• Phosphatome.Net

Gene aque_DUSP12

aque_DUSP12
Species: A.queenslandica
Alias: aque_DUSP12
External Links:
Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Superfamily: Cx5R-I
Family: DSP
Subfamily: DSP12
Protein domain

Protein domains of aque_DUSP12.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit phosphatase group/family/subfamily, which is helpful to understand the relationship between phosphatases. Transmembrane region is predicted by TMHMM 2.0. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking. View complete domain list.

Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Phosphatase aque_DUSP12.AA Subfamily.DSP12.PD 1-146 50 2.1e-55 177.5 In-house 2-142 (143) Show / Hide 
Range on Protein: 1-146
Range on HMM: 2-142/143
Sequence Identity: 50% (73 aa)

MVEILPGLLLGGMSDVQYlLRRKSTVKLTHLLSVVKEALdwsDLHSPSPGPIScKLIQAIDLPSTDLLIHFPEATDFIQETMDTGGTILVHCEYGLSRSA
..||||||.|||...||.  ......|.||.|||.||.|   . .. ..| .| ||||..| |..||| |..||..||.|.....|..||||..|.|||.
vseilpglylggleavqe-rellkelkithvlsvikeel---pelqkekgvks-kliqilDepeedlLshldeavrFieeglekegavlvHClagvSRSv

TIVIAYFIKYHKMSFNEAIDFVKEKKPDIRPNAGFISQLKLWYKMK
||||||..|..|.|...|...|||||..|.||.||..||||..|||
tiviAYlmkkeklslekAlklvkekkkeiepNegFleQLklfekmk
Phosphatase aque_DUSP12.AA DSPc 1-145 31 3.2e-35 124.24 SMART 2-172 (172) Show / Hide 
Range on Protein: 1-145
Range on HMM: 2-172/172
Sequence Identity: 31% (54 aa)

MVEILPGLLLGGMSDVQ-YLLRRKSTVKLTHLLSVVKEALDWSDLHS------------PSPGPISCKLIQAIDL--------PSTDLLIHFPEATDFIQ
..||.|.| ||. .. .   .. ..  . || ..| .|  .|.. |             .... .  . |..||         ..|... .|||..|||.
PSEITPHLYLGSYPHHMEPNPCFLKKHNITHVINVTME-CPWNFHHCQKNDMHYTNEWIYHNSHFQYMHIPMIDDIYYHIRWNHCTNISQYFPEVYDFIH

ETMDTGGTILVHCEYGLSRSATIVIAYFIKYHKMSFNEAIDFV-----KEKK-PDIRPNAGFISQLKLWYKM
.    || .||||  |.|||||..||| .||..|| |.|..||     |... | |.||..|. ||..|...
DCRQKGGKVLVHCQAGISRSATLCIAYLMKYMNMSYNDAYHFVYIYHIKQRRCPIICPNFNFWHQLCEWERK
Phosphatase aque_DUSP12.AA DSPc 8-145 30 3.2e-35 124.37 Pfam 1-151 (151) Show / Hide 
Range on Protein: 8-145
Range on HMM: 1-151/151
Sequence Identity: 30% (47 aa)

LLLGGMSDVQYLLRRKSTVKLTHLLSVVKEAL-DWSDLHSPSPGPISCKLIQAIDL----------PSTDLLIHFPEATDFIQETMDTGGTILVHCEYGL
| ||. ....  ..  .  . || ... .|   .    . .... .  . |....           ..|..  .||.|||||.  .  || .||||  |.
LYLGSYPHHMADPAFLQKHGITHVINCTMECPNN----WFYHNSHFHYMWIPHVHDHIHYYHIHWNHCTNISQYFPMATDFIDDCRQKGGKVLVHCQAGI

SRSATIVIAYFIKYHKMSFNEAIDFV-----KEKK-PDIRPNAGFISQLKLWYKM
||||...||| .||..|| |||.|||     |... | |.||..|. ||  ....
SRSACLCIAYLMKYRNMSYNEAYDFVYIYHMKQRRCPMISPNMNFWRQLCEYERQ
Phosphatase aque_DUSP12.AA Subfamily.DSP19.PD 2-141 40 1.2e-34 109.9 In-house 3-135 (139) Show / Hide 
Range on Protein: 2-141
Range on HMM: 3-135/139
Sequence Identity: 40% (56 aa)

VEILPGLLLGGmSDVQYLLRRKSTVKLTHLLSVVKEaldWSDLhspSPGPISCKLIQAIDLPSTDLLIHFPEATDFIQETMDTGGTILVHCEYGLSRSAT
.|. | |.||   || . ..  .. |.||.|.|  .     ..    |  ...| |. .||| |.|| ...||.|||.|. ...|..||||. | ||||.
aevkprlylgs-qdvaadkeilkklkitHilnvavg---vpnv---fpkdftyksieilDlpetkllsylkealdFieearskdgrvlvHCnAGvSRsas

IVIAYFIKYHKMSFNEAIDFVKEKKPDIRPNAGFISQLKL
.||||..| ...|...|.. |.|..| |.||.||| ||| 
vviaylmkdeelslekalekvrearpcikPneGFikqLke
Phosphatase aque_DUSP12.AA Family.DSP.PD 1-178 28 1.3e-34 110.9 In-house 107-278 (387) Show / Hide 
Range on Protein: 1-178
Range on HMM: 107-278/387
Sequence Identity: 28% (52 aa)

MVEILPGLLLGGMSDVqYLLRRKSTVKLTHLLSVVkealD------WsdlhspsPGPISCKLIQAIDLPSTDLLIHFPEATDFIQETMDTGGTILVHCEY
..||||.| ||..... . |   .. . |. ...     |      .        . |    |. .| ....| ..| .| |||.|  |..|..||||  
pseilphlylgsllaa-knlewlkelgvtkivnlt----ddkpqftk-------elgikylripidDhnapplenlfekaidfieegndskgvVlVHCka

GLSRSATIVIAYFIKYHKMSFNEAIDFVKEKKP-DIRPNAGFISQLKLWYKMKGTLNETDKSYKSYRLSHQAKAMkDNGYMKSME
|..||.|..|||..|.......||.|.|..|.|  |.|| ||..||| ..|.| .....   .. .. |. .. . . .  .|..
GkgRsgtliiaYlmksegltleealdwvrskRpgvitpnqgflkqlkdlekeklkvssevmelrfvissivqnlg-svevsvsvl
Phosphatase aque_DUSP12.AA Subfamily.DSP1.PD 2-143 38 2e-30 96.4 In-house 3-137 (139) Show / Hide 
Range on Protein: 2-143
Range on HMM: 3-137/139
Sequence Identity: 38% (54 aa)

VEILPGLLLGGMSDVQYLlRRKSTVKLTHLLSVVKEALDWsdlhspSPGPISCKLIQAIDLPSTDLLIHFPEATDFIQETMDTGGTILVHCEYGLSRSAT
||||. | ||. ..   | .  ...|.|.|| | .|  .        .   . | |.  | ...|.. .| || |||..  ..|| .||||.|.||||||
veildfLyLGsaehasnl-qlLkelkitallnvsaelpnv------feelfkyksipvednkkadisslfeeaidfidsvkkkgGrvlvhCqaGisrsat

IVIAYFIKYHKMSFNEAIDFVKEKKPDIRPNAGFISQLKLWY
|.||..| .|....|| .|||...  | || ||. ||  .  
ivlayLmkekkvrleeafefvkqrrsiisPnfgfvgqLlefe
Phosphatase aque_DUSP12.AA Subfamily.DSP10.PD 2-139 37 4.5e-30 95.1 In-house 3-135 (141) Show / Hide 
Range on Protein: 2-139
Range on HMM: 3-135/141
Sequence Identity: 37% (52 aa)

VEILPGLLLGGMSDVQYLLRRkSTVKLTHLLSVVKEAldwsDLHSPSPGPISCKLIQAIDLPSTDLLIHFPEATDFIQETMDTGGTILVHCEYGLSRSAT
..||| ||||   | .      . . ....| | ...     ...   | .  | |.. | . ..|  .| || .||.|   .|...||||. |.|||||
ssilpflllGnekdaadkdal-drlgikyvlnvttsv----PnffeekglvrykripvsdsgkqnlkqkfeealefieearkrgsrvlvhchaGisrsat

IVIAYFIKYHKMSFNEAIDFVKEKKPDIRPNAGFISQL
.|||| .|. ..|..||  |||||.| | || .|. ||
vviayvmkhlslslseaykfvkekrPiisPnlnfmGql
Phosphatase aque_DUSP12.AA Subfamily.DSP6.PD 2-141 37 2.3e-29 92.6 In-house 3-137 (141) Show / Hide 
Range on Protein: 2-141
Range on HMM: 3-137/141
Sequence Identity: 37% (52 aa)

VEILPGLLLGGMSDVQYLlRRKSTVKLTHLLSVVKEAldwSDLHSpSPGPISCKLIQAIDLPSTDLLIHFPEATDFIQETMDTGGTILVHCEYGLSRSAT
||||| | ||   | . |    . .|. ..| | ..     . .  . | .  | | . |  |..|  .|||| .||.|.  .  ..|||||.||| |..
veilpllylGsakdasnl-evlkklkikyvlnvtsnl---pnkfe-esgelkykqipiedhlsqnlakffPeaiefidearskkskvlvhclaGvsrsvt

IVIAYFIKYHKMSFNEAIDFVKEKKPDIRPNAGFISQLKL
.||..|....|.|.| |.||.||..| ||  |. ||.   
vtlaylmkklalslndaydlvkkkksnisPnfnfmgqlld
Phosphatase aque_DUSP12.AA Subfamily.DSP3.PD 52-140 43 9.4e-28 87.7 In-house 55-143 (148) Show / Hide 
Range on Protein: 52-140
Range on HMM: 55-143/148
Sequence Identity: 43% (39 aa)

ISCKLIQAIDLPSTDLLIHFPEATDFIQETMDT-GGTILVHCEYGLSRSATIVIAYFIKYHKMSFNEAIDFVKEKKpDIRPNAGFISQLK
|.   ... |.|..||  .| ||.|||.|.... .| .||||. |.|||||.|.||.. ..|.. .|||  |..|. .| || ||..|| 
ikylGvevsDvpefdlskyfeeaadfidealsqkngkvlvhcvvGisRsatlvlayLmirrkltlkeaiktvrkkr-eilPneGflkqLl
Phosphatase aque_DUSP12.AA Subfamily.DSP14.PD 54-140 49 1.1e-27 87.5 In-house 47-133 (138) Show / Hide 
Range on Protein: 54-140
Range on HMM: 47-133/138
Sequence Identity: 49% (41 aa)

CKLIQAIDLPSTDLLIHFPEATDFIQETMDTGGTILVHCEYGLSRSATIVIAYFIKYHKMSFNEAIDFVKEKKPDIRPNAGFISQLK
|.  | |...|  || |..| |.|   .|| .||||  | ||||..|.||..||.|.| .||  .||...| |||| || .||    
tvkikveDkpeaklaehfdevadkieevkkkgGktlvhCvaGvsRsAslvlaylmkyeklsLreayklvksaRpiirPnvGFwkqli
Phosphatase aque_DUSP12.AA Subfamily.Slingshot.PD 49-142 42 2.6e-26 82.8 In-house 43-136 (139) Show / Hide 
Range on Protein: 49-142
Range on HMM: 43-136/139
Sequence Identity: 42% (40 aa)

PGPISCKLIQAIDLPSTDLLIHFPEATDFIQETMDTGGTILVHCEYGLSRSATIVIAYFIKYHKMSFNEAIDFVKEKKPDIRPNAGFISQLKLW
|. .. . |.  | ..|||| |. |. .||... ..|  .||||  |.||||..|||| .| ...|..||...|||..  |.||.||..||| .
pekfkylnirvydeeetdllkhwnetykfiekakekgskvlvhckmGvsrsastviayamkeyelsleealeyvkerrsiikpnkgflkqlkvy
Phosphatase aque_DUSP12.AA Subfamily.LRR-DSP.PD 3-142 35 4e-26 82.2 In-house 4-134 (137) Show / Hide 
Range on Protein: 3-142
Range on HMM: 4-134/137
Sequence Identity: 35% (50 aa)

EILPGLLLGGMSDVQYlLRRKSTVKLTHLLSVvkealdwSDLHSPSPGPISCKLIQAIDLPSTDLLIHFPEATDFIQETMDTGGtILVHCEYGLSRSATI
.|...| ||..   .       . ..||.|.|       .|..   |  .    |.. | . .|.  || |   ||.|  . || .|.||  |.|||||.
liidklylgcresamn-ksilkdnnvthilav-------adfkplypdlfkyliidiedvdeadiyqhfkemnafidegrekgg-vlihcragvsrsatl

VIAYFIKYHKMSFNEAIDFVKEKKPDIRPNAGFISQLKLW
||||..|.... |.||.|.|..|.| |.|| ||. ||| .
viaylmkknslkfkealdlvikkrpriypnrgfldqlkkf
Phosphatase aque_DUSP12.AA Subfamily.DSP15.PD 1-143 34 1e-25 81.0 In-house 2-136 (138) Show / Hide 
Range on Protein: 1-143
Range on HMM: 2-136/138
Sequence Identity: 34% (49 aa)

MVEILPGLLLGGMSDVQYLlRRKSTVKLTHLLSVVKEAldwsDLHSPSpgpISCKLIQAIDLPSTDLLIHFPEATDFIQETMDTGGTILVHCEYGLSRSA
| ..|||| .|.. | .    . .  |.||.||.  .|    . . .    |. . |.| | |..||  .| |. ||| ..   ||..||||  |.||| 
mnkvlpGlyvGnfrdakdk-eqleenkithilsihdsa----kplled---ikylcikaadsPdqdlskffkesidfihkcrleggnvlvhclaGisrsv

TIVIAYFIKYHKMSFNEAIDFVKEKKPDIRPNAGFISQLKLWY
|.|.|| .   ..|...|.  ||  ..   ||.|| .||. ..
tlvvayimtvtelswedalkavkaarsvanPnvGfrrqlqefe
Phosphatase aque_DUSP12.AA Subfamily.STYX.PD 1-142 31 6.8e-24 75.1 In-house 2-143 (146) Show / Hide 
Range on Protein: 1-142
Range on HMM: 2-143/146
Sequence Identity: 31% (45 aa)

MVEILPGLLLGGMSDVQ-YLLRRKSTVKLTHLLSVvKEALDWSDLHSPSPGPISCKLIQAIDLPSTDLLIHFPEATDFIQETMDTGGTILVHCEYGLSRS
| |||||| ||  |  .   |       .||.. . ..... . ..   |  .   ...  | .  ... ..|.. .||......|| .|||. |.||||
mqeilpglflgpysaamksklevlkehgithivci-rqnieanlikpnfpdrfrylvldvadntveniirylptvkefiddslqkggkvlvhgnagisrs

ATIVIAYFIKYHKMSFNEAIDFVKEKKPDIRPNAGFISQLKLW
..||||... . . . ||  .|.|..  | ||.||.|||| . 
aalviayimetyglkyreafayvqerrfcinpnegfvsqlkey
Phosphatase aque_DUSP12.AA Subfamily.STYXL1.PD 2-144 29 8.9e-24 75.1 In-house 3-142 (143) Show / Hide 
Range on Protein: 2-144
Range on HMM: 3-142/143
Sequence Identity: 29% (42 aa)

VEILPGLLLGGMSDVQYLLRRKSTVKLTHLLSVVKEALDwsdLHSPSPGPISCKLIQAIDLPSTDLLIHFPEATDFIQETMDTGGTILVHCEYGLSRSAT
||.||| |  |     .  . |  .|.   . | ..| .   | .  ..      |.  | . .||| .. |. .||..   .| ..||. |.||||...
vevlPgklylGnykqaqnpaikkdlkvkahvnvssdaek---liagladvakllhiavedeneadllerlkevvqfiekhkkegevvlvfsnkGisrsaa

IVIAYFIKYHKMSFNEAIDFVKEKKPDIRPNAGFISQLKLWYK
|||.. ..|.....| ...|. |....|| .|..||. | |  
viiaylmyskkitlkkaykylkkckenvkPnrafveqlseWek
Phosphatase aque_DUSP12.AA Subfamily.DSP8.PD 66-144 48 1.4e-23 74.2 In-house 62-140 (143) Show / Hide 
Range on Protein: 66-144
Range on HMM: 62-140/143
Sequence Identity: 48% (38 aa)

DLLIHFPEATDFIQETMDTGGTILVHCEYGLSRSATIVIAYFIKYHKMSFNEAIDFVKEKKPDIRPNAGFISQLKLWYK
.|| .|..|..||. .  . |..||||  | |||||..||| .|. .||..||  |||||.| | ||  |. ||  ..|
kllpwfdkalefidkarsangkvlvhclaGisrsatvaiayimktlemsldeayrfvkekrptispnlnflgqLleyek
Phosphatase aque_DUSP12.AA Subfamily.PTPMT1.PD 70-144 34 8.2e-17 52.1 In-house 71-145 (146) Show / Hide 
Range on Protein: 70-144
Range on HMM: 71-145/146
Sequence Identity: 34% (26 aa)

HFPEATDFIQETMDTGGTILVHCEYGLSRSATIVIAYFIKYHKMSFNEAIDFVKEKKPDIRPNAGFISQLKLWYK
.  |. .||..... | .. |||  | .||||.|..| .| .|.| .||..|.|.|.| || .   .. |. ...
kleegvefiekvaskgssvYvHCkAGrtRsatlvacylmkkkklspeeavkflkkkRpqirlkskqwralqefke
Phosphatase aque_DUSP12.AA Subfamily.CDC14.PD 76-127 33 5.9e-11 33.2 In-house 189-240 (258) Show / Hide 
Range on Protein: 76-127
Range on HMM: 189-240/258
Sequence Identity: 33% (17 aa)

DFIQETMDTGGTILVHCEYGLSRSATIVIAYFIKYHKMSFNEAIDFVKEKKP
|.. | .. |.| |||  || | .|.. .|.||..... .|.| ...  .| 
kfleitekaeGaiavhCkaGLGrtgtligcylikhyrftaaetiawlriarP
Phosphatase aque_DUSP12.AA Subfamily.DSP23.PD 75-127 26 1.3e-09 29.0 In-house 56-108 (128) Show / Hide 
Range on Protein: 75-127
Range on HMM: 56-108/128
Sequence Identity: 26% (13 aa)

TDFIQETMDTGGTILVHCEYGLSRSATIVIAYFIKYHKMSFNEAIDFVKEKKP
..|. . .... |||  || |. |..  |..| .... ..||  |.....   
vriveeaekkeeavgvhcalGlGrtGtllacylvkeeglaaddaiaevrkrrk
Phosphatase aque_DUSP12.AA Subfamily.PTPDC1.PD 84-128 33 6e-09 26.4 In-house 165-209 (229) Show / Hide 
Range on Protein: 84-128
Range on HMM: 165-209/229
Sequence Identity: 33% (15 aa)

TGGTILVHCEYGLSRSATIVIAYFIKYHKMSFNEAIDFVKEKKPD
. | | |||  || |   .. .|..  .... .|||..|..|.|.
eegkiavHCHAGlGRtGvliacylvyakrltaeeaiklvrskrpk
Phosphatase aque_DUSP12.AA Subfamily.DSP11.PD 65-124 27 2.8e-08 24.4 In-house 60-120 (141) Show / Hide 
Range on Protein: 65-124
Range on HMM: 60-120/141
Sequence Identity: 27% (17 aa)

TDLLIHFPEA-TDFIQETMDTGGTILVHCEYGLSRSATIVIAYFIKYHKMSFNEAIDFVKE
.. . .| || ..|.... |..  | |||  |. |.  ..  |.|. . .| ..||.  .|
kedvkkfkeavkefleknkdndkligvhCthGvnrtGyliCrylidvegyspedaieafee
Phosphatase aque_DUSP12.AA Subfamily.RNGTT.PD 84-139 26 4.2e-07 20.5 In-house 78-133 (140) Show / Hide 
Range on Protein: 84-139
Range on HMM: 78-133/140
Sequence Identity: 26% (15 aa)

TGGTILVHCEYGLSRSATIVIAYFIKYHKMSFNEAID-FVKEKKPDIRpNAGFISQL
. .| ||| .|  |   ...||...  ..| ..|.. | | ..| |    .....| 
PdevigvhCthGfnrtGflivayLvekedwsveaavalfakarppGiy-kedylkel
Phosphatase aque_DUSP12.AA Subfamily.R_Nematode_3.PD 74-116 27 1.5e-06 18.5 In-house 187-228 (267) Show / Hide 
Range on Protein: 74-116
Range on HMM: 187-228/267
Sequence Identity: 27% (12 aa)

ATDFIQETMDTGGTILVHCEYGLSRSATIVIAYfIKYHKMSFN
|.. |.  .    ...|||  | |||||.. .  . | ... .
alelikfveksktpvvVHCsdGisRsatlaaie-lgyqliiks
Phosphatase aque_DUSP12.AA Subfamily.PTEN.PD 85-126 30 2.6e-06 17.7 In-house 94-136 (305) Show / Hide 
Range on Protein: 85-126
Range on HMM: 94-136/305
Sequence Identity: 30% (12 aa)

GGTILVHCEYGLSRSATIVIAYFIKYHKMSFN-EAIDFVKEKK
. |||  |  |. ... ||..|. ... . ||... .||.   
snVvavHCkaGkGRtGvmicayLlksgikksadealaiydekR
Phosphatase aque_DUSP12.AA Subfamily.Laforin.PD 65-127 25 9.8e-06 16.1 In-house 84-146 (165) Show / Hide 
Range on Protein: 65-127
Range on HMM: 84-146/165
Sequence Identity: 25% (15 aa)

TDLLIHFPEATDFIQETMDTGGTILVHCEYGLSRSATIVIAYFIKYHKMSFNEAIDFVKEKKP
.  .|.|  ...  .. |  . |||. |. ||..||  ..    . |..    |.  |.|   
esrvenlpqavyllhallekghivyvhcnagvgrstaivcgflqyvlgwslakvqyfllakrp
Sequence
Name Sequence Type Origin Length Description Download
aque_DUSP12.AA Protein None 331 None Fasta, JSON
aque_DUSP12.NA RNA None 1017 None Fasta, JSON
aque_DUSP12.AA.PD_1-168 Protein Phosphatase Domain None 168 None Fasta, JSON