• Phosphatome.Net

Gene VW02B12L.2

VW02B12L.2
Species: C.elegans
Alias: VW02B12L.2
External Links:
Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Superfamily: Cx5R-I
Family: Classic_PTP
Subfamily: N_Nematode_5
Protein domain

Protein domains of VW02B12L.2.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit phosphatase group/family/subfamily, which is helpful to understand the relationship between phosphatases. Transmembrane region is predicted by TMHMM 2.0. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking. View complete domain list.

Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Phosphatase VW02B12L.2.AA PTPc_motif 1-100 18 6.6e-07 27.68 SMART 12-92 (92) Show / Hide 
Range on Protein: 1-100
Range on HMM: 12-92/92
Sequence Identity: 18% (20 aa)

ET---------LPIIKMIHQFHSEQQFRSLGMCVVSTFGSGRACTFIGALYAIHQLNNGVEPNVTKNLFECFTKILFQIFEIMKTIKQQRPGAIESFPQY
.           .|...|.....        ..|..  | ||..||... ....|                     . ||...| ...||||..... ||
DHVEKDSGVPEDSILEFIRHVRK-------PIVVHCSAGCGRTGTFCAIDMMMQQ---------------------VDIFQTVKEMRKQRPGMVQTEEQY

SGVYAIVLD
  .|...|.
IFCYRCILE
Phosphatase VW02B12L.2.AA Subfamily.N_Nematode_5.PD 2-102 45 6.2e-34 107.3 In-house 171-257 (258) Show / Hide 
Range on Protein: 2-102
Range on HMM: 171-257/258
Sequence Identity: 45% (46 aa)

TLPIIK-MIHQFHSEQQFRSLGMCVVSTFGSGRACTFIGALYAIHQLNNGVEPNvtknlfecftkilfqIFEIMKTIKQQRPGAIESFPQYSGVYAIVLD
. ..|| .|....|..|... ...|||..|.|||.||.....||.|||||.|||               | ||.|.|..|||||.||. ||. |||.|||
vkkvikraiekvlskkqgknapvvvvsdlGlgRagtflllsvaieqlnngkepn---------------ideilkkirsqRpgavesliqyasvyaavld

YI
||
yi
Phosphatase VW02B12L.2.AA Y_phosphatase 2-100 22 5.4e-13 46.79 Pfam 157-243 (243) Show / Hide 
Range on Protein: 2-100
Range on HMM: 157-243/243
Sequence Identity: 22% (23 aa)

TLPIIKMIHQFHSEQQFRSLG---MCVVSTFGSGRACTFIGALYAIHQLNNGVEPNVTKNLFECFTKILFQIFEIMKTIKQQRPGAIESFPQYSGVYAIV
. .....|.|... |.    |   ..|..  |.||..||... ....|. .. ..                ||.| |.. .||||..... ||  .| ..
PKSMLDFIRQVRKWQPNPDHGCPPIVVHCSAGCGRTGTFCAIDIMCQQMEHEGTV---------------DIFQIVKHMRNQRPGMVQTEEQYIFCYQCI

LD
|.
LE
Phosphatase VW02B12L.2.AA Subfamily.N12.PD 4-102 19 8.3e-10 28.2 In-house 183-269 (270) Show / Hide 
Range on Protein: 4-102
Range on HMM: 183-269/270
Sequence Identity: 19% (19 aa)

PIIKMIHQFHSEQQFRSLGMCVVSTFGSGRACTFIGALYAIHQLNNGVEPNvtkNlfecftkilFQIFEIMKTIKQQRPGAIESFPQYSGVYAIVLDYI
.....|..... |.  .  ..|  . | ||. | |   |. ..|...  |.   .         ...|... ....||. .. .  ||. |||....  
sllelielvrelqesedaPlvvhCsaGvGrtGtiiaidyvrellkaekipe---e---------ldvfdlvlelrkqraalvqtkeqyelvykavaelv
Phosphatase VW02B12L.2.AA Subfamily.N5_RR.PD 5-102 17 1.9e-08 24.0 In-house 182-264 (265) Show / Hide 
Range on Protein: 5-102
Range on HMM: 182-264/265
Sequence Identity: 17% (17 aa)

IIKMIHQFHSEQQFRSLGMCVVSTFGSGRACTFIGALYAIHQLNNgvepnvtknlfecftKILFQIFEIMKTIKQQRPGAIESFPQYSGVYAIVLDYI
... ... ..|.. .   . |  . | ||.  ||... |..||..               .|   ...|.  ....| | ...  ||  ....  |  
lvleveesreeenaklaPvvvhcsaGiGrtGcfiaisiavrqlre---------------eivvdvlkivcnlrldrGGmvqtseqyelihralclyl
Phosphatase VW02B12L.2.AA Subfamily.RA.PD 5-102 23 5.4e-07 19.2 In-house 182-265 (266) Show / Hide 
Range on Protein: 5-102
Range on HMM: 182-265/266
Sequence Identity: 23% (23 aa)

IIKMIHQFHSEQQFRSL-GMCVVSTFGSGRACTFIgalyAIHQLNNGVEpnvtknlfecfTKILFQIFEIMKTIKQQRPGAIESFPQYSGVYAIVLDYI
..|.... .. ||  .   . |  . | ||. |||    .. .. . |.           .. . ..||..|....|||  ...  ||  .| ..|.||
mlkllkkvkklqqqsanhpivvhcsaGvGrtGtfi----vldavlervk-----------aerkldvfeavkrlrlqrpqmvqtleqyefiykvlleyi
Phosphatase VW02B12L.2.AA Subfamily.R_Ecdysozoa.PD 6-102 23 1.3e-06 17.8 In-house 182-268 (269) Show / Hide 
Range on Protein: 6-102
Range on HMM: 182-268/269
Sequence Identity: 23% (24 aa)

IKMIHQFHSEQQFR-----SLGMCVVSTFGSGRACTFIGALYAIHQLNNgvEPNVtknlfecftkilfQIFEIMKTIKQQRPGAIESFPQYSGVYAIVLD
.|.|.| .. ...         . |    |.||. .|.     ..||..  | .|             .|||..| ...||.  ..|. ||. .|  ..|
lklieqvrelyklnklsgsrsPivvhCsaGvgrsgifvaldlllqqlka--edkv-------------difetvkkLrsqrnllvqsleqyvflyralad

YI
|.
ys
Phosphatase VW02B12L.2.AA Subfamily.N_Nematode_4.PD 3-101 16 5.6e-06 15.9 In-house 181-262 (264) Show / Hide 
Range on Protein: 3-101
Range on HMM: 181-262/264
Sequence Identity: 16% (16 aa)

LPIIKMIHQFHSeqQFRSLGMCVVSTFGSGRACTFIGALYAIHQLNNgvEPNVtknlfecftkilfQIFEIMKTIKQQRPGAIESFPQYSGVYAIVLDY
|.||..   .   . ..  ..|  . | ||..|..|  ||  ....   ...             .. .|.. ... | .|.|  |.  .. .....  
apviklykavkk--kkkekPivvhcsaGvGrtatlvGidyatirire--nsei-------------evldivrelramrlkavqshlqflfllvvliel
Phosphatase VW02B12L.2.AA Subfamily.N13.PD 4-100 17 5.8e-06 16.0 In-house 176-256 (259) Show / Hide 
Range on Protein: 4-100
Range on HMM: 176-256/259
Sequence Identity: 17% (17 aa)

PIIKMIHQFHSEQQfRSLGMCVVSTFGSGRACTFIgALYAIhqlnngvepnvtKN-----LfecftkiLFQIFEIMKTIKQQRPGAIESFPQYSGVYAIV
...... . .. |.  .. . |  . | ||. ..| .....             .              |.. ||......|| | . .  |||| ..|.
elvqfvaevrllqt-dagPivvhcsaGiGrsGvli-tidvv------------lglierdk-------efdvkeivrklreqrqgvvqtkdqyifvykai

LD
  
le
Phosphatase VW02B12L.2.AA Subfamily.R_Anemone_1.PD 68-102 30 6.4e-06 16.0 In-house 223-257 (258) Show / Hide 
Range on Protein: 68-102
Range on HMM: 223-257/258
Sequence Identity: 30% (10 aa)

FQIFEIMKTIKQQRPGAIESFPQYSGVYAIVLDYI
||...|.|...|| ....  ||. .. .||...  
vDifnyvkairedrphmvqtkeqyvfihlavleal
Phosphatase VW02B12L.2.AA Subfamily.RK.PD 6-102 24 6.8e-06 15.4 In-house 184-266 (267) Show / Hide 
Range on Protein: 6-102
Range on HMM: 184-266/267
Sequence Identity: 24% (24 aa)

IKMIHQFHSEQQFRSLGMCVVS-TFGSGRACTFIgalyAIHQLNNGVEpnvtknlfeCftKILFQIFEIMKTIKQQRPGAIESFPQYSGVYAIVLDYI
.|.|.. .. |.  . |  ||  . |.||. |||    ||. . . .|         .  . .  .|...||......  .|   ||  || ..|...
lklirrvkksqeeeeeGrivvhClaGaGrsGtfi----aidivlemie---------r--egvvdvfnavktlrnrkvnmveteeqykfvydvileal
Phosphatase VW02B12L.2.AA Subfamily.RG.PD 5-102 20 8.2e-06 15.4 In-house 181-263 (264) Show / Hide 
Range on Protein: 5-102
Range on HMM: 181-263/264
Sequence Identity: 20% (20 aa)

IIKMIHQFHSEQQFRSLGMCVVSTFGSGRACTFIgalyAIHQLNNGVEPNVTKNlfecftkilfqIFEIMKTIKQQRPGAIESFPQYSGVYAIVLDYI
. ....    .. ..  . |.   |.|||.|.|    |.  | . .| . . |           .....|.|...||| ...  ||  .| ..|. . 
vlifvkkeeaankeeaGPivvhdsaGvgragtyi----aldtllqqlekeeavn-----------vyqvlklirakRpglvtteEqyvfiydallelv
Sequence
Name Sequence Type Origin Length Description Download
VW02B12L.2.AA Protein None 143 None Fasta, JSON
VW02B12L.2.NA RNA None 429 None Fasta, JSON
VW02B12L.2.AA.PD_1-100 Protein Phosphatase Domain None 100 None Fasta, JSON