Gene TAB1
TAB1
Classification
Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.
Protein domain
Protein domains of TAB1.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit phosphatase group/family/subfamily, which is helpful to understand the relationship between phosphatases. Transmembrane region is predicted by TMHMM 2.0. Visualized by pviz.
Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking. View complete domain list.
| Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
|---|---|---|---|---|---|---|---|---|---|
| Phosphatase | TAB1.AA | PP2Cc | 26-363 | 17 | 1.7e-44 | 155.08 | SMART | 1-338 (338) | Show / Hide |
Range on Protein: 26-363 Range on HMM: 1-338/338 Sequence Identity: 17% (69 aa) LSGVGSASNRSYSA--DGKGTESHPPEDSWLKFRSENNCFLYGVFNGYDGNRVTNFVAQRLSAELLLGQLNAEHAEAD--------------------VR | .|..|. .|. . ... || ||... . .| .|| .|| .. |. .. . ...| . HS-MGYNSGWRYGYMESSMQGWRHPMEDAHVCRP---------FFGVFDG-HGGHECAQYCRKHLHEHLAEELQFHKDDDYKENDEMQDEPEMWWRMWHD RVLLQAFDVVERSFLESIDDALAEKASLQSQLPEGVPQHQLPPQYQKILERLKTLEREISGGAMAVVAVLLNNKLYVANVGTNRALLCKSTVDGLQ---- . ... |. ...||. .. ..||||.. .||||||||| || ||.. | . KWFEDWEDALRKAFLRMDEEI-----------------------------------------CTAVVALIRGNKLYVANVGDSRAVLCRNGND-NWWGIR ---VTQLNVDHTTENEDELFRLSQLGL--------DAGKIKQ--VGIICG---QESTRRIGDYKVK----------YGYTDIDLLSAAKSKPIIAEPEIH ..|| .||. .||||. |..|.| .. . . . . .. .| .||.. | ..|...|. . .|. ..||||... HYTAHQLTEDHKPDNEDERRRIEQAGGRVMPMHRQWVMNWNCDVWRVNGVPIPLAVSRAFGDHYYKWKEDEKIEWNRWYQMFDPRLPFKEPYVIAEPDVT GAQPL-----DGVTGFLVLMSEGLYKALEAAHGPGQANQEIAAMIDTEFAKQTSLD---------AVAQAVVDRVKRIHSDTFASGGERARFCPRHEDMT . . ||.|.. ||. .. . . . .. .... .|..... ...... . ||.. . .|| HHELWQMTVPTPDDDFLILCCDGLWDVMSNQEVVDIVRKCLRKWHHK-PVKNQAQENAHMMRHRQKKHNDPMEAAKRLCDCAI------------CDNMT LLVR .| VIVV |
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| Phosphatase | TAB1.AA | Subfamily.TAB1.PD | 27-363 | 51 | 1e-150 | 491.2 | In-house | 2-336 (336) | Show / Hide |
Range on Protein: 27-363 Range on HMM: 2-336/336 Sequence Identity: 51% (175 aa) SGVGSASNRSYSADGKGTESHPPEDSWLKfRSENNCFLYGVFNGYDGNRVTNFVAQRLSAELLLGQLnAEHAEADVRRVLLQAFDVVERSFLESIDDALA ||.|...|..||..|. .|.| .||.... |.|....||.||.||||.....||.|||.||||||.| .|.|||.....|||... |||.|.||||||.| sgiGisnneryskegsssedhenedkvfs-rteddiilyavfdGydGekaaefveqrLvaelllgdl-seeaeaepkllllqvieeverkffesiddava EKASLQSQLPEGVPQHQLPPQYQKILERLKTLEREISGGAMAVVAVLLNNKLYVANVGTNRALLCKSTVDGLQVTQLNVDHTTENEDELFRLSQLGLDAG |.|.|.|.||.||....| .|.. ..|||.||.|||||..||||..|||||||||||..||.|..|..||..|.||.|||...|||||.||..||||.. eradlkstlpkgvasyeleekyeekinrlkeleseisgGttavvalilnnkLyvaNvGdsrAilvesekdgikvkQLsvdHnvdNedElkRlkdLGldie KIKQVGIICGQESTRRIGDYKVKYGYTDIDLLSAAKSKPIIAEPEIHGAQPLDGVTGFLVLMSEGLYKALEAAHGPGQANQEIAAMIDTEFAKQTSLDAV .|||.......|.||.|||||.|.||...|.||.||..||||.|.|.|........|||.|||.||||||.....|..|....|.....|..|...||.| qikqnkrlgskeaTRsiGdykikkgykevdvlssAkgePiiatPdingpkdindlegfllLmSdGlykalieltnpptadvslallviqeaeksatlddv AQAVVDRVKRIHSDTFASGGERARFCPRHEDMTLLVR |||||||||| |.|...|...|...|....||||.|. aqavvdrvkrkhrdvylssakrsticrkrddmTlivl |
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| Phosphatase | TAB1.AA | PP2C | 69-334 | 20 | 3.5e-58 | 204.4 | Pfam | 1-284 (284) | Show / Hide |
Range on Protein: 69-334
Range on HMM: 1-284/284
Sequence Identity: 20% (59 aa)
NGYDGNRVTNFVAQRLSAELLLGQLNAEHAEADVRRVLLQAFDVVERSFLESIDDALAE-----KASLQSQLPEG---VPQHQLPPQYQK--ILERLKT-
.|...| .. . . |.... ..|.. ..... . ... || . . .. .. .. .. .....||| ....| .... . . ...
WDYGFCRMQGWRHFMEDAHHCYPNMNCS-SSGKDSWHFFAVFDGHGGHQAAKYCRKHLHKAMNTILKERKSFPEGNPKDVEQALRKSFLECDTDMMFYSA
---LER-----EISGGAMAVVAVLLNNK--LYVANVGTNRALLCKSTVDGLQVTQLNVDHTTENEDELFRLSQLGLDAGKIKQVGIICGQ--ESTRRIGD
.. ...|..||.|.. |.| |||||.|. ||.||.. ....|.|| .||. .|||| |..|.| .. ... ..|. . .| .||
PWHEQNVMHWECWHSGCTAVCAYIRNQKNILYVANCGDSRAVLCRNGNAHNWVHQLTYDHKPSNEDERRRIRQAGGWVMWW-GFWRVNGVWLAVSRAFGD
YKVKYGYTDIDLLSAAKSKPIIAEPEIH-GAQPLDGVTGFLVLMSEGLYKALEAAHGPGQANQEIAAM-IDTEFAKQTSLDAVAQAVVDRV
. |...|. ..|..|..|||.|. .. .... ||.|.. ||. .. . . . |.. .. .|..... ...|....| .
FHYKPNHTC-----FPKEQPVTAEPDITPEHKITPDHDEFLILACDGLWDVMSDQEVCDIVRQCRSDWNDPMEACEKLVDYCIAYGSEDNI
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| Phosphatase | TAB1.AA | Group.PPM.PD | 35-365 | 21 | 4.8e-46 | 147.1 | In-house | 38-321 (459) | Show / Hide |
Range on Protein: 35-365 Range on HMM: 38-321/459 Sequence Identity: 21% (76 aa) RSYSADGKGTESHPPEDSW-LKFRSENN-CFlYGVFNGYDGNRVTNFVAQRLSAeLLLGQLNAEHAE----------------ADVRRVLLQAFDVVERS .|... . .. ||.. . . .|| .| .||| |. |... .|.|..|. |. ||. ...| ..|...| .|| ... . lrygvasmqgwrkemEDrhvivenfdnndsf-fgVfDGHgGaeaaefaakkLpk-ilkkqlkkkkdevskksaeasldnddrgekvkkalrsaflelded FLESIDDALaekaslqsqlpegvpqhqlppqyqkilerlktlEREISGGAMAVVAVLLNNKLYVANVGTNRALLCKSTvdglQVTQLNVDHTTENEDELF |..... |.....|. ||||.. ..||||||.| ||.||.. .. .| ||..||..| | lseeaneke---------------------------------epgkdsGtTAvvalingkklyvANaGDSravLcrng----kavplskdHkpenpeEre RLSQLGldaGKIKQVGIIC-GQESTRRIGDYKVKYgytdidllsaaKSKPIIAEPEIHgAQPLDGVTGFLVLMSEGLYKALEaahgpgqaNQEIAAMIDT . ..| |... | . . . .| .||...| .. ..|||... .|. ||||.| ||. |. |.|.. .. .. RIekag---GsveidgRvnGilavsRalGdhdlkk-----------eeqmvsaePdvs-vvklteedeflvlAsDGlWdvls--------neevvefvre EFAK-----QTSLDAVAQAVVDRVKRIhsdtfasgGERaRFCPRHEDMTLLVRNF ..| . .|...|...||. . | . . . . ..| .| . tlekkkkelkkdleeiaerlvdealak--------gst-gdgtscDNiTvivvtl |
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| Phosphatase | TAB1.AA | Family.PPM.PD | 38-365 | 21 | 1.4e-41 | 132.3 | In-house | 20-286 (495) | Show / Hide |
Range on Protein: 38-365
Range on HMM: 20-286/495
Sequence Identity: 21% (73 aa)
SADGkGtESHPPEDSW---LKFRSENNCFLYGVFNGYDGNRVTNFVAQRLSAeLLLGQLNAEHAE----------ADVRRVLLQAFDVVERSFLESIDDA
... | .... ||. ........ |.||| |..|... .|.|..| |. ||. ...| ..|...| .|| ... . |.....
asmq-g-wrsemeDahvvvenlennedfslfgvfDGhgGaeaaefaakklhk-ilkkqlekkddeksstsaessaekvkealrkafleldeelseelnek
LaekaslqsqlpegvpqhqlppqyqkilerlktleREISGGAMAVVAVLLNNKLYVANVGTNRALLCKSTvdglQVTQLNVDHTTENEDELFRLSQLG--
.. ..|. |||... ..||||||.| ||.||.. .. .|. ||..||..||....| ..
s----------------------------------agkdsGtTAvvvlirgkklyvAnaGDsravLcrng----kavelskdHkpenpeEreRIekagGk
LDAgkikQVGIIC-GQESTRRIGDYKVKYgytdidllsaaKSK-PIIAEPEIHgAQPLD-GVTGFLVLMSEGLYKALEaahgpgqaNQEIAAMIDTEF-A
. | . . . .| .||...| ... ..|||.|. .|. . ||||.| ||. |. |.|.. .. ... |.
vvi----rdgrvnGvlavsRalGdfdlkk-----------eeqaivsaePdit-svkltqeedeflvlasdGlWdvls--------neevvelvretlee
KQTSLDAVAQAVVDRVKRIHSDtfasggerarfcprhEDMTLLVRNF
..|...|...||.. . | ...| || .
keedleeiaeeLvdealakgsr---------------DNiTvlvval
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| Phosphatase | TAB1.AA | Subfamily.PPM1G2.PD | 46-334 | 20 | 4.8e-21 | 64.9 | In-house | 27-255 (275) | Show / Hide |
Range on Protein: 46-334 Range on HMM: 27-255/275 Sequence Identity: 20% (59 aa) SHPPEDSWLKFRSENNCFLYGVFNGYDGNRVTNFVAQRlsaelllgqlnaehaeadvrrvllqafdvversflesIDDALAEKASLQSQLPEGVPQHQLP .| |. |. . .... |..||.|. |..|....... . .|.| |....| . .. . . ahilenelleksddkslalfavfDGhGGakvakyagkk-------------------------------------likkiakkksfkegaleqilkdafl PQYQKILERlKTLEREISgGAMAVVAVLLNNKLYVANVGTNRALLCKSTvdglQVTQLNVDHTTENEDELFRLSQlgldAGKIKQVGIICGQES-TRRIG ...|. ..|. | . |. |||... ..||||||.| ||.|.... .| .| .|| ..|.| |. . || . ... ..|. . | .||. etDeellkd-eklkdesa-GstavvvlikeeklyvanaGDsravlsskg----nvkalsfDhkPqeesekkriia----agGfvelnrvngnLalsralg DYKVKYGYTdidllSAAKSKPIIAEPEIHgAQPLDGVTGFLVLMSEGLYKALEaahgpgqaNQEIAAMIDTEFAKQTSLDAVAQAVVDRV . | . . .. . . |.|.. . || . |||| .|.. |. |.|. ..........||.... ..|. Dfefkknvk-----kkpeeqivtavPDvl-vkkldeddeflvLaCDGiWDvlt--------nkevvdlvrerlvsgakldeiieelldkc |
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| Phosphatase | TAB1.AA | Subfamily.PDP.PD | 158-298 | 26 | 1.3e-16 | 50.8 | In-house | 160-315 (409) | Show / Hide |
Range on Protein: 158-298 Range on HMM: 160-315/409 Sequence Identity: 26% (41 aa) LEREISgGAMAVVAVLLNNKLYVANVGTNRALLCKSTVDG-LQVTQLNVDHTTENEDELFRLSQLGLDAGK---IKQVGIICGQESTRRIGDYKVKY-GY |. .| ||.|..|.. ...|.|||.| ||.|... .| ....|. |.|..||.|. |. . . . |.. .. .| ||.. |. lkvals-GacallaliegtelhvAntGDcravlgvqeeegsweavkLskdqtadneeEveRikkeHPgeesktvirngRlLgeLaPlRAFGdvryKwske TDIDLLSAA----KSKP--------IIAEPEIHGaQPLDGVTGFLVLMSEGLYKALEA .. .|. ..| ..||||. ..| . |||| . ||. |. lqkkvlekllevkvvepkdyktPPYltaePevts-hklrendkFLvlatDGLwdllsn |
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| Phosphatase | TAB1.AA | Subfamily.PPM1A.PD | 162-334 | 25 | 7.8e-15 | 44.7 | In-house | 111-262 (309) | Show / Hide |
Range on Protein: 162-334 Range on HMM: 111-262/309 Sequence Identity: 25% (42 aa) ISGGAMAVVAVLLNNKLYVANVGTNRALLCKSTvdglQVTQLNVDHTTENEDELFRLSQLGldaGKIKQVGiICGQ-ESTRRIGDYKVKygytDIDLLsA |. |||... ..|||.||.| ||.|.. .|. || . ...| |... | |.. . ..|. .| .|||. |. . . |... .. dksGsTavvvlvspkklylancGDsRavlsrng----kvvfateDHkpsdpkEkeRienAg---GsvmikR-vnGsLAvsRalGDydyk----ekpek-k AKSKPIIAEPEIHGAQPLDGVTgFLVLMSEGLYKALEaahgpgqaNQEIAAMIDTEFAKQTSLDAVAQAVVDRV .|||.. . . . |||| ..|.. .. |.|.|... .... .. |..||....|. ateqlvspepevtvierdeede-flvlacDGiwDvms--------neevaefvksrlevtddleevanelldtc |
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| Phosphatase | TAB1.AA | Subfamily.PPM1G.PD | 164-298 | 32 | 5.9e-14 | 41.9 | In-house | 307-429 (482) | Show / Hide |
Range on Protein: 164-298 Range on HMM: 307-429/482 Sequence Identity: 32% (43 aa) GGAMAVVAVLLNNKLYVANVGTNRALLCKStvdGlQVTQLNVDHTTENEDELFRLSQLGldaGKIKQVGII-CGQESTRRIGDYKVKYGYTdidlLsAAK |. ||||.. ..||.|||.| |. |... | . .| .|| |.| || |. . | ||... | . | | .||. | .| |. . | sGttavvaLvkgkklivanaGDsRcvlsrn---G-kaldlsiDhkPeDeveleRiekaG---GkvtldgRvnGGLnlsRalGDhaYktnee----L-pae SKPIIAEPEIHGaQPLDGVTGFLVLMSEGLYKALEA | |.|. . | |||| ..|.. .... eqmisalPDikk-lilteedeFlvlacDGiWnvmss |
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| Phosphatase | TAB1.AA | Subfamily.ILKAP.PD | 164-300 | 27 | 1.9e-13 | 40.2 | In-house | 117-243 (298) | Show / Hide |
Range on Protein: 164-300
Range on HMM: 117-243/298
Sequence Identity: 27% (39 aa)
GGAMAVVAVLLNNKLYVANVGTNRALLCKSTVDGL-------QVTQLNVDHTTENEDELFRLSQLGldaGKIKQVGIICGQESTRRIGDYKVKYGYtdid
|. |||.....|.|||||.| .|.|.. .| .. .| .|||. ...| |. . | | ... .. | | ||| .|
dGstavvvlvvdnvlyvanlGDskavlaRakeegdkagestiasvlLskdHtpasyeerkriqkaG---gvvrdgRvlGvlevsRsiGDgrfkelg----
llsaakskpIIAEPEIHGAQpLDGVTGFLVLMSEGLYKALEAAH
.|..|... . |. |.|| .||.| .|| .
---------vistPdvkkce-LtenDlfvvlaCDGLwkvfeade
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| Phosphatase | TAB1.AA | Subfamily.LRR-PP2C.PD | 139-297 | 24 | 4.2e-12 | 35.8 | In-house | 76-216 (257) | Show / Hide |
Range on Protein: 139-297 Range on HMM: 76-216/257 Sequence Identity: 24% (38 aa) VPQHQLPPQYQKILERLktLEREISGGAMAVVAVLLNNKLYVANVGTNRALLC-KSTVdglqVTQLNVDHTTENEDELFRLSQLGldaGKIKQVgiicgQ |.. | |..| .. || . |. |........| |.|||| |..|| | .. ..| .|| .|.| |.|.|||.. . . ..| nPlkslkkaykeistqi--serpkfiGttaasvliiedkvyianvGdsrvvlcqkdgt----akrlsldhkPseeseekriselG---Gtvvst-----v ESTRRIGDYKVKYGYTDIDLlsaakSKPIIAEPEIHGAQPLDGVTGFLVLMSEGLYKALE | | |. | . ....|..... ||.| .|.. . vtsrvnGtlavsralGdsfl-----ePfvvpdPdlsqsleiskkdkflilacdGiwdlis |
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| Phosphatase | TAB1.AA | Subfamily.PPM1H.PD | 158-220 | 38 | 2.2e-11 | 33.1 | In-house | 158-214 (402) | Show / Hide |
Range on Protein: 158-220 Range on HMM: 158-214/402 Sequence Identity: 38% (24 aa) LEREISGGAMAVVAVLLNNKLYVANVGTNRALLCKSTvdglQVTQLNVDHTTENEDElfRLSQ . .|.|| |.||..|..|||||| | ||.|... ....| |.| | | . || . eayrikGGCtalvalvllgklYvanaGDsRailvrkd----eiiplsadftPeteRq--Rlqe |
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| Phosphatase | TAB1.AA | Subfamily.PPM1L.PD | 62-297 | 20 | 3.2e-11 | 33.0 | In-house | 42-231 (273) | Show / Hide |
Range on Protein: 62-297
Range on HMM: 42-231/273
Sequence Identity: 20% (49 aa)
CFLYGVFNGYDGNRVTNFVAQRLSAELLLGQLNAehaeadvrrvllqafdvversflesidD-------AlaekaslqSQLpEGVPQHQLPPQYQKILER
...||.|. |. ..|. ..|. ... .. | . . . .....|.||..|. |
esffavfdGhGGefaaefakdvlvkaiknkliel---------------------------dadkentvp--------inf-sklltdeilsvdekllek
LKTLErEISgGAMAVVAVLLNNKLYVANVGTNRALLCKStvDGLQVtQLNVDHTTENEDELFRLSQLGLD---AGKIKQVGIICgqeSTRRIGDYKVKyg
.|. |. |..|.. ...| ||||| | .|. .| . | || .. | |. . | | . |.. .| .||| .|
akrae-dia-GttalialvqesdlivanvGdsrGvlydk--rGkai-plsfdhkpqqvkerkrikkaGGfiafrGvwrvaGvla---tsralGdyplk--
ytdidllsaaKSKPIIAEPEIHGAQPLDGVTGFLVLMSEGLYKALE
. . .||.|.| . | ||.| |.||. ..
----------dknlviadpdiltfdlddhkpeflilasdGlwdtfs
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| Phosphatase | TAB1.AA | Subfamily.PPM1E.PD | 158-336 | 24 | 4.2e-11 | 32.4 | In-house | 103-255 (269) | Show / Hide |
Range on Protein: 158-336
Range on HMM: 103-255/269
Sequence Identity: 24% (43 aa)
LEREISGGAMAVVAVLLNNKLYVANVGTNRALLCKSTvdglQVTQLNVDHTTENEDELFRLSQLGLDAGKIKQVGIICGQESTRRIGDYKVKygytdidl
. .. .|. |||... ...|||| .| .|||.. . .. || | |.||| |. ..| .| . . .| |||.||
ereklksGstavvvliekdqlyvaWlGDsqallvrkg----eavqlmkpHkPeredEkkRieeagGlvvvigawRvnGvLsvsRaiGDvklk--------
lsaaksKPIIAEPEIHgAQPLDGVTGFLVLMSEGLYKALEaahgpgqaNQEIAAMIDTEFAKQT-SLDAVAQAVVDRVKR
. ...|... .||| . .|.| ..||. .. ..|. ... .|... .|. ||. .|. |
------pyvsgeadva-eveldgsedylilacDGlwDvvn--------eeevvklveefladgaedlsevakllveaake
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| Phosphatase | TAB1.AA | Subfamily.PPM1K.PD | 159-296 | 25 | 2.7e-09 | 26.4 | In-house | 99-222 (264) | Show / Hide |
Range on Protein: 159-296 Range on HMM: 99-222/264 Sequence Identity: 25% (34 aa) EREISGGAMAVVAVLLN-NKLYVANVGTNRALLCKSTvdglQVTQLNVDHTTENEDELFRLSQLGldaGKIKQVGIicgqESTRRIGDYKVKYGYTDIDL . . | |. | |..| . |.| .|..| ||.||. . ..| ||. |...| |. . | |... . . . . .|.|| | aellssGttatvsllrdGnelvlaslGdsrailcrnG----kakkltkdhdPerkeekerikaag---Gsvewnsl----gkplvnsrlamtrslGdldl lsaaKSKPIIAEPEIHGAQPLDGVTGFLVLMSEGLYKAL . .||.|| . . . ||||...|. . ----kryGviatPetkslkvkhaadsflvlitdgisfvv |
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| Phosphatase | TAB1.AA | Subfamily.PPM1D.PD | 164-224 | 32 | 1.6e-07 | 20.7 | In-house | 114-176 (311) | Show / Hide |
Range on Protein: 164-224 Range on HMM: 114-176/311 Sequence Identity: 32% (20 aa) GGAMAVVAVLLNNKLYVANVGTNRALLCKSTV--DGLQVTQLNVDHTTENEDELFRLSQLGLD |. | | .. ..|||||.|| ...| .. . |. ..| .|| |. .| |. .|| . aGttasvviirreklyvahvGDsgivlgvkepkekklrakeltkdHkPespeEkerieelGGe |
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| Phosphatase | TAB1.AA | Subfamily.ILKAP.PD | 64-121 | 26 | 4.1e-07 | 19.4 | In-house | 49-108 (298) | Show / Hide |
Range on Protein: 64-121 Range on HMM: 49-108/298 Sequence Identity: 26% (15 aa) LYGVFNGYDGNRVTNFVAQRLSAELL--LGQLNAEHAEADVRRVLLQAFDVVERSFLESI |.||.|. |.| ..|.|..| .. | . . . .... |..|| ....||. yyavfDGhaGsrasefaaeklhkviveklpkedvsakdkeikkclvdafkktDeeflkla |
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| Phosphatase | TAB1.AA | Subfamily.PPM1K.PD | 59-133 | 25 | 5.5e-06 | 15.6 | In-house | 34-104 (264) | Show / Hide |
Range on Protein: 59-133 Range on HMM: 34-104/264 Sequence Identity: 25% (19 aa) ENNCFLYGVFNGYDGNRVTNFVAQRLSAELllGQLNaeHAEADVRRVLLQAFDVVERSFLESIDDALAEKASLQS ... . ..||.|. | ..|| ..| . .| . | |...|| |||. ... . . .||. |.| dpdllyfavfdGhgGssaadfvhdkleeiv--rrll--ekekdleevlkqafeeldkklkrylefsvaeaellss |
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