYNRL .|.... |.||||..|.. |...|.|...|.|. . |... . |... . .....|.......|..|..| ivvtlndamrrqleivkkeevleeelafmvaelteksgltallsvqlklldaqaeeeitsvqdglqvtdrngeiiyqgl |
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| Phosphatase | PPM1A.AA | Subfamily.PPM1A.PD | 13-322 | 68 | 2.4e-157 | 513.0 | In-house | 1-309 (309) | Show / Hide |
Range on Protein: 13-322 Range on HMM: 1-309/309 Sequence Identity: 68% (213 aa) HNAQGQGNGLRYGLSSMQGWRVEMEDAHTAVIGLPSGLESWSFFAVYDGHAGSQVAKYCCEHLLDHITNNQDFKGSAGAPSVENVKNGIRTGFLEIDEHM .|..|.||||||||||||||||||||||||||.|||.|..||||||.||||||.|.|||..|||..|.....||.|. ..|.|.||...|.||||.||.. eneegegnglryglssmqgwRvemEDahtavidlpsklkdwsffavfDGHaGskvskycakhlleaileeeefkaskeksskekvkealrkgfLelDeki RVMSEKKHGADRSGSTAVGVLISPQHTYFINCGDSRGLLCRNRKVHFFTQDHKPSNPLEKERIQNAGGSVMIQRVNGSLAVSRALGDFDYKCVHGKGPTE | ..|...|.|.||||||.||.||...|..||||||..|.||.||.| |.|||||.| |||||.||||||||.||||||||||||||.|||. . |..|| rklvelskgedksGsTavvvlvspkklylancGDsRavlsrngkvvfateDHkpsdpkEkeRienAgGsvmikRvnGsLAvsRalGDydykekpekkate QLVSPEPEVHDIERSEEDDqFIILACDGIWDVMGNEELCDFVRSRLEVTDDLEKVCNEVVDTCLYKGSRDNMSVILICFPNAPKVSPEAVKKEAELDKYL |||||||||. |||.|||. |..|||||||||| |||...||.||||||||||.|.||..|||| |||||||||||...|.||||| ||.|||.|||| | qlvspepevtvierdeede-flvlacDGiwDvmsneevaefvksrlevtddleevanelldtcLekgsrDNmsvilvllpgapkvseeaikkekeldkel ECRVEEIIKK |..|||...| eekveevlek |
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| Phosphatase | PPM1A.AA | PP2C | 22-284 | 41 | 2.4e-116 | 397.62 | Pfam | 1-284 (284) | Show / Hide |
Range on Protein: 22-284 Range on HMM: 1-284/284 Sequence Identity: 41% (121 aa) LRYGLSSMQGWRVEMEDAHTAVIGLP---SGLESWSFFAVYDGHAGSQVAKYCCEHLL----DHITNNQDFKGS-AGAPSVENVKNGIRTGFLE--IDEH ..||...||||| .|||||.. . || .||.||||.|||.|.|.||||..|| ... ....|... . ..|....| .||| .|.. WDYGFCRMQGWRHFMEDAHHCYPNMNCSSSGKDSWHFFAVFDGHGGHQAAKYCRKHLHKAMNTILKERKSFPEGNP-----KDVEQALRKSFLECDTDMM MRV---MSEK-KHG-ADRSGSTAVGVLISPQH--TYFINCGDSRGLLCRNRKVH----FFTQDHKPSNPLEKERIQNAGGSVM---IQRVNGS-LAVSRA .. ... .|. ..||.||| ..|..|. |. ||||||..||||...| . |.||||||..|..||..|||.|| .||||. |||||| FYSAPWHEQNVMHWECWHSGCTAVCAYIRNQKNILYVANCGDSRAVLCRNGNAHNWVHQLTYDHKPSNEDERRRIRQAGGWVMWWGFWRVNGVWLAVSRA LGDFDYKCVHGKGPTEQLVSPEPEVH-DIERSEEDDQFIILACDGIWDVMGNEELCDFVRSRLEVTDDLEKVCNEVVDTCLYKGSRDNM .|||.||. |...|.||.|..||... .......|.|.||||||.|||| ..|.||.||.... ..|....|...||.|. .||.||. FGDFHYKPNHTCFPKEQPVTAEPDITPEHKITPDHDEFLILACDGLWDVMSDQEVCDIVRQCRSDWNDPMEACEKLVDYCIAYGSEDNI |
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| Phosphatase | PPM1A.AA | Family.PPM.PD | 12-363 | 37 | 3.6e-114 | 372.0 | In-house | 5-358 (495) | Show / Hide |
Range on Protein: 12-363
Range on HMM: 5-358/495
Sequence Identity: 37% (134 aa)
KHNAQGQGNGLRYGLSSMQGWRVEMEDAHTAVIGLPSGLeSWSFFAVYDGHAGSQVAKYCCEHLLDHITNNQDFKGSAGAP-----SVENVKNGIRTGFL
... ....|||||| .|||||| ||||||..| .| . ..|.|.|.|||.|...|... ..| .........|... | |.||. .|..||
arteasssnglrygvasmqgwrsemeDahvvvenlenne-dfslfgvfDGhgGaeaaefaakklhkilkkqlekkddeksstsaessaekvkealrkafl
EIDEHMRVMSEKKHGADRSGSTAVGVLISPQHTYFINCGDSRGLLCRNRKVHFFTQDHKPSNPLEKERIQNAGGSVMI--QRVNGSLAVSRALGDFDYKC
|.|| .. . ..|. ..||.||| |||.... |. |.|||| .|||| |.. ..||||.|| |.|||..|||.|.| .||||.|||||||||||.|
eldeelseelneksagkdsGtTAvvvlirgkklyvAnaGDsravLcrngkavelskdHkpenpeEreRIekagGkvvirdgrvnGvlavsRalGdfdlkk
vhgkgpTEQL-VSPEPEVHDIERSEEDDQFIILACDGIWDVMGNEELCDFVRSRL-EVTDDLEKVCNEVVDTCLYKGSRDNMSVILICFPNAPKVSPEAV
.||. ||.||... .. ..|.|.|..||.||.|||. |||....||..| | . |||....|.||..| ||||||..|.........|.. ..|
------eeqaivsaePditsvkltqeedeflvlasdGlWdvlsneevvelvretleekeedleeiaeeLvdealakgsrDNiTvlvvalyenikqqnrfv
KKEAELDKYLECRVEEIIKKQGEGVPDLVHVMRTLASENIPSLPPGGELASKRNVIEAVYN
... .|.. ............ | . . .. . . .... | .... ........ ..|
lnknslmtrrstfedttlrrlqeeispptgnlamvftdiksstflwelfpnamrtaikthn
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| Phosphatase | PPM1A.AA | PP2Cc | 13-289 | 30 | 1.1e-108 | 368.3 | SMART | 1-338 (338) | Show / Hide |
Range on Protein: 13-289
Range on HMM: 1-338/338
Sequence Identity: 30% (113 aa)
HNAQGQGNGLRYGL--SSMQGWRVEMEDAHTAVIGLPSGLESWSFFAVYDGHAGSQVAKYCCEHLLDHITNNQDFKGSA-------------------GA
|. |...|.|||. |||||||..||||| ... ||.|.|||.|...|.||..||..|. .. .|. . .
HS-MGYNSGWRYGYMESSMQGWRHPMEDAHVCRP----------FFGVFDGHGGHECAQYCRKHLHEHLAEELQFHKDDDYKENDEMQDEPEMWWRMWHD
PSVENVKNGIRTGFLEIDEHMRVMSEKKHGADRSGSTAVGVLISPQHTYFINCGDSRGLLCRNRK----------VHFFTQDHKPSNPLEKERIQNAGG-
.. |.... .| .||..|| . .||| .||.... |. |.|||| |||| . .|. |.||||.|. |..||..|||
KWFEDWEDALRKAFLRMDEEI--------------CTAVVALIRGNKLYVANVGDSRAVLCRNGNDNWWGIRHYTAHQLTEDHKPDNEDERRRIEQAGGR
-------SVMIQ-----RVNGS---LAVSRALGDFDYKCVH----------------GKGPTEQLVSPEPEVHDIERS-----EEDDQFIILACDGIWDV
|| . ||||. ||||||.||..||. . ....|..|..||.|...|.. .||.|.||.|||.|||
VMPMHRQWVMNWNCDVWRVNGVPIPLAVSRAFGDHYYKW-KEDEKIEWNRWYQMFDPRLPFKEPYVIAEPDVTHHELWQMTVPTPDDDFLILCCDGLWDV
MGNEELCDFVRSRL-----------------------EVTDDLEKVCNEVVDTCLYKGSRDNMSVILI
| |.|..|.||..| ... |.........| .. .|||.||..
MSNQEVVDIVRKCLRKWHHKPVKNQAQENAHMMRHRQKKHNDPMEAAKRLCDCAI----CDNMTVIVV
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| Phosphatase | PPM1A.AA | Subfamily.PPM1G2.PD | 16-289 | 41 | 3.3e-85 | 275.7 | In-house | 4-275 (275) | Show / Hide |
Range on Protein: 16-289
Range on HMM: 4-275/275
Sequence Identity: 41% (114 aa)
QGQGNGLRYGLSSMQGWRVEMEDAHTA---VIGLPSGlESWSFFAVYDGHAGSQVAKYCCEHLLDHITNNQDFKgsagapsVENVKNGIRTGFLEIDEHM
.|. . .. |.|||||.|..|||||. .. .. .| ..|||.||| |..||||. ..| |.....|| ..... ...|||.||...
sganariavgvssmqGyrlnmeDahilenelleksdd-kslalfavfDGhGGakvakyagkklikkiakkksfk-------egaleqilkdafletDeel
RVMseKKHGADRSGSTAVGVLISPQHTYFINCGDSRGLLCRNRKVHFFTQDHKPSNPLEKERIQNAGGSVMIQRVNGSLAVSRALGDFDYKCVHGKGPTE
.| . .||||| |||. .. | |.|||| .|. . .|. .. ||||.. ||.||..||| | ..||||.||.||||||| .| . |.| ||
lkd--eklkdesaGstavvvlikeeklyvanaGDsravlsskgnvkalsfDhkPqeesekkriiaagGfvelnrvngnLalsralgDfefkknvkkkpee
QLVSPEPEVHDIERSeEDDQFIILACDGIWDVMGNEELCDFVRSRLEVTDDLEKVCNEVVDTCLYKGSR------DNMSVILI
.| .|.| ... ||| |..|||||||||. |.|..|.||.|| .|.....|..|.|| . |.|||.|...
qivtavPDvlvkkld-eddeflvLaCDGiWDvltnkevvdlvrerlvsgakldeiieelldkclapdssntgvGcDnmtvviv
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| Phosphatase | PPM1A.AA | Subfamily.PPM1E.PD | 27-289 | 34 | 4.7e-56 | 180.1 | In-house | 16-267 (269) | Show / Hide |
Range on Protein: 27-289 Range on HMM: 16-267/269 Sequence Identity: 34% (91 aa) SSMQGWRVEMEDAHTAVIGLPSGL-----ESWSFFAVYDGHAGSQVAKYCCEHLLDHITNNQDFKGSAGapsvenvkNGIRTGFLEIDEHMRVMSEKKhg .... | ||| | |. | . . . .||||.|||.|.. ||| .|| .. .....| .. . .. .| ..||...|.. . .| aavknkrrkmEDrhvaledlnelfelkdekeraffavfDGHgGveaakyaaahlhellvrqeklkedpa--------ealkeafkltDerflqkaere-- ADRSGSTAVGVLISPQHTYFINCGDSRGLLCRNRKVHFFTQDHKPSNPLEKERIQNAGGSVMI---QRVNGSLAVSRALGDFDYKcvhgkgpteQLVSPE ||||| |||. .. | |||..||.|.... ... |||... ||.||..||| |. ||||.|.||||.||..| . || |..| . klksGstavvvliekdqlyvaWlGDsqallvrkgeavqlmkpHkPeredEkkRieeagGlvvvigawRvnGvLsvsRaiGDvklk---------pyvsge PEVHDIERsEEDDQFIILACDGIWDVMGNEELCDFVRSRLEVTD-DLEKVCNEVVDTCLYKGSRDNMSVILI .| .......||||||.|||. .||... |.. |. . ||..| ...|.. .||.||..|... advaevel-dgsedylilacDGlwDvvneeevvklveefladgaedlsevakllveaakeagssDnitvvvv |
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| Phosphatase | PPM1A.AA | PP2C_C | 285-364 | 71 | 4.5e-54 | 180.68 | Pfam | 1-82 (82) | Show / Hide |
Range on Protein: 285-364 Range on HMM: 1-82/82 Sequence Identity: 71% (59 aa) SVILICFPNAPKVSPEAVKKEAELDKYLECRVEEIIKK--QGEGVPDLVHVMRTLASENIPSLPPGGELASKRNVIEAVYNR |.|.||||.|||||.||||||||||||||.||||||.| ...|||.|||..||||.|| ||||| |.|||..||||||. SIIIICFPGAPKVSEEAVKKEAELDKYLEQRVEEIIEKMHSEHEYPDLLHVMKCLASEDIPNLPPGGGLHSKRSCIEAVYNQ |
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| Phosphatase | PPM1A.AA | Subfamily.LRR-PP2C.PD | 17-289 | 34 | 5.1e-51 | 163.6 | In-house | 5-255 (257) | Show / Hide |
Range on Protein: 17-289 Range on HMM: 5-255/257 Sequence Identity: 34% (92 aa) GQGNGLRYGLSSMQGWRVEMEDAHTaVIGLPSGLESWSFFAVYDGHAGSQVAKYCCEHLLDHITNNQDFKGSagaPSVENVKNgirtGFLEIDEHMrvmS .... .. | | | | | ||| . . | . . ..|..|||.|.. ||...|.| ... | . . . .. .|.. ||. . ||. sdssrfkvgfsdmiGrrptmedelv-iyGsfrdksdedyyalfdGhgGraaakfaseelykilaelldlnna---nPlkslkk----aykeistqi---s EKKhgaDRSGSTAVGVLISPQHTYFINCGDSRGLLC-RNRKVHFFTQDHKPSNPLEKERIQNAGGSVMIQ----RVNGSLAVSRALGDFdYkcvhgkgpT . |.||. ||| ...| | |||| .|| .. . . |||||.. |..||...|| |. . |||| ||||||||| . | | erp---kfiGttaasvliiedkvyianvGdsrvvlcqkdgtakrlsldhkPseeseekriselGGtvvstvvtsrvnGtlavsralGds-f--------l EQLVSPEPEVHDIERSEEDDQFIILACDGIWDVMGNEELCDFVRSrlevTDDLEKVCNEVVDTCLYKGSRDNMSVILI |.|.... . ..|.|.|||||||||.. .|| .. | . | || .... |.|| ||.|||.| ePfvvpdPdlsqsleiskkdkflilacdGiwdlisdeeaveivag----isdpekaaeklrdlayssGstdnisvivi |
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| Phosphatase | PPM1A.AA | Subfamily.PPM1G.PD | 117-290 | 40 | 1.1e-48 | 156.8 | In-house | 300-481 (482) | Show / Hide |
Range on Protein: 117-290 Range on HMM: 300-481/482 Sequence Identity: 40% (74 aa) EKKHGADrSGSTAVGVLISPQHTYFINCGDSRGLLCRNRKVHFFTQDHKPSNPLEKERIQNAGGSVM-IQRVNGSLAVSRALGDFDYKCVHGKGPTEQLV . . | | ||.||| |. .. . | |||| |.|| | . |||| .. |.|||..||| | |||| | .|||||| || ... ||..| seepGkd-sGttavvaLvkgkklivanaGDsRcvlsrnGkaldlsiDhkPeDeveleRiekaGGkvtldgRvnGGLnlsRalGDhaYktneeLpaeeqmi SPEPEVHDIeRSEEDDQFIILACDGIWDVMGNEELCDFVRSRLEVT---DDLEKVCNEVVDTCLYKGS------RDNMSVILIC |... |.|.|..|||||||.|| .| ||||..|. . | ..|.|..|.|| . |||.|... salPDikkl-ilteedeFlvlacDGiWnvmssqevvdFvraklkeseeskklseiceeLlDaCLapdtsgDGtGCDnmtvvivq |
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| Phosphatase | PPM1A.AA | Subfamily.ILKAP.PD | 25-288 | 31 | 2.2e-47 | 151.9 | In-house | 12-297 (298) | Show / Hide |
Range on Protein: 25-288
Range on HMM: 12-297/298
Sequence Identity: 31% (92 aa)
GLSSMQGWRVEMEDAHTAVIGLP-------SGLESWSFFAVYDGHAGSQVAKYCCEHLLDHITNNQDfKGSAGAPSvENVKNGIRTGFLEIDEHMRVMSE
. .. .| | ||||||. . | | . . |..||.||||||. .... |.| ..| .. | . | ...| .. | .||.. ...|
afaerkGereemeDahvilndldeqtrkekskvsrvsyyavfDGhaGsrasefaaeklhkviveklp-kedvsakd-keikkclvdafkktDeeflklas
KKHGADRSGSTAVGVLISPQHTYFINCGDSRGLLCRNRKV-----------HFFTQDHKPSNPLEKERIQNAGGSVMIQRVNGSLAVSRALGDFDYKCVH
.. . ..||||| ||. . | | |||. .|.|... ..||.|.. |..|||.|||.|. ||.|.|.|||..|| .| .
kakPvWkdGstavvvlvvdnvlyvanlGDskavlaRakeegdkagestiasvlLskdHtpasyeerkriqkaGgvvrdgRvlGvlevsRsiGDgrfkelg
gkgpteqlVSPEPEVHDIERSEEdDQFIILACDGIWDVMGNEELCDFVRSRLEVTDD---------------LEKVCNEVVDTCLYKGSRDNMSVIL
|. .|.|. .| .|. |.|..|||||.|.|. ..| .|. . || || .| .|. . . .|| ||..|.|
--------vistPdvkkceLten-DlfvvlaCDGLwkvfeadevvkfilkvlededdrkikqeegksaeevrfevacerlAseavkrgssDnvtvll
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| Phosphatase | PPM1A.AA | Subfamily.PPM1L.PD | 28-291 | 32 | 1.5e-42 | 136.1 | In-house | 18-273 (273) | Show / Hide |
Range on Protein: 28-291 Range on HMM: 18-273/273 Sequence Identity: 32% (84 aa) SMQGWRVEMEDAHTAVIGLPSGLEsWSFFAVYDGHAGSQVAKYCCEHLLDHITNNQ-DFKGSAGAPSVENVKNGIRTGFLEIDEHMrvMSEKKHGADRSG |..| | .||| . .. . . |||||.||| | |... . | . | |. ... . | .. . | .||.. . .|. | .|. svlGrrprmedrfeieediknktg-esffavfdGhGGefaaefakdvlvkaiknklieldadkentvpinfsklltdeilsvdekl--lekakraediaG STAVGVLISPQHTYFINCGDSRGLLCRNRKV-HFFTQDHKPSNPLEKERIQNAGGSVMI---QRVNGSLAVSRALGDFDYKcvhgkgpTEQLVSPEPEVH ||. |.. .. | |||||.|. .| .. |||| .. |. ||..||| . . ||.| ||.||||||. |..|| ..|.. .. . . ttalialvqesdlivanvGdsrGvlydkrGkaiplsfdhkpqqvkerkrikkaGGfiafrGvwrvaGvlatsralGdyplk-------dknlviadpdil DIERSEEDDQFIILACDGIWDVMGNEELCDFVRSRLEVTDDLEKvcnEVVDTCLYKGSRDNMSVILICF .|.|||.||.|| . ||| . |.. ||. | | .| . ..|| ||..|... . tfdlddhkpeflilasdGlwdtfsneeavrfikerlkepdfGak---slvlesfkrGsvdnitvlvvkl |
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| Phosphatase | PPM1A.AA | Subfamily.PPM1K.PD | 24-290 | 31 | 7.3e-42 | 133.5 | In-house | 12-263 (264) | Show / Hide |
Range on Protein: 24-290 Range on HMM: 12-263/264 Sequence Identity: 31% (85 aa) YGLSSMQGWRVEMEDAHTaVIGLPsglESWSFFAVYDGHAGSQVAKYCCEHLLDHITNNQDfkgsagapSVENVKNGIRTGFLEIDEHMRVMSEKK---H | |..| | | || . . | . .|||.|||.|| | .. ..| .. . . ..... . |.|.|....| . . vGkdsliGkraenedrfk-lkeld---pdllyfavfdGhgGssaadfvhdkleeivrrlle--------kekdleevlkqafeeldkklkrylefsvaea GADRSGSTAVGVLISP-QHTYFINCGDSRGLLCRNRKVHFFTQDHKPSNPLEKERIQNAGGSVMI-----QRVNGSLAVSRALGDFDYKCVhGkgpteql ||.|| .|. .. . |||| .|||| | . .|.||.|.. |||||..||||| .||. ||..|.|||.| | | | . ellssGttatvsllrdGnelvlaslGdsrailcrnGkakkltkdhdPerkeekerikaagGsvewnslgkplvnsrlamtrslGdldlkry-G------- VSPEPEVHDIERSEEDDQFIILACDGIWDVMGNEELCDFVRsrleVTDDLEKVCNEVVDTCLYKGSRDNMSVILIC || . .. . ..| |..| ||| .|. ..||||.|| . | |. . |... | || || ..... viatPetkslkvkhaadsflvlitdgisfvvnsqelcdlvr----lchdpeeaahavteqalqygsednatavvvp |
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| Phosphatase | PPM1A.AA | Subfamily.PPM1D.PD | 26-185 | 33 | 7.6e-31 | 97.6 | In-house | 12-180 (311) | Show / Hide |
Range on Protein: 26-185 Range on HMM: 12-180/311 Sequence Identity: 33% (56 aa) LSSMQGWRVEMEDAHTAVI-GLPSG-LESWSFFAVYDGHAGSQVAKYCCEHLLDHITNNQDFkgsaGAPSVENVKNGIRTGFLEIDEHMRVMSE----KK .. || | ||| . |. .|. . ..|.||.||| | . ||. |||. |.....| . . |.| . || .||.. | |.. .|.| seadqGgrkymeDvvaivlereesaeeaeaafvavfDGHGGkeAakfarehlwsvikkqkkf----lssepedvleAireaflatheamkkklaeWpktk HG-ADRSGSTAVGVLISPQHTYFINCGDSRGLLCRNRK------VHFFTQDHKPSNPLEKERIQNAGGSVMIQ .|.|| |.| .. | . |||. .| . . . |.||||..| |||||...||.|... sgllstaGttasvviirreklyvahvGDsgivlgvkepkekklrakeltkdHkPespeEkerieelGGevaak |
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| Phosphatase | PPM1A.AA | Subfamily.PPM1G.PD | 17-113 | 39 | 3e-25 | 79.4 | In-house | 5-91 (482) | Show / Hide |
Range on Protein: 17-113 Range on HMM: 5-91/482 Sequence Identity: 39% (38 aa) GQGNGLRYGLSSMQGWRVEMEDAHTAVIGLPsglESWSFFAVYDGHAGSQVAKYCCEHLLDHITNNQDFKGsagapsvENVKNGIRTGFLEIDEHMR .. . | || |.||||||.|||||.... | | .|.||||||| |. ||||| ..| | ..... .| ..|..... ||..|.... esneelsygasamqGWRvsmeDahncildld---edtslfavyDGhGGkevakycakklPdllkeskayke-------gdvekaleeaflkvDkkll |
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| Phosphatase | PPM1A.AA | Subfamily.PDP.PD | 96-270 | 26 | 3.7e-19 | 59.4 | In-house | 126-338 (409) | Show / Hide |
Range on Protein: 96-270 Range on HMM: 126-338/409 Sequence Identity: 26% (56 aa) NVKNGIRTGFLEIDEHMR--VM--------SEKKHGADRSGSTAVGVLISPQHTYFINCGDSRGLLCRNRKVH-----FFTQDHKPSNPLEKERIQNAG- .|.. ....||..|. .. . .|. . ||..|. .||.... . | ||.| .|..... ...|. .|. | |||... kveealkkaFlrlDkdislealkkleekvleeavlkvalsGacallaliegtelhvAntGDcravlgvqeeegsweavkLskdqtadneeEveRikkeHP --GS---VMIQRVNGSLAVSRALGDFDYKC---VHGKG----PTEQLVSP-----------EPEVHDIeRSEEDDQFIILACDGIWDVMGNEELCDFVRS | .. .|. |.|| .|| ||. || .. | . .. | | |||| . .|.|.|..|| ||.||.. ||| . | geesktvirngRlLgeLaPlRAFGdvryKwskelqkkvlekllevkvvepkdyktPPYltaePevtsh-klrendkFLvlatDGLwdllsneevvslVge RLEVTDDLEKVCNE |. ... .|| .| hlakkknkakvaae |
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| Phosphatase | PPM1A.AA | Subfamily.PPM1D.PD | 191-287 | 33 | 2e-14 | 43.7 | In-house | 207-309 (311) | Show / Hide |
Range on Protein: 191-287 Range on HMM: 207-309/311 Sequence Identity: 33% (36 aa) LAVSRALGDF-DYKCVHGkgptEQLVSPEPEVHDIERSEEDDQFIILACDGIWDVMGNEELCDFVRSRLEVTDDL----EKVCNEVVDTCLYKGSR---- |||.|.|||. |. | | .|||||.| . .. ....||||| ||.|.|. |. ..|.. |.. ..| . .|.. |. .. LavaRslGDlWsynaksg----eyvvsPePdvkvrtldpneekfiilasDGlwnvltpedavsvvekeeekkelkeeqsrsvakalvkealqrwrskklr -DNMSVI ||.||| aDnvsvi |
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| Phosphatase | PPM1A.AA | Subfamily.TAB1.PD | 124-273 | 24 | 1.3e-13 | 40.7 | In-house | 136-305 (336) | Show / Hide |
Range on Protein: 124-273 Range on HMM: 136-305/336 Sequence Identity: 24% (40 aa) RSGSTAVGVLISPQHTYFINCGDSRGLLCRNR----KVHFFTQDHKPSNPLEKERIQNAG---GSVMIQRVNGSLAVSRALGDFDYKCVHGK-----GPT . |.||| .|| .. | .|.|||| .|... ||. .|| |. | .|... | . . ... || |..||. | .... . .|. sgGttavvalilnnkLyvaNvGdsrAilvesekdgikvkQLsvdHnvdNedElkRlkdLGldieqikqnkrlgskeaTRsiGdykikkgykevdvlssAk EQLVSPEPEVHDIERSEEDDQFIILACDGIWDVMG--------NEELCDFVRSRLEVTDDLEKVCNEVVD .. .. .|..| ||. . . . .| .| ...|. .|..| ..||| gePiiatPdingpkdindlegfllLmSdGlykalieltnpptadvslallviqeaeksatlddvaqavvd |
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| Phosphatase | PPM1A.AA | Subfamily.PPM1H.PD | 185-265 | 35 | 5.2e-13 | 38.7 | In-house | 277-360 (402) | Show / Hide |
Range on Protein: 185-265 Range on HMM: 277-360/402 Sequence Identity: 35% (30 aa) QRVNGSLAVSRALGDFDYKCVHGKGPTEQLVSPEPEVH--DIER-SEEDDQFIILACDGIWDVMGNEELCDFVRSRLEVTDDLE .|. . ..|.| ||| . | |. . ..||.|||. |.. ....|. .||| ||.|||. ||| ||. |. .|. . aRllatigvtRGlGDheLkvvdtnlsikPfLspvPevrvldltqvesleDdvlilatDGLWdvlsneevaeivrevlskvdsed |
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| Phosphatase | PPM1A.AA | Subfamily.PPM1H.PD | 97-177 | 29 | 1.2e-10 | 30.9 | In-house | 138-214 (402) | Show / Hide |
Range on Protein: 97-177 Range on HMM: 138-214/402 Sequence Identity: 29% (24 aa) VKNGIRTGFLEIDEHMRvmSEKKHGADRSGSTAVGVLISPQHTYFINCGDSRGLLCRNRKVHFFTQDHKPSNplEKERIQN |. . . |||.|| .. |... .. | ||. .|. . | | |||| .|.|..... . .|. | |..|.|. viGalesaflemDeqia--rereayrikGGCtalvalvllgklYvanaGDsRailvrkdeiiplsadftPet--eRqRlqe |
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| Phosphatase | PPM1A.AA | Subfamily.PHLPP.PD | 143-257 | 26 | 2.7e-08 | 23.4 | In-house | 123-229 (257) | Show / Hide |
Range on Protein: 143-257 Range on HMM: 123-229/257 Sequence Identity: 26% (30 aa) NCGDSRGLLCRNRK-VHFFTQDHKPSNPLEKERIQNAGGSVMI-QRVNGSLAVSRALGDFdykCVHgkgPteqLVSPEPEVHDIERSEeDDQFIILACDG | |. . |.|| | . . .. | .||..| . . ..||| .. .| || . .. | | |.|.|... .| .|..|| ... nvgkcklvlirnGkplplskvyileiddeelkrikeakaiitednkvnGviestrilGyt---flf---P---vvlPkphvrsvlLte-qdEllilGnka IWDVMGNEELCDFVRSR |.|. .|. . || lWevlsideaveavrnv |
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