Gene PPM1D
PPM1D
Classification
Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.
Protein domain
Protein domains of PPM1D.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit phosphatase group/family/subfamily, which is helpful to understand the relationship between phosphatases. Transmembrane region is predicted by TMHMM 2.0. Visualized by pviz.
Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking. View complete domain list.
| Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
|---|---|---|---|---|---|---|---|---|---|
| Phosphatase | PPM1D.AA | PP2Cc | 1-373 | 18 | 3.2e-79 | 270.41 | SMART | 1-338 (338) | Show / Hide |
Range on Protein: 1-373
Range on HMM: 1-338/338
Sequence Identity: 18% (86 aa)
MAGLYSLGVSVFSD-----QGGRKYMEDVTQIVVEPEPTAEEKPSPRRSLSQPLPPRPSPAALPGGEVSGKGPAVAAREARDPLPDAGASPAPSRCCRRR
. ... . .... || |..|||. ....
HS-MGYNSGWRYGYMESSMQGWRHPMEDAHVCRP------------------------------------------------------------------
SSVAFFAVCDGHGGREAAQFAREHLWGFIKKQKGFTSSEP-----------------------AKVCAAIRKGFLACHLAMWKKLAEWPKTMTGLPSTSG
||.|.||||| |.||..|.||. ...... | .... ....|.||.||... ..
----FFGVFDGHGGHECAQYCRKHLHEHLAEELQFHKDDDYKENDEMQDEPEMWWRMWHDKWFEDWEDALRKAFLRMDEEI-------------------
TTASVVIIRGMKMYVAHVGDSGVVLGIQDDPKDDFV----RAVEVTQDHKPELPKERERIEGLGGSVMNKSGVNRVVWKRPRLTHNGPVRRSTV--IDQI
.||.|..||| |.|||.|||| .||. ... .... .|...|.||||. ..||.|||..|| || . .|.. |.. .. .
CTAVVALIRGNKLYVANVGDSRAVLCRNGND-NWWGIRHYTAHQLTEDHKPDNEDERRRIEQAGGRVM-------------P-MHRQWVMNWNCDVWRVN
PF---LAVARALGDLWSYDFF-------------------SGEFVVSPEPDTSVHTLD-----PQKHKYIILGSDGLWNMIPPQDAISMCQDQE------
.. |||.||.|| . . . | |..|||...|.|. ..... .||..||||.....|.........
GVPIPLAVSRAFGDHYYKW-KEDEKIEWNRWYQMFDPRLPFKEPYVIAEPDVTHHELWQMTVPTPDDDFLILCCDGLWDVMSNQEVVDIVRKCLRKWHHK
-----------------EKKYLMGEHGQSCAKMLVNRALGRWRQRMLRADNTSAIVI
.|. | . ..... ||...||.
PVKNQAQENAHMMRHRQKKHNDPMEAAKRLCDCAI-------------CDNMTVIVV
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| Phosphatase | PPM1D.AA | Subfamily.PPM1D.PD | 3-373 | 66 | 1.8e-153 | 500.3 | In-house | 4-311 (311) | Show / Hide |
Range on Protein: 3-373 Range on HMM: 4-311/311 Sequence Identity: 66% (205 aa) GLYSLGVSVFSDQGGRKYMEDVTQIVVEPEPTAEekpsprrslsqplpprpspaalpggevsgkgpavaareardplpdagaspapsrccrrRSSVAFFA |.|| |....|||||||||||..||.|.|..||||.||.|||||.|||.|||||||..|||||.|.||||..|..|||..|||.| ||.|||||||||.. elvslrvtseadqGgrkymeDvvaivlereesae----------------------------------------------------------eaeaafva VCDGHGGREAAQFAREHLWGFIKKQKGFTSSEPAKVCAAIRKGFLACHLAMWKKLAEWPKTMTGLPSTSGTTASVVIIRGMKMYVAHVGDSGVVLGIQDD ||.||.||||||||||..|.|||||||||.|||.... |....|| |.|.||||| |.|.|||| |||.|..||||.|||||||||.|||| ||||. vfDGHGGkeAakfarehlwsvikkqkkflssepedvleAireaflatheamkkklaeWpktksgllstaGttasvviirreklyvahvGDsgivlgvkep pKDDFVRAVEVTQDHKPELPKERERIEGLGGSVMNKSGVNRVVWKRPRLTHNGPvrrsTVIDQIPFLAVARALGDLWSYDFFSGEFVVSPEPDTSVHTLD ||||||||.|||||||...|||.|||||||..|.||||...|.|||.||||||...|.||.|.....||||.|..|...|.||.||..||.|||...||| -kekklrakeltkdHkPespeEkerieelGGevaaksGvkRvvWkRprlehngp----tvideiPFLavaRslGDlWsynaksgeyvvsPePdvkvrtld PQKHKYIILGSDGLWNMIPPQDAISMCQDQEEKKYLMGEHGQSCAKMLVNRALGRWRQRMLRADNTSAIVI ||.|.||. pneekfiilasDGlwnvltpedavsvvekeeekkelkeeqsrsvakalvkealqrwrskklraDnvsvivv |
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| Phosphatase | PPM1D.AA | PP2C | 65-368 | 28 | 1.7e-94 | 325.03 | Pfam | 1-284 (284) | Show / Hide |
Range on Protein: 65-368
Range on HMM: 1-284/284
Sequence Identity: 28% (89 aa)
GKGPAVAAREARDPLPDAGASPAPSRCC-RRRSSVAFFAVCDGHGGREAAQFAREHLW----GFIKKQKGFTSSEPAKVCAAIRKGFLACHLAMWKKLAE
... . ...|... || ......|. . ..|..||||.|||||..||...|.||. ..|..| | ...|..|..|.||.||.|. .|....|.
WDYGFCRMQGWRHFMEDAHHCYPNMNCSSSGKDSWHFFAVFDGHGGHQAAKYCRKHLHKAMNTILKERKSFPEGNPKDVEQALRKSFLECDTDMMFYSAP
WPKTM--TGLPSTSGTTASVVIIRGMK--MYVAHVGDSGVVLGIQDDPKDDFVRAVEVTQDHKPELPKERERIEGLGGSVMNKSGVNRVVWKRPRLTHNG
| ... ......||.|| ...||..| .|||..||| .||......... ....|.||||. ..||.||...||.||.. |..|| .
WHEQNVMHWECWHSGCTAVCAYIRNQKNILYVANCGDSRAVLCRNGNAHNW---VHQLTYDHKPSNEDERRRIRQAGGWVMWW-GFWRVNGV--------
PVRRSTVIDQIPFLAVARALGDLWSYDFFS---GEFVVSPEPDTS-VHTLDPQKHKYIILGSDGLWNMIPPQDAISMCQDQEEKKYLMGEHGQSCAKMLV
.|||.||.||.. ..... |..|..|||.. .|...|......||..||||.....|.............. |..
------------WLAVSRAFGDFHYKPNHTCFPKEQPVTAEPDITPEHKITPDHDEFLILACDGLWDVMSDQEVCDIVRQCRSDWN---------DPMEA
NRALGRWRQRMLRADNT
. | .. ... ||.
CEKLVDYCIAYGSEDNI
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| Phosphatase | PPM1D.AA | Group.PPM.PD | 5-386 | 28 | 6.1e-85 | 275.6 | In-house | 36-332 (459) | Show / Hide |
Range on Protein: 5-386 Range on HMM: 36-332/459 Sequence Identity: 28% (111 aa) YSLGVSVFSDQGGRKYMEDVTQIVVEPEPTAeekpsprrslsqplpprpspaalpggevsgkgpavaareardplpdagaspapsrccrrrssvAFFAVC . |...| |.||.||.||| || ... . .||.|. nglrygvasmqgwrkemEDrhvivenfdnnd---------------------------------------------------------------sffgVf DGHGGREAAQFAREHLWGFIKKQKGFTSSEP---------------AKVCAAIRKGFLACHLAMWKKLAEWPktmtGLPSTSGTTASVVIIRGMKMYVAH |||||.|||.||...|. ..|||... ..| .||..|.|..||... ..... .|.. .....||||| |..|.||.|||.. DGHgGaeaaefaakkLpkilkkqlkkkkdevskksaeasldnddrgekvkkalrsafleldedlseeaneke----epgkdsGtTAvvalingkklyvAN VGDSGVVLGiQ-DdpkddfvRAVEVTQDHKPELPKERERIEGLGGSVMNKSgvnRVVwkrprlthngpvrrstvidqiPFLAVARALGDlwsYDFFSGEF ||| .||. . . .||....||||| |.|||||| .||||.... || ..||| |||||.|. ..|..||. aGDSravLc-rng-------kavplskdHkpenpeEreRIekagGsveidg---Rvn---------------------GilavsRalGd---hdlkkeeq VVSPEPDTSVHTLDPQkHKYIILGSDGLWNMIPPQDAISMCQDQEEK-KYLMGEHGQSCAKMLVNRALGRWRQ-RMLRADNTSAIVICISPEVDNQGNFT |||.||..|... .....|.|||||... ........... || | .... ...|..||..||..... .....|| ..||.... .| . . mvsaePdvsvvkltee-deflvlAsDGlWdvlsneevvefvretlekkkkelkkdleeiaerlvdealakgstgdgtscDNiTvivvtlndamrrqleiv |
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| Phosphatase | PPM1D.AA | Family.PPM.PD | 6-390 | 27 | 3.7e-78 | 253.2 | In-house | 14-301 (495) | Show / Hide |
Range on Protein: 6-390 Range on HMM: 14-301/495 Sequence Identity: 27% (109 aa) SLGVSVFSDQGGRKYMEDVTQIVVEPEPTAeekpsprrslsqplpprpspaalpggevsgkgpavaareardplpdagaspapsrccrrrsSVAFFAVCD .|...| |.|| |..|||....| . | ....|.|.| glrygvasmqgwrsemeDahvvvenlenne-------------------------------------------------------------dfslfgvfD GHGGREAAQFAREHLWGFIKKQKGFTSSEP---------AKVCAAIRKGFLACHLAMWKKLAEWPktmtgLPSTSGTTASVVIIRGMKMYVAHVGDSGVV ||||.|||.||...|. ..|||. ....|. .||..|.||.||... .....|.|.. ....||||| ||.||| |.|||..||| .| GhgGaeaaefaakklhkilkkqlekkddeksstsaessaekvkealrkafleldeelseelneks-----agkdsGtTAvvvlirgkklyvAnaGDsrav LGiqddpK-DdfvRAVEVTQDHKPELPKERERIEGLGGSVMNksgvnrvvwkrprltH----NGpvrrstvidqipFLAVARALGDlwsYDFFSGEFV-V |. . .|||...||||| |.|||||| .||.|.. . || .|||.|||||.|. . |.. ||.| Lc-----rng---kavelskdHkpenpeEreRIekagGkvvi---------------rdgrvnG------------vlavsRalGd---fdlkkeeqaiv SPEPDTSVHTLDPQKHKYIILGSDGLWNMIPPQDAISMCQDQEekkYLMGEHGQSCAKMLVNRALGRWRQrmlraDNTSAIVICISPEVDNQGNFTNEDE ||.....|.........| |||||... ........... ..|. ...|..||..|| .. . ||....|.... .. .| .|..... saePditsvkltqeedeflvlasdGlWdvlsneevvelvretl---eekeedleeiaeeLvdealakgsr-----DNiTvlvvalyenikqqnrfvlnkn |
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| Phosphatase | PPM1D.AA | Subfamily.LRR-PP2C.PD | 96-331 | 32 | 1.9e-33 | 106.0 | In-house | 38-226 (257) | Show / Hide |
Range on Protein: 96-331 Range on HMM: 38-226/257 Sequence Identity: 32% (76 aa) SSVAFFAVCDGHGGREAAQFAREHLWGFIKKQKGFTSSEPAKVcaaIRKGFLACHLAMwkklAEWPktmtglpSTSGTTASVVIIRGMKMYVAHVGDSGV | ..|. ||||||.||.|| |.| ... ...| |. ..| . . .. . .|.| |||| .|.| .|.|.| |||| || sdedyyalfdGhgGraaakfaseelykilaelldlnnanPlks---lkkaykeistqi----serp-------kfiGttaasvliiedkvyianvGdsrv VLGiqddpK-DdfVRAVEVTQDHKPELPKERERIEGLGGSVMNKsgvnrvvwkrprlthngpVRRSTVIDQipfLAVARALGDLwsydfFSGEFVVsPEP |. . | |. .. |||| ..|..||. ||| |... | | | . |||.||||| | ||| |.|| vlc-----qkd--gtakrlsldhkPseeseekriselGGtvvst------------------vvtsrvnGt---lavsralGds-----flePfvv-pdP DTSVHTLDPQKHKYIILGSDGLWNMIPPQDAISMCQD | .|.|..|| ||.|..| ..|... . dlsqsleiskkdkflilacdGiwdlisdeeaveivag |
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| Phosphatase | PPM1D.AA | Subfamily.PPM1A.PD | 94-238 | 38 | 5.3e-29 | 91.5 | In-house | 37-173 (309) | Show / Hide |
Range on Protein: 94-238 Range on HMM: 37-173/309 Sequence Identity: 38% (58 aa) RRSSVAFFAVCDGHGGREAAQFAREHLWGFIKKQKGFT----SSEPAKVCAAIRKGFLACHLAMWkKLAEWPKTMtglpSTSGTTASVVIIRGMKMYVAH . . .|||| |||.|....... .|| | ... |. .|. .|| |.|||||.. .. ||.|. |.. ||.|| ||... |.|.|. klkdwsffavfDGHaGskvskycakhlleaileeeefkaskeksskekvkealrkgfLelDekir-klvelskge----dksGsTavvvlvspkklylan VGDSGVVLGIQDdpkddfvRAVEVTQDHKPELPKERERIEGLGGSVMNK .||| || . ..| |.|||| |||.|||| |||||.| cGDsRavlsrng-------kvvfateDHkpsdpkEkeRienAgGsvmik |
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| Phosphatase | PPM1D.AA | Subfamily.PPM1E.PD | 96-244 | 34 | 1.2e-28 | 90.2 | In-house | 45-174 (269) | Show / Hide |
Range on Protein: 96-244 Range on HMM: 45-174/269 Sequence Identity: 34% (52 aa) SSVAFFAVCDGHGGREAAQFAREHLWGFIKKQKGFTSsEPAkvcAAIRKGFLACHLAMWKKLAEwpKTMtglpsTSGTTASVVIIRGMKMYVAHVGDSGV . ||||| ||||| |||..| .||. .. .|. ... .|| |....| .. .. .| .. ... .||.|| ||.|.. ..||| .||| . keraffavfDGHgGveaakyaaahlhellvrqeklke-dpa---ealkeafkltDerflqkaer--ekl-----ksGstavvvliekdqlyvaWlGDsqa VLGIQddpkddfVRAVEVTQDHKPELPKERERIEGLGGSVMNKsGVNRV .| . ..||.... |||| ..|..||| .|| |.. |. || llvrk-------geavqlmkpHkPeredEkkRieeagGlvvvi-gawRv |
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| Phosphatase | PPM1D.AA | Subfamily.PPM1G2.PD | 96-236 | 32 | 2.9e-25 | 79.0 | In-house | 41-164 (275) | Show / Hide |
Range on Protein: 96-236 Range on HMM: 41-164/275 Sequence Identity: 32% (46 aa) SSVAFFAVCDGHGGREAAQFAREHLWGFIKKQKGFTssePAKVCAAIRKGFLACHLAMWKKlaewpKTMTGlpSTSGTTASVVIIRGMKMYVAHVGDSGV .|.|.||| |||||...|..| ..| .|.|.| |. .. .....||.. . |. ... ...|.|| ||.|. |.||| .||| kslalfavfDGhGGakvakyagkklikkiakkksfk---egaleqilkdafletDeellkd-----eklkd--esaGstavvvlikeeklyvanaGDsra VLGIQDDPKdDFvravevTQDHKPELPKERERIEGLGGSVM || .. . | . . ||||. .|..||. || | vlsskgnvk-al------sfDhkPqeesekkriiaagGfve |
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| Phosphatase | PPM1D.AA | Subfamily.PPM1L.PD | 96-332 | 32 | 3.7e-23 | 72.4 | In-house | 40-242 (273) | Show / Hide |
Range on Protein: 96-332
Range on HMM: 40-242/273
Sequence Identity: 32% (76 aa)
SSVAFFAVCDGHGGREAAQFAREHLWGFIKKQK-GFTSSEPAKVCAAIRKGFLACHLAMWKKLAEWPKTMTglpSTSGTTASVVIIRGMKMYVAHVGDSG
. |||| ||||| ||.||.. | ||.. . .. .| . | . |.. .|| | |. . ..|||| . .... ..|| |||| |
tgesffavfdGhGGefaaefakdvlvkaiknklieldadkentvpinfsklltdeilsvdekllekakrae---diaGttalialvqesdlivanvGdsr
VVLgiqddpKDDFVRAVEVTQDHKPELPKERERIEGLGGSVMNkSGVNRVvwkrprlthNGpvrrstVidqipfLAVARALGDlwsYDFFSGEFVVsPEP
| | .|. .. ||||. .||| ||. || . || || .| | ||..||||| | . ..|. ..||
Gvl------ydkrGkaiplsfdhkpqqvkerkrikkaGGfiaf-rGvwrv---------aG------v------latsralGd---yplkdknlvi-adp
DTSVHTLDPQKHKYIILGSDGLWNMIPPQDAISMCQDQ
|| .| ...|| |||||. . ..|. . ...
diltfdlddhkpeflilasdGlwdtfsneeavrfiker
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| Phosphatase | PPM1D.AA | Subfamily.ILKAP.PD | 89-237 | 26 | 2e-21 | 66.7 | In-house | 38-187 (298) | Show / Hide |
Range on Protein: 89-237 Range on HMM: 38-187/298 Sequence Identity: 26% (40 aa) SRCCRRRSSVAFFAVCDGHGGREAAQFAREHLWGFIKKQkgFTSSEPAKVCAAIRKGFLACHLAMWKKLAEWPKTMTGLpSTSGTTASVVIIRGMKMYVA .. . . |.|...|| |||.|..|..|| |.| |... ..... .. |.| .. . . ... . . . .|.|| ||.. . ..||| rkekskvsrvsyyavfDGhaGsrasefaaeklhkvivek--lpkedvsakdkeikkclvdafkktDeeflklaskakPv-WkdGstavvvlvvdnvlyva HVGDSGVVLGIQ-DDPK---DDFVRAVEVTQDHKPELPKERERIEGLGGSVMN .||| || . .... . . .| ...||.| .||.||. ||.|.. nlGDskavlaRakeegdkagestiasvlLskdHtpasyeerkriqkaGgvvrd |
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| Phosphatase | PPM1D.AA | Subfamily.PPM1K.PD | 97-336 | 26 | 5.3e-20 | 61.8 | In-house | 36-241 (264) | Show / Hide |
Range on Protein: 97-336
Range on HMM: 36-241/264
Sequence Identity: 26% (65 aa)
SVAFFAVCDGHGGREAAQFAREHLWGFIKKQKgftsSEPAKVCAAIRKGFLACHLAMWKKLAEW-PKTmtgLPSTSGTTASVVIIR-GMKMYVAHVGDSG
. .||| ||||| ||.|. ..| ... . . . . . |. . .. . | ... .|||||.|...| |....| .||| .
dllyfavfdGhgGssaadfvhdkleeivrrll----ekekdleevlkqafeeldkklkrylefsvaea---ellssGttatvsllrdGnelvlaslGdsr
VVLGIQDDPKddfvravEVTQDHKPELPKERERIEGLGGSVMNKSGVNRVVwkrprlthNGpvrRstvidqipfLAVARALGDLwsyDFfsGEFVVSPEP
| . ..| .|.||.|| .|.||| |||| .| . | |. | ||..|.|||| |. .. | .|.|
ailcrnGkak-------kltkdhdPerkeekerikaagGsvewnslgkplv--------ns---r---------lamtrslGdl---dl--kryGviatP
DTSVHTLDPQKHKYIILGSDGLWNMIPPQ---DAISMCQDQEEKK
.. .. ...| .||. ... | | ...|.| ||
etkslkvkhaadsflvlitdgisfvvnsqelcdlvrlchdpeeaa
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| Phosphatase | PPM1D.AA | Subfamily.PPM1G.PD | 169-242 | 41 | 2.2e-15 | 46.9 | In-house | 305-371 (482) | Show / Hide |
Range on Protein: 169-242 Range on HMM: 305-371/482 Sequence Identity: 41% (31 aa) STSGTTASVVIIRGMKMYVAHVGDSGVVLGIQddpkddfVRAVEVTQDHKPELPKERERIEGLGGSVMNKSGVN . ||||| | ...| |..|| .||| || . .|... ||||| ..|.|||| || | || kdsGttavvaLvkgkklivanaGDsRcvlsrn-------GkaldlsiDhkPeDeveleRiekaGGkvtldgRvn |
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| Phosphatase | PPM1D.AA | Subfamily.PPM1A.PD | 269-390 | 25 | 1.3e-13 | 40.9 | In-house | 179-294 (309) | Show / Hide |
Range on Protein: 269-390 Range on HMM: 179-294/309 Sequence Identity: 25% (33 aa) LAVARALGDLwSY----DFFSGEFVVSPEPDTSVHTLDPQKHkYIILGSDGLWNMIPPQDAISMCQDQEEkkylMGEHGQSCAKMLVNRALGRWRQrmlr |||.||||| .| . . | .|||||.. | . | ... ...| .||.| .. ...... ... | .... .. |. |....|. . LAvsRalGDy-dykekpekkateqlvspepevtvierdeede-flvlacDGiwDvmsneevaefvksrle----vtddleevanelldtcLekgsr---- aDNTSAIVICI--SPEVDNQgNFTNEDE || |.|.... .|.|... ..| | -DNmsvilvllpgapkvsee-aikkeke |
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| Phosphatase | PPM1D.AA | Subfamily.PPM1E.PD | 269-372 | 28 | 2.6e-11 | 33.4 | In-house | 178-266 (269) | Show / Hide |
Range on Protein: 269-372
Range on HMM: 178-266/269
Sequence Identity: 28% (28 aa)
LAVARALGDLwsydffSGEFVVSPEPDTSVHTLDpQKHKYIILGSDGLWNMIPPQDAISMCQDQEEKkylMGEHGQSCAKMLVNRALGRWrqrmlRADNT
|.|.||.|| . . || |.|.. .|| ....|.||..||||........... .. .. |. .. ||.||. | ..|| ...|
LsvsRaiGDv------klkpyvsgeadvaeveld-gsedylilacDGlwDvvneeevvklveeflad---gaedlsevakllveaakeag-----ssDni
SAIV
tvvv
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| Phosphatase | PPM1D.AA | Subfamily.PPM1G2.PD | 269-373 | 20 | 3.8e-10 | 29.5 | In-house | 172-275 (275) | Show / Hide |
Range on Protein: 269-373 Range on HMM: 172-275/275 Sequence Identity: 20% (22 aa) LAVARALGDLWSYDFF---SGEFVVSPEPDTSVHTLDpQKHKYIILGSDGLWNMIPPQDAISMCQDQEEKKylmgEHGQSCAKMLVNRALGRWRQ-RMLR ||..||||| . . | .| .|| |. || ... ...| ||.|... .. . ... . .. . .. .. |....|. . . . LalsralgDfefkknvkkkpeeqivtavPDvlvkkld-eddeflvLaCDGiWDvltnkevvdlvrerlvsg----akldeiieelldkclapdssntgvG ADNTSAIVI || ..... cDnmtvviv |
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| Phosphatase | PPM1D.AA | Subfamily.PDP.PD | 137-229 | 28 | 5e-10 | 29.4 | In-house | 126-221 (409) | Show / Hide |
Range on Protein: 137-229 Range on HMM: 126-221/409 Sequence Identity: 28% (28 aa) KVCAAIRKGFLACHLAMWK-KLAEWPKTMTG---L-PSTSGTTASVVIIRGMKMYVAHVGDSGVVLGIQDDPKDdfVRAVEVTQDHKPELPKERERIE ||. |..|.|| . . . |.. ..... | ...||..| .. |.| ...|| .||. ||| |.. ..||....|. . ..||||. kveealkkaFlrlDkdislealkkleekvleeavlkvalsGacallaliegtelhvAntGDcravlgvqeeegs--weavkLskdqtadneeEveRik |
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| Phosphatase | PPM1D.AA | Subfamily.PPM1G.PD | 97-150 | 32 | 5.6e-10 | 29.1 | In-house | 37-87 (482) | Show / Hide |
Range on Protein: 97-150 Range on HMM: 37-87/482 Sequence Identity: 32% (17 aa) SVAFFAVCDGHGGREAAQFAREHLWGFIKKQKGFTSSepaKVCAAIRKGFLACH ...||| |||||.| |... ..| ...|..|.. .| .|... ||.. dtslfavyDGhGGkevakycakklPdllkeskaykeg---dvekaleeaflkvD |
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| Phosphatase | PPM1D.AA | Subfamily.TAB1.PD | 171-232 | 37 | 1.1e-08 | 24.5 | In-house | 137-195 (336) | Show / Hide |
Range on Protein: 171-232 Range on HMM: 137-195/336 Sequence Identity: 37% (23 aa) SGTTASVVIIRGMKMYVAHVGDSGVVLgIQDDpKDDfVRAVEVTQDHKPELPKERERIEGLG |||| |..| |.||| |||| .| .. . ||. .... .|| . ..| .|...|| gGttavvalilnnkLyvaNvGdsrAil-vese-kdg-ikvkQLsvdHnvdNedElkRlkdLG |
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| Phosphatase | PPM1D.AA | Subfamily.ILKAP.PD | 268-351 | 22 | 2.2e-08 | 23.9 | In-house | 193-273 (298) | Show / Hide |
Range on Protein: 268-351 Range on HMM: 193-273/298 Sequence Identity: 22% (19 aa) FLAVARALGDLwsyDFFSGEfvVSPEPDTSVHTLDPQkHKYIILGSDGLWNMIPPQDAISMCQDQ---EEKKYLMGEHGQSCAKMLV |.|.|..|| | . . |. .||.. .|... ....| ||||. . ..... .... |... . .|.|.| ... vlevsRsiGDg---rfkelg--vistPdvkkceLten-DlfvvlaCDGLwkvfeadevvkfilkvlededdrkikqeegksaeevrf |
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| Phosphatase | PPM1D.AA | Subfamily.PDP.PD | 290-337 | 27 | 3.9e-08 | 23.1 | In-house | 284-330 (409) | Show / Hide |
Range on Protein: 290-337 Range on HMM: 284-330/409 Sequence Identity: 27% (13 aa) VSPEPDTSVHTLDPQkHKYIILGSDGLWNMIPPQDAISMCQDQEEKKY .. ||. | | .. |...|..||||... .....|. .. .|| ltaePevtshklren-dkFLvlatDGLwdllsneevvslVgehlakkk |
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| Phosphatase | PPM1D.AA | Subfamily.PPM1G.PD | 271-332 | 24 | 9.3e-06 | 15.1 | In-house | 376-439 (482) | Show / Hide |
Range on Protein: 271-332 Range on HMM: 376-439/482 Sequence Identity: 24% (16 aa) VARALGDLW---SYDFFSGEFVVSPEPDTSVHTLDPQkHKYIILGSDGLWNMIPPQDAISMCQDQ ..||||| . | .| || ...| .. .....| .||.||.. |. . ... lsRalGDhaYktneeLpaeeqmisalPDikkliltee-deFlvlacDGiWnvmssqevvdFvrak |
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