Gene PPTC7
PPTC7
Species: Human
Alias: DKFZp686M07120, TA-PP2C, TAPP2C, MGC133072, PPTC7
External Links:
COSMIC
,
Entrez Gene
Classification
Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.
Protein domain
Protein domains of PPTC7.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit phosphatase group/family/subfamily, which is helpful to understand the relationship between phosphatases. Transmembrane region is predicted by TMHMM 2.0. Visualized by pviz.
Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking. View complete domain list.
| Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
|---|---|---|---|---|---|---|---|---|---|
| Phosphatase | PPTC7.AA | Subfamily.PPTC7.PD | 38-299 | 60 | 4.4e-126 | 409.1 | In-house | 2-263 (263) | Show / Hide |
Range on Protein: 38-299 Range on HMM: 2-263/263 Sequence Identity: 60% (159 aa) TAGCGFGKDFRKGLLKKGACYGDDACFVARHRSADVLGVADGVGGWRDYGVDPSQFSGTLMRTCERLVKEGRFVPSNPIGILTTSYCELLQNKVPLLGSS .. ||| ||..| .|| ...|.||.||.....||||||||||||||.||.|||.|| .||..|||.|||..|....| ||...|.|||..|||..||| svvcgfakdllkqkskkrskfGeDayFvssnkvadvlgVADgvggwreygidpsefskelmkkcerivkeskfkerkpkkileaayqelleekvpvvGss TACIVVLDRTSHRLHTANLGDSGFLVVRGGEVVHRSDEQQHYFNTPFQLSIAPPEAEGVVLSDSPDAADSTSFDVQLGDIILTATDGLFDNMPDYMILQE |||||||||....|..|||||||||||| |.|||||.|||||||||.||||.|.|..| |..|.|.|||||||.|. ||.||.||||.|||.....||.. tacivvldredkklesaNlGDSgflVvRngkvvhrskeqqhyFNtPyqLsipPeerdgkvildkpeaadstsfevkkgDlillatDGvfDNlsedeilev LKKLKNSNYESIQQTARSIAEQAHELAYDPNYMSPFAQFACDNGLNVRGGKPDDITVLLSIV ||.||....|..|..|.|.||.|.||..||.|.||||. |..|||...|||||||||.|..| lkelkerdeeelqllanslaekarelsldpkyespFakkakknglaasGGKpDDitvvlalv |
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| Phosphatase | PPTC7.AA | Family.PPTC7.PD | 39-299 | 62 | 1.1e-128 | 417.7 | In-house | 2-262 (262) | Show / Hide |
Range on Protein: 39-299 Range on HMM: 2-262/262 Sequence Identity: 62% (163 aa) AGCGFGKDFRKGLLKKGACYGDDACFVARHRSADVLGVADGVGGWRDYGVDPSQFSGTLMRTCERLVKEGRFVPSNPIGILTTSYCELLQNKVPLLGSST . ||| ||..|. .|| ...|.||.||.....||||||||||||||.||||.|.|| .||..|||||||..| |..| .|...|.|||..|||..|||| vkcgfakdllkqkskkrskfGeDayFvssnkvadvlgvADgvggwreygvdssafsselmkkcerlvkeskfkplkpkkllkaayaelleekvpvvGsst ACIVVLDRTSHRLHTANLGDSGFLVVRGGEVVHRSDEQQHYFNTPFQLSIAPPEAEGVVLSDSPDAADSTSFDVQLGDIILTATDGLFDNMPDYMILQEL ||.|||||....|..|||||||||||| |.|||||.|||||||||.||||.|.|..| |.||||.|||||||.|. |||||.||||.|||.....||.|| AcvvvldredkklesanlGDsgflvvRegkvvhrskeqqhyFntPyqLsipPeerdgkvisdspeaAdstsfevkkgDiillatDGvfDnlsedqileel KKLKNSNYESIQQTARSIAEQAHELAYDPNYMSPFAQFACDNGLNVRGGKPDDITVLLSIV |.||....|..|..|.|.||.|.||..||.|.||||| |...||...|||||||||.|..| kelkerdeeelqllanslaekareLsfdpkyespFaqkakkrglaasGGKpDDitvvlavv |
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| Phosphatase | PPTC7.AA | Group.PPM.PD | 60-174 | 17 | 1.5e-11 | 32.7 | In-house | 53-187 (459) | Show / Hide |
Range on Protein: 60-174 Range on HMM: 53-187/459 Sequence Identity: 17% (23 aa) DDACFVARHRSA--DVLGVADGVGGWRDYGVDPSQFSGTLMRTCERLV------------------KEGRFVPSNPIGILTTSYCELLQNKV--PLLGSS |....... . ...|| || ||.. . .... |.. ... .. . . . . | . ..| ..| .. .||. EDrhvivenfdnndsffgVfDGHgGaeaaefaakkLpkilkkqlkkkkdevskksaeasldnddrgekvkkalrsafleldedlseeanekeepgkdsGt TACIVVLdRTShRLHTANLGDSGFLVVRGGEVVHRSD .... . . |..||.||| ...| |..|. | TAvvali-ngk-klyvANaGDSravLcrngkavplsk |
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| Phosphatase | PPTC7.AA | Group.PPM.PD | 198-297 | 14 | 3.4e-08 | 21.7 | In-house | 235-319 (459) | Show / Hide |
Range on Protein: 198-297 Range on HMM: 235-319/459 Sequence Identity: 14% (15 aa) LSDSPDAAdstSFDVQLG-DIILTATDGLFDNMPDYMILQELKKLKNSN----YESIQQTARSIAEQAhelaYDPNymspfaqfacdnglN-VRGGKPDD .| .|| ..... . . |.|||.| . . ... ... ... .. ...|......| . .. . .|...|. vsaePdvs---vvklteedeflvlAsDGlWdvlsneevvefvretlekkkkelkkdleeiaerlvdea----lakg--------------stgdgtscDN ITVLLS |||.. iTvivv |
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| Phosphatase | PPTC7.AA | PP2Cc | 38-297 | 11 | 5.5e-08 | 22.85 | SMART | 1-338 (338) | Show / Hide |
Range on Protein: 38-297
Range on HMM: 1-338/338
Sequence Identity: 11% (43 aa)
TAGCGFGKDFRKGL----LKKGACYGDDACFVARHRSADVLGVADGVGGWRDYGVDPSQFSGTLMRTCERLVKEGRFVPS--------------------
. |.....| |. .. .. ||... . ||.|| | . .|... . | |..| |. .
HS-MGYNSGWRYGYMESSMQGWRHPMEDAHVCRP-----FFGVFDG-----HGGHECAQYCRKHLH--EHLAEELQFHKDDDYKENDEMQDEPEMWWRMW
------NPIGILTTSYCELLQNKVPLLGSSTACIVVLDRTSHRLHTANLGDSGFLVVRGGE----------VVHRSDEQQH-------------------
.. .| .. .. .||...... |..||.||| . |.|. .. . .. .
HDKWFEDWEDALRKAFLRMDEEI------CTAVVALIRGNK--LYVANVGDSRAVLCRNGNDNWWGIRHYTAHQLTEDHKPDNEDERRRIEQAGGRVMPM
-------------YFNTP---FQLSIAP-------------------------PEAEGVVLSDSPDAADSTSFD----VQLGDIILTATDGLFDNMPDYM
..| ..| | .... .. || . . . .. .| .. ..|||.|.|..
HRQWVMNWNCDVWRVNGVPIPLAVSRAFGDHYYKWKEDEKIEWNRWYQMFDPRLPFKEPYVIAEPDVTHHELWQMTVPTPDDDFLILCCDGLWDVMSNQE
ILQELKKLKNSNYE------------------SIQQTARSIAEQAHELAYDPNYMSPFAQFACDNGLNVRGGKPDDITVLLS
. . ..| .... . .. . . ..|. ...|. |..||..
VVDIVRKCLRKWHHKPVKNQAQENAHMMRHRQKKHNDPMEAAKRLCDCAI-----------------------CDNMTVIVV
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| Phosphatase | PPTC7.AA | PP2C_SIG | 60-299 | 14 | 1.3e-07 | 32.58 | SMART | 1-250 (250) | Show / Hide |
Range on Protein: 60-299 Range on HMM: 1-250/250 Sequence Identity: 14% (41 aa) DDACFVARHRS----------------AD----VLGVADGVGGWRDYGVDPSQFSGTLMRTCERLVKEGRFVPSNPIGILTTSYCELLQNK--VPLLGSS || .... . .. .. ..|..| | |. . ..| . . .. | .. . .... . .. . DDHWDIYQYYEDATQVCGDWYDFWKIPEGQDRYFFVIGDVMG-WA-HGLPAALMMGMARTMMRTFWHE-------SPPQILERCNRWIYQNNHEECGMFT TACIVVL--DRTSHRLHTANLGDSGFLVVR--GGEVVHRSDE-------------------QQHYFNTPFQLSIAPPEAEGVVLSDSPDAADSTSFDVQL |.|. |. | ..|.|. .. |.| ....| .|. |.. .. .. ..| . | . | .|...|... TMCCCVYMPDFATHTLWYCHCGHSPPYLYRAMDGGRVEHTHDHYLVQHYVMRIIDEEDAKHHPWHNWTGPPLGMEPDYM-----------YDVQEFQYEP GDIILTATDGLFDNMPD-------YMILQELKKLKNSNYESIQQTARSIAEQAHELAYDPNYMSPFAQFACDNGLNVRGGKPDDITVLLSIV ||... .|||..... . . .. |... .. |. |..|.....|.. |.|. .||.||.. | GDRFVMCTDGVTEARNPQGEFFGEEWLQEILEEHQ---CCCPQEIAQRIMQELMEHMGDHNG-------------------HDDMTVIVVKV |
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| Phosphatase | PPTC7.AA | Family.PPM.PD | 128-175 | 28 | 3.4e-07 | 18.2 | In-house | 114-160 (495) | Show / Hide |
Range on Protein: 128-175 Range on HMM: 114-160/495 Sequence Identity: 28% (14 aa) QNKV-PLLGSSTACIVVLDRTShrLHTANLGDSGFLVVRGGEVVHRSDE ..| . . .||..|.. .. |..||.||| ...| |..|. | . neksagkdsGtTAvvvlirgkk--lyvAnaGDsravLcrngkavelskd |
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| Phosphatase | PPTC7.AA | Subfamily.PPM1E.PD | 214-263 | 23 | 1.2e-06 | 17.1 | In-house | 207-256 (269) | Show / Hide |
Range on Protein: 214-263 Range on HMM: 207-256/269 Sequence Identity: 23% (11 aa) LGDIILTATDGLFDNMPDYMILQELKKLKNSNYESIQQTARSIAEQAHEL |... |.|||.| ... ... ... ... |. .. |... |.|.| sedylilacDGlwDvvneeevvklveefladgaedlsevakllveaakea |
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