Gene PPM1L
PPM1L
Species: Human
Alias: PPM1L, PPM1-LIKE, PP2C-epsilon, MGC132545, MGC132547, PP2CE
External Links:
COSMIC
,
Entrez Gene
Classification
Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.
Protein domain
Protein domains of PPM1L.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit phosphatase group/family/subfamily, which is helpful to understand the relationship between phosphatases. Transmembrane region is predicted by TMHMM 2.0. Visualized by pviz.
Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking. View complete domain list.
| Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
|---|---|---|---|---|---|---|---|---|---|
| Phosphatase | PPM1L.AA | PP2Cc | 77-349 | 25 | 1.5e-76 | 261.51 | SMART | 1-338 (338) | Show / Hide |
Range on Protein: 77-349
Range on HMM: 1-338/338
Sequence Identity: 25% (94 aa)
VLEAEFSKTWEFKNHNVAVYSIQGRRDHMEDRFEVLTDLANKTHPSIFGIFDGHGGETAAEYVKSRLPEALKQHLQDYEKD-------------------
. ... . | . .. |.||.| .|||.. . . .||.|||||| .|.|. ..|.|.|...|| . |
HS-MGYNSGWRYGY---MESSMQGWRHPMEDAHVCRP---------FFGVFDGHGGHECAQYCRKHLHEHLAEELQFHKDDDYKENDEMQDEPEMWWRMW
KENSVLSYQTILEQQILSIDREMLEKLTVSYDEAGTTCLIALLSDKDLTVANVGDSRGVLCDKDG---------NAIPLSHDHKPYQLKERKRIKRAGG-
... .. .|.. .|..| |. .|...||.....| |||||||| ||| ... |..|. ||||.. .||.||..|||
HDKWFEDWEDALRKAFLRMDEEI------------CTAVVALIRGNKLYVANVGDSRAVLCRNGNDNWWGIRHYTAHQLTEDHKPDNEDERRRIEQAGGR
-------FISFNGS--WRVQGI---LAMSRSLGDYPLKNLN-----------------------VVIPDPDILTFDLD-----KLQPEFMILASDGLWDA
...... ||| | ||.||..||. .|. . ||..||. . .|. . .|.||..|||||
VMPMHRQWVMNWNCDVWRVNGVPIPLAVSRAFGDHYYKW-KEDEKIEWNRWYQMFDPRLPFKEPYVIAEPDVTHHELWQMTVPTPDDDFLILCCDGLWDV
FSNEEAVRFIKERL--------------------------DEPHFGAKSIVLQSFYRGCPDNITVMVV
.||.|.| .....| .| || .. . ||.||.||
MSNQEVVDIVRKCLRKWHHKPVKNQAQENAHMMRHRQKKHNDPMEAAKRLCDCAI----CDNMTVIVV
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| Phosphatase | PPM1L.AA | Subfamily.PPM1L.PD | 80-351 | 65 | 3.7e-155 | 505.3 | In-house | 2-273 (273) | Show / Hide |
Range on Protein: 80-351 Range on HMM: 2-273/273 Sequence Identity: 65% (179 aa) AEFSKtWEFKNHNVAVYSIQGRRDHMEDRFEVLTDLANKTHPSIFGIFDGHGGETAAEYVKSRLPEALKQHLQDYEKDKENSV-LSYQTILEQQILSIDR ||..| ||.|..||||||..|||..||||||. .|..|||..|.|..|||||||.|||..|..|..|.|..|.....||||.| ......|...|||.|. aevak-welkkqnvavysvlGrrprmedrfeieediknktgesffavfdGhGGefaaefakdvlvkaiknklieldadkentvpinfsklltdeilsvde EMLEKLTVSYDEAGTTCLIALLSDKDLTVANVGDSRGVLCDKDGNAIPLSHDHKPYQLKERKRIKRAGGFISFNGSWRVQGILAMSRSLGDYPLKNLNVV ..|||.....|.||||.||||....||.|||||||||||.||.|.|||||.||||.|.|||||||.|||||.|.|.|||.|.||.||.|||||||. |.| kllekakraediaGttalialvqesdlivanvGdsrGvlydkrGkaiplsfdhkpqqvkerkrikkaGGfiafrGvwrvaGvlatsralGdyplkdknlv IPDPDILTFDLDKLQPEFMILASDGLWDAFSNEEAVRFIKERLDEPHFGAKSIVLQSFYRGCPDNITVMVVKF |.||||||||||...|||.|||||||||.||||||||||||||.||.|||||.||.||.||..|||||.|||. iadpdiltfdlddhkpeflilasdGlwdtfsneeavrfikerlkepdfGakslvlesfkrGsvdnitvlvvkl |
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| Phosphatase | PPM1L.AA | Group.PPM.PD | 79-359 | 38 | 5.4e-89 | 289.0 | In-house | 25-329 (459) | Show / Hide |
Range on Protein: 79-359
Range on HMM: 25-329/459
Sequence Identity: 38% (112 aa)
EAEF-SKTWEFKNHNVAVYSIQGRRDHMEDRFEVLTDLANKThpSIFGIFDGHGGETAAEYVKSRLPEALKQHLQDYEKDKENSV-----------LSYQ
| . |.. . ..... | | ||.|..||||. . ... |.. |.||.||||||. |||.....||. ||..|...... ....... |.. .| .|..
ehhlessagsgnglrygvasmqgwrkemEDrhvivenfdnnd--sffgVfDGHgGaeaaefaakkLpkilkkqlkkkkdevskksaeasldnddrgekvk
TILEQQILSIDREMLEKLTVSY---DEAGTTCLIALLSDKDLTVANVGDSRGVLCdKDGNAIPLSHDHKPYQLKERKRIKRAGGFISFNGswRVQGILAM
. |. . ...|||...||...|.| |||.||||.||| ..|.|.||| |||| . .||.||..|||.. .| ||.||||.||.|||..||.
kalrsafleldedlseeanekeepgkdsGtTAvvalingkklyvANaGDSravLc-rngkavplskdHkpenpeEreRIekagGsveidg--RvnGilav
SRSLGDYPLKNL-NVVIPDPDILTFDLDKLqPEFMILASDGLWDAFSNEEAVRFIKERLDE--------PHFGAKSIVLQSFYRGCP------DNITVMV
.|...||. ...|.. ||..|||||||| .||||.|.|..|.|.. . |...| . .|.|||||.||.. .. ....
sRalGdhdlkkeeqmvsaePdvsvvkltee-deflvlAsDGlWdvlsneevvefvretlekkkkelkkdleeiaerlvdealakgstgdgtscDNiTviv
VKFRNSSKTEE
vtlndamrrql
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| Phosphatase | PPM1L.AA | Family.PPM.PD | 86-359 | 38 | 2.4e-87 | 283.5 | In-house | 10-294 (495) | Show / Hide |
Range on Protein: 86-359 Range on HMM: 10-294/495 Sequence Identity: 38% (111 aa) WEFKNHNVAVYSIQGRRDHMEDRFEVLTDLANKTHPSIFGIFDGHGGETAAEYVKSRLPEALKQHLQDYEKDKE-----NSVLSYQTILEQQILSIDREM . ..... |.| ||.|..|||.. |...| |... |.||.||||||. |||.....|.. ||..|......|. .| .....|....|..|.|. sssnglrygvasmqgwrsemeDahvvvenlennedfslfgvfDGhgGaeaaefaakklhkilkkqlekkddeksstsaessaekvkealrkafleldeel LEKLTVSY--DEAGTTCLIALLSDKDLTVANVGDSRGVLCdKDGNAIPLSHDHKPYQLKERKRIKRAGGFISFnGSWRVQGILAMSRSLGDYPLKN---L |.| . ...|||....|...|.| |||.|||| ||| ..|.|..|| |||| . .||.||..|||... ...||.|.||.||.|||.||. . . seelneksagkdsGtTAvvvlirgkklyvAnaGDsravLc-rngkavelskdHkpenpeEreRIekagGkvvi-rdgrvnGvlavsRalGdfdlkkeeqa nVVIPDPDILTFDLDKLQPEFMILASDGLWDAFSNEEAVRFIKERL----DEPHFGAKSIVLQSFYRGCPDNITVMVVKFRNSSKTEE |...||| ...|.. . ||..|||||||| .||||.|....|.| ... |...| . .|. |||||.||.. .. |... -ivsaePditsvkltqeedeflvlasdGlWdvlsneevvelvretleekeedleeiaeeLvdealakgsrDNiTvlvvalyenikqqn |
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| Phosphatase | PPM1L.AA | Subfamily.PPM1A.PD | 90-359 | 33 | 1e-67 | 218.7 | In-house | 9-286 (309) | Show / Hide |
Range on Protein: 90-359 Range on HMM: 9-286/309 Sequence Identity: 33% (94 aa) NHNVAVYSIQGRRDHMEDRFEVLTDLANKT-HPSIFGIFDGHGGETAAEYVKSRLPEALKQHLQDYEKDKENSVLSYQTILEQQILSIDREMLEKLTVS- . .... | || | .||| . . .||..|. | |..||||.|.....| ...| ||. .. . .. ...|. ... |.. |..| .. .. ..| glryglssmqgwRvemEDahtavidlpsklkdwsffavfDGHaGskvskycakhlleaileeeefkaskeksskekvkealrkgfLelDekirklvelsk -YDEAGTTCLIALLSDKDLTVANVGDSRGVLCDkDGNAIPLSHDHKPYQLKERKRIKRAGGFISFNgswRVQGILAMSRSLGDYPLKNL-------NVVI |..|.|. .|.|.| | .||.||||.||. .|... ..||||.. ||..||. |||.. . ||.|.||.||.|||| |. ..|. gedksGsTavvvlvspkklylancGDsRavlsr-ngkvvfateDHkpsdpkEkeRienAgGsvmik---RvnGsLAvsRalGDydykekpekkateqlvs PDPDILTFDLDKlQPEFMILASDGLWDAFSNEEAVRFIKERL---DEPHFGAKSIVLQSFYRGCPDNITVMVVKFRNSSKTEE |.|.. ... |. . ||..||.||.|| ||||...|.|.|| |... |.... .. .| ||..|..|. .. |..| pepevtvierde-edeflvlacDGiwDvmsneevaefvksrlevtddleevanelldtcLekgsrDNmsvilvllpgapkvse |
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| Phosphatase | PPM1L.AA | PP2C | 91-344 | 28 | 9.5e-65 | 226.21 | Pfam | 1-284 (284) | Show / Hide |
Range on Protein: 91-344 Range on HMM: 1-284/284 Sequence Identity: 28% (82 aa) HNVAVYSIQGRRDHMEDRFEVLTDLAN----KTHPSIFGIFDGHGGETAAEYVKSRLP----EALKQHLQDYEKD--KENSVLSYQTIL--EQQILSI-- . . . ..||.|..|||. . .. . | . ..|..|||||| ||.| ...|. . || ...| . ... .|.... . . . WDYGFCRMQGWRHFMEDAHHCYPNMNCSSSGKDSWHFFAVFDGHGGHQAAKYCRKHLHKAMNTILKERKSFPEGNPKDVEQALRKSFLECDTDMMFYSAP -DREMLEKLTVSYDEAGTTCLIALLSDKD--LTVANVGDSRGVLCDKDGNA---IPLSHDHKPYQLKERKRIKRAGGFIS-FNGSWRVQGI-LAMSRSLG .... .. . |.|...|...... | |||.||||.|||.... . .|. ||||. .||.||..|||... | ||| | ||.||..| WHEQN--VMHWECWHSGCTAVCAYIRNQKNILYVANCGDSRAVLCRNGNAHNWVHQLTYDHKPSNEDERRRIRQAGGWVMWW-GFWRVNGVWLAVSRAFG DYPLKNLN-------VVIPDPDIL-TFDLDKLQPEFMILASDGLWDAFSNEEAVRFIKERLDE---PHFGAKSIVLQSFYRGCPDNI |. .|. .|...||| . .... ||.|||.||||| |..|.. ........ | .. .| . .|. ||| DFHYKPNHTCFPKEQPVTAEPDITPEHKITPDHDEFLILACDGLWDVMSDQEVCDIVRQCRSDWNDPMEACEKLVDYCIAYGSEDNI |
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| Phosphatase | PPM1L.AA | Subfamily.PPM1G2.PD | 89-324 | 36 | 6e-59 | 189.5 | In-house | 8-241 (275) | Show / Hide |
Range on Protein: 89-324 Range on HMM: 8-241/275 Sequence Identity: 36% (91 aa) KNHNVAVYSIQGRRDHMEDRFEV---LTDLANKTHPSIFGIFDGHGGETAAEYVKSRLPEALKQhlqdyekD---KENSVlsyQTILEQQILSIDREMLE .. .|.| |.|| | .||| . | .. .... ..|..||||||...|.|. ..| . ... ||... ..||...|..|.|.|.. ariavgvssmqGyrlnmeDahilenelleksddkslalfavfDGhGGakvakyagkklikkiak-------kksfkegal---eqilkdafletDeellk KLTVSYDEAGTTCLIALLSDKDLTVANVGDSRGVLCDKdGNAIPLSHDHKPYQLKERKRIKRAGGFISFNgswRVQGILAMSRSLGDYPLKNLN------ ... ..||.|....|.....| |||.|||| ||. | ||. || |||| . .|.|||. ||||...| ||.| ||.||.|||. |. . deklkdesaGstavvvlikeeklyvanaGDsravlssk-gnvkalsfDhkPqeesekkriiaagGfveln---rvngnLalsralgDfefkknvkkkpee -VVIPDPDILTFDLDkLQPEFMILASDGLWDAFSNEEAVRFIKERLDEP .| ||.|. .|| . ||..|| ||.|| ..|.| | ...||| . qivtavPDvlvkkld-eddeflvLaCDGiWDvltnkevvdlvrerlvsg |
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| Phosphatase | PPM1L.AA | Subfamily.PPM1E.PD | 89-349 | 33 | 1.9e-57 | 184.6 | In-house | 9-267 (269) | Show / Hide |
Range on Protein: 89-349 Range on HMM: 9-267/269 Sequence Identity: 33% (91 aa) KNHNVAVYSIQGRRDHMEDRFEVLTD------LANKTHPSIFGIFDGHGGETAAEYVKSRLPEALKQHLQDYEKDKensvlsyqTILEQQILSIDREMLE |...| .......| .||||. .| | | .... . |..|||||| ||.| ...|.| | .. .. | . . |.. ..|. .|.| keyevsiaavknkrrkmEDrhvaledlnelfelkdekeraffavfDGHgGveaakyaaahlhellvrqeklkedpa--------ealkeafkltDerflq KLTVSYDEAGTTCLIALLSDKDLTVANVGDSRGVLCdKDGNAIPLSHDHKPYQLKERKRIKRAGGFISFNGSWRVQGILAMSRSLGDYPLKNlnVVIPDP . ..|.| ..|.. . | || .|||...|. ..|.|. | . ||| . .|.|||. |||.. . | ||| |.|..||..||. ||. |. ..|. kaereklksGstavvvliekdqlyvaWlGDsqallv-rkgeavqlmkpHkPeredEkkRieeagGlvvvigawRvnGvLsvsRaiGDvklkp--yvsgea DILTFDLDKLQpEFMILASDGLWDAFSNEEAVRFIKERLDEPH----FGAKSIVLQSFYRGCPDNITVMVV ...||. . ...|||.||||| . .||.|. ..| | ... ||..| .. .| |||||.|| dvaeveldgse-dylilacDGlwDvvneeevvklveefladgaedlsevakllveaakeagssDnitvvvv |
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| Phosphatase | PPM1L.AA | Subfamily.LRR-PP2C.PD | 91-351 | 36 | 3.3e-56 | 180.6 | In-house | 10-257 (257) | Show / Hide |
Range on Protein: 91-351 Range on HMM: 10-257/257 Sequence Identity: 36% (92 aa) HNVAVYSIQGRRDHMEDRFEVLTDLANKTHPSIFGIFDGHGGETAAEYVKSRLPEALKQHLQDYEKDKENSVL-SYQTIlEQQIlsidremleklT--Vs .|. . ||| |||.. . .|.. .. .||||||..||.. .|. |.. |. .. . ..|. .|..| . ||. ||| .| fkvgfsdmiGrrptmedelviyGsfrdksdedyyalfdGhgGraaakfaseelykilaelldlnnanPlkslkkaykei-stqi-----------serp- yDEAGTTCLIALLSDKDLTVANVGDSRGVLCDKDGNAIPLSHDHKPYQLKERKRIKRAGGFISFN-GSWRVQGILAMSRSLGDYPLKNlnVVIPDPDIL- . .. .||||||| |||.||| | || |||| . .|.|||...||.. . . || | ||.||.||| |. |.||||. ... . . .|. -kfiGttaasvliiedkvyianvGdsrvvlcqkdgtakrlsldhkPseeseekriselGGtvvstvvtsrvnGtlavsralGdsfleP--fvvpdPdlsq TFDLdKLQPEFMILASDGLWDAFSNEEAVRFIKErLDEPHFGAKSIVLQSFYRGCPDNITVMVVKF ||| ||.|| |.|||| . . .|. |. . ... .| |||.|.|.|. slei-skkdkflilacdGiwdlisdeeaveivag-isdpekaaeklrdlayssGstdnisvivikl |
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| Phosphatase | PPM1L.AA | Subfamily.PPM1K.PD | 92-350 | 33 | 1e-50 | 162.5 | In-house | 11-263 (264) | Show / Hide |
Range on Protein: 92-350 Range on HMM: 11-263/264 Sequence Identity: 33% (87 aa) NVAVYSIQGRRDHMEDRFEVlTDLANKTHpsIFGIFDGHGGETAAEYVKSRLPEALKQHLqDYEKDkensvlsYQTILEQQILSIDREMLEKLTVS---- .| . |..|.| ||||.. .| .. |..|||||| .||..| .| | ... | . ||| ...| | . .|...|. | . svGkdsliGkraenedrfkl-keldpdll--yfavfdGhgGssaadfvhdkleeivrrll-ekekd-------leevlkqafeeldkklkrylefsvaea -YDEAGTTCLIALLSD-KDLTVANVGDSRGVLCdKDGNAIPLSHDHKPYQLKERKRIKRAGGFISFN--GSWRVQGILAMSRSLGDYPLKNLNvVIPDPD ..||| ..|| | ..| .|..|||| .|| ..|.| |..||.| . .|..|||.|||....| | .| . |||.||||| ||. || .|. . ellssGttatvsllrdGnelvlaslGdsrailc-rnGkakkltkdhdPerkeekerikaagGsvewnslgkplvnsrlamtrslGdldlkryG-viatPe ILTFDLDKLQPEFMILASDGLWDAFSNEEAVRFIKErLDEPHFGAKSIVLQSFYRGCPDNITVMVVK ..... . |..| .||. . ...| ... .|. |.... |.. |. || |..|| tkslkvkhaadsflvlitdgisfvvnsqelcdlvrl-chdpeeaahavteqalqygsednatavvvp |
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| Phosphatase | PPM1L.AA | Subfamily.ILKAP.PD | 96-349 | 29 | 1.1e-47 | 152.9 | In-house | 14-298 (298) | Show / Hide |
Range on Protein: 96-349
Range on HMM: 14-298/298
Sequence Identity: 29% (85 aa)
YSIQGRRDHMEDRFEVLTDLANK--------THPSIFGIFDGHGGETAAEYVKSRLPEALKQHLQDyeKDKENSVLSYQTILEQQILSIDREMLEKLTVS
. .|.|..||| .| || .. .. | ...||||.|. |.|.....| . ....| .| . ... | . . |.|.|.. . .
aerkGereemeDahvilndldeqtrkekskvsrvsyyavfDGhaGsrasefaaeklhkviveklpk--edvsakdkeikkclvdafkktDeeflklaska
--YDEAGTTCLIALLSDKDLTVANVGDSRGVLCDKDGN----------AIPLSHDHKPYQLKERKRIKRAGGFISFNgswRVQGILAMSRSLGDYPLKNL
|.| ..|. | | |||.|||. ||. .. . ...||.||.| . .|||||..|||.. .. ||.|.|..|||.|| |.|.
kPvWkdGstavvvlvvdnvlyvanlGDskavlaRakeegdkagestiasvlLskdHtpasyeerkriqkaGgvvrdg---RvlGvlevsRsiGDgrfkel
NvVIPDPDILTFDLDKLqPEFMILASDGLWDAFSNEEAVRFIKERLDEP--------------HF----GAKSIVLQSFYRGCPDNITVMVV
|| .||. . .|.. |..|| ||||. |...|.|.|| . |.. . ... .. ||. ||.||..|
g-vistPdvkkceLten-DlfvvlaCDGLwkvfeadevvkfilkvlededdrkikqeegksaeevrfevacerlAseavkrgssDnvtvllv
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| Phosphatase | PPM1L.AA | Subfamily.PPM1D.PD | 89-321 | 29 | 6.5e-41 | 130.6 | In-house | 6-271 (311) | Show / Hide |
Range on Protein: 89-321 Range on HMM: 6-271/311 Sequence Identity: 29% (75 aa) KNHNVAVYSIQGRRDHMEDRFEVLTDLAN---KTHPSIFGIFDGHGGETAAEYVKSRLPEALKQHlQDYEKDKENSVLSY----QTILEQQILSIDREML .. .|.. . || | .|||.. . .. . .. .....||||||. ||......| . .|.. ... .....||. ..... .| vslrvtseadqGgrkymeDvvaivlereesaeeaeaafvavfDGHGGkeAakfarehlwsvikkq-kkflssepedvleAireaflatheamkkklaeWp EKLTVSYDEAGTTCLIALLSDKDLTVANVGDSRGVLCDKDG-----NAIPLSHDHKPYQLKERKRIKRAGGFISFN-GSWRV---------QG------- .. . . ||||. . .. ..| ||.||||. || |. .| .| .|||| ...|..||...|| .. . | ||.| ||..||| ktksgllstaGttasvviirreklyvahvGDsgivlgvkepkekklrakeltkdHkPespeEkerieelGGevaaksGvkRvvWkRprlehngptvidei -ILAMSRSLGDY----PLKNLNVVIPDPDILTFDLDKLQPEFMILASDGLWDAFSNEEAVRFIKERL || .. || |.||. . || . .|.||||||||. . |.||..... PFLavaRslGDlWsynaksgeyvvsPePdvkvrtldpneekfiilasDGlwnvltpedavsvvekee |
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| Phosphatase | PPM1L.AA | Subfamily.PPM1G.PD | 188-324 | 43 | 1.8e-37 | 119.7 | In-house | 304-443 (482) | Show / Hide |
Range on Protein: 188-324 Range on HMM: 304-443/482 Sequence Identity: 43% (58 aa) YDEAGTTCLIALLSDKDLTVANVGDSRGVLCdKDGNAIPLSHDHKPYQLKERKRIKRAGGFISFNGswRVQGILAMSRSLGDYPLKNLNVV-------IP ...||| ..||. .|.|.|||.|||| ||. ..|.|. || |||| .|..||..||| . .| || | | .|| |||. |. . .||| . | . GkdsGttavvaLvkgkklivanaGDsRcvls-rnGkaldlsiDhkPeDeveleRiekaGGkvtldg--RvnGGLnlsRalGDhaYktneeLpaeeqmisa DPDILTFDLDKlQPEFMILASDGLWDAFSNEEAVRFIKERLDEP . ||..||.||.|.. | .| | |....| | lPDikklilte-edeFlvlacDGiWnvmssqevvdFvraklkes |
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| Phosphatase | PPM1L.AA | Subfamily.PHLPP.PD | 120-349 | 25 | 1.5e-22 | 70.1 | In-house | 38-257 (257) | Show / Hide |
Range on Protein: 120-349 Range on HMM: 38-257/257 Sequence Identity: 25% (59 aa) HPSIFGIFDGHGGETAAEYVKSRLPEALKQHLQDYEKDKEnsVLSYQTILEQQILSIDREMLEKLTVSYDEAGTTCLIAllSDKDLTVANVGDSRGVLCd ...|..|| . .. .. . . ||...| ..... . . .. | . . | .. . || | ||.||||. . ||. .. veavyGlidGdrnselpsllqctmadvlkeevqkdkneev--yianillvshrklGeaGqklGasallirikedrvdia--ssftltaanvgkcklvli- KDGNAIPLSHDHKPYQL-KERKRIKRAGGFISFNGswRVQGILAMSRSLGDYPLknLNVVIPDPDILTFDLDKlQPEFMILASDGLWDAFSNEEAVRFIK | .|||. . . .| |||| | ..| .. .| |... .| || . | ||.|.| . | . | |..||...||. .| .|||. ... rnGkplplskvyileiddeelkrikeakaiitedn--kvnGviestrilGytfl--fPvvlPkphvrsvlLte-qdEllilGnkalWevlsideaveavr ERlDEPHFGAKSIVLQSFYRGCPDNITVMVV ..| || .| . |. |.....|| nv-edplvaAkklvdlaqsygaadsvsalvv |
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| Phosphatase | PPM1L.AA | Subfamily.PPM1G.PD | 91-182 | 30 | 2.6e-16 | 50.0 | In-house | 10-92 (482) | Show / Hide |
Range on Protein: 91-182 Range on HMM: 10-92/482 Sequence Identity: 30% (28 aa) HNVAVYSIQGRRDHMEDRFEVLTDLANKThpSIFGIFDGHGGETAAEYVKSRLPEALKQHlQDYEKDKENSVlsyqtiLEQQILSIDREMLE .... ..|| |. ||| ....|| ..| |.|...|||||. |.|. ..||. ||.. . |.... .. ||. |..|...|. lsygasamqGWRvsmeDahncildldedt--slfavyDGhGGkevakycakklPdllkes-kaykegdveka------leeaflkvDkkllt |
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| Phosphatase | PPM1L.AA | Subfamily.TAB1.PD | 190-309 | 37 | 1.4e-14 | 43.9 | In-house | 136-270 (336) | Show / Hide |
Range on Protein: 190-309 Range on HMM: 136-270/336 Sequence Identity: 37% (46 aa) EAGTTCLIALLSDKDLTVANVGDSRGVLCDKD--G-NAIPLSHDHKPYQLKERKRIKRAGGFISFNGSWRVQGILAMSRSLGDYPLKNL----------- . ||| ..||. ..| |||||||| .|.... | .. || || .| ||.| | | . .. | ||.||| .|... .| ||| sgGttavvalilnnkLyvaNvGdsrAilvesekdgikvkQLsvdHnvdNedElkRlkdLGldieqikqnkrlgskeaTRsiGdykikkgykevdvlssAk -NVVIPDPDIL-TFDLDKLQPeFMILASDGLWDAFS . |...|. |..| |||| .|. gePiiatPdingpkdindleg-fllLmSdGlykali |
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| Phosphatase | PPM1L.AA | Subfamily.PDP.PD | 174-245 | 29 | 9.3e-13 | 38.4 | In-house | 148-223 (409) | Show / Hide |
Range on Protein: 174-245 Range on HMM: 148-223/409 Sequence Identity: 29% (22 aa) LSIDREMLEKLTVSYDEAGTTCLIALLSDKDLTVANVGDSRGVLCDKDGNA----IPLSHDHKPYQLKERKRIKRA . ....||..... .|...|.||.....| |||.||.| ||. ..... ..||.|. .| .|||.. kkleekvleeavlkvalsGacallaliegtelhvAntGDcravlgvqeeegsweavkLskdqtadneeEveRikke |
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| Phosphatase | PPM1L.AA | Subfamily.PPM1H.PD | 169-244 | 35 | 6.5e-12 | 35.1 | In-house | 142-214 (402) | Show / Hide |
Range on Protein: 169-244 Range on HMM: 142-214/402 Sequence Identity: 35% (27 aa) LEQQILSIDREMLEKLTVSYDEAGTTCLIALLSDKDLTVANVGDSRGVLCdKDGNAIPLSHDHKPYqlKERKRIKR ||. |..| . . . .. | | |.||. .. | ||| |||| .|. . .. ||||.|. | ||.|... lesaflemDeqiarereayrikGGCtalvalvllgklYvanaGDsRailv-rkdeiiplsadftPe--teRqRlqe |
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| Phosphatase | PPM1L.AA | Subfamily.PPM1H.PD | 256-323 | 32 | 5.9e-10 | 28.6 | In-house | 278-355 (402) | Show / Hide |
Range on Protein: 256-323 Range on HMM: 278-355/402 Sequence Identity: 32% (25 aa) RVQGILAMSRSLGDYPLKNLNVV-------IPDPDILTFDLDKLQ---PEFMILASDGLWDAFSNEEAVRFIKERLDE |. . ....| |||. || .. | |.. ..||.... . .|||.||||| ||||. . ..| |.. RllatigvtRGlGDheLkvvdtnlsikPfLspvPevrvldltqvesleDdvlilatDGLWdvlsneevaeivrevlsk |
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| Phosphatase | PPM1L.AA | Subfamily.PDP.PD | 281-325 | 37 | 1.3e-09 | 28.0 | In-house | 287-330 (409) | Show / Hide |
Range on Protein: 281-325 Range on HMM: 287-330/409 Sequence Identity: 37% (17 aa) DPDILTFDLDKlQPEFMILASDGLWDAFSNEEAVRFIKERLDEPH .|.... | . . |..||.||||| .||||.|. ..| |.. . ePevtshklre-ndkFLvlatDGLwdllsneevvslVgehlakkk |
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| Phosphatase | PPM1L.AA | Subfamily.PPTC7.PD | 117-225 | 22 | 1.5e-08 | 24.8 | In-house | 31-134 (263) | Show / Hide |
Range on Protein: 117-225 Range on HMM: 31-134/263 Sequence Identity: 22% (25 aa) NKTHPSIFGIFDGHGGETAAEYVKSRLPEALKQHLQDYEKDKENSVLSYQTILEQQILSIDREMLEKLtvsydeAGTTCLIALLSDKD--LTVANVGDSr ... ...|. || || . .|.. . | .... |. . . . ..|||... .. .| .. ..|. |. |. .| |.||.||| | snkvadvlgVADgvggwreygidpsefskelmkkcerivkeskfkerkpkkileaayqelleekvpvv------GsstacivvldredkklesaNlGDS- GVLCDKDGNAI .| ..|. . gflVvRngkvv |
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| Phosphatase | PPM1L.AA | Subfamily.PDP.PD | 105-153 | 36 | 6.3e-08 | 22.4 | In-house | 23-69 (409) | Show / Hide |
Range on Protein: 105-153 Range on HMM: 23-69/409 Sequence Identity: 36% (18 aa) MEDRFEVLTDLanKTHPSIFGIFDGHGGETAAEYVKSRLPEALKQHLQD .||| . . | ... .||.|||||| ..|| |. ||.. . ..| . iEDrrseakll--esngvlfgvfDGHggaacaeavskrLlkyvaasllk |
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| Phosphatase | PPM1L.AA | Family.PPTC7.PD | 117-225 | 22 | 6.8e-08 | 22.6 | In-house | 30-133 (262) | Show / Hide |
Range on Protein: 117-225 Range on HMM: 30-133/262 Sequence Identity: 22% (25 aa) NKTHPSIFGIFDGHGGETAAEYVKSRLPEALKQHLQDYEKDKENSVLSYQTILEQQILSIDREMLEKLtvsydEAGTTCLIAL-LSDKDLTVANVGDSrG ... ...|. || || . .|.. . | .... |. . . |. ...|.... .. .| .. . | |...| .|| | .||.||| | snkvadvlgvADgvggwreygvdssafsselmkkcerlvkeskfkplkpkkllkaayaelleekvpvv-----GsstAcvvvldredkklesanlGDs-g VLCDKDGNAI .| ..|. . flvvRegkvv |
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| Phosphatase | PPM1L.AA | Subfamily.TAB1.PD | 94-184 | 25 | 9e-08 | 21.5 | In-house | 10-94 (336) | Show / Hide |
Range on Protein: 94-184 Range on HMM: 10-94/336 Sequence Identity: 25% (23 aa) AVYSIQGRRDHMEDRFEVLTDlANKTHPSIFGIFDGHGGETAAEYVKSRLPEALK-QHLqDYEKDKENsvlsyQTILEQQILSIDREMLEKL .||..|.... .. . . ... ....|||. || |||.|. || | .| |.. | . .|.| | ..|...|.. eryskegsssedhenedkvfs-rteddiilyavfdGydGekaaefveqrLvaelllgdl-seeaeaep-----kllllqvieeverkffesi |
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| Phosphatase | PPM1L.AA | PP2C_SIG | 103-351 | 11 | 4.9e-07 | 25.53 | SMART | 1-250 (250) | Show / Hide |
Range on Protein: 103-351
Range on HMM: 1-250/250
Sequence Identity: 11% (33 aa)
DHMEDRFEVLTDLAN-----------KTH--PSIFGIFDGHG--GETAAEYVKSRLPEALKQHLQDYEKDKENSVLSYQTILEQQILSIDREMLEKLTVS
|. | . .| . . . .| | |..| . .|. . ... ......... ..| . ..| . ..
DDHWDIYQYYEDATQVCGDWYDFWKIPEGQDRYFFVIGDVMGWAHGLPAALMMGMARTMMRTFWHE--------------SPPQILERCNRWIYQN-NHE
YDEAGTTCLIALL----SDKDLTVANVGDSRGVLCD--KDGNAIPLSH------DHKPYQLKERKRIKRAGGFISFNGSWRVQGILAMSRSLGDYPLKNL
.. .||...... ... | ....|.|.. | . .| ..... ... | . .. ..... . . . .
ECGMFTTMCCCVYMPDFATHTLWYCHCGHSPPYLYRAMDGGRVEHTHDHYLVQHYV-MRIIDEEDAKHHPWHNWTGPPLGMEPDYM--------------
NVVIPDPDILTFDLDKLQPEFMILASDGLWDA-------FSNEEAVRFIKERLDEPHFGAKSI----VLQSFYRGC--PDNITVMVVKF
.|. .|.... . .....||...| | .|. . ..| . . .. . | .. .. .|..||.|||.
------YDVQEFQYEP--GDRFVMCTDGVTEARNPQGEFFGEEWLQEILEEHQ-CCCPQEIAQRIMQELMEHMGDHNGHDDMTVIVVKV
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| Phosphatase | PPM1L.AA | Subfamily.PPM1H.PD | 116-154 | 39 | 2.4e-06 | 16.8 | In-house | 59-97 (402) | Show / Hide |
Range on Protein: 116-154 Range on HMM: 59-97/402 Sequence Identity: 39% (15 aa) ANKTHPSIFGIFDGHGGETAAEYVKSRLPEALKQHLQDY ..| . .||.||||.|..|| | . ||..|.| eeklplayfglfDGhaGsgaalvaskllhkhlkekledv |
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