Gene PPM1E
PPM1E
Species: Human
Alias: PPM1E, POPX1, DKFZp781F1422, PP2CH, CaMKP-N, KIAA1072
External Links:
COSMIC
,
Entrez Gene
Classification
Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.
Protein domain
Protein domains of PPM1E.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit phosphatase group/family/subfamily, which is helpful to understand the relationship between phosphatases. Transmembrane region is predicted by TMHMM 2.0. Visualized by pviz.
Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking. View complete domain list.
| Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
|---|---|---|---|---|---|---|---|---|---|
| Phosphatase | PPM1E.AA | PP2Cc | 219-486 | 28 | 9.9e-74 | 252.17 | SMART | 1-338 (338) | Show / Hide |
Range on Protein: 219-486
Range on HMM: 1-338/338
Sequence Identity: 28% (104 aa)
DFPLRRRPQLYYETSIHAIKNMRRKMEDKHVCIPDFNMLFNLEDQEEQAYFAVFDGHGGVDAAIYASIHLHVNLVRQEMFP-------------------
. .. ....| ....... |..||| |||.| .|.||||||| ..| |.. ||| .|.... |.
HS-MGYNSGWRYGYMESSMQGWRHPMEDAHVCRP---------------FFGVFDGHGGHECAQYCRKHLHEHLAEELQFHKDDDYKENDEMQDEPEMWW
--------HDPAEALCRAFRVTDERFVQKAARESLRCGTTGVVTFIRGNMLHVAWVGDSQVMLVRKGQ----------AVELMKPHKPDREDEKQRIEAL
.|. .|| .||. .||.. .| || .|||| |.||.||||...| |.|. |..| . ||||.|||..|||..
RMWHDKWFEDWEDALRKAFLRMDEEI------------CTAVVALIRGNKLYVANVGDSRAVLCRNGNDNWWGIRHYTAHQLTEDHKPDNEDERRRIEQA
GGCVV-----WFGAW-----RVNGS---LSVSRAIGDAEHK------------------------PYICGDADSASTVL------DGTEDYLILACDGFY
|| | | | ||||. | ||||.|| . | ||. . | .. | . | |||.||| .
GGRVMPMHRQWVMNWNCDVWRVNGVPIPLAVSRAFGDHYYKWKEDEKIEWNRWYQMFDPRLPFKEPYVIAEPDVTHHELWQMTVPTPDDDFLILCCDGLW
DTVNPDEAVKVVSDHL----------------------KENNGDSSMVAHKLVASARDAGSSDNITVIVV
| ....|.| .| ..| ....| ...| .|. |. .||.|||||
DVMSNQEVVDIVRKCLRKWHHKPVKNQAQENAHMMRHRQKKHNDPMEAAKRLCDCAI----CDNMTVIVV
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| NLS | PPM1E.AA | NLS | 666-700 | 100 | 1e-300 | None | Paper | 666-700 (35) | Show / Hide |
Range on Protein: 666-700 Range on HMM: 666-700/35 Sequence Identity: 100% (34 aa) RLSHLRHHYSKKWHRFRFNPKFYSFLSAQEPSHKI |||||||||||||||||||||||||||||||||| RLSHLRHHYSKKWHRFRFNPKFYSFLSAQEPSHKI |
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| Phosphatase | PPM1E.AA | Subfamily.PPM1E.PD | 221-488 | 63 | 9.80000000001e-136 | 441.4 | In-house | 2-269 (269) | Show / Hide |
Range on Protein: 221-488 Range on HMM: 2-269/269 Sequence Identity: 63% (170 aa) PLRRRPQLYYETSIHAIKNMRRKMEDKHVCIPDFNMLFNLEDQEEQAYFAVFDGHGGVDAAIYASIHLHVNLVRQEMFPHDPAEALCRAFRVTDERFVQK ||. ..| .||.||.|.||.||||||.||...|.|.||.|.|..|.|.||||||||||.|| ||. ||| .|||||....||||||..||..|||||.|| PlevksqkeyevsiaavknkrrkmEDrhvaledlnelfelkdekeraffavfDGHgGveaakyaaahlhellvrqeklkedpaealkeafkltDerflqk AARESLRCGTTGVVTFIRGNMLHVAWVGDSQVMLVRKGQAVELMKPHKPDREDEKQRIEALGGCVVWFGAWRVNGSLSVSRAIGDAEHKPYICGDADSAS |.||.|..|.|.||..|....|.|||.||||..|||||.||.|||||||.|||||.|||..||.||..|||||||.|||||||||...|||..|.|| |. aereklksGstavvvliekdqlyvaWlGDsqallvrkgeavqlmkpHkPeredEkkRieeagGlvvvigawRvnGvLsvsRaiGDvklkpyvsgeadvae TVLDGTEDYLILACDGFYDTVNPDEAVKVVSDHLKENNGDSSMVAHKLVASARDAGSSDNITVIVVFL . |||.||||||||||..|.||..|.||.|...|.....|.|.||..||..|..|||||||||.|||| veldgsedylilacDGlwDvvneeevvklveefladgaedlsevakllveaakeagssDnitvvvvfl |
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| Phosphatase | PPM1E.AA | Group.PPM.PD | 235-495 | 34 | 2.9e-76 | 247.0 | In-house | 43-328 (459) | Show / Hide |
Range on Protein: 235-495 Range on HMM: 43-328/459 Sequence Identity: 34% (100 aa) HAIKNMRRKMEDKHVCIPDFNMLFnledqeeqAYFAVFDGHGGVDAAIYASIHLHVNLVRQEMFP-------------------HDPAEALCRAFRVTDE .. .. |..|||.||.. .|. ..|.||||||| || .|. .|. .| .| . ... .|| ||.||.. asmqgwrkemEDrhvivenfdnnd--------sffgVfDGHgGaeaaefaakkLpkilkkqlkkkkdevskksaeasldnddrgekvkkalrsaflelde RFVQKAARES---LRCGTTGVVTFIRGNMLHVAWVGDSQVMLVRKGQAVELMKPHKPDREDEKQRIEALGGCVVWFGawRVNGSLSVSRAIGDAEHKPY- ..|.... . ||| || .|.|. |.||..|||...|.|.|.||.| | |||....|..|||..|| |.. | ||||.|.||||.||. | . dlseeanekeepgkdsGtTAvvalingkklyvANaGDSravLcrngkavplskdHkpenpeEreRIekagGsveidg--RvnGilavsRalGdhdlkkee --ICGDADSASTVLDGTEDYLILACDGFYDTVNPDEAVKVVSDHLKE----NNGDSSMVAHKLVASARDAGSS------DNITVIVVFLRDMNKAV . | . |. ...|.||.|| .| ....|.|..| ..|.. .. |....| .|| .|. .||. ||||||||.| |. . qmvsaePdvsvvklteedeflvlAsDGlWdvlsneevvefvretlekkkkelkkdleeiaerlvdealakgstgdgtscDNiTvivvtlndamrrq |
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| Phosphatase | PPM1E.AA | PP2C | 230-481 | 33 | 5.2e-76 | 263.63 | Pfam | 1-284 (284) | Show / Hide |
Range on Protein: 230-481 Range on HMM: 1-284/284 Sequence Identity: 33% (97 aa) YETSIHAIKNMRRKMEDKHVCIPDFNMLFNLEDQEEQAYFAVFDGHGGVDAAIYASIHLH----VNLVRQEMFPHD----PAEALCRAFRV--TDERFVQ .. ..... . |..||| |.|.|..| ..... ..|||||||||..|| |.. ||| | ....|| . . .|| ..|. ||. | . WDYGFCRMQGWRHFMEDAHHCYPNMNCS--SSGKDSWHFFAVFDGHGGHQAAKYCRKHLHKAMNTILKERKSFPEGNPKDVEQALRKSFLECDTDMMFYS ---KAAR----ESLRCGTTGVVTFIRGNM--LHVAWVGDSQVMLVRKGQAV----ELMKPHKPDREDEKQRIEALGGCVVWFGAWRVNGS-LSVSRAIGD .... | ...|.| |. .||.. |.||..|||...| |.|.|. .|.. |||..|||. ||...|| | | | |||||. |.||||.|| APWHEQNVMHWECWHSGCTAVCAYIRNQKNILYVANCGDSRAVLCRNGNAHNWVHQLTYDHKPSNEDERRRIRQAGGWVMWWGFWRVNGVWLAVSRAFGD AEHKP---------YICGDADSA-STVLDGT-EDYLILACDGFYDTVNPDEAVKVVSDHLKENNGDSSMVAHKLVASARDAGSSDNI . || .. . | .. .. ...|||||||..| ....|.. .| ......| | .... ||| ... ||.||| FHYKPNHTCFPKEQPVTAEPDITPEHKITPDHDEFLILACDGLWDVMSDQEVCDIVRQCRSDWN-DPMEACEKLVDYCIAYGSEDNI |
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| Phosphatase | PPM1E.AA | Family.PPM.PD | 231-495 | 36 | 2.1e-75 | 244.1 | In-house | 16-293 (495) | Show / Hide |
Range on Protein: 231-495 Range on HMM: 16-293/495 Sequence Identity: 36% (104 aa) ETSIHAIKNMRRKMEDKHVCIPDFNMLFnledqeEQAYFAVFDGHGGVDAAIYASIHLHVNLVRQEMFP-------------HDPAEALCRAFRVTDERF ...... . |..|||.||.. ... . ..|.||||||| || .|. .|| .| .|. . .. ||| .|| .||.. rygvasmqgwrsemeDahvvvenlenne------dfslfgvfDGhgGaeaaefaakklhkilkkqlekkddeksstsaessaekvkealrkafleldeel VQKAARES--LRCGTTGVVTFIRGNMLHVAWVGDSQVMLVRKGQAVELMKPHKPDREDEKQRIEALGGCVVWfGAWRVNGSLSVSRAIGDAEHKP----Y ......| . ||| || .|||. |.||..|||...|.|.|.|||| | |||....|..|||..|| ||. . .||||.|.||||.|| .|. .. seelneksagkdsGtTAvvvlirgkklyvAnaGDsravLcrngkavelskdHkpenpeEreRIekagGkvvi-rdgrvnGvlavsRalGdfdlkkeeqai ICGDADSASTVLDGT-EDYLILACDGFYDTVNPDEAVKVVSDHLKENNGDSSMVAHKLVASARDAGSSDNITVIVVFLRDMNKAV . | |. |.. ...|.||.|| .| ....|.|..| ..|.|.. | ...|..|| .| .||.|||||.||.| . | vsaePditsvkltqeedeflvlasdGlWdvlsneevvelvretleekeedleeiaeeLvdealakgsrDNiTvlvvalyenikqq |
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| Phosphatase | PPM1E.AA | Subfamily.PPM1A.PD | 234-494 | 31 | 1.8e-57 | 185.0 | In-house | 14-284 (309) | Show / Hide |
Range on Protein: 234-494 Range on HMM: 14-284/309 Sequence Identity: 31% (86 aa) IHAIKNMRRKMEDKHVCIPDFNmlfnlEDQEEQAYFAVFDGHGGVDAAIYASIHLHVNLVRQEMF--------PHDPAEALCRAFRVTDERFVQKAARES . . .. |..|||.|... |.. . .....|||||||.| ... |.. ||. .....| | .. ||| ..| .||..... .. lssmqgwRvemEDahtavidlp-----sklkdwsffavfDGHaGskvskycakhlleaileeeefkaskeksskekvkealrkgfLelDekirklvelsk --LRCGTTGVVTFIRGNMLHVAWVGDSQVMLVRKGQAVELMKPHKPDREDEKQRIEALGGCVVwfgAWRVNGSLSVSRAIGDAEHKPY---------ICG ..|.| ||.... . | .| .||| .|.|.|..| . ||| ...||.|||. || |. |||||| ||||.||..| . .... gedksGsTavvvlvspkklylancGDsRavlsrngkvvfateDHkpsdpkEkeRienAgGsvm---ikRvnGsLAvsRalGDydykekpekkateqlvsp DADSASTVLDGTEDYLILACDGFYDTVNPDEAVKVVSDHLKENnGDSSMVAHKLVASARDAGSSDNITVIVVFLRDMNKA ... | ...|.||||| .|... .|....| ..|. . | ..||..|. . || ||..||.|.| . |. epevtvierdeedeflvlacDGiwDvmsneevaefvksrlevt-ddleevanelldtcLekgsrDNmsvilvllpgapkv |
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| Phosphatase | PPM1E.AA | Subfamily.LRR-PP2C.PD | 239-486 | 36 | 2.1e-51 | 164.9 | In-house | 19-255 (257) | Show / Hide |
Range on Protein: 239-486 Range on HMM: 19-255/257 Sequence Identity: 36% (90 aa) NMRRKMEDKHVCIPDFNmlfnleDQEEQAYFAVFDGHGGVDAAIYASIHLHVNLVRQ-EMFPHDPAEALCRAFRVTDERFvqkaAR-EsLRCGTTGVVTF | |||. | |. |.... |.|.|||||| .|| .|| .|. | .... .| ..| .|.. .. .. ...||| .. .| ... GrrptmedelviyGsfr------dksdedyyalfdGhgGraaakfaseelykilaelldlnnanPlkslkkaykeistqi----serp-kfiGttaasvl IRGNMLHVAWVGDSQVMLV-RKGQAVELMKPHKPDREDEKQRIEALGGCVVWF-GAWRVNGSLSVSRAIGDAEHKPYICGDADSA-STVLDGTEDYLILA .| ||||.|.| ..| |. | ||| |.|..||..||| || . |||| |.||||.||. .|.. | | | .. .||||||| .| iiedkvyianvGdsrvvlcqkdgtakrlsldhkPseeseekriselGGtvvstvvtsrvnGtlavsralGdsflePfvvpdPdlsqsleiskkdkflila CDGFYDTVNPDEAVKVVSdhlkeNNGDSSMVAHKLVASARDAGSSDNITVIVV . .|||..| . |. | || | ||.|||.|||. cdGiwdlisdeeaveiva-----gisdpekaaeklrdlayssGstdnisvivi |
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| Phosphatase | PPM1E.AA | Subfamily.ILKAP.PD | 235-486 | 30 | 7e-48 | 153.6 | In-house | 13-298 (298) | Show / Hide |
Range on Protein: 235-486 Range on HMM: 13-298/298 Sequence Identity: 30% (88 aa) H-AIKNMRRKMEDKHVCIPDFNMLFNLEDQ--EEQAYFAVFDGHGGVDAAIYASIHLHVNLV----RQEMFP--HDPAEALCRAFRVTDERFVQKAA--R . | |..|||.|| . |.. . |.. . .|.||||||.| |. .| .|| ..| .... .. .| ||. ||||...|. . faerkGereemeDahvilndldeqtrkekskvsrvsyyavfDGhaGsrasefaaeklhkviveklpkedvsakdkeikkclvdafkktDeeflklaskak ESLRCGTTGVVTFIRGNMLHVAWVGDSQVMLVRKG---Q--------AVELMKPHKPDREDEKQRIEALGGCVvWFGawRVNGSLSVSRAIGDAEHKPY- . . |.|.|| .. .|.|.|| .|||. .|.|. . .| | | |.| ..|..||. || | ..| ||.|.| |||.||| ..| . PvWkdGstavvvlvvdnvlyvanlGDskavlaRakeegdkagestiasvlLskdHtpasyeerkriqkaGgvv-rdg--RvlGvlevsRsiGDgrfkelg ICGDADSASTVLDGTEDYLILACDGFYDTVNPDEAVKVVSDHLKEN----------NGDSSM----VAHKLVASARDAGSSDNITVIVV . | . |. . ...||||| ..... ||.|| ... |... . .. . ....| .| . |||||.||..| vistPdvkkceLtenDlfvvlaCDGLwkvfeadevvkfilkvlededdrkikqeegksaeevrfevacerlAseavkrgssDnvtvllv |
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| Phosphatase | PPM1E.AA | Subfamily.PPM1G2.PD | 231-486 | 33 | 1.2e-47 | 152.4 | In-house | 11-275 (275) | Show / Hide |
Range on Protein: 231-486 Range on HMM: 11-275/275 Sequence Identity: 33% (89 aa) ETSIHAIKNMRRKMEDKHVCIPDfnmLFNLEDQEEQAYFAVFDGHGGVDAAIYASIHLHVNLVRQEMFPHDPA-EALCRAFRVTDERFVQKAARESLRCG .... ... | .||| |. .. |....|... |.||||||||| ..| ||. .|. ..... | .. ..| || ||| .... . . .| avgvssmqGyrlnmeDahilene---lleksddkslalfavfDGhGGakvakyagkklikkiakkksfkegaleqilkdafletDeellkdeklkdesaG TTGVVTFIRGNMLHVAWVGDSQVMLVRKGQAVELMKPHKPDREDEKQRIEALGGCVVwfgAWRVNGSLSVSRAIGDAEHKPYI-CGDA--------DSAS .| ||. |. . | || .|||. .| ||.. | |||..|.||.||.| || | ||||.|..|||.|| |.|. | . || stavvvlikeeklyvanaGDsravlsskgnvkalsfDhkPqeesekkriiaagGfve---lnrvngnLalsralgDfefkknvkkkpeeqivtavPDvlv TVLDGTEDYLILACDGFYDTVNPDEAVKVVSDHLKENnGDSSMVAHKLVASARDAGSS------DNITVIVV ...|.||||| .| .. .| |..| .|... . . ....|. .. || ||.||..| kkldeddeflvLaCDGiWDvltnkevvdlvrerlvsg-akldeiieelldkclapdssntgvGcDnmtvviv |
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| Phosphatase | PPM1E.AA | Subfamily.PPM1L.PD | 231-487 | 33 | 1.5e-43 | 139.3 | In-house | 13-272 (273) | Show / Hide |
Range on Protein: 231-487 Range on HMM: 13-272/273 Sequence Identity: 33% (89 aa) ETSIHAIKNMRRKMEDKhvcipdFNMLFNLEDQEEQAYFAVFDGHGGVDAAIYASIHLHVNLVRQ---------EMFPHDPAEALCRAFRVTDERFVQKA ........ | .|||. |.. ..... .. .||||||||| || .| | .. .. . | . .. |||....|| |. nvavysvlGrrprmedr------feieediknktgesffavfdGhGGefaaefakdvlvkaiknklieldadkentvpinfsklltdeilsvdeklleka ARESLRCGTTGVVTFIRGNMLHVAWVGDSQ-VMLVRKGQAVELMKPHKPDREDEKQRIEALGGCVVWFGAWRVNGSLSVSRAIGDAE--HKPYICGDADS ||| ........ | || ||||. |. ..|.|. | ||| . |..||. || . . |.|||.| |..|||.|| .| . | | . || kraediaGttalialvqesdlivanvGdsrGvlydkrGkaiplsfdhkpqqvkerkrikkaGGfiafrGvwrvaGvlatsralGdyplkdknlviadpdi ASTVLDGT-EDYLILACDGFYDTVNPDEAVKVVSDHLKENNgdssMVAHKLVASARDAGSSDNITVIVVF ..||||.||..|| .|||. . ..||| . . |. || . || |||||.|| ltfdlddhkpeflilasdGlwdtfsneeavrfikerlkepd----fGakslvlesfkrGsvdnitvlvvk |
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| Phosphatase | PPM1E.AA | Subfamily.PPM1K.PD | 263-487 | 34 | 1.1e-38 | 123.1 | In-house | 34-263 (264) | Show / Hide |
Range on Protein: 263-487
Range on HMM: 34-263/264
Sequence Identity: 34% (81 aa)
QEEQAYFAVFDGHGGVDAAIYASIHLHVNLVRQEMFPHDPAEALCRAFRVTDERFVQKA-----ARESLRCGTTGVVTFIR-GNMLHVAWVGDSQVMLVR
... ||||||||||. || .. .|. . | .| | | .|| |... . . .| | ||| |...| || | .| .|||. .| |
dpdllyfavfdGhgGssaadfvhdkleeivrrllekekdleevlkqafeeldkklkrylefsvaeaellssGttatvsllrdGnelvlaslGdsrailcr
KGQAVELMKPHKPDREDEKQRIEALGGCVVW--FGAWRVNGSLSVSRAIGDAEHKPY-ICGDADSASTVL-DGTEDYLILACDGFYDTVNPDEAVKVVSD
.|.| | | |.|.|..||.|| | || | | | .||. |...|..|| . |.| . . .. | . ... .|.||| . || | ..|.
nGkakkltkdhdPerkeekerikaagGsvewnslgkplvnsrlamtrslGdldlkryGviatPetkslkvkhaadsflvlitdgisfvvnsqelcdlvrl
HLkenngDSSMVAHKLVASARDAGSSDNITVIVVF
| || .. | . || || |..||
ch-----dpeeaahavteqalqygsednatavvvp
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| Phosphatase | PPM1E.AA | Subfamily.PPM1D.PD | 238-486 | 34 | 6.3e-33 | 104.4 | In-house | 16-311 (311) | Show / Hide |
Range on Protein: 238-486 Range on HMM: 16-311/311 Sequence Identity: 34% (96 aa) KNMRRKMEDKHVCIPDFNMLFNledQEEQAYFAVFDGHGGVDAAIYASIHLHVNLVRQEMFPHDPAE----ALCRAFRVTDERF-------VQKAARESL . |. ||| . . . . ..|.|..|||||||| .|| .|. || .. .|. | .. | |. .|| | |.... . ||| | qGgrkymeDvvaivlereesae---eaeaafvavfDGHGGkeAakfarehlwsvikkqkkflssepedvleAireaflatheamkkklaeWpktksglls RCGTTGVVTFIRGNMLHVAWVGDSQVMLVRKGQ------AVELMKPHKPDREDEKQRIEALGGCVVWF-GAWR---------VNGS--------LSVSRA .||.. |.|| ||||...| | . | ||.| |||. .||.||| ||| | | ||| |.|.|..|| |. . |. . taGttasvviirreklyvahvGDsgivlgvkepkekklrakeltkdHkPespeEkerieelGGevaaksGvkRvvWkRprlehngptvideiPFLavaRs IGD-----AEHKPYICG-DADSASTVLDGTED-YLILACDGFYDTVNPDEAVKVVSDHLKENNG---DSSMVAHKLVASARDAGSS-----DNITVIVV | ..||. |. ..||| ||... ..|..||.||... . . |. ||..|| .| . .| ||..|||| lGDlWsynaksgeyvvsPePdvkvrtldpneekfiilasDGlwnvltpedavsvvekeeekkelkeeqsrsvakalvkealqrwrskklraDnvsvivv |
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| Phosphatase | PPM1E.AA | Subfamily.PPM1G.PD | 327-486 | 38 | 2.9e-29 | 92.7 | In-house | 306-480 (482) | Show / Hide |
Range on Protein: 327-486 Range on HMM: 306-480/482 Sequence Identity: 38% (63 aa) RCGTTGVVTFIRGNMLHVAWVGDSQVMLVRKGQAVELMKPHKPDREDEKQRIEALGGCVVWFGawRVNGSLSVSRAIGDAEHKP---------YICGDAD ||| ||. ..|. | || .||| .| |.|.|..| |||. | |..|||. || | | |||| | .|||.|| .|| | ..| ...| dsGttavvaLvkgkklivanaGDsRcvlsrnGkaldlsiDhkPeDeveleRiekaGGkvtldg--RvnGGLnlsRalGDhaYktneeLpaeeqmisalPD SASTVLDGTEDYLILACDGFYDTVNPDEAVKVVSDHLKENN--GDSSMVAHKLVAS------ARDAGSSDNITVIVV .||||| ..... .| | | ..|||.. | . .|. | ||.||..| ikklilteedeFlvlacDGiWnvmssqevvdFvraklkeseeskklseiceeLlDaCLapdtsgDGtGCDnmtvviv |
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| Phosphatase | PPM1E.AA | Subfamily.PHLPP.PD | 341-486 | 26 | 7.3e-15 | 44.9 | In-house | 118-257 (257) | Show / Hide |
Range on Protein: 341-486 Range on HMM: 118-257/257 Sequence Identity: 26% (39 aa) MLHVAWVGDSQVMLVRKGQAVELMKPHKPDRE-DEKQRIEALGGCVVwfGAWRVNGSLSVSRAIGDAEHKPYICGDADSASTVLDGTEDYLILACDGFYD | .| ||. ...|.| |. . | | . . . .| .|| . . .||| .. .| .| |.. . |..| ...||| ...... tltaanvgkcklvlirnGkplplskvyileiddeelkrikeakaiit--ednkvnGviestrilGytflfPvvlPkphvrsvlLteqdEllilGnkalWe TVNPDEAVKVVsdhlkENNGDSSMVAHKLVASARDAGSSDNITVIVV .. ||||. | |. |. ..| ||| | | .|.....|| vlsideaveav-----rnvedplvaAkklvdlaqsygaadsvsalvv |
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| Phosphatase | PPM1E.AA | Subfamily.PPM1G.PD | 234-326 | 30 | 2.7e-12 | 36.7 | In-house | 14-99 (482) | Show / Hide |
Range on Protein: 234-326 Range on HMM: 14-99/482 Sequence Identity: 30% (28 aa) IHAIKNMRRKMEDKHVCIPDFNmlfnledqEEQAYFAVFDGHGGVDAAIYASIHLHVNLVRQEMFPHD-PAEALCRAFRVTDERFVQKAARESL . |.. | ||| | || |.. |. . |||.||||| . | |.. .| | .... .. ..||. || |. ....... | asamqGWRvsmeDahncildld--------edtslfavyDGhGGkevakycakklPdllkeskaykegdvekaleeaflkvDkkllteeilkel |
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| Phosphatase | PPM1E.AA | Subfamily.TAB1.PD | 324-409 | 35 | 3e-11 | 32.9 | In-house | 133-222 (336) | Show / Hide |
Range on Protein: 324-409 Range on HMM: 133-222/336 Sequence Identity: 35% (32 aa) ESLRCGTTGVVTFIRGNMLHVAWVGDSQVMLVRKG----QAVELMKPHKPDREDEKQRIEALGGCVVWFGAWRVNGSLSVSRAIGDAEHK . .. ||| ||. | | |.|| ||||. .||.. ... | | | ||| .|.. || . .. || |.||| . | seisgGttavvalilnnkLyvaNvGdsrAilvesekdgikvkQLsvdHnvdNedElkRlkdLGldieqikqnkrlgskeaTRsiGdykik |
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| Phosphatase | PPM1E.AA | Subfamily.PDP.PD | 410-464 | 27 | 5.2e-09 | 26.0 | In-house | 282-336 (409) | Show / Hide |
Range on Protein: 410-464 Range on HMM: 282-336/409 Sequence Identity: 27% (15 aa) PYICGDADSASTVLDGTEDYLILACDGFYDTVNPDEAVKVVSDHLKENNGDSSMV ||. . . | | .. .|.|| || .|.....|.|..|..||.... .... PYltaePevtshklrendkFLvlatDGLwdllsneevvslVgehlakkknkakva |
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| Phosphatase | PPM1E.AA | Subfamily.PPM1H.PD | 305-381 | 33 | 3.1e-08 | 22.9 | In-house | 141-215 (402) | Show / Hide |
Range on Protein: 305-381 Range on HMM: 141-215/402 Sequence Identity: 33% (26 aa) ALCRAFRVTDERFVQKAARESLRCGTTGVVTFIRGNMLHVAWVGDSQVMLVRKGQAVELMKPHKPdrEDEKQRIEAL || || || . . .. | | .|. . . |.|| |||. .||||.. ..| . . | | |.||. | alesaflemDeqiarereayrikGGCtalvalvllgklYvanaGDsRailvrkdeiiplsadftP--eteRqRlqel |
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| Phosphatase | PPM1E.AA | Subfamily.PDP.PD | 309-409 | 30 | 4.6e-07 | 19.6 | In-house | 146-254 (409) | Show / Hide |
Range on Protein: 309-409 Range on HMM: 146-254/409 Sequence Identity: 30% (33 aa) AFRVTDERFVQKAARESLRCGTTGVVTFIRGNMLHVAWVGDSQVMLVRK---G--QAVELMKPHKPDREDEKQRIEALG-----GCVVWFGawRVNGSLS |.. ..|. ...|. . |.. ....|.|. |||| .||.. .| .. | .||.| | . | |.| .||.. |. ||. |.| . alkkleekvleeavlkvalsGacallaliegtelhvAntGDcravlgvqeeegsweavkLskdqtadneeEveRikkeHPgeesktvirng--RlLgeLa VSRAIGDAEHK || ||...| PlRAFGdvryK |
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| Phosphatase | PPM1E.AA | Subfamily.PPTC7.PD | 264-361 | 19 | 1.2e-06 | 18.5 | In-house | 33-134 (263) | Show / Hide |
Range on Protein: 264-361 Range on HMM: 33-134/263 Sequence Identity: 19% (20 aa) EEQAYFAVFDGHGGVDAAIYASIHLHVNLVRQ-EMFPHDPAEALCRAFRVTDERFVQKAARESLRCG-TTG-VVTFIRGN-MLHVAWVGDSQVMLVRKGQ . . ..| || || . . .. .|... | . ... . .. .. .... . . .. . | .| .|.. | . |..| .|||.. ||.|. kvadvlgVADgvggwreygidpsefskelmkkcerivkeskfkerkpkkileaayqelleekvpvvGsstacivvldredkklesaNlGDSgflVvRngk AV | vv |
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| Phosphatase | PPM1E.AA | Subfamily.PPM1H.PD | 265-294 | 50 | 1.9e-06 | 17.0 | In-house | 63-92 (402) | Show / Hide |
Range on Protein: 265-294 Range on HMM: 63-92/402 Sequence Identity: 50% (15 aa) EQAYFAVFDGHGGVDAAIYASIHLHVNLVR . |||..||||.| ||. || || | . playfglfDGhaGsgaalvaskllhkhlke |
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| Phosphatase | PPM1E.AA | Subfamily.PPTC7.PD | 416-480 | 26 | 2.8e-06 | 17.3 | In-house | 169-232 (263) | Show / Hide |
Range on Protein: 416-480 Range on HMM: 169-232/263 Sequence Identity: 26% (17 aa) ADSASTVLDgTEDYLILACDGFYDTVNPDEAVKVVSDHLKENNGDSSMVAHKLVASARDAGSSDN |||.| . ..| ..|| || .| . || ..|... .... . ..|..|. || . . . adstsfevk-kgDlillatDGvfDNlsedeilevlkelkerdeeelqllanslaekarelsldpk |
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| Phosphatase | PPM1E.AA | Family.PPTC7.PD | 264-361 | 19 | 8.2e-06 | 15.8 | In-house | 32-133 (262) | Show / Hide |
Range on Protein: 264-361 Range on HMM: 32-133/262 Sequence Identity: 19% (20 aa) EEQAYFAVFDGHGGVDAAIYASIHLHVNLVRQ-EMFPHDPAEALCRAFRVTDERFVQKAARESLRCG-TTGVVTFI--RGNMLHVAWVGDSQVMLVRKGQ . . ..| || || . | .. .|... | . ... . .. .. .... . . .. . | .| .| . . . |..| .||| ..||.|. kvadvlgvADgvggwreygvdssafsselmkkcerlvkeskfkplkpkkllkaayaelleekvpvvGsstAcvvvldredkklesanlGDsgflvvRegk AV | vv |
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| Phosphatase | PPM1E.AA | Subfamily.PPM1H.PD | 425-475 | 36 | 8.3e-06 | 15.0 | In-house | 324-378 (402) | Show / Hide |
Range on Protein: 425-475 Range on HMM: 324-378/402 Sequence Identity: 36% (19 aa) GTEDYLILACDGFYDTVNPDEAVKVVSDHLKEN-NGD---SSMVAHKLVASARDA ..| |||| || .| .. .|. ..|.. |.. . | ..||..|||.|| leDdvlilatDGLWdvlsneevaeivrevlskvdsedkkrytavaqeLvaaarGk |
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| NLS | PPM1E.AA | NLS | 704-740 | 100 | 1e-300 | None | Paper | 704-740 (37) | Show / Hide |
Range on Protein: 704-740 Range on HMM: 704-740/37 Sequence Identity: 100% (37 aa) LSSLTGSGKRNRIRSSLPWRQNSWKGYSENMRKLRKT ||||||||||||||||||||||||||||||||||||| LSSLTGSGKRNRIRSSLPWRQNSWKGYSENMRKLRKT |
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