• Phosphatome.Net

Gene aque_PTEN

aque_PTEN
Species: A.queenslandica
Alias: aque_PTEN
External Links:
Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Superfamily: Cx5R-I
Family: DSP
Subfamily: PTEN
Protein domain

Protein domains of aque_PTEN.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit phosphatase group/family/subfamily, which is helpful to understand the relationship between phosphatases. Transmembrane region is predicted by TMHMM 2.0. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking. View complete domain list.

Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Phosphatase aque_PTEN.AA Subfamily.PTEN.PD 25-345 36 1.3e-76 249.2 In-house 1-303 (305) Show / Hide 
Range on Protein: 25-345
Range on HMM: 1-303/305
Sequence Identity: 36% (112 aa)

DMTFIKPNIVAMGFPSEKLEGVYRNKMSDVQRYFDTHYTDHYKVYNLCSERFYDPKKFH-KVTVYPFDDHNPPPFELIQPFCEDVDGWLKEDNRNVAVIH
|...| .|......| |..|....... |. ....| | ...|...|.... ..  .|. .|.||||||||||..||.....|||| |||||..||...|
disyilvnlivlsypvetyekllyrnslddlillltvykgkgklrilnargekedsdfdgrvavypfdDhnpptleLleeivedvdkwLkedksnVvavH

CKAGKGRTGVMICSYLLHDRLFDTVKDALQFYGEARTQNAKGVTIPSQRRYVQYYGHLIRNNLQYSPRTILLHAIRLEGIPNFSGGTCAPFFIVRKHKVV
|||||||||||||.|||.   ... ..||..|.|.||.. ||||||||||||||. .|..... ||  .. .  ||.|   |      .|         |
CkaGkGRtGvmicayLlksgikksadealaiydekRtkdkkGVtiPSQrRYvqYfsklvkssvpyskvslnvceirfsesscvqnlgmvecsisvlhdsa

LYTSKVYESI-RRTDAFAE--LMLTKPIPLCDDIKVEFyhnprfgSKASYTEKMFLFWFNTFFVDWHVmQQEAQNAMatNslsvSwlYtashfrVVILPK
      | .   ||.. |.|.|.       .| |  . .  ||.|||||  .    |.. ..  |       |      .  | |.|||  .|| .||..
tenakpdrlktlpidfqksfvltikpsipvsgdvkfel-------tkkspdkiichfwlntffvrnys-pcesdgtv--n----k--y------ihtlsk

NEIDKANKDKKHKQYPCNFKVHMVL
  .||. .|.               
seiddvhkdsehkrfseefkisivf
Phosphatase aque_PTEN.AA Family.DSP.PD 26-284 23 3.7e-41 133.0 In-house 94-343 (387) Show / Hide 
Range on Protein: 26-284
Range on HMM: 94-343/387
Sequence Identity: 23% (61 aa)

MTFIKPNIVAMGFPSEKLEGVYRNKMSDVQRYFDTHYTDHYKVYNLCserfYDPKKFHK-----VTVYPFDDHNPPPFELIqpFCEDVDgWLKEDN--RN
|. . . |. | ||| |...|  ......     .   . |. ||.    .|...|.|     .  .|.||||.||.|..  |....| ...|.|..|..
dtydhfervengkpseilphlylgsllaaknlewlkelgvtkivnlt----ddkpqftkelgikylripidDhnapplenl--fekaid-fieegndskg

VAVIHCKAGKGRTGVMICSYLLHDrLFDTVKDALQFYGEARtqnaKGVTIPSQRrYVQYYGHLIRNNLQYSPRTILLHAIRLEGIPNFSG-GTCAPFFIV
.||||||||.|..|. ||..     | ..||... ..|    .||..|.|. ..... .|  ..|. | ... |. .. ....|.   .. ..  .   .
vVlVHCkaGkgRsgtliiaYlmks-egltleealdwvrskR----pgvitpnqg-flkqlkdlekeklkvssevmelrfvissivqnlgsvevsvsvlkk

RKHKVVLYTSKVYESIRRTDAFAeLMLTKPIPLCDDIKVEFYHNprfGSKASYTEKMFLFWFNTFFV
 . ... .   |  .. .  . .   .|| .|.|||...      . .. . .. ..|.| ..    
vatekakldrlkiLvideqekvv-itikdglplsgDVkvelfkk---nldkiirdiilntfFvtnyi
Phosphatase aque_PTEN.AA Subfamily.TPIP.PD 84-289 33 2.5e-39 126.6 In-house 4-214 (245) Show / Hide 
Range on Protein: 84-289
Range on HMM: 4-214/245
Sequence Identity: 33% (72 aa)

KVTVYPFDDHNPPPFELIQPFCEDVDGWLKEDNRNVAVIHCKAGKGRTGVMICSYLLHDRLFDTVKDALQFYGEARTQNA-----KGVTIPSQRRYVQYY
.|.    |||| | .| .  |...|. ||..|..|| .|||| |||||| ..|..|..  .| | ...|...|| ||...     .||  |||.|||.|.
rvsrimiddhnvPtleelvvftkevkewlakdlenvvaihckGGkgrtGtivcalliaseifltaeesldyfgerrtdkthsnkfqGvetPsqnryvgyl

GHLIR-NNLQYSPRTILLhaIRLEGIPNFSGGTCAPF-FIVRKHKVVLYTSKVYESIRRTDAFAELML---TKPIPLCDDIKVEFYHNPRfgsKASYTEK
 ....  | .  || ||.  |.   | .  |  |     .| ..|||. .. . .     |  .. .|       || ||.||.|. .        | . 
aqvkhlynwnlpprrilf--ikrfiiysirgdvcdlkvqvvmekkvvfsstslgncsilhdietdkilinvydgpplyddvkvqffssnl---pkyydnc

MFLFWFNTFFVDWHVM
 |.||||| |..   .
pfffwfntsfiqnnrl
Phosphatase aque_PTEN.AA PTEN_C2 188-347 30 5.5e-37 133.99 Pfam 1-141 (141) Show / Hide 
Range on Protein: 188-347
Range on HMM: 1-141/141
Sequence Identity: 30% (52 aa)

YSPRTILLHAIRL-EGIPNF-SGGTC-APFFIVRKHKVVL-YTSKVYESIRRT--DAFAELMLTKPIPLCDDIKVEFYHN--PRFGSKASYTEKMFLFWF
. |... ||.|.. .||||| .||.|  |.. .  ..... ||.| |.  ..   .  .  .. .|.|...|.|...||.  ..   . .| |.|| |||
PPPKPLFLHCIIMDHGIPNFKQGGGCWRPYIQIYQNDQKVFYTCKKYWHCKKYKQQKCCIFKFPQPCPVQGDVKIQCYHKGPSDL--PWMYEECMFRFWF

NTFFVDWHVMQQEAQNAMATNSLSVSWLYTASHFRVVILPKNEIDKANKDKKHKQYPCNFKVHMVLSE
||.|..                             ....||||.|||.||||.|..| .|||. |.||
NTCFIEH-------------------------NNNRLTFPKNELDKAWKDKKWKRFPPDFKVEVVFSE
Phosphatase aque_PTEN.AA Subfamily.Tensin.PD 84-281 33 2.6e-35 113.2 In-house 4-201 (237) Show / Hide 
Range on Protein: 84-281
Range on HMM: 4-201/237
Sequence Identity: 33% (66 aa)

KVTVYPFDDHNPPPFELIQPFCEDVDGWLKEDNRNVAVIHCKAGKGRTGVMICSYLLHDRLFDTVKDALQFYGEARTQN--AKGVTIPSQRRYVQYYGHL
||. . . |.  ||.| .   |. .. ||| | .|| |.||| ||||.||.|..|. . .. .. . ||. .   |  .   .||| |||||||.|.  |
kvldlGWPdllaPpleklcsickalesWlkadpqnvvvlhckGgkGrigvvisaymhyskisasadaaldrfalkrfyddkvsgvtqPsqrryveyfsgl

IRNNLQYSPRTILLHAIRLEGIPNF-SGGTCAPFFIVRKHKVVLYTSKVYESIRRTDAFAELMLTKPIPLCDDIKVEFYHNPRfgsKASYTEKMFLFWFN
. .... . . ..|| . |.||||| |.|.| ||. . .   ..||| ||.          . .   . |  |. |. ||...  . .|   | |     
lsgsiklnssplflhyvilhgipnfdskggcrpflkiyqalqlvytsgvynvagedterlcitiepalllkgdvlvkcyhkkl---rsttrdvvfrvqfh

T
 
t
Phosphatase aque_PTEN.AA Subfamily.DSP11.PD 73-160 30 5e-12 37.1 In-house 31-123 (141) Show / Hide 
Range on Protein: 73-160
Range on HMM: 31-123/141
Sequence Identity: 30% (28 aa)

SERFYDPKKFHKVTVY----PFDDHNPPPFELIQPFCEDVDGWLK--EDNRNVAVIHCKAGKGRTGVMICSYLLHDRLFDTvKDALQFYGEART
.|.|..|.... .|         |. |  | .. |.| |. .|.  .|| ..  .||  |  ||| .|| ||..   ... .||.. . |||  
tdryykkkeltdegvkykklncpGhevpekedvkkfkeavkefleknkdndkligvhCthGvnrtGyliCrylidvegysp-edaieafeearG
Phosphatase aque_PTEN.AA Subfamily.RNGTT.PD 55-161 25 1.1e-10 32.7 In-house 11-122 (140) Show / Hide 
Range on Protein: 55-161
Range on HMM: 11-122/140
Sequence Identity: 25% (29 aa)

QRYFDTHYTDHYKVYNLC-SERFYDPKKFHKVTV----YPF-DDHNPPPFELIQPFCEDVDGWLKEDNRNVAVIHCKAGKGRTGVMICSYLLHDRLFDtV
. |..|. .    | .|   .|.|| ....|  |           . |  | .. | . |. .||.   .|  .||  |  ||| .|..||..   .. |
ksylktlkvklglvidltntsryydkeelekegvkyiklqcrGrGeaPtkeqtklfiklvkeflkkkPdevigvhCthGfnrtGflivayLvekedws-v

KDALQFYGEARTQ
..|.. . .|| .
eaavalfakarpp
Phosphatase aque_PTEN.AA Subfamily.PRL.PD 67-160 29 1.2e-10 32.7 In-house 27-122 (140) Show / Hide 
Range on Protein: 67-160
Range on HMM: 27-122/140
Sequence Identity: 29% (28 aa)

KVYNLCSERFYDPKKFH----KVTVYPFDDHNPPPFELIQPFCEDVDGWLKEDNRNVAVIHCKAGKGRTGVMICSYLLHDRLfdTVKDALQFYGEART
|    . |  || .|..    .|. ..||| ..|| |... . | .    ||.. ..  .|| || ||. |...  |. . .  . .||..|| |   
kevvrvcepsydaeklkeegievldlafddGavPpkevvdeWlellkekfkeepkstvavhcvaGlGraPvlvalalieaGm--kyedavefirekrr
Phosphatase aque_PTEN.AA Subfamily.CDC14.PD 33-146 27 5.1e-10 30.7 In-house 115-227 (258) Show / Hide 
Range on Protein: 33-146
Range on HMM: 115-227/258
Sequence Identity: 27% (31 aa)

IVAMGFPS--EKLEGVYRN-KMSDVQRYFDTHYTDhyKVYNLcSERFYDPKKFHKVTVY----PFDDHNPPPFELIQPFCEDVDGWlkednRNVAVIHCK
..|.  |.  .|.|  |   .   . .||  .     ..  |  .. || ||| .  .      | |   |. .... | | ...  ...||||| ||||
fialagphnkskvedGytllaPeklleyfrknnvt--tivrL-nkklYdakkftdaGfahlDlffiDGtvPsdailkkfleiteka-----eGaiavhCk

AGKGRTGVMICSYLLHDRLFD
..| .||..   |        
aGLGrtgtligcylikhyrft
Phosphatase aque_PTEN.AA Subfamily.PTPDC1.PD 88-180 26 5.2e-10 30.4 In-house 140-225 (229) Show / Hide 
Range on Protein: 88-180
Range on HMM: 140-225/229
Sequence Identity: 26% (24 aa)

YPFDDHNPPPFELIQPFCEDVDGWLkeDNRNVAvIHCKAGKGRTGVMICSYLLHDRLFDTvKDALQFYgeaRTQNAKGVTIPSQRRYVQYYGH
....|.. .. | |      ||  |   . ..| .|| ||.|||||.|..||.. . ... ..|...    | . .| .   .| . |.. . 
fglkDygvasleriLdivkvvdfal--eegkia-vHCHAGlGRtGvliacylvyakrlta-eeaiklv---rskrpksiqtreqvelveeFal
Phosphatase aque_PTEN.AA Subfamily.DSP23.PD 89-179 25 1.6e-09 29.2 In-house 40-124 (128) Show / Hide 
Range on Protein: 89-179
Range on HMM: 40-124/128
Sequence Identity: 25% (22 aa)

PFDDHNPPPFELIQPFCEDVDGWlKEDNRNVAvIHCKAGKGRTGVMICSYLLHDRLFdTVKDALQfygEARTQNAKGVTIPSQRRYVQYYG
.|. ||  | .. . . |.   .. .  |. .||  | |||| ..  ||.. . . . .||.    | | .    .    | . |. |   
dipdfcPPaleqvarlvriveea-ekkeeavg-vhcalGlGrtGtllacylvkeegl-aaddaia---evrkrrkGsietveqekavkdye
Phosphatase aque_PTEN.AA Subfamily.PTPMT1.PD 84-161 20 5.5e-08 24.1 In-house 55-129 (146) Show / Hide 
Range on Protein: 84-161
Range on HMM: 55-129/146
Sequence Identity: 20% (16 aa)

KVTVYPFDDHNPPPFELIQPFCEDVDGWLKEDnrNVAVIHCKAGKGRTGVMICSYLLHDRLFdTVKDALQFYGEARTQ
....   |  . | .| ..   | ..   ..   .   .|||||..| . .. .||.. . . . ..| .|  . | |
qlqlatvDfteapslekleegvefiekvaskg--ssvYvHCkAGrtRsatlvacylmkkkkl-speeavkflkkkRpq
Phosphatase aque_PTEN.AA Subfamily.R_Anemone_2.PD 80-174 28 6e-08 23.8 In-house 159-252 (262) Show / Hide 
Range on Protein: 80-174
Range on HMM: 159-252/262
Sequence Identity: 28% (26 aa)

KKFHkVTVYPFDDHNPPPFELIQpFCEDVDGWLKEDNRNVAVIHCKAGKGRTGVMICSYLLHDRL-FDTVKDALQFYGEARTQNAKGVTIPSQRRY
..|| .| .|  .    . .|.. .  .|. . .| .... |.|| || ||||| |    | .|.  ... | .|.  . |.|| . .|  .    
rqfh-ytsWpdegvpesgaslld-lvrqvekaqqesgagpivvhcsaGvGrtGvfiavdillerikaealvdvfqtvkqlreqrnlmvqtkdqyef
Phosphatase aque_PTEN.AA Subfamily.N5_RR.PD 58-161 21 1.6e-07 22.3 In-house 134-242 (265) Show / Hide 
Range on Protein: 58-161
Range on HMM: 134-242/265
Sequence Identity: 21% (23 aa)

FDTHYTDHYKVYNLCSERFYD-PKKFHKVTVYPF-DDHNPPPFELIQPFCEDVDGWLKEDNRN--VAVIHCKAGKGRTGVMICSYLLHDRLF-DTVKDAL
..  ...|.| .|  .   . ... .      . | . |   . .  ....|.   .|.| .    |.|| || ||||..|.  .   .|..| | |.  
eeiverndysvrklvlkylerversvkhywytdWPdhksPddintlldlvleveesreeenaklaPvvvhcsaGiGrtGcfiaisiavrqlreeivvdvl

QFYGEARTQ
 . | .   
kivcnlrld
Phosphatase aque_PTEN.AA Subfamily.DSP19.PD 79-158 21 4.3e-07 21.2 In-house 43-119 (139) Show / Hide 
Range on Protein: 79-158
Range on HMM: 43-119/139
Sequence Identity: 21% (17 aa)

PKKFHKVTVYPFDDHNPPPFELIQPFCEDVDGWLKEDnrNVAVIHCKAGKGRTGVMICSYLLHDRLFdTVKDALQFYGEA
||.|. ...  .|. .    . ..  .. ..  ...|  .. ..||.||  |.  .. .||..|.   ....||.   ||
pkdftyksieilDlpetkllsylkealdFieearskd--grvlvHCnAGvSRsasvviaylmkdeel-slekalekvrea
Phosphatase aque_PTEN.AA Subfamily.RB.PD 64-143 23 2.1e-06 18.6 In-house 138-219 (261) Show / Hide 
Range on Protein: 64-143
Range on HMM: 138-219/261
Sequence Identity: 23% (19 aa)

DHYKVYNLCSERFYDPKKFHKVTVYPFDDHNPP-PFELIQPFCEDVDGWLKED-NRNVAVIHCKAGKGRTGVMICSYLLHDR
|.. . ..  |.  . .| ...    . ||. |   . .  |.. |. ..... ...  |.|| || ||||. |    | ..
dewvirefkiekgkekrkvrqyhftsWpdhgvPektktlldfvrtvreaiekkaskkPivvHCsaGvGRtGtfialdrllqa
Phosphatase aque_PTEN.AA Subfamily.N_Choan_1.PD 103-152 36 3.7e-06 17.8 In-house 179-224 (262) Show / Hide 
Range on Protein: 103-152
Range on HMM: 179-224/262
Sequence Identity: 36% (18 aa)

PFCEDVDGWLKEDNRNVAVIHCKAGKGRTGVMICsyllHDRLFDTVKDAL
| ..|    |...    |||| || ||||. |      |||...|.. . 
efrkavlkatkkktkaplvihCsaGvGrtGtyia----lDrlvkaveeka
Phosphatase aque_PTEN.AA Subfamily.N_Fungi_PTP1.PD 111-145 32 3.8e-06 17.4 In-house 254-290 (343) Show / Hide 
Range on Protein: 111-145
Range on HMM: 254-290/343
Sequence Identity: 32% (12 aa)

WLKEDNRNVAVIHCKAGKGRTGVMIC-SYLLHDR-LF
.|.... .  ..|| || ||||...   .||.|   .
hldnarsspilvhCsaGvGrtGtlvtlDsllsdfeil
Phosphatase aque_PTEN.AA Subfamily.N14.PD 117-142 54 4.3e-06 17.4 In-house 207-232 (275) Show / Hide 
Range on Protein: 117-142
Range on HMM: 207-232/275
Sequence Identity: 54% (13 aa)

RNVAVIHCKAGKGRTGVMICSYLLHD
.   ..|| || |||||.| | ||  
kPPvlvhCsaGvGrtGvlilsdllia
Phosphatase aque_PTEN.AA Subfamily.RK.PD 101-140 27 4.7e-06 17.2 In-house 183-222 (267) Show / Hide 
Range on Protein: 101-140
Range on HMM: 183-222/267
Sequence Identity: 27% (11 aa)

IQPFCEDVDGWLKEDNRNVAVIHCKAGKGRTGVMICSYLL
.  .   |. . .|..    |.|| || ||.|. |    .
llklirrvkksqeeeeeGrivvhClaGaGrsGtfiaidiv
Phosphatase aque_PTEN.AA Subfamily.N12.PD 64-144 24 5e-06 17.1 In-house 146-226 (270) Show / Hide 
Range on Protein: 64-144
Range on HMM: 146-226/270
Sequence Identity: 24% (20 aa)

DHYKVYNLCSERFYDPKKFHKVTVYPFDDHNPP-PFELIQPFCEDVDGWLKeDNRNVAVIHCKAGKGRTGVMICSYLLHDRL
| . .  |  |.  . .|...     . ||. |   . .  . |.|    . .. .  |.|| || ||||..|   . .. |
ddflirtLkveaqkesrkvyqfhytaWPDhgvPssaksllelielvrelqe-sedaPlvvhCsaGvGrtGtiiaidyvrell
Phosphatase aque_PTEN.AA Subfamily.R_Sponge_2.PD 81-170 21 8.5e-06 16.7 In-house 154-248 (262) Show / Hide 
Range on Protein: 81-170
Range on HMM: 154-248/262
Sequence Identity: 21% (20 aa)

KFHKVTVYPF---DDHN-PPPFELIQPFCEDVDGWLKEDNRNVAVIHCKAGKGRTGVMICSYLLHDRLF-DTVKDALQFYGEARTQNAKGVTIPS
. ..|| . |    .|. |     .  . ..|    |... .. ...|..| ||||  |. . . .||  . . |  ..  ..||.|   .    
geadvtqfhfvaWpehevPkdatsllelikrvlraqkksgnkaitvvCsdgvgrtGtfialdsvlerlkaeeeidvfevlktlrtkriglvqdaa
Sequence
Name Sequence Type Origin Length Description Download
aque_PTEN.AA Protein None 400 None Fasta, JSON
aque_PTEN.NA RNA None 1200 None Fasta, JSON
aque_PTEN.AA.PD_81-183 Protein Phosphatase Domain None 103 None Fasta, JSON