Gene F55H12.5
F55H12.5
Species: C.elegans
Alias: F55H12.5
External Links:
Classification
Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.
Protein domain
Protein domains of F55H12.5.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit phosphatase group/family/subfamily, which is helpful to understand the relationship between phosphatases. Transmembrane region is predicted by TMHMM 2.0. Visualized by pviz.
Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking. View complete domain list.
| Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
|---|---|---|---|---|---|---|---|---|---|
| Phosphatase | F55H12.5.AA | PTPc | 55-282 | 14 | 4.5e-09 | -3.56 | SMART | 1-308 (308) | Show / Hide |
Range on Protein: 55-282 Range on HMM: 1-308/308 Sequence Identity: 14% (44 aa) GVAEFYKETYLES------------PTFFNYFKSPK--DKNFSE-NVWLYDATRVIVPGV----------DYYHASWVDGL-KPNQYILAQAPRDASAAK |..| ... . . .. .. . ||| . .. || |||. . || .|...|| .|..||..|.| . GFWEEFERLQRMTPWDLMSNYDPCCSCTCACWPENREMDKNRYKCDIPCYDHTRVKLKPPPGESHCYEGSDYINANYIDGYWRPKRYICTQGPL-PHTIE DFFKLLEHVKAEGLIVAEGADE-----------------FSSAITAKFEKGTGKNDFVSTAV--IKENGLHLKAIK-------------------FCRWA || . . | . . .| . . . .... | .. . . .. . .. . . | DFWRMVWQQKCHIIVMLCNCMEKCTENRDQNGREKCHQYWPDE-PMTYGHITVTCKSEEKCPDDYTMRTFEVTNTGCNCKYSMACSETRTVTHYHYTNWP E---PLSAIEINDMLEKSRKY------------------LGCPLKGPLVIVCKDGAAKSGLVAFIDTEADRLMKHGKAKHTDTIKQIRFMRSNTFDTFDS . | |. . |.... |.. .. . || |..| .|. .| . ||. ... . ...|..| .| . ..|.. DHGVPESPDSFLDFIRQVRHWQSHSPNMYMNMVSSNSKYHHTCPTGPIVVHCSAGCGRTGTFCAIDIMCQQIEN---VDIFQIVKMMRNQRPGMVQTEEQ YDLGINSLIELCN | . ..|.. YIFCYRCILEYIK |
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| Phosphatase | F55H12.5.AA | Y_phosphatase | 77-130 | 32 | 1.1e-10 | 38.63 | Pfam | 1-61 (243) | Show / Hide |
Range on Protein: 77-130 Range on HMM: 1-61/243 Sequence Identity: 32% (20 aa) PKDKNFSENVWLYDATRVIV------PGVDYYHASWVDGL--KPNQYILAQAPRDASAAKDF |.|| . .. || |||.. .. ||..|...|| .|..||..|.| . . .|| NKEKNRYKDIPCYDHTRVKLQPIPGDEDSDYINANYIDGPYWNPKAYICTQGPMP-HTIEDF |
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| Phosphatase | F55H12.5.AA | Subfamily.N_Nematode_5.PD | 71-163 | 23 | 1.4e-10 | 31.5 | In-house | 19-113 (258) | Show / Hide |
Range on Protein: 71-163 Range on HMM: 19-113/258 Sequence Identity: 23% (23 aa) FNYFKSPKDKNFSENVWLYDATRVIVPG--VDYYHASWVD--GLKPnQYILAQAPRDASAaKDFFKLLEHVKAEGLIVAEGADEFSSAITAKFEKGT .. |.. ..|| |..| ..|.|||... ..|..||... |. ..||.| | .. .|| .. . | . .... . .|... . | . | ckafeknlkknrskdvkilDetrVkltdeddsYinaskiklddlek-kliltQlPlpdte-edFWrmvyqekitsvvllvedeelketavsffplet |
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| Phosphatase | F55H12.5.AA | Subfamily.RG.PD | 179-278 | 20 | 2.3e-08 | 24.5 | In-house | 159-260 (264) | Show / Hide |
Range on Protein: 179-278 Range on HMM: 159-260/264 Sequence Identity: 20% (20 aa) LHLKAIKFCRWAEPLSAIEINDMLEKSRKYLGCPLK--GPLVIVCKDGAAKSGLVAFIDTEADRLMKHGKAKHTDTIKQIRFMRSNTFDTFDSYDLGINS . . .. .| .. | . . ..| . .| . . ||.|.... |....| .|| . .| |. .. ...|.|| .| . . | . |. |. rvvrqyhytkWPdmgsPestlfvlifvkkeeaankeeaGPivvhdsaGvgragtyialdtllqqlekeeavnvyqvlklirakRpglvtteEqyvfiyda LI ll |
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| Phosphatase | F55H12.5.AA | Subfamily.N_Choan_1.PD | 79-140 | 33 | 3.1e-08 | 24.1 | In-house | 28-95 (262) | Show / Hide |
Range on Protein: 79-140 Range on HMM: 28-95/262 Sequence Identity: 33% (23 aa) DKNFSENVWLYDATRVIV------PGVDYYHASWVDG-LKPNQYILAQAPRDASAaKDFFKLLEHVKAE || .|. |||||| | || |..|.| ....|| .|.| || ..|.... |.. lknrysnivayDatrvkvtpneenkntDyinanfvpgykgekeyiatqgPvPasl-vsfWqmvweqkvs |
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| Phosphatase | F55H12.5.AA | Subfamily.R_Sponge_2.PD | 184-272 | 19 | 4.7e-08 | 23.6 | In-house | 161-252 (262) | Show / Hide |
Range on Protein: 184-272 Range on HMM: 161-252/262 Sequence Identity: 19% (17 aa) IKFCRWAE---PLSAIEINDMLEKSRKYLGCPLKGPLVIVCKDGAAKSGLVAFIDTEADRLMKHGKAKHTDTIKQIRFMRSNTFDTFDSYDL .| |.| | .| . ..... .. ......||.||....| .|. .|| . .. ...|..|..| ... |. fhfvaWpehevPkdatsllelikrvlraqkksgnkaitvvCsdgvgrtGtfialdsvlerlkaeeeidvfevlktlrtkriglvqdaaqYvf |
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| Phosphatase | F55H12.5.AA | PTPc_motif | 97-279 | 10 | 6.1e-08 | 33.62 | SMART | 1-92 (92) | Show / Hide |
Range on Protein: 97-279
Range on HMM: 1-92/92
Sequence Identity: 10% (20 aa)
PGVDYYHASWVDG-----LKPNQYILAQAPRDASAAKDFFKLLEHVKAEGLIVAEGADEFSSAITAKFEKGTGKNDFVSTAVIKENGLHLKAIKFCRWAE
|.. .| | .| ... ....||..
TVHHYHYTNWPDHVEKDSGVPE--------------DSILEFIRHVRK----------------------------------------------------
PLSAIEINDMLEKSRKYLGCPLKGPLVIVCKDGAAKSGLVAFIDTEADRLMKHGKAKHTDTIKQIRFMRSNTFDTFDSYDLGINSLIE
|.|..| .|. .| .. ||. .. .|.|..| .| . . |.. | . ..|
------------------------PIVVHCSAGCGRTGTFCAIDMMMQQ------VDIFQTVKEMRKQRPGMVQTEEQYIFCYRCILE
|
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| Phosphatase | F55H12.5.AA | Subfamily.N9.PD | 209-280 | 24 | 6.2e-08 | 23.2 | In-house | 202-273 (275) | Show / Hide |
Range on Protein: 209-280 Range on HMM: 202-273/275 Sequence Identity: 24% (17 aa) LGCPLKGPLVIVCKDGAAKSGLVAFIDTEADRLMKHGKAKHTDTIKQIRFMRSNTFDTFDSYDLGINSLIEL | . . |.|. | | ..| . .| .|| . |... ..|.|..| |. . | . | . ...| kghlsgPPivvhcsaGiGrtGtfitldiclarleevgtvdvvetvkllrtqrafsiqtpeqyefcylavley |
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| Phosphatase | F55H12.5.AA | Subfamily.R_Sponge_2.PD | 78-143 | 29 | 7.2e-08 | 22.9 | In-house | 26-96 (262) | Show / Hide |
Range on Protein: 78-143 Range on HMM: 26-96/262 Sequence Identity: 29% (21 aa) KDKNFSENVWLYDATRVIV-----PGVDYYHASWVDGLK-PNQYILAQAPRDaSAAKDFFKLLEHVKAEGLI . || ... || .|| . .. || ||.|||.| ...|| .|.| ....||.... .| . .. vgKnRfkeilpydmsRvrLrtdgskdsDYinAsfvdgykrrkayiatqgPlk-etveDfWRmvweykvstiv |
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| Phosphatase | F55H12.5.AA | Subfamily.RG.PD | 74-140 | 28 | 7.3e-08 | 22.9 | In-house | 24-96 (264) | Show / Hide |
Range on Protein: 74-140 Range on HMM: 24-96/264 Sequence Identity: 28% (21 aa) FKSPKDKNFSENVWLYDATRVI---VPG---VDYYHASWVDGL-KPNQYILAQAPRdASAAKDFFKLLEHVKAE .. | || |. .. .|| .|| || ||..|| . ..|| .| | .. ..||.... .|. keenkeknReinivaversRvklsplpgkdgkDYinAsyidGyrrskeyivtqgpl-ketiedFWrmiWehnaq |
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| Phosphatase | F55H12.5.AA | Subfamily.R_Ecdysozoa.PD | 80-154 | 24 | 1.2e-07 | 21.9 | In-house | 30-110 (269) | Show / Hide |
Range on Protein: 80-154 Range on HMM: 30-110/269 Sequence Identity: 24% (20 aa) KNFSENVWLYDATRVIVPGV------DYYHASWVDGL-KPNQYILAQAPRDAsAAKDFFKLLEHVKAEGLIVAEGADEFSSA || .|.. .| |||... . || ||.. | . ...| ||.| .| ...||.... . . ... .| . . knryedikafDktrvkLkkingkedsdyinasfikgykekkkfiaaqdPvea-tigDfWrmiaeqevtlivmlsnlteknrk |
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| Phosphatase | F55H12.5.AA | Subfamily.RK.PD | 179-281 | 21 | 2.1e-07 | 21.1 | In-house | 160-266 (267) | Show / Hide |
Range on Protein: 179-281 Range on HMM: 160-266/267 Sequence Identity: 21% (22 aa) LHLKAIKFCRWAE----PLSAIEINDMLEKSRKYLGCPLKGPLVIVCKDGAAKSGLVAFIDTEADRLMKHGKAKHTDTIKQIRFMRSNTFDTFDSYDLGI .. ..| .|.| | |. . ... . | .|..|. | .|| .|| ||. . . ..| ..|..| ..| .| .| . . revrqfqflgWpeyrdvPvskrsllklirrvkksqeeeeeGrivvhClaGaGrsGtfiaidivlemieregvvdvfnavktlrnrkvnmveteeqykfvy NSLIELC .| . dvileal |
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| Phosphatase | F55H12.5.AA | Subfamily.R_Ecdysozoa.PD | 202-279 | 24 | 2.7e-07 | 20.7 | In-house | 191-266 (269) | Show / Hide |
Range on Protein: 202-279 Range on HMM: 191-266/269 Sequence Identity: 24% (19 aa) LEKSRKYLGCplKGPLVIVCKDGAAKSGLVAFIDTEADRLMKHGKAKHTDTIKQIRFMRSNTFDTFDSYDLGINSLIE |.| | |. ..|.|. |. |. .||.. .| ..| . |.. .|.|..| |. .. .. | .|.. lyklnklsgs--rsPivvhCsaGvgrsgifvaldlllqqlkaedkvdifetvkkLrsqrnllvqsleqyvflyralad |
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| Phosphatase | F55H12.5.AA | Subfamily.N_Nematode_4.PD | 70-140 | 28 | 5.4e-07 | 20.0 | In-house | 19-92 (264) | Show / Hide |
Range on Protein: 70-140 Range on HMM: 19-92/264 Sequence Identity: 28% (21 aa) FFNYFKSPKDKNFSENVWLYDATRVIV----PGVDYYHASWVDGLKPNQYILAQAPRDASaAKDFFKLLEHVKAE . .. .||| ... |.|||.. | || ||||. .|| .| | . . .||. .. |.. tasaseknsdknryadilcidetrvvlknrdpdndyihaswmrmPdkfryistqGPlket-lsdfwhmvytekia |
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| Phosphatase | F55H12.5.AA | Subfamily.N_Nematode_1.PD | 69-141 | 31 | 9.5e-07 | 19.1 | In-house | 16-94 (265) | Show / Hide |
Range on Protein: 69-141 Range on HMM: 16-94/265 Sequence Identity: 31% (24 aa) TFFNYFKSPKD--KNFSENVWLYDATRVIV----PGVDYYHASWVD-GLKPNQYILAQAPRDASAaKDFFKLLEHVKAEG . ||. .. || ..| | .||.. || || .| .|...| |||| | . .||. .. | | ekvkafkeaqeadknrykdvgcldknrvklaeeplpsdyihanyvgtptnpkrficaqaPldkti-adfwymvlqekvea |
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| Phosphatase | F55H12.5.AA | Subfamily.N_Nematode_5.PD | 215-274 | 18 | 9.5e-07 | 19.0 | In-house | 191-250 (258) | Show / Hide |
Range on Protein: 215-274 Range on HMM: 191-250/258 Sequence Identity: 18% (11 aa) GPLVIVCKDGAAKSGLVAFIDTEADRLMKHGKAKHTDTIKQIRFMRSNTFDTFDSYDLGI |.|.|.. |. ..| ...... . | . . . ...|.|| | . ..... | . apvvvvsdlGlgRagtflllsvaieqlnngkepnideilkkirsqRpgavesliqyasvy |
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| Phosphatase | F55H12.5.AA | Subfamily.R_Anemone_2.PD | 78-137 | 34 | 1.3e-06 | 19.0 | In-house | 28-93 (262) | Show / Hide |
Range on Protein: 78-137 Range on HMM: 28-93/262 Sequence Identity: 34% (22 aa) KDKNFSENVWLYDATRVI------VPGVDYYHASWVDGLK-PNQYILAQAPRdASAAKDFFKLLEHV | || |. || ||| ..| || |...|| . ..|| .||| . . .||.... kaknryanilaydktrvklqmlegeegsdyinanyidGyrrkkayiatqaPl-petiedfWrmvWeq |
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| Phosphatase | F55H12.5.AA | Subfamily.N_Choan_2.PD | 198-281 | 22 | 1.6e-06 | 18.3 | In-house | 181-265 (266) | Show / Hide |
Range on Protein: 198-281 Range on HMM: 181-265/266 Sequence Identity: 22% (19 aa) INDMLEKSRKYLGCPLKG-PLVIVCKDGAAKSGLVAFIDTEADRLMKHGKAKHTDTIKQIRFMRSNTFDTFDSYDLGINSLIELC . .||.. |. |. ||.. | .| ..|.. ||. | ...|. . |...| | . .. . | | ....| . llkmlravrrvrkeldkaePllvHcsaGvgRtGtliaiDiavrlLeetkkvdvlaiieelRkdRmalvqhpeqyellykavveya |
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| Phosphatase | F55H12.5.AA | Subfamily.N13.PD | 179-271 | 22 | 1.9e-06 | 18.3 | In-house | 155-248 (259) | Show / Hide |
Range on Protein: 179-271 Range on HMM: 155-248/259 Sequence Identity: 22% (21 aa) LHLKAIKFCRW---AEPLSAIEINDMLEKSRKYLGcpLKGPLVIVCKDGAAKSGLVAFIDTEADRLMKHGKAKHTDTIKQIRFMRSNTFDTFDSYD .. ..| .| | ||.|. .. . |. .||.|. | | .|| . ||. . . .. . . .......| | | || revahlnfvkwPdhgvPssaaelvqfvaevrllqt--dagPivvhcsaGiGrsGvlitidvvlglierdkefdvkeivrklreqrqgvvqtkdqyi |
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| Phosphatase | F55H12.5.AA | Subfamily.N20.PD | 181-279 | 21 | 2e-06 | 18.3 | In-house | 156-254 (257) | Show / Hide |
Range on Protein: 181-279 Range on HMM: 156-254/257 Sequence Identity: 21% (21 aa) LKAIKFCRWAEPLSAIEINDMLEKSRKYLGCPLKGPLVIVCKDGAAKSGLVAFIDTEADRLMKHGKAKHTDTIKQIRFMRSNTFDTFDSYDLGINSLIE .| ..| .| . . . ... | . | ||.|. | | ..|.. .| ..| . | . |.| || .| . | .. ..| vkqlqftkwpdhgtpasadsfikyiryarkshltgpmvvhcsagigrtgvflcvdvvfcaivkncsfnimdivaqmreqrsgmvqtkeqyhfcydivle |
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| Phosphatase | F55H12.5.AA | Subfamily.RA.PD | 78-144 | 28 | 3.2e-06 | 17.4 | In-house | 28-100 (266) | Show / Hide |
Range on Protein: 78-144 Range on HMM: 28-100/266 Sequence Identity: 28% (21 aa) KDKNFSENVWLYDATRVIVP------GVDYYHASWVDGLKP-NQYILAQAPRDaSAAKDFFKLLEHVKAEGLIV |.|| .. || .|||.. || ||..|| . ...| || |.. . .||.... |. ... kkknrvvqilpydfsrvilsvkeGeeesdyinasfidGyrekdkfiaaqGpke-etvedfwrmiweqksativm |
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| Phosphatase | F55H12.5.AA | Subfamily.N9.PD | 74-139 | 28 | 4.1e-06 | 17.2 | In-house | 21-94 (275) | Show / Hide |
Range on Protein: 74-139 Range on HMM: 21-94/275 Sequence Identity: 28% (21 aa) FKSP--KDKNFSENVWLYDATRVIVP------GVDYYHASWVDGLK-PNQYILAQAPRDAsAAKDFFKLLEHVKA .|.. .|| ..| || ||| .. || .|..||| | .. .|..| | . . .||.... .. sklranleknrytdvlcydetrvklakldedeasdyinanfvdGykqkkafiatqGplkk-tvsdfwrmvweqev |
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| Phosphatase | F55H12.5.AA | Subfamily.N_Choan_2.PD | 96-150 | 20 | 5e-06 | 16.6 | In-house | 40-101 (266) | Show / Hide |
Range on Protein: 96-150 Range on HMM: 40-101/266 Sequence Identity: 20% (13 aa) VP------GVDYYHASWVDGLK--PNQYILAQAPRDASaAKDFFKLLEHVKAEGLIVAEGADE .. |. | .| | . ...|| |..| ... |.|.... ..|.. .... | | leeleedsataYinAnyvrGfdgekkkYiaamgPlptt-lksfwrmiweekvtaivmttgleE |
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| Phosphatase | F55H12.5.AA | Subfamily.RC.PD | 98-168 | 26 | 6.5e-06 | 16.3 | In-house | 72-141 (288) | Show / Hide |
Range on Protein: 98-168 Range on HMM: 72-141/288 Sequence Identity: 26% (19 aa) GVDYYHASWVDGL-KPNQYILAQAPRDASaAKDFFKLLEHVKAEGLIVAEGADEFSSAITAKFEkGTGKNDF | .| ||..|. ||..|| || |.. . ||.... . |.. ... .| . |.. . ||. . gskyinasfidsykkpekyiaaqGplket-vddfwrmiferkvkvivmltelkeGdrekcaeyw-eeGkray |
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| Phosphatase | F55H12.5.AA | Subfamily.R_Nematode_3.PD | 198-266 | 24 | 7.3e-06 | 16.2 | In-house | 187-251 (267) | Show / Hide |
Range on Protein: 198-266 Range on HMM: 187-251/267 Sequence Identity: 24% (17 aa) INDMLEKSRKYlgcplKGPLVIVCKDGAAKSGLVAFIDTEADRLMKHG-KAKHTDTIKQIRFMRSNTFDT . ..... .|. | |.|. |.|| .|. |.|. . ..|. | . .. ||..| .| . . | alelikfveks-----ktpvvVHCsdGisRsatlaaielgyqliikskgkldllslikelrkqRagaiqt |
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| Phosphatase | F55H12.5.AA | Subfamily.N_Nematode_4.PD | 178-264 | 16 | 7.6e-06 | 16.2 | In-house | 160-246 (264) | Show / Hide |
Range on Protein: 178-264 Range on HMM: 160-246/264 Sequence Identity: 16% (14 aa) GLHLKAIKFCRWAEPLSAIEINDMLEKSRKYLGCPLKGPLVIVCKDGAAKSGLVAFIDTEADRLMKHGKAKHTDTIKQIRFMRSNTF | .| ... .| . .. .. ... . . ..|.|. | | .. . || |.. .. . | ....| ||.. plvvkhvqvdwwrdqvaPldaapviklykavkkkkkekPivvhcsaGvGrtatlvGidyatirirenseievldivrelramrlkav |
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| Phosphatase | F55H12.5.AA | Subfamily.N12.PD | 188-281 | 23 | 8.5e-06 | 15.8 | In-house | 171-269 (270) | Show / Hide |
Range on Protein: 188-281 Range on HMM: 171-269/270 Sequence Identity: 23% (23 aa) RWA---EPLSAIEINDMLEKSRKYLGcPLKGPLVIVCKDGAAKSGLVAFIDTEADRLMKHGKAKHT---DTIKQIRFMRSNTFDTFDSYDLGINSLIELC | | || .. ...|. |.. . . |||. | | . | . || . | .. ... | . ..| |. | . | |....||. aWPDhgvPssaksllelielvrelqe-sedaPlvvhCsaGvGrtGtiiaidyvrellkaekipeeldvfdlvlelrkqraalvqtkeqyelvykavaelv |
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| Phosphatase | F55H12.5.AA | Subfamily.N_Nematode_6.PD | 73-144 | 29 | 1e-05 | 15.9 | In-house | 20-93 (253) | Show / Hide |
Range on Protein: 73-144 Range on HMM: 20-93/253 Sequence Identity: 29% (22 aa) YFKSPKDKNFSENVWLYDATRVIVPGV-D-YYHASWVD-GLKPNQYILAQAPRDASaAKDFFKLLEHVKAEGLIV | . ||.| .|. .||.|. . . | | ||. |. . ||...| .||| ... ..|.|.. . | ... aflkfkdrnrytniqCcdagrlkladdedfyihanlvkistkprrlictqaplegt-ieefwkmilssgveyivm |
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Sequence
| Name | Sequence Type | Origin | Length | Description | Download |
|---|---|---|---|---|---|
| F55H12.5.AA | Protein | None | 287 | None | Fasta, JSON |
| F55H12.5.NA | RNA | None | 861 | None | Fasta, JSON |
| F55H12.5.AA.PD_55-282 | Protein Phosphatase Domain | None | 228 | None | Fasta, JSON |