Gene PPP2CA
PPP2CA
Classification
Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.
Protein domain
Protein domains of PPP2CA.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit phosphatase group/family/subfamily, which is helpful to understand the relationship between phosphatases. Transmembrane region is predicted by TMHMM 2.0. Visualized by pviz.
Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking. View complete domain list.
| Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
|---|---|---|---|---|---|---|---|---|---|
| Phosphatase | PPP2CA.AA | Family.PPP.PD | 3-294 | 49 | 7.69999999999e-133 | 432.9 | In-house | 48-341 (349) | Show / Hide |
Range on Protein: 3-294 Range on HMM: 48-341/349 Sequence Identity: 49% (145 aa) EKVFTKELDQWIEQLNECKQLSESQVKSLCEKAKEILTKESNVQEVRCPVTVCGDVHGQFHDLMELFRIGGKSPDT-NYLFMGDYVDRGYYSVETVTLLV .|. .. .. .|...| |||....|..|.|.|||.| ||.|..|| .|.|||||.||||.||..||.|.|. |.. .|||.|||||||..|||...||. fkltpdlvkelveafkekkqleakevlelleeakellkkepnlleveapitvcGDihGqfdDLlrlfdinglppaenkylFlGDyVDRGkfsvEvilllf ALKVRYRERITILRGNHESRQITQVYGFYDECLRKYGN-ANVWKYFTDLFDYLPLTALVDGQIFCLHGGLSPSIDTLDHIRALDRLQEVPHEGPMCDLLW |||..| .|...||||||||....|||||.|. .|| . ......|...|..|||.||.|..|.|.||||||.. .||.||...| .|.|.||..||||| alkllypsrffllRGnhEsrsvnkvygfyeevkskykkgeeiyelfqevFnwLPlaalidekilcvhGGlspeltsldqirkierpleppkegllcdllW SDPDDRGGWGISPRGAGYTFGQDISETFNHANGLTLVSRAHQLVMEGYNWCHDRNVVTIFSAPNYCYRCGNQAAIMELDDTLKYSFLQFDPAPR |||... || ..||.|..||.|. | | . |.| |. |||..|.|||.....|..||||||||||....|.||....|..||.|. ||.|... sdpeeqkgwkpnkRGvgfvFgpdavekflkknnldliiRahevveeGyeffanrklvTifsapnYcgeysnkaavlkvdknlklsivqfkpskh |
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| Phosphatase | PPP2CA.AA | Subfamily.PPP2C.PD | 23-293 | 93 | 8.49999999999e-189 | 615.3 | In-house | 1-271 (271) | Show / Hide |
Range on Protein: 23-293 Range on HMM: 1-271/271 Sequence Identity: 93% (253 aa) LSESQVKSLCEKAKEILTKESNVQEVRCPVTVCGDVHGQFHDLMELFRIGGKSPDTNYLFMGDYVDRGYYSVETVTLLVALKVRYRERITILRGNHESRQ |.|..||.|||||||||.|||||.||.||||||||||||||||.|||||||||||||||||||||||||||||||||||||||||.|||||||||||||| leeeevkklcekakeilskesnvkevkcpvtvcgdvhgqfhdllelfriggkspdtnylfmgdyvdrgyysvetvtllvalkvrykeritilrgnhesrq ITQVYGFYDECLRKYGNANVWKYFTDLFDYLPLTALVDGQIFCLHGGLSPSIDTLDHIRALDRLQEVPHEGPMCDLLWSDPDDRGGWGISPRGAGYTFGQ ||||||||||||||||||||||||||||||||||||||.|||||||||||||||||.||||||||||||||||||||||||||||||||||||||||||. itqvygfydeclrkygnanvwkyftdlfdylpltalvdnqifclhgglspsidtldkiraldrlqevphegpmcdllwsdpddrggwgisprgagytfgk DISETFNHANGLTLVSRAHQLVMEGYNWCHDRNVVTIFSAPNYCYRCGNQAAIMELDDTLKYSFLQFDPAP ||||.||..|||||||||||||||||||.||||||||||||||||||||||||.||||.|||||||||||| diseefnktngltlvsrahqlvmegynwshdrnvvtifsapnycyrcgnqaailelddelkysflqfdpap |
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| Phosphatase | PPP2CA.AA | PP2Ac | 23-293 | 43 | 2.1e-157 | 530.15 | SMART | 1-321 (321) | Show / Hide |
Range on Protein: 23-293
Range on HMM: 1-321/321
Sequence Identity: 43% (141 aa)
LSESQVKSLCEKAKEILTKESNVQEVR----CPVTVCGDVHGQFHDLMELF---RIGG-KSPDTNYLFMGDYVDRGYYSVETVTLLVALKVRYRERITIL
.... ...||...|||. .|.|. || |||||||.||||.||..|| ...| .|.|||.|.|||||||..|.|...||...|..| .....|
MHKHEIYQLCHEVKEIFRQEPNMVEVEETPTPPVTVCGDIHGQFDDLLRLFKKEDKNGKPPPYTNYVFLGDYVDRGPWSIECICLLFCYKICYPNNFFLL
RGNHESRQIT---QVYGFYDECLRKYGNANVWKYFTDLFDYLPLTALVDGQIFCLHGGLSP------SIDTLDHIRALDR----LQEVPHEGPMCDLLWS
|||||.|... |.||||||| |||.....||.|...|...||.||....|.| |||||| .| ||| || .|| || |..|.|||||||
RGNHECRHMNMWVQYYGFYDECKRKYYHKRIWKIFQECFSWMPLCALINNKILCMHGGLSPRECQTDHIHTLDDIRNIDRPQHPPQEPPDWGLMCDLLWS
DP---------DDRGGWGISP-RGAGYTFGQDISETFNHANGLTLVSRAHQLVM----EGYNWCHDR-----NVVTIFSAPNYCYRCGNQAAIMEL----
|| .. ||.... ||..|.||.|. . | ..|.| |. ||||.|. .|| ..||| ..|||||||||..|.| ||.|..
DPVDFQWFHDDQWVPGWQPNCMRGMSYYFGPDVVDEFCKKNNLDLIIRAHQCVQYQMMDGYEFWHDRDTRVHKLITIFSAPNYCDQCDNHAAVMKVNDHK
------DDTLKYSFLQFDPAP
|. || .| ||.|..
VIQYKMDKNLKCHFVQFKPQM
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| Phosphatase | PPP2CA.AA | Subfamily.PPP4C.PD | 24-292 | 69 | 1.5e-145 | 473.4 | In-house | 2-270 (271) | Show / Hide |
Range on Protein: 24-292 Range on HMM: 2-270/271 Sequence Identity: 69% (185 aa) SESQVKSLCEKAKEILTKESNVQEVRCPVTVCGDVHGQFHDLMELFRIGGKSPDTNYLFMGDYVDRGYYSVETVTLLVALKVRYRERITILRGNHESRQI .|..||.||.||.||| .|||||.| .|||||||.||||.||.|||..||. |.|||||.||.||||.||||| ||.|||||| .|||..||||||||| keeevkalcakareilveesnvqrvdspvtvcgdihgqfydllelfkvggdvpetnylflgdfvdrgfysvetfllllalkvrypdritlirgnhesrqi TQVYGFYDECLRKYGNANVWKYFTDLFDYLPLTALVDGQIFCLHGGLSPSIDTLDHIRALDRLQEVPHEGPMCDLLWSDPDDRGGWGISPRGAGYTFGQD |||||||||||||||.|.||.| |..||||.|.|..||.|||.||||||||.|||.||..|| ||||||||.||||||||.|||..||||||| ||.|.. tqvygfydeclrkygsaevwryctevfdylslaaiidgkifcvhgglspsistldeirsidrkqevphegplcdllwsdpedaegwavsprgagylfgsd ISETFNHANGLTLVSRAHQLVMEGYNWCHDRNVVTIFSAPNYCYRCGNQAAIMELDDTLKYSFLQFDPA |.||.||...|..||||||||||.. ...|.|..||||||||||| |||.|||..|.. | |. | vveqfneandielicrahqlvmegyklhfnekvltvwsapnycyrcgnvaaileldeeldkdfkifeaa |
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| Phosphatase | PPP2CA.AA | Subfamily.PPP6C.PD | 23-289 | 59 | 2.4e-133 | 433.3 | In-house | 1-267 (271) | Show / Hide |
Range on Protein: 23-289 Range on HMM: 1-267/271 Sequence Identity: 59% (160 aa) LSESQVKSLCEKAKEILTKESNVQEVRCPVTVCGDVHGQFHDLMELFRIGGKSPDTNYLFMGDYVDRGYYSVETVTLLVALKVRYRERITILRGNHESRQ |.|...| ||.. ...| .||||| |..|||||||.||||.||.|||| ||. |||.|.|.||.|||||||.||.|.|..||..| .|||.||||||||| lpenelkklcdlvldllleesnvqpvsspvtvcgdihgqfydleelfrtggqvpdtsyvflgdfvdrgyysletftrlltlkakypdritllrgnhesrq ITQVYGFYDECLRKYGNANVWKYFTDLFDYLPLTALVDGQIFCLHGGLSPSIDTLDHIRALDRLQEVPHEGPMCDLLWSDPDDRGGWGISPRGAGYTFGQ ||||||||||||.||||||.|||.|..|| |...|..|.|..|.|||||| . |||.|| ..| ||.||.|..|||.||||.| | .||||||| ||. itqvygfydeclnkygnanawkyctkvfdlltiaaiideqvlcvhgglspdvktldqirvieraqeiphkgafcdlvwsdpedvetwavsprgagylfgs DISETFNHANGLTLVSRAHQLVMEGYNWCHDRNVVTIFSAPNYCYRCGNQAAIMELDDTLKYSFLQF ... |.| | | |..||||||.||... | ..||..||||||||||| |.|..|.|. . .. | kvtkefvhinnlklicrahqlveeglkymfdeklvtvwsapnycyrcgniasilaledaeereaklf |
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| Phosphatase | PPP2CA.AA | Group.PPP.PD | 3-294 | 49 | 7.69999999999e-133 | 432.9 | In-house | 48-341 (349) | Show / Hide |
Range on Protein: 3-294 Range on HMM: 48-341/349 Sequence Identity: 49% (145 aa) EKVFTKELDQWIEQLNECKQLSESQVKSLCEKAKEILTKESNVQEVRCPVTVCGDVHGQFHDLMELFRIGGKSPDT-NYLFMGDYVDRGYYSVETVTLLV .|. .. .. .|...| |||....|..|.|.|||.| ||.|..|| .|.|||||.||||.||..||.|.|. |.. .|||.|||||||..|||...||. fkltpdlvkelveafkekkqleakevlelleeakellkkepnlleveapitvcGDihGqfdDLlrlfdinglppaenkylFlGDyVDRGkfsvEvilllf ALKVRYRERITILRGNHESRQITQVYGFYDECLRKYGN-ANVWKYFTDLFDYLPLTALVDGQIFCLHGGLSPSIDTLDHIRALDRLQEVPHEGPMCDLLW |||..| .|...||||||||....|||||.|. .|| . ......|...|..|||.||.|..|.|.||||||.. .||.||...| .|.|.||..||||| alkllypsrffllRGnhEsrsvnkvygfyeevkskykkgeeiyelfqevFnwLPlaalidekilcvhGGlspeltsldqirkierpleppkegllcdllW SDPDDRGGWGISPRGAGYTFGQDISETFNHANGLTLVSRAHQLVMEGYNWCHDRNVVTIFSAPNYCYRCGNQAAIMELDDTLKYSFLQFDPAPR |||... || ..||.|..||.|. | | . |.| |. |||..|.|||.....|..||||||||||....|.||....|..||.|. ||.|... sdpeeqkgwkpnkRGvgfvFgpdavekflkknnldliiRahevveeGyeffanrklvTifsapnYcgeysnkaavlkvdknlklsivqfkpskh |
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| Phosphatase | PPP2CA.AA | Subfamily.PPP1C.PD | 23-290 | 48 | 1.1e-103 | 336.3 | In-house | 1-268 (271) | Show / Hide |
Range on Protein: 23-290 Range on HMM: 1-268/271 Sequence Identity: 48% (131 aa) LSESQVKSLCEKAKEILTKESNVQEVRCPVTVCGDVHGQFHDLMELFRIGGKSPDTNYLFMGDYVDRGYYSVETVTLLVALKVRYRERITILRGNHESRQ |.|.....||.||.||. .. . |...|. ..||.|||..||. || || |..||||.||||||| |.||..||.|.|..| |.. .||||||. . lkeaeirklclkareiflsqpilleleaplkivGdihGqyadllrlfekggfppesnylflGdyvdrGkqsletivlllaykikypenffllrGnhecas ITQVYGFYDECLRKYgNANVWKYFTDLFDYLPLTALVDGQIFCLHGGLSPSIDTLDHIRALDRLQEVPHEGPMCDLLWSDPDDR-GGWGISPRGAGYTFG |...||||||| |.| | ..|| |.| |. ||..|.|| .|||.||||||.. .|..|| . | .||..| .|||||||||.. ||| . || .||| inriygfydeckrry-niklwktfvdcfnclpvaaivdekifcvhGGlspdlksleqirriarptdvpdkGllcdllwsdpdkevkgwgendrgvsftfg QDISETFNHANGLTLVSRAHQLVMEGYNWCHDRNVVTIFSAPNYCYRCGNQAAIMELDDTLKYSFLQFD .|. |.| . . | |. ||||.| .||.. ..|..||.||||||| . | .|.| .|..| || .. advvekflkkhdldlivrahqvvedgyeffakrqlvtlfsapnycgefdnagavmsvdeellcsfqilk |
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| Phosphatase | PPP2CA.AA | Subfamily.PPP_Nematode_6.PD | 24-290 | 45 | 1.9e-97 | 315.5 | In-house | 2-269 (272) | Show / Hide |
Range on Protein: 24-290 Range on HMM: 2-269/272 Sequence Identity: 45% (121 aa) SESQVKSLCEKAKEILTKESNVQEVRCPVTVCGDVHGQFHDLMELFRIGGKSPDTNYLFMGDYVDRGYYSVETVTLLVALKVRYRERITILRGNHESRQI .|.....|.|.||....|.. . || |..||||.|||. ||. || || ||.||||.||||||| .|.|...||.| ||.. ... .|||||| .| keeellkllelakkvfkkqkslveveapikvcGdihGqysdllrlfdkggfppdanylflGdyvdrGrqslevillllaykvkfpnnffllrGnheceai TQVYGFYDECLRKYGNANVWKYFTDLFDYLPLTALVDGQIFCLHGGLSPSIDTLDHIRALDRLQEVPHEGPMCDLLWSDPDD-RGGWGISPRGAGYTFGQ .|||||||. |.| ...... | ..|..||||||| |.|.|.|||||... .||..|.| | .. ..| |||||||.. || . ||....||. nrvyGfydevqrrykstrlyaafqevfnalpltalvsgrilcmhGGlskklksldqlrelkrpldskeeslaidllwsdpenavkgwaensrGvsvvfGe DISETFNHANGLTLVSRAHQLVMEGYNWCHDRNVVTIFSAPNYCYRCGNQAAIMELDDTLKYSFLQFD | . . . . || ||||.| .||.. ....|||||||.|| .| ||.|..|. |. || . davkkllekldidlvarahqvvqdGyeffaekklvtifsaphycgqfdnaaavmkvdeklvvsfevlk |
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| Phosphatase | PPP2CA.AA | Subfamily.PPP_Nematode_4.PD | 26-292 | 41 | 1e-86 | 280.5 | In-house | 4-270 (271) | Show / Hide |
Range on Protein: 26-292 Range on HMM: 4-270/271 Sequence Identity: 41% (110 aa) SQVKSLCEKAKEILTKESNVQEVRCPVTVCGDVHGQFHDLMELFRIGGKSPDTNYLFMGDYVDRGYYSVETVTLLVALKVRYRERITILRGNHESRQITQ ...|. .|..|...|... |. |. | ||.|.||.||..|| . |. |.. ..|.||||||| ..|.. ||..||.|||.|| .|||||| .. .. eeiisvireaeaifsdekalveieapikvvgdlhaqfqdlirlfdllgrvpeeklvflgdyvdrgpqgievlillfclkiryrdrivllrgnheiasvnk VYGFYDECLRKYGNaNVWKYFTDLFDYLPLTALVDGQIFCLHGGLSPSIDTLDHIRALDRLQEVPHEGPMCDLLWSDPDDRG-GWGISPRGAGYTFGQDI ||||.|| |||. ..| | |. ||..||. ...|.||||||.. .||..| . |.. | . ||||.|||... .| | ||..||||... | kygfyeecvtkyge-elwadfqrcfnrlpisaliakkvlcmhgglspelisldelrnipkpienldrgllidllwadpdnkveewkasirgisytfgkgv SETFNHANGLTLVSRAHQLVMEGYNWCHDRNVVTIFSAPNYCYRCGNQAAIMELDDTLKYSFLQFDPA . .. |. ||||.|..||. |...|.||.||||| ||.. ||..|. |. .. |. vedvckslevdliirahqvvqdgyevlsgrklitvfsvpnycaqfknaaavlkldenleislvalvpe |
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| Phosphatase | PPP2CA.AA | Subfamily.PPP5C.PD | 4-290 | 38 | 1.8e-85 | 276.8 | In-house | 51-343 (346) | Show / Hide |
Range on Protein: 4-290 Range on HMM: 51-343/346 Sequence Identity: 38% (114 aa) KVFTKELDQWIEQLNECKQLSESQVKSLCEKAKEILTKESNVQEVRCP----VTVCGDVHGQFHDLMELFRIGGK-SPDTNYLFMGDYVDRGYYSVETVT |. .. ... .|.... |.| . . .. .|||.| |.. . |.. | .|||||.||||.||...|.. |. |.. ||| ||.|||| .|||.. kitkefvkellelfkkqkklhkkyalkilleakellkklpslveitipetkkitvCgdihgqfyDllnifelnGlpseenpylfngDfvdrGsfsvevil LLVALKVRYRERITILRGNHESRQITQVYGFYDECLRKYgNANVWKYFTDLFDYLPLTALVDGQIFCLHGGLSPSI-DTLDHIRALDRLQEVPHEGPMCD .|...|. | ... . |||||| .. ..||| .|. || ...| . ||..|..|||. ... ... .|||| . |||..| .|| .. |.||.... tllgfkllypnhfflsrGnhesdnmnklyGfegevkaky-tekvadlftevfnwlPlahvinekvlvvhGGlfsedgvtlddlrkidrnaqppeegllle LLWSDPDDRGGWGISPRGAGYTFGQDISETFNHANGLTLVSRAHQLVMEGYNWCHDRNVVTIFSAPNYCYRCGNQAAIMEL-DDTLKYSFLQFD ||||||... | . | || | .|| |... | . |.|.|. |.|.. .|||. || ...|.||||||| . ||..|...| .| || | .|. llwsdpqeanGrspskrGvgiqfGpdvtkkflkennleliirshevkeeGyevehdGklitvfsapnycdqmgnkgafitlrgddlkpkfktfe |
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| Phosphatase | PPP2CA.AA | Subfamily.PPP3C.PD | 23-280 | 42 | 1e-84 | 274.1 | In-house | 1-271 (292) | Show / Hide |
Range on Protein: 23-280 Range on HMM: 1-271/292 Sequence Identity: 42% (115 aa) LSESQVKSLCEKAKEILTKESNVQEVRCPVTVCGDVHGQFHDLMELFRIGGKSPDTNYLFMGDYVDRGYYSVETVTLLVALKVRYRERITILRGNHESRQ |.|... . |.| ..| ||... || |.||.||.||||.||..|| .||| .|.|||.||||||||.|.|.| | |||. | .|. .||||||.|. leeesalkiieeaakllkkeetlleveapitviGdihGqfydllklfevgGkpastkylflGdyvdrGyfsiecvlylyalkiaypsrlfllrGnhecrh ITQVYGFYDECLRKYGNaNVWKYFTDLFDYLPLTALVDGQIFCLHGGLSPSIDTLDHIRALDRLQEVPHEGPMCDLLWSDPDDRGGW--------GISPR .|. . | .|. ||.. .|.. ... || |||.||.... .|.|||||| |..|| |..|||..|.|. ||.||||||||.. | |.|| lteyftfkeevkikyse-evyealmesfdslplaallnqkflcvhGGlspeikslddikkldrfkeppasGplcdllwsdpledygeeetseeflpnsvr GAGYTFGQDISETFNHANGLTLVSRAHQLVMEGYNWCHD------RNVVTIFSAPNYCYRCGNQAAIMELDD | .. . .| . | | . |||. .||. .. ..|.||||||. |.||...... GcsyfysykavceflqkndllsiiraheaqdaGyrmyrkseatgfpslitlfsapnyldvynnkaavlkyen |
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| Phosphatase | PPP2CA.AA | Subfamily.PPP_Nematode_5.PD | 24-291 | 37 | 4.1e-76 | 245.4 | In-house | 2-272 (274) | Show / Hide |
Range on Protein: 24-291 Range on HMM: 2-272/274 Sequence Identity: 37% (100 aa) SESQVKSLCEKAKEILTKESNVQEVRCPVTVCGDVHGQFHDLMELFRIGGKSPDTNYLFMGDYVDRGYYSVETVTLLVALKVRYRERITILRGNHESRQI |.... .. ||.|..| . . ||. |.|..||.|||..||. .| |..|...|||.||||||| |.| . || .||..| ... .|||||| ..| sdkdilevlekikstlkplaalleveapitivGdihGqlddllrifnavGaapkvqylflGdyvdrGakslevslllfslkiaypkkvhllrgnhevkki TQVYGFYDECLRKYGnANVWKYFTDLFDYLPLTALVDGQIFCLHGGLSPSIDTLDHIRALDRLQE--VPHEGPMCDLLWSDPDDRgGWGIS---PRGAGY ..|||..| .|.. ...| | |.| .||| | |. .|.|.|||.|| ...|| ..|| . ..|| . ||||.||. .. |. ||. nklygfkeelkkkrq-eslykkfndvfselplcarvskrilcmhGGispklksldslkalkkpttplacdeglqvdllwadpekd-aktfelnkiraisv TFGQDISETFNHANGLTLVSRAHQLVMEGYNWCHDRNVVTIFSAPNYCYRCGNQAAIMELDDTLKYSFLQFDP . . . .. |. |||... |||.. |. .||.|||||. . | .|.. ....|. || .. | vfGkkevddllkkldidlivrahevseeGyaflfdkrlvtvfsapyysgedtnlgavvvvskslelsfvvlkp |
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| Phosphatase | PPP2CA.AA | Subfamily.PPP_Nematode_2.PD | 39-282 | 42 | 1e-74 | 240.9 | In-house | 17-270 (281) | Show / Hide |
Range on Protein: 39-282 Range on HMM: 17-270/281 Sequence Identity: 42% (107 aa) LTKES---NVQEVRCPVTVCGDVHGQFHDLMELFRIGGKSPDTNYLFMGDYVDRGYYSVETVTLLVALKVRYRERITILRGNHESRQITQVYGFYDECLR ... | .|.| |||| .|.|||. ||. .| | . . ..|||.||||||| |||.| ||.|.| .| . . .|||||| . | |||.|||| flefsallrvdeeclpvtvvadlhgqsidllriflineapgiskylflgdyvdrgrqsvevvllllaykhlypdhlfllrgnhedvnttltygffdecle KYGN--ANVWKYFTDLFDYLPLTALVDGQIFCLHGGLSPSIDTLDHIRALDRLQEVPHEGPMCDLLWSDPD--DRGGWGISPRGAGYTFGQDISETFNHA ||.. ||... | |..|||.||. ....|.|||.|| .. |. | ..| || | ||||||||. .| ||..| || ..|.. . | | . kyndkgekvwlmiidafnhlplaalildkvlcahggisphlekledidkierplvvpsyglacdllwsdpektervgwslsargisfsfddivvekfcad NGLTLVSRAHQLVME----GYNWCHDRNVVTIFSAPNYCyRCGNQAAIMELDDTL |.| || |||||. | |. . . .|..||| || .|..... |. ndldlvvrahqlskemirqghklrangrlvslfsalnyl-smkndssvlkleevk |
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| Phosphatase | PPP2CA.AA | Subfamily.PPP_Nematode_3.PD | 77-291 | 44 | 1.4e-72 | 234.4 | In-house | 92-306 (308) | Show / Hide |
Range on Protein: 77-291 Range on HMM: 92-306/308 Sequence Identity: 44% (95 aa) DTNYLFMGDYVDRGYYSVETVTLLVALKVRYRERITILRGNHESRQITQVYGFYDECLRKYgNANVWKYFTDLFDYLPLTALVDGQIFCLHGGLSPSIDT .|||.||||||| .|.| |.||.|||..| .....|||||||| . . |||| |. ..| .|.... | | |||.|.|. .|.|.|||.| .. |. ykkylflGdyvdrGpfsievvillfalkllypdkvfllrGnhesrpvntqyGfyrevkkry-saalyeafqlafnvlplcavvnkkilcmhGGiseelld LDHIRALDRLQEVPHEGPMCDLLWSDPDDR-GGWGISPRGAGYTFGQDISETFNHANGLTLVSRAHQLVMEGYNWCHDRNVVTIFSAPNYCYRCGNQAAI . .|.| ..| | ..|| |.||| . |. |.|||| ||.. . |.. | || ||||.|..||.. ||..|||||||.|| . | ||... lkqldklkrpldipdvGvladltwadpdaevkgykesarGagkvfGakavkeflkkldldlvvrahqvvedGyeffadrklvtifsapsycGqldniaav MELDDTLKYSFLQFDP .|. |. |. . | lsvdkklvisltvlrp |
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| Phosphatase | PPP2CA.AA | Subfamily.PPP_Nematode_7.PD | 24-285 | 34 | 5.4e-60 | 192.8 | In-house | 2-288 (296) | Show / Hide |
Range on Protein: 24-285 Range on HMM: 2-288/296 Sequence Identity: 34% (97 aa) SESQVKSLCEKAKEILTKESNVQEVRCPVTVCGDVHGQFHDLMELF----------RIGGKS-PDTNYLFMGDYVDRGYYSVETVTLLVALKVRYRERIT |.... ||....|| . || .. |. |||. ||.|||..||. . .. . | . ..|.|||||||..|.| ..|..|||. | ... sknellslidavkelfkkektlaeispPvtivGdihGqyeDLvriLnarvskeeakqksalsfvrkkfvfLGdYvdrGsksieCisLvfalkilyptkyi ILRGNHESRQITQVYGFYDE---CLRKYGNANVWKYFTDLFDYLPLTALVDGQIFCLHGGLSPSIDTLDHIRALDR-LQEVPHEGPMCDLLWSDPDDRGG .||||||.. | |.| | | | .... | . | ..||.||| .|.|.|||.||...|..|. ..| |.|| .. |||..|| | . llrGnhetkainfayefreelenrlskidgkeiyekfnevfsfmplaalvgekilcvhggispklesledinsierPlaevtedslakdllfadpldvql WGISPRGAGYTFGQ--DISETFNHA--------NGLTLVSRAHQLVMEGYNWCHDRNVVTIFSAPNYCYRCGNQAAIMELDDTLKYS .. . . |.. . ..| .||.| ..| |. |||| .||... |. ..||||||.| .|. |..... | | laavsekpkyeknevrglsvvfneaavedvCrklnlklivrahqkipegfkffadkkLltifsaprymnesdnsgavlkveangkls |
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| Phosphatase | PPP2CA.AA | Metallophos | 50-245 | 26 | 1.3e-40 | 146.09 | Pfam | 1-124 (124) | Show / Hide |
Range on Protein: 50-245 Range on HMM: 1-124/124 Sequence Identity: 26% (52 aa) CPVTVCGDVHGQFHDLMELFRIGGKSPDTNYLFMGDYVDRGYYSVETVTLLVALKVRYRERITILRGNHESRQITQVYGFYDECLRKYGNANVWKYFTDL ....|||.|||..||..||.|. . ......|.|||||||..| |.. ||...|..| .. ..||||........|||| | |.| .. .. MRILHCGDIHGQYDDLNRLFEII-E-KPDFVIFTGDYVDRGPWSDECIWLLFCYKMNYPGPVYWVRGNHDYMHGNDFYGFY-E--------NDW-MWWWW FDYLPLTALVDGQIFCLHGGLSPSIDTLDHIRALDRLQEVPHEGPMCDLLWSDPDDRGGWGISPRGAGYTFGQDISETFNHANGLTLVSRAHQLVM | ..|| |.|. |.| ||.. | ||. .| |.|. |. F-WMPLA-LDDWKILCMHGPP---------------------------------------------------------FCK-NGVDYVIRGHTHVP |
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| Phosphatase | PPP2CA.AA | Subfamily.PPP7C.PD | 7-185 | 34 | 6e-39 | 123.6 | In-house | 21-205 (338) | Show / Hide |
Range on Protein: 7-185 Range on HMM: 21-205/338 Sequence Identity: 34% (62 aa) TKELDQWIEQLNECKQLSESQVKSLCEKAKEILTKESNVQEVRC----PVTVCGDVHGQFHDLME-LFRIGGKSPDTNYLFMGDYVDRGYYSVETVTLLV ...... .|.... |.| | . ..|..| . |...| ||||||.||...||. |.. | |.. .|.| ||.||||||| . .|.|| lddveklleafklkkllhakyvllilretkkvlkqlpnisrvstaiskevtvcgdlhgklddlllilyknGlpsaenpyvfnGdfvdrGkesveillilf ALKVRYRERITILRGNHESRQITQVYGFYDECLRKY--GNANVWKYFTDLFDYLPLTALVDGQIFCLHGGLSPSIDtLDHIRALDR . | . . . ||||| . ||| | || .... . . |.| .|||..|.| .|. .|||.| . | |. ...| alllvypkevylnrGnhedyilnlryGfikeveskykvhgkkilrlledvfawlplatlidekilivhGGisdktd-lelldkier |
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| Phosphatase | PPP2CA.AA | Subfamily.PPP_Nematode_1.PD | 30-287 | 23 | 1.9e-33 | 105.8 | In-house | 8-265 (273) | Show / Hide |
Range on Protein: 30-287 Range on HMM: 8-265/273 Sequence Identity: 23% (59 aa) SLCEKAKEILTKESNVQEVRCPVTVCGDVHGQFHDLMELFRIGGKSPDTNYLFMGDYVDRGYYSVETVTLLVALKVRYRERITILRGNHESRQITQVYGF | |.| .|. . | .. . .|||.||. ... ||...... | .. .||.|. .| | .|.|.. .|. |. | ...||||..| . .. elledalkiaeetslleyieadvtviGdirsryadlldilkltGwPfeqkilflGnlldsGkssleellillcskkcyPknvvilrGeyetelvksdrrl YDECLRKYGNANVWKYF----TDLFDYLPLTALVDGQIFCLHGGLSPSIDTLDHIRALDRLQEVPHEGPMCDLLWSDPDDRggwgiSPRGAGYTFGQ-DI | .. ..| |. | ||. |... .......|.|. | ... |..| ... .. . | | || . ... | igelrvrfpdsnkwralnaiikrllkrlPvaavlnkkllavysgvssnikekknvvavkrgiifenhstrvevqfldidiP-----sPvtendidekski SETFNHANGLTLVSRAHQLVMEGYNWCHDRNVVTIFSAPNYCYRCGNQAAIMELDDTLKYSFL | .... |....| ||| . . ...|..||...|. ... .| || .| vkellkatdmsvmirsnsvvreGylftlknrlitltsatklqkdynnrGvvlsidkdlkvtfk |
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| Phosphatase | PPP2CA.AA | Subfamily.PPP7C.PD | 195-289 | 36 | 2.9e-22 | 68.7 | In-house | 239-334 (338) | Show / Hide |
Range on Protein: 195-289 Range on HMM: 239-334/338 Sequence Identity: 36% (34 aa) MCDLLWSDPDDR-GGWGISPRGAGYTFGQDISETFNHANGLTLVSRAHQLVMEGYNWCHDRNVVTIFSAPNYCYRCGNQAAIMELDDTLKYSFLQF . |.||||| . | . . ||.| || |... . . .|.|. |.|. .|||...|...|.||||| || |. | . | ..|...|. ildilwsdpkaqeGckpntlrGgGsyfGpdvtkkllqkynlellirsheckpeGyefthnkkvltifsasnyyeeGsnrGayvklgkdltprivqy |
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| Phosphatase | PPP2CA.AA | Subfamily.PPP_Nematode_3.PD | 25-73 | 42 | 3.5e-13 | 39.3 | In-house | 3-51 (308) | Show / Hide |
Range on Protein: 25-73 Range on HMM: 3-51/308 Sequence Identity: 42% (21 aa) ESQVKSLCEKAKEILTKESNVQEVRCPVTVCGDVHGQFHDLMELFRIGG |... || .|.|.. || |...|||..||.||||.||. |. . | ekelielcyrarelfwkeplkleleapvtivGdihGqfedllalldlnG |
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