• Phosphatome.Net

Gene F54C8.4

F54C8.4
Species: C.elegans
Alias: F54C8.4
External Links:
Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Superfamily: Cx5R-I
Family: DSP
Subfamily: DSP11
Protein domain

Protein domains of F54C8.4.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit phosphatase group/family/subfamily, which is helpful to understand the relationship between phosphatases. Transmembrane region is predicted by TMHMM 2.0. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking. View complete domain list.

Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Phosphatase F54C8.4.AA Subfamily.DSP11.PD 44-184 51 6.1e-65 207.5 In-house 2-141 (141) Show / Hide 
Range on Protein: 44-184
Range on HMM: 2-141/141
Sequence Identity: 51% (72 aa)

KEQRFTTNDLFRQLSERGQYLGLVVDLSDTDRYYDKKDITGMCVQYEKVNCPGRGFIERDDcVESFHQVIQDYTDKCDDPDALIGVHCTNGINRCGYLIC
.|.||...||...|.|....||||.||..|||||.||..| ..|.|.|.||||. ..|..| |..|.........|..| |.|||||||.|.||.|||||
eeerfapedlleklqeknkklGLvidltntdryykkkeltdegvkykklncpGhevpeked-vkkfkeavkefleknkdndkligvhCthGvnrtGyliC

RFLIDRLGWSSHEAIDAFEQARGYSIEKGAYVMALHKAAKD
|.|||. |.|...||.|||.|||.|.|. .|...|.|.|||
rylidvegyspedaieafeearGhslerenyledLkklakd
Phosphatase F54C8.4.AA Subfamily.RNGTT.PD 45-182 37 9.3e-37 116.0 In-house 2-137 (140) Show / Hide 
Range on Protein: 45-182
Range on HMM: 2-137/140
Sequence Identity: 37% (51 aa)

EQRFTTNDLFRQLSERGQYLGLVVDLSDTDRYYDKKDITGMCVQYEKVNCPGRGFIERDDCVESFHQVIQDYTDKcdDPDALIGVHCTNGINRCGYLICR
|..|... |.  |... . ||||.|| .|.|||||....   |.| |..| |||     . ...| ........|   || .|||||| ||| |.||. .
eeafepemlksylktlkvklglvidltntsryydkeelekegvkyiklqcrGrGeaPtkeqtklfiklvkeflkk--kPdevigvhCthGfnrtGfliva

FLIDRLGWSSHEAIDAFEQARGYSIEKGAYVMALHKAA
|.... || ..|.. | .||   | |  |.  | |   
yLvekedwsveaavalfakarppGiykedylkelfkry
Phosphatase F54C8.4.AA Family.DSP.PD 106-187 24 7.4e-15 45.3 In-house 170-249 (387) Show / Hide 
Range on Protein: 106-187
Range on HMM: 170-249/387
Sequence Identity: 24% (20 aa)

VesFHQVIQdYTDKCDDPDALIGVHCTNGINRCGYLICRFLIDRLGWSSHEAIDAFEQARG-YSIEKGAYVMALHKAAKDKRD
.  | ..|. ......|.   . |||. |..| | ||. .|. . |.. .||.| . ..|    . .  ..  |..  | |. 
l--fekaid-fieegndskgvVlVHCkaGkgRsgtliiaYlmksegltleealdwvrskRpgvitpnqgflkqlkdlekeklk
Phosphatase F54C8.4.AA DSPc 127-166 30 4.1e-08 30.15 Pfam 88-133 (151) Show / Hide 
Range on Protein: 127-166
Range on HMM: 88-133/151
Sequence Identity: 30% (14 aa)

IGVHCTNGINRCGYLICRFLIDRLGWSSHEAIDAF-----EQAR-G
. |||. ||.| ..|....|... ..|. ||.| .     .| | .
VLVHCQAGISRSACLCIAYLMKYRNMSYNEAYDFVYIYHMKQRRCP
Phosphatase F54C8.4.AA Subfamily.DSP23.PD 106-171 26 5.3e-08 23.2 In-house 52-113 (128) Show / Hide 
Range on Protein: 106-171
Range on HMM: 52-113/128
Sequence Identity: 26% (17 aa)

VESFHQVIqdytDKCDDPDALIGVHCTNGINRCGYLICRFLIDRLGWSSHEAIDAFEQARGYSIEK
|. . ...    .. .. .  .||||  |. | | |.  .|.   | .. .||    . |  ||| 
varlvriv----eeaekkeeavgvhcalGlGrtGtllacylvkeeglaaddaiaevrkrrkGsiet
Phosphatase F54C8.4.AA Subfamily.CDC14.PD 110-165 26 1.4e-07 21.6 In-house 184-239 (258) Show / Hide 
Range on Protein: 110-165
Range on HMM: 184-239/258
Sequence Identity: 26% (15 aa)

HQVIQDYTDKCDDPDALIGVHCTNGINRCGYLICRFLIDRLGWSSHEAIDAFEQAR
..... ... ... .  | |||  |. | |.||  .|| . . . .|.|  .  ||
dailkkfleitekaeGaiavhCkaGLGrtgtligcylikhyrftaaetiawlriar
Phosphatase F54C8.4.AA Subfamily.PTEN.PD 109-166 24 1.7e-07 21.0 In-house 81-137 (305) Show / Hide 
Range on Protein: 109-166
Range on HMM: 81-137/305
Sequence Identity: 24% (14 aa)

FHQVIQDYTDKcdDPDALIGVHCTNGINRCGYLICRFLIDRLGWSSH-EAIDAFEQARG
. . .. . ..  | .  . |||  |  | | .|| .|. ..  .|  ||.. ....| 
ivedvdkwLke--dksnVvavHCkaGkGRtGvmicayLlksgikksadealaiydekRt
Phosphatase F54C8.4.AA Subfamily.PTPDC1.PD 126-178 32 2.4e-07 20.6 In-house 168-220 (229) Show / Hide 
Range on Protein: 126-178
Range on HMM: 168-220/229
Sequence Identity: 32% (17 aa)

LIGVHCTNGINRCGYLICRFLIDRLGWSSHEAIDAFEQARGYSIEKGAYVMAL
|.|||  |  | | ||. .|.     ...|||.   . |  ||     |  . 
kiavHCHAGlGRtGvliacylvyakrltaeeaiklvrskrpksiqtreqvelv
Phosphatase F54C8.4.AA Subfamily.DSP12.PD 104-165 14 2.7e-07 21.0 In-house 62-122 (143) Show / Hide 
Range on Protein: 104-165
Range on HMM: 62-122/143
Sequence Identity: 14% (9 aa)

DCVESFHQViQDYTDKCDDPDALIGVHCTNGINRCGYLICRFLIDRLGWSSHEAIDAFEQAR
| .. . ..  .. ... . .  . |||. |. |   ..  .|. . ..| ..|... ....
dlLshldea-vrFieeglekegavlvHClagvSRSvtiviAYlmkkeklslekAlklvkekk
Phosphatase F54C8.4.AA Subfamily.PRL.PD 100-170 20 3.9e-07 20.1 In-house 59-126 (140) Show / Hide 
Range on Protein: 100-170
Range on HMM: 59-126/140
Sequence Identity: 20% (14 aa)

IERDDCVESFHQVIQDYTdkCDDPDALIGVHCTNGINRCGYLICRFLIDRlGWSSHEAIDAFEQARGYSIE
.. |... .....    ...|.. ..|||  |. |.  |..  ||.  | ....|..   . |  .|.   
vPpkevvdeWlellkekf--keepkstvavhcvaGlGraPvlvalaliea-Gmkyedavefirekrrgain
Phosphatase F54C8.4.AA Subfamily.DSP1.PD 103-166 25 7.2e-07 19.5 In-house 59-121 (139) Show / Hide 
Range on Protein: 103-166
Range on HMM: 59-121/139
Sequence Identity: 25% (16 aa)

DDCVESFHQVIqDYTDKCDDPDALIGVHCTNGINRCGYLICRFLIDRLGWSSHEAIDAFEQARG
|  . |...| |. |.. . .  . |||  || |   ..  .|. .  .. .|| .   | |  
adisslfeeai-dfidsvkkkgGrvlvhCqaGisrsativlayLmkekkvrleeafefvkqrrs
Phosphatase F54C8.4.AA Subfamily.TPIP.PD 109-162 25 3.8e-06 16.8 In-house 24-76 (245) Show / Hide 
Range on Protein: 109-162
Range on HMM: 24-76/245
Sequence Identity: 25% (14 aa)

FHQVIQDYTDKcdDPDALIGVHCTNGINRCGYLICRFLIDRL-GWSSHEAIDAFE
| . .... .|  |.. .. .||  | .| | ..| .||       ..|..| | 
ftkevkewlak--dlenvvaihckGGkgrtGtivcalliaseifltaeesldyfg
Phosphatase F54C8.4.AA DSPc 54-184 15 6e-06 7.04 SMART 1-172 (172) Show / Hide 
Range on Protein: 54-184
Range on HMM: 1-172/172
Sequence Identity: 15% (26 aa)

FRQLSERGQYLGLVVDLS-DTDRYYDKKDIT-GMCVQ---------------------------YEKVNCPGRGF-------IERDDCVESFHQVIQDYT
  .    ..|||   . . .  .  .|..||  ..|.                           .. ...|   .        . .. .  | .|. |. 
GPSEITPHLYLGSYPHHMEPNPCFLKKHNITHVINVTMECPWNFHHCQKNDMHYTNEWIYHNSHFQYMHIPMIDDIYYHIRWNHCTNISQYFPEVY-DFI

DKCDDPDALIGVHCTNGINRCGYLICRFLIDRLGWSSHEAIDAF-----EQARGYSIEKG-AYVMALHKAAKD
..|      . |||  ||.| ..|.. .|... ..|...|....      |.|  .|     ..  |.   . 
HDCRQKGGKVLVHCQAGISRSATLCIAYLMKYMNMSYNDAYHFVYIYHIKQRRCPIICPNFNFWHQLCEWERK
Sequence
Name Sequence Type Origin Length Description Download
F54C8.4.AA Protein None 359 None Fasta, JSON
F54C8.4.NA RNA None 1077 None Fasta, JSON
F54C8.4.AA.PD_54-184 Protein Phosphatase Domain None 131 None Fasta, JSON