Gene Y22D7AR.1+2
Y22D7AR.1+2
Species: C.elegans
Alias: Y22D7AR.1+2
External Links:
Classification
Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.
Protein domain
Protein domains of Y22D7AR.1+2.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit phosphatase group/family/subfamily, which is helpful to understand the relationship between phosphatases. Transmembrane region is predicted by TMHMM 2.0. Visualized by pviz.
Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking. View complete domain list.
| Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
|---|---|---|---|---|---|---|---|---|---|
| FTH | Y22D7AR.1+2.AA | FTH | 52-192 | 32 | 6.7e-46 | 163.61 | Pfam | 1-149 (149) | Show / Hide |
Range on Protein: 52-192 Range on HMM: 1-149/149 Sequence Identity: 32% (49 aa) RQDIDAFLMCISKR-EKCVNLKRLMFERLSINDILFLIPFFNFQVLQF----WYSDTKDRFERITHLNQWGNTKSFG-LWDSALDSKLIERLFHFETISV |... . . | .||.. |.. ....| ||.. ..|.|. ..|. |.. | ||.|....|| | |.| .| . .... || .|||| ... REKCFEWFKNMLKSLKKCIHVKKISLWGFSFNDVASILPCFDPGTLEEIHIHWCE-DIDQFEEIVCMEQWKNAKKFHIIWWFCFFCFPIEHFFHFEHFDI -GIRRFTVKTAIKIRDNLLKRSTFKQCII--RHTSRNYLNLAKVFKPDYV ...|.| ||||||.|.|.|.|..|.| .. . | ..|.||.|||. YHLDSFSVQDAIKIRDMLMKSSHFQSCYIYFWFPNWNPIEIARVFDPDYE |
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| WSN | Y22D7AR.1+2.AA | WSN | 227-295 | 44 | 9.5e-29 | 106.38 | Pfam | 1-72 (72) | Show / Hide |
Range on Protein: 227-295 Range on HMM: 1-72/72 Sequence Identity: 44% (32 aa) DGFKSSLTKMQMISRITTGIYLQHGLSTGSITSDDLIPELLHFGSITPTQISAINT---DKLSKIVEGINEL . .. .. .||||||.|.|||||.||..||| .||.| |||..||... || .|.. ||.........|| SNLQTIYERMQMISRVTNGIYLQQGLIDGSIPIDDVIAELLNIGSGNFSQIMNIDPDKLDKIDEHINKMHEL |
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| WSN | Y22D7AR.1+2.AA | WSN | 227-298 | 40 | 3.3e-28 | 100.96 | SMART | 1-72 (72) | Show / Hide |
Range on Protein: 227-298 Range on HMM: 1-72/72 Sequence Identity: 40% (29 aa) DGFKSSLTKMQMISRITTGIYLQHGLSTGSITSDDLIPELLHFGSITPTQISAINTDKLSKIVEGINELPGK . . .. .|||..|.|..||||.||. ||| .||.| |||..|.|.|.|.|.|......||....|.. . SKLQTIIENMQMLARVTNAIYLQAGLINGSIPIDDVIAELLNIGTIDPVQFSDIMNVDPTKIDKWMNKMKER |
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| Phosphatase | Y22D7AR.1+2.AA | PTPc | 1046-1271 | 14 | 4.8e-10 | 13.63 | SMART | 1-308 (308) | Show / Hide |
Range on Protein: 1046-1271
Range on HMM: 1-308/308
Sequence Identity: 14% (49 aa)
KVESFSLTLLVAI------------KYVTDLHLV-----------SIPLIENTRVILKKYGSR----FKDGFLHANYVTCP-NGAQLILTQSPQCEILEP
... .| . . . . || .. |||.||. .. . ... .|||. .. .. . |.|| |.
GFWEEFERLQRMTPWDLMSNYDPCCSCTCACWPENREMDKNRYKCDIPCYDHTRVKLKPPPGESHCYEGSDYINANYIDGYWRPKRYICTQGPL------
KLAMKGDKHAEMMPRRNSTIGK------QEKAQQIVMMCDVVER---SIQTGRIVEMCSRYFPEKVNCEIKVDGINVECTAKVTSD-GVERRSLRVTFEL
.|| |.| ..|||.|. .|. .. .| | .|.|.. . . ..| |.|. ... . .. .| ..||.
----------------PHTIEDFWRMVWQQKCHIIVMLCNCMEKCTENR-DQNGREKCHQYWPDE---PMTYGHITVTCKSEEKCPDDYTMRTFEVTNTG
V---FSLVKNGDTIFVTHNLISSWTFVNTQETTDTMVSMVRYLNKCKG----------------------SPIVVHDFDGISRSASLA------------
. . ..| .||| .| .. |..| . ...|. .... .||||| .|..|.....
CNCKY-SMACSETRTVTHYHYTNWPDHGVPESPDSFLDFIRQVRHWQSHSPNMYMNMVSSNSKYHHTCPTGPIVVHCSAGCGRTGTFCAIDIMCQQIENV
----------------------------------C
DIFQIVKMMRNQRPGMVQTEEQYIFCYRCILEYIK
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| Phosphatase | Y22D7AR.1+2.AA | Subfamily.R_Nematode_3.PD | 1053-1271 | 43 | 8.9e-74 | 237.6 | In-house | 21-217 (267) | Show / Hide |
Range on Protein: 1053-1271 Range on HMM: 21-217/267 Sequence Identity: 43% (96 aa) TllvaiKYVTDLHLVSIPLIENTRVILKKYGSRFKDGFLHANYVTCPNGAQLILTQSPQCEILEPKlamkgdkhaemmprRNSTIGK------QEKAQQI . |.|.. . |..||.|.|||.||.||.||||.|.|||.|.||||..||||||||....|.| ..||| | |||..|. s-----kkvsedrrvevpllektrvvLkgygkrfkddfihAnvvecpnglklIltqsPqkkdkekk--------------kkstieKfwwmieqekveqv VMMCDVVErsiQTGRIVEMCSRYFPEKVNCEIKVDGINVEC--TAKVTSDGVERRSLRVTFElvfslvkNGDTIFVTHNLISSWTFVNTQETTDTMVSMV ||.||.|| ..|. .|.||.|.||||..|.|..|..|.| ..| .|..||.|.|.||||..... |||.|...|. |..|.............|.| vmlcdfve---edgeeeekcseYypekvdgelkfegvsvkctdikkelsedvekrtlvvtfe-------kkkeftvthllykgWkelnapeepkealeli RYLNKCKgSPIVVHDFDGISRSASLAC .|.|||..|||||||.||. kfveksk-tpvvVHCsdGisRsatlaa |
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| Phosphatase | Y22D7AR.1+2.AA | Y_phosphatase | 1140-1271 | 23 | 6.6e-20 | 71.11 | Pfam | 67-197 (243) | Show / Hide |
Range on Protein: 1140-1271 Range on HMM: 67-197/243 Sequence Identity: 23% (33 aa) QEKAQQIVMMCDVVERSIQTGRIVEM-CSRYFPE-KVNCEIKVDGINVECTAKVTSDGVERRSLRVTFEL-VFSLVKNGDTIFVTHNLISSWTFVNTQET |.| . |||.|...|.. |. |..|.|. |.. ... ... |.|. . . ... | ..||. ...| .||| .|. .. |. QQKCTCIVMLCNCMEMGR-----DEKTCHQYWPDNKEGQPMTYGDFQVTCVSEEHCPDYTVRTFEVTN-GDQ-----KQETRTVTHYHYTNWPDHGVPES -TDTMVSMVRYLNKCKGS------PIVVHDFDGISRSASLAC .. |....|...|.... ||||| .|..|.. ... QPKSMLDFIRQVRKWQPNPDHGCPPIVVHCSAGCGRTGTFCA |
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| Phosphatase | Y22D7AR.1+2.AA | Subfamily.N_Nematode_4.PD | 1069-1269 | 27 | 6.9e-16 | 47.8 | In-house | 35-213 (264) | Show / Hide |
Range on Protein: 1069-1269
Range on HMM: 35-213/264
Sequence Identity: 27% (54 aa)
IPLIENTRVILKKYGSrfKDGFLHANYVTCPNGAQLILTQSPQCEILEpklamkgDkHAEMMprrnstigKQEKAQQIVMMCDVVERSiqtgriVEMCSR
| |..|||.||. . ..||.... |.. . | || | | |. | |. .||.. .||.|| .| || |.|
ilcidetrvvlknrdp--dndyihaswmrmPdkfryistqGPlketls-------d-fwhmv--------ytekiavvvmlcdlieeg------vekcar
YFPEKVNCEIKVDGINVECTAKVTS--DGVERRSLRVTFELvFSLVKNGDTIFVTHNLISSWTFVNTQETTDTMVSMVRYLN-KCKGSPIVVHDFDGISR
|.||| . |. ... . | . .| .||.|| .. . . ..| | .. |. ... ... . .... | | .||||| |. |.|.|
yypeksekvvkfGkyritlvekkeeviadvilnslkvtnte-kkkdapseplvvkhvqvdwwrdqvaPldaapviklykavkkkkkekPivvhcsaGvGr
SASL
tatl
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| Phosphatase | Y22D7AR.1+2.AA | Subfamily.R_Nematode_2.PD | 1068-1269 | 24 | 2.8e-14 | 42.5 | In-house | 37-210 (261) | Show / Hide |
Range on Protein: 1068-1269 Range on HMM: 37-210/261 Sequence Identity: 24% (51 aa) SIPLIENTRVILKKYGSRFKdgfLHANYVTCP-NGAQLILTQSPQCEILEPKLAMkgdkhaemMprrnstigKQEKAQQIVMMCDVVERsiqtgrIVEMC ..| ..|.| . | | .|||.| . | . | ||.| . | || . ||| ..|||.| .||. |.| dvPCkpetavevivdgkrvp---ihanwvptagnpkrfiatqgPlentsedfWam--------v--------iqekvekivmlcqkvek------ekekc SRYFPEKVNCEIKVDGINVECT--AKVTSDGVERRSLRVTFElvfslVKNGDTIFVTHNLISSWTFVNTQETTDTMVSMVRYLNKCKgSPIVVHDFDGIS ..||| ... ..... .... . |. .| .|.|.|.|. . .. .| ||| ..|. .. .. . . .. . | . ||||| || eeYfpletsqkldlgrfsiktvsaekilkdeiekrtlkveds-----tgkfatrtvthyqyeeWpdrgvPkshaelfeLlelvkkse-kPivvhCsaGiG RSASL |. .. Rtmaf |
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| Phosphatase | Y22D7AR.1+2.AA | Subfamily.N_Nematode_1.PD | 1069-1269 | 22 | 9.3e-12 | 34.2 | In-house | 35-213 (265) | Show / Hide |
Range on Protein: 1069-1269
Range on HMM: 35-213/265
Sequence Identity: 22% (44 aa)
IPLIENTRVILKKYGSrfKDGFLHANYVTCPNG-AQLILTQSPQCEILEPKLAMkgdkhaemMprrnstigKQEKAQQIVMMCDVVERSiqtgRivEMCS
.. ....||.|.. .. ..|||||..| ..| .|.| . .. .| . ||| ..|||.|...|.. . |.
vgcldknrvklaeepl--psdyihanyvgtptnpkrficaqaPldktiadfwym--------v--------lqekveaivmlckliekg----k--kkca
RYFPEKVNCEIKVDGINVECTA-KVTSDGVERRSLRVTFELVFSLVKNG-DTIFVTHNLISSWTFVNTQETTDTMVSMVRYLNKCKgSPIVVHDFDGISR
||| | . ..... . ..| .... .. | . |... .| .| ||| . |.. ... .. .. | .||||| || |. ..
eyfpakegeklefkekgqkitvenslgvkkleedeevikvtvlevegaGektrkvthyqWtdWPdrGvPpadlaalelleavrgsk-gPivvhCsaGiGr
SASL
tGti
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| Phosphatase | Y22D7AR.1+2.AA | Subfamily.N5_RR.PD | 1073-1266 | 22 | 1.1e-10 | 30.8 | In-house | 36-211 (265) | Show / Hide |
Range on Protein: 1073-1266
Range on HMM: 36-211/265
Sequence Identity: 22% (43 aa)
ENTRVILKKYGSRFK-DGFLHANYVTCPNGAQ--LILTQSPQCEILEPKLAMKGdkhaemmprrnstigkQEKAQQIVMMCDVVERSIQtgriveMCSRY
||.||.|.. |. . .. |||. ... . . || | . .. | ||..| |||. .. |. ||..|||.. ..
ensrvllesessededssyinanyikGydeeskayvatqGPlpntiadfWrmiy----------------qeevqvivmltklkeanrq------kcavy
FPEKVNCEIKV--DGINVECTAKVTSDGVERRSLRVTFELVfsLVKNgdtifVTHNLISSWTFVNTQETTDTMVSMVRYLNKC------KGSPIVVHDFD
||. ...... . .|. .. . |.| ... . .. |.| . ..| .. . ..|....|... | .|.||| || |
fPdaedyeiserygdveikveeiverndysvrklvlkyler--vers-----vkhywytdWPdhksPddintlldlvleveesreeenaklaPvvvhcsa
GISRS
GiGrt
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| Phosphatase | Y22D7AR.1+2.AA | Subfamily.N_Choan_2.PD | 1074-1267 | 21 | 1.9e-10 | 29.8 | In-house | 35-213 (266) | Show / Hide |
Range on Protein: 1074-1267 Range on HMM: 35-213/266 Sequence Identity: 21% (43 aa) NTRVILKKYGSRFKDGFLHANYVTCPNG--AQLILTQSPQCEILEPKLAMKGDKHAemmprrnstigkqekaQQIVMMCDVVERsiqtGRivEMCSRYFP .|||.|.. . . .. |||| .| .. | ...|. |. . | .... . |||. ...|.|| . |.||.|.... atRvrleeleedsataYinAnyvrGfdgekkkYiaamgPlpttlksfwrmiweekv----------------taivmttgleEk----gr--kkCerYWp EKVNCEIKV--DGINVECTAKVTSDGVERRSLRVTfelvfslvKNGDTIFVTHNLISSWT---FVNTQE---TTDTMVSMVRYLNKCK-----GSPIVVH ..|. |.| .... ..| .. ||.. |.|.| ..| .| ......|| ...|.| ... . ..|..||. .|. | aepkekvkladgkikvlalseekeegyiltrlrle--------kkgetrrlvHfwyntWpdhgvpreedsslstdqllkmlravrrvrkeldkaePllvH DFDGISRSA . csaGvgRtG |
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| Phosphatase | Y22D7AR.1+2.AA | Subfamily.N_Nematode_egg.PD | 1048-1269 | 24 | 5.5e-10 | 28.5 | In-house | 14-204 (257) | Show / Hide |
Range on Protein: 1048-1269
Range on HMM: 14-204/257
Sequence Identity: 24% (52 aa)
ESFSLTLLVAIKYVTDLHLVSIPLIENTRVILKKYGSRFKDGFLHANYVTC-PNGAQLILTQSPQCEILEpklamkgdKHAEMMprrnstigKQEKAQQI
. ||| .. | . .. | .|| |. .. | |.|||.| | ..||.|.| . ||. ||| | |||. .|
deislttaasdnylekarskrvhckessrvklelrrGqylddfihanrvkGkpllnefilaqaplkntve--------dfwrmv--------fqekvqyi
VMMCDVVERsiqtgrivEMCSRYFPEKVNCEIKV--DGINVECTaKVTSDgvERRSLRVTFELVfsLVKNGDTIFVTHnliSSWTFVNTQEtTDTMVSMV
| | |.| . ... ....|. || | .|||. . . . |. | . . .. . . . ..| | . |.||.|
vmltsakes--------erceyywpkaeseslvtvpGslrienl-kvdsk--adplfrvtklkl--vGgddeelfleh---wqgdvnylsd-vysplrvl
RYLNKcKGSPIVVHDFDGISRSASL
..|.|..|.|
rklrn-lskpvvvqdilGvskaatl
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| Phosphatase | Y22D7AR.1+2.AA | Subfamily.N12.PD | 1073-1268 | 20 | 6.8e-08 | 21.4 | In-house | 45-215 (270) | Show / Hide |
Range on Protein: 1073-1268 Range on HMM: 45-215/270 Sequence Identity: 20% (40 aa) ENTRVILKKYGSRFKDGFLHANYVTCPNGA-QLILTQSPQCEILepklamkgDKHAEMMPRRNSTIgkqekaqqIVMMCDVVERsiqtGRIveMCSRYFP ...||.|.| . ..... ||.. ..| . | .|.| . | | . |. | .| .||.| .|| |..| ||.||.. dksrvelskieeeegsdyinanfikgvegkleyiaaqgPLpktl--------ddfWrmiweknvei--------vvmaCrevel----gkk--kCeryWp EKVNCEIKVDGINVECTAK-VTSDGVERRSLRVTFElvfslvknGDTIFVTHNLISSWTFVNTQETTDTMVSMVRYL---NKCKGSPIVVHDFDGISRSA . |.... ..|..... ..|. |.|.|... ... |. .| .. ........... . ... .|.||| |. | eegeeelefgefevtleeekavdddflirtLkveaq--------kesrkvyqfhytaWPDhgvPssaksllelielvrelqesedaPlvvhCsaGvGrtG S t |
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| Phosphatase | Y22D7AR.1+2.AA | Subfamily.RB.PD | 1140-1266 | 24 | 8e-08 | 21.4 | In-house | 91-207 (261) | Show / Hide |
Range on Protein: 1140-1266 Range on HMM: 91-207/261 Sequence Identity: 24% (32 aa) QEKAQQIVMMCDVVERsiqtGRivEMCSRYFPEKVNCEIkVDGINVECTAKVTSDGVERRSLRVTfelvfslvKNGDTIFVTHNLISSWTFVNTQETTDT ..|.. |||. .||. |. | | .|.|.. . . |.|. .|. . | |..... |. .. |.. ||... |.|.|.. ekkssiivmltqlvEk----gk--ekceeYWPadeepvl-yGdikvtllaekeldewvirefkie--------kgkekrkvrqyhftsWpdhgvPektkt MVSMVRYLNK-----CKGSPIVVHDFDGISRS ..|| ... .. .||||| |. |. lldfvrtvreaiekkaskkPivvHCsaGvGRt |
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| Phosphatase | Y22D7AR.1+2.AA | Subfamily.N3.PD | 1139-1267 | 23 | 2.3e-07 | 19.8 | In-house | 90-208 (261) | Show / Hide |
Range on Protein: 1139-1267 Range on HMM: 90-208/261 Sequence Identity: 23% (30 aa) KQEKAQQIVMMCDVVERsiqtGRIveMCSRYFPEKVNcEIKVDGINVECTAKvtsdgvERRSLRVTFELVFSLVKNGDTIFVTHNLISSWTFVNTQETTD ...|.. |||. ..||| ||. | .|.||. . |.. ...|.|. . .... |. ||| . .. . ... .|.. . .. . weqkstlivmlttlver----Grv--kChqyWPeted-elefgefsvrceke------detksyvlrelvlkdketkeerkilqlqylaWpdhgvPddsa TMVSMVRYLNKCK---GSPIVVHDFDGISRSA ...|. ..|.. .|.||| || |. dflefvervrklrsgkeePvvvhCsaGigrtG |
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| Phosphatase | Y22D7AR.1+2.AA | Y_phosphatase | 1069-1111 | 33 | 4.9e-07 | 25.81 | Pfam | 10-54 (243) | Show / Hide |
Range on Protein: 1069-1111 Range on HMM: 10-54/243 Sequence Identity: 33% (15 aa) IPLIENTRVILKKYGSRFKDGFLHANYVTCP--NGAQLILTQSPQ || ..|||.|. ..... . . .|||.. | |. . |.|| |. IPCYDHTRVKLQPIPGDEDSDYINANYIDGPYWNPKAYICTQGPM |
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Sequence
| Name | Sequence Type | Origin | Length | Description | Download |
|---|---|---|---|---|---|
| Y22D7AR.1+2.AA | Protein | None | 1271 | None | Fasta, JSON |
| Y22D7AR.1+2.NA | RNA | None | 3813 | None | Fasta, JSON |
| Y22D7AR.1+2.AA.PD_1046-1271 | Protein Phosphatase Domain | None | 226 | None | Fasta, JSON |