Gene pir-1
pir-1
Species: C.elegans
Alias: pir-1
External Links:
Classification
Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.
Protein domain
Protein domains of pir-1.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit phosphatase group/family/subfamily, which is helpful to understand the relationship between phosphatases. Transmembrane region is predicted by TMHMM 2.0. Visualized by pviz.
Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking. View complete domain list.
| Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
|---|---|---|---|---|---|---|---|---|---|
| Phosphatase | pir-1.AA | DSPc | 85-231 | 19 | 3e-44 | 154.23 | SMART | 1-172 (172) | Show / Hide |
Range on Protein: 85-231 Range on HMM: 1-172/172 Sequence Identity: 19% (34 aa) DGKNMPVELQFGVKTLIS---LAQQANKQIGLVIDLT------------NTDRYYKKTEWADHGVKYLKLNCP-GHE-----VNEREDLVQDFINAVKEF . .... .|..| .. .. ........| .||..| | |..| ..||..|. ... ...| .. ...... .......|..| GPSEITPHLYLGSYPHHMEPNPCFLKKHNITHVINVTMECPWNFHHCQKN-DMHY-TNEWIYHNSHFQYMHIPMIDDIYYHIRWNHCTNISQYFPEVYDF VNDKENDGKLIGVHCTHGLNRTGYLICRYMIDVDNYSASDAISMF-----EYYR-GHPMEREHYKKSLYEAERK ..| ...|. . ||| .|..|...|.. |... .|.|..||.... ..| .. .. ......|.| ||| IHDCRQKGGKVLVHCQAGISRSATLCIAYLMKYMNMSYNDAYHFVYIYHIKQRRCPIICPNFNFWHQLCEWERK |
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| Phosphatase | pir-1.AA | Subfamily.DSP11.PD | 91-230 | 60 | 3e-68 | 219.4 | In-house | 2-140 (141) | Show / Hide |
Range on Protein: 91-230 Range on HMM: 2-140/141 Sequence Identity: 60% (84 aa) VELQFGVKTLISLAQQANKQIGLVIDLTNTDRYYKKTEWADHGVKYLKLNCPGHEVNEREDlVQDFINAVKEFVNDKENDGKLIGVHCTHGLNRTGYLIC .|..|....|.. .|..||..|||||||||||||||.|..|.|||| |||||||||.|.|| |..|..|||||........||||||||||.|||||||| eeerfapedlleklqeknkklGLvidltntdryykkkeltdegvkykklncpGhevpeked-vkkfkeavkefleknkdndkligvhCthGvnrtGyliC RYMIDVDNYSASDAISMFEYYRGHPMEREHYKKSLYEAER ||.|||..||..|||..||..|||..|||.|...|..... rylidvegyspedaieafeearGhslerenyledLkklak |
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| Phosphatase | pir-1.AA | Subfamily.RNGTT.PD | 93-228 | 40 | 8.8e-40 | 127.0 | In-house | 3-136 (140) | Show / Hide |
Range on Protein: 93-228 Range on HMM: 3-136/140 Sequence Identity: 40% (54 aa) LQFGVKTLISLAQQANKQIGLVIDLTNTDRYYKKTEWADHGVKYLKLNCPGHEVNEREDLVQDFINAVKEFVNDkeNDGKLIGVHCTHGLNRTGYLICRY .| ..|.| ... ....|||||||||.|||.| | ..|||| ||.| |. . .. .. ||. ||||... . ...|||||||| ||||.||. |. eafepemlksylktlkvklglvidltntsryydkeelekegvkyiklqcrGrGeaPtkeqtklfiklvkeflkk--kPdevigvhCthGfnrtGflivay MIDVDNYSASDAISMFEYYRGHPMEREHYKKSLYEA ... ..| ..|...| | . .|.| |.|.. LvekedwsveaavalfakarppGiykedylkelfkr |
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| Phosphatase | pir-1.AA | DSPc | 93-231 | 18 | 6.9e-38 | 133.66 | Pfam | 1-151 (151) | Show / Hide |
Range on Protein: 93-231 Range on HMM: 1-151/151 Sequence Identity: 18% (30 aa) LQFGVKTLIS--LAQQANKQIGLVIDLT-----NTDRYYKKTEWADHGVKYLKLNCP-GHEV-------NEREDLVQDFINAVKEFVNDKENDGKLIGVH |..| .. .. .|......| .||..| | |..|. .......| |.. ..... ..........|..| ...|. . || LYLGSYPHHMADPAFLQKHGITHVINCTMECPNN---------WFYHNSHFHYMWIPHVHDHIHYYHIHWNHCTNISQYFPMATDFIDDCRQKGGKVLVH CTHGLNRTGYLICRYMIDVDNYSASDAISMF-----EYYR-GHPMEREHYKKSLYEAERK |..|..|...|...|... .|.|...|.... ...| .. ... .....|.| ||. CQAGISRSACLCIAYLMKYRNMSYNEAYDFVYIYHMKQRRCPMISPNMNFWRQLCEYERQ |
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| Phosphatase | pir-1.AA | Family.DSP.PD | 101-233 | 21 | 6.6e-22 | 69.6 | In-house | 123-248 (387) | Show / Hide |
Range on Protein: 101-233 Range on HMM: 123-248/387 Sequence Identity: 21% (30 aa) ISLAQQANKQIGLVIDLTntdryY------KktewaDHGVKYLKLNCPGHEVNEREDLvqdFINAVKeFVNDKENDGKLIGVHCTHGLNRTGYLICRYMI ..| . ..... ...|| . | ..|.|||..... |.. | | |..|.. |......... . |||..|..|.| ||.|.. knlewlkelgvtkivnlt-----ddkpqftk-----elgikylripidDhnapplenl---fekaid-fieegndskgvVlVHCkaGkgRsgtliiaYlm DVDNYSASDAISMFEYYR-GHPMEREHYKKSLYEAERKKK ......|. .. | |. .....| | . | .| ksegltleealdwvrskRpgvitpnqgflkqlkdlekekl |
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| Phosphatase | pir-1.AA | Subfamily.PTPMT1.PD | 125-226 | 21 | 6.8e-11 | 33.5 | In-house | 44-141 (146) | Show / Hide |
Range on Protein: 125-226 Range on HMM: 44-141/146 Sequence Identity: 21% (21 aa) KKTEWADHGVKYLKLNCPGHevNEREDlvQDFINAVKEFVNDKENDGKLIGVHCTHGLNRTGYLICRYMIDVDNYSASDAISMFEYYRGHPMEREHYKKS .. || ..||..|.| . | . .. .. ||.... ..|. . ||| | | . |. |.. ..|. .|..... | .... ..|. steewkklGveqlqlatvDf--teaps--lekleegvefiekvaskgssvYvHCkAGrtRsatlvacylmkkkklspeeavkflkkkRpqirlkskqwra LY lq |
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| Phosphatase | pir-1.AA | Subfamily.DSP23.PD | 156-219 | 31 | 1.1e-10 | 33.1 | In-house | 51-114 (128) | Show / Hide |
Range on Protein: 156-219 Range on HMM: 51-114/128 Sequence Identity: 31% (19 aa) FINAVKEFVNDKENDGKLIGVHCTHGLNRTGYLICRYMIDVDNYSASDAISMFEYYRGHPMERE .. . . |.. |. .. .|||| || ||| |. |.. ....|.||| | .| qvarlvriveeaekkeeavgvhcalGlGrtGtllacylvkeeglaaddaiaevrkrrkGsietv |
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| Phosphatase | pir-1.AA | Subfamily.PTEN.PD | 151-213 | 25 | 2.7e-10 | 31.4 | In-house | 76-137 (305) | Show / Hide |
Range on Protein: 151-213 Range on HMM: 76-137/305 Sequence Identity: 25% (16 aa) DLVQDFINAVKEFVndKENDGKLIGVHCTHGLNRTGYLICRYMIDVDNYSAS-DAISMFEYYRG .|...... |... ||.. . . ||| | ||| .|| |.. .. .|..... | eLleeivedvdkwL--kedksnVvavHCkaGkGRtGvmicayLlksgikksadealaiydekRt |
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| Phosphatase | pir-1.AA | Subfamily.CDC14.PD | 122-209 | 25 | 2.8e-10 | 31.6 | In-house | 157-236 (258) | Show / Hide |
Range on Protein: 122-209 Range on HMM: 157-236/258 Sequence Identity: 25% (22 aa) RYYKKTEWADHGVKYLKLNCPGHEVNErEDLVQDFINAVKEFvndkendGKLIGVHCTHGLNRTGYLICRYMIDVDNYSASDAISMFE . |..... |.|...| | | . . ... |.... . | ||| || |||.|| |.| ...|...|. . klYdakkftdaGfahlDlffiDGtvPs-dailkkfleiteka-------eGaiavhCkaGLGrtgtligcylikhyrftaaetiawlr |
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| Phosphatase | pir-1.AA | Subfamily.PTPDC1.PD | 120-211 | 27 | 4.9e-10 | 30.5 | In-house | 121-206 (229) | Show / Hide |
Range on Protein: 120-211 Range on HMM: 121-206/229 Sequence Identity: 27% (24 aa) TDRYYKKTEWADHGVKYLKLNCPGHEVNEREDLVqDFINAVKEFVndkeNDGKlIGVHCTHGLNRTGYLICRYMIDVDNYSASDAISMFEYY . |.. | .|. . . . ..| | .. | . |. . ..|| |.||| || ||| ||. |.. .....|..||.. sGfsYdpeelmrqgiyfynfglkDygvasleriL-divkvvdfal----eegk-iavHCHAGlGRtGvliacylvyakrltaeeaiklvrsk |
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| Phosphatase | pir-1.AA | Subfamily.DSP12.PD | 147-211 | 19 | 2.3e-09 | 28.8 | In-house | 58-121 (143) | Show / Hide |
Range on Protein: 147-211 Range on HMM: 58-121/143 Sequence Identity: 19% (12 aa) NEREDLVQDfINAVKEFVNDKENDGKLIGVHCTHGLNRTGYLICRYMIDVDNYSASDAISMFEYY ...|||.. .. . .|... . .. . |||. |. | .. |.. .. | ..|... . epeedlLsh-ldeavrFieeglekegavlvHClagvSRSvtiviAYlmkkeklslekAlklvkek |
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| Phosphatase | pir-1.AA | PTPc_motif | 120-231 | 20 | 1e-08 | 36.24 | SMART | 1-92 (92) | Show / Hide |
Range on Protein: 120-231 Range on HMM: 1-92/92 Sequence Identity: 20% (23 aa) TDRYYKKTEWADHGVKYLKLNCPGHEVNEREDLVQDFINAVKEFVNDKENDGKLIGVHCTHGLNRTGYLICRYMIDVDNYSASDAISMFEYYRGHPMERE | . | | | ||. |.... | . .||..|.. | ||| .| .||| ... .|. . . . . .. .| . .. | TVHHYHYTNWPDHVEKDSGVPE---------DSILEFIRHVRK----------PIVVHCSAGCGRTGTFCAIDMMMQQ-VDIFQTVKEMRKQRPGMVQTE HYKKSLYEAERK . . .|.. . EQYIFCYRCILE |
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| Phosphatase | pir-1.AA | Subfamily.TPIP.PD | 143-213 | 28 | 2.3e-08 | 25.3 | In-house | 12-80 (245) | Show / Hide |
Range on Protein: 143-213 Range on HMM: 12-80/245 Sequence Identity: 28% (20 aa) GHEVNEREDLVQdFINAVKEFVNDKENdgKLIGVHCTHGLNRTGYLICRYMIDVDNYS-ASDAISMFEYYRG |.| . |.||. | . |||... .. ... .|| | .||| ..| ..| . .. | ... | | dhnvPtleelvv-ftkevkewlakdle--nvvaihckGGkgrtGtivcalliaseifltaeesldyfgerrt |
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| Phosphatase | pir-1.AA | Subfamily.DSP10.PD | 110-207 | 21 | 1.4e-07 | 22.9 | In-house | 27-117 (141) | Show / Hide |
Range on Protein: 110-207 Range on HMM: 27-117/141 Sequence Identity: 21% (21 aa) QIGLVIDLTNTDRYYKKTEwadHGVKYLKLNCpghEVNEREDLVQDFINAVkEFVNDKENDGKLIGVHCTHGLNRTGYLICRYMIDVDNYSASDAISM .| |...|.. . . . |.| ... . .....| | | .|. ||... . |. . |||. |. |. .. |.. . ||.| . gikyvlnvttsvPnffeek---glvrykripv---sdsgkqnlkqkfeeal-efieearkrgsrvlvhchaGisrsatvviayvmkhlslslseaykf |
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| Phosphatase | pir-1.AA | Subfamily.DSP19.PD | 148-209 | 16 | 1.7e-07 | 22.5 | In-house | 56-117 (139) | Show / Hide |
Range on Protein: 148-209 Range on HMM: 56-117/139 Sequence Identity: 16% (10 aa) EREDLVQDFINAVKEFVNDKENDGKLIGVHCTHGLNRTGYLICRYMIDVDNYSASDAISMFE . | . ...... .|... . . . ||| | |. .. |.. . | ..|... lpetkllsylkealdFieearskdgrvlvHCnAGvSRsasvviaylmkdeelslekalekvr |
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| Phosphatase | pir-1.AA | Subfamily.DSP6.PD | 109-207 | 20 | 2.3e-07 | 21.9 | In-house | 26-117 (141) | Show / Hide |
Range on Protein: 109-207 Range on HMM: 26-117/141 Sequence Identity: 20% (20 aa) KQIGLVIDLTNT-DRYYKKTEwadhGVKYLKLNCPGHevnEREDLVQDFINAVkEFVNDKENDGKLIGVHCTHGLNRTGYLICRYMIDVDNYSASDAISM .| |...|. . ..... .||... | ..| . | .|. ||... .. . . ||| |. |. .. |... ..| || . lkikyvlnvtsnlpnkfeesg----elkykqipiedh---lsqnlakffPeai-efidearskkskvlvhclaGvsrsvtvtlaylmkklalslndaydl |
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| Phosphatase | pir-1.AA | Subfamily.DSP1.PD | 145-207 | 21 | 2.4e-07 | 22.2 | In-house | 54-115 (139) | Show / Hide |
Range on Protein: 145-207 Range on HMM: 54-115/139 Sequence Identity: 21% (13 aa) EVNEREDLVQDFINaVKEFVNDKENDGKLIGVHCTHGLNRTGYLICRYMIDVDNYSASDAISM | |...|. . | . . .|... .. | . ||| |. |. .. |.. .... ..| ednkkadisslfee-aidfidsvkkkgGrvlvhCqaGisrsativlayLmkekkvrleeafef |
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| Phosphatase | pir-1.AA | Subfamily.PRL.PD | 120-209 | 22 | 3.7e-07 | 21.4 | In-house | 33-118 (140) | Show / Hide |
Range on Protein: 120-209 Range on HMM: 33-118/140 Sequence Identity: 22% (20 aa) TDRYYKKTEWADHGVKYLKLNCPGHEVnEREDLVQDFINAVKEFVndKENDGKLIGVHCTHGLNRTGYLICRYMIDVdNYSASDAISMFE . |. .. ..|.. | |. | ...|..... .|| ||.... ..||| || |. |.. .|. . ||... cepsydaeklkeegievldlafddGav-PpkevvdeWlellkekf--keepkstvavhcvaGlGraPvlvalaliea-Gmkyedavefir |
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| Phosphatase | pir-1.AA | Subfamily.R_Sponge_2.PD | 135-218 | 25 | 3.7e-07 | 21.2 | In-house | 160-240 (262) | Show / Hide |
Range on Protein: 135-218 Range on HMM: 160-240/262 Sequence Identity: 25% (21 aa) KYLKLNCPGHEVNEREDLVQDFINAVKEfvNDKENDGKLIGVHCTHGLNRTGYLICRYMIdVDNYSASDAISMFEYYRGHPMER .. .. | ||| . . . ..|. |.. . |.. .| | |.| .|. ||| |. ... .. | . | .||. .. ..| qfhfvaWpehevPkdatsllelikrvlr--aqkksgnkaitvvCsdgvgrtGtfialdsv-lerlkaeeeidvfevlktlrtkr |
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| Phosphatase | pir-1.AA | Subfamily.RB.PD | 139-208 | 27 | 8.2e-07 | 20.0 | In-house | 162-229 (261) | Show / Hide |
Range on Protein: 139-208 Range on HMM: 162-229/261 Sequence Identity: 27% (19 aa) LNCPGHEVNEREDLVQDFINAVKEFVNDKENDGKLIgVHCTHGLNRTGYLICRYMIdVDNYSASDAISMF . | |.| |. . . ||...|.| ...| ... .. |||. |. ||| | .. ... ...| . .| tsWpdhgvPektktlldfvrtvreaiekkaskkPiv-vHCsaGvGRtGtfialdrl-lqaieendyvdvf |
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| Phosphatase | pir-1.AA | Subfamily.N_Choan_2.PD | 123-190 | 26 | 9.2e-07 | 19.6 | In-house | 157-217 (266) | Show / Hide |
Range on Protein: 123-190 Range on HMM: 157-217/266 Sequence Identity: 26% (18 aa) YYKKTEWADHGVKYLKlncpGHeVNEREDLVqDFINAVKEFVNDKENDGKLIgVHCTHGLNRTGYLIC .. ..| |||| . .. . . ..|. . ..||... .. .. . |. |||. |..||| || HfwyntWpdhgvpree----ds-slstdqll-kmlravrrvrkeldkaePll-vHcsaGvgRtGtlia |
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| Phosphatase | pir-1.AA | Subfamily.N12.PD | 139-190 | 28 | 2.5e-06 | 18.1 | In-house | 170-218 (270) | Show / Hide |
Range on Protein: 139-190 Range on HMM: 170-218/270 Sequence Identity: 28% (14 aa) LNCPGHEVNEREDLVQDFINAVKEFVNdkeNDGKLIGVHCTHGLNRTGYLIC . | |.| .... . ..|..|.|. . .. . . |||. | ||| .| taWPDhgvPssaksllelielvrelqe---sedaPlvvhCsaGvGrtGtiia |
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| Phosphatase | pir-1.AA | Subfamily.DSP15.PD | 150-223 | 23 | 2.6e-06 | 18.7 | In-house | 58-130 (138) | Show / Hide |
Range on Protein: 150-223 Range on HMM: 58-130/138 Sequence Identity: 23% (17 aa) EDLVQdFINAVKEFVNDKENDGKLIGVHCTHGLNRTGYLICRYMIDVDNYSASDAISMFEYYRGHPMEREHYKK ||.. | . .|. .|. . ||| |. |. |. |.. | ..| ||... .. | ... qdlsk-ffkesidfihkcrleggnvlvhclaGisrsvtlvvayimtvtelswedalkavkaarsvanPnvGfrr |
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| Phosphatase | pir-1.AA | Subfamily.N6.PD | 136-195 | 27 | 2.7e-06 | 18.2 | In-house | 190-249 (295) | Show / Hide |
Range on Protein: 136-195 Range on HMM: 190-249/295 Sequence Identity: 27% (17 aa) YLKLNCPGHEVNEREDLVQDFINAVKEFVNDKENDGKLIgVHCTHGLNRTGYLICRYMI-D | . | |.|.. | .|.. |.. .. |. | .. |||. |. ||| .| .. . yhfkaWPdhgvpkdpgvvlnfledvnkkqeelekagpiv-vhcsaGiGrtGtfividivlk |
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| Phosphatase | pir-1.AA | Subfamily.DSP3.PD | 128-208 | 25 | 3.2e-06 | 18.4 | In-house | 49-126 (148) | Show / Hide |
Range on Protein: 128-208 Range on HMM: 49-126/148 Sequence Identity: 25% (21 aa) EWADHGVKYLKLNCpgHEVNeREDLVQDFINAVkEFVNDK--ENDGKlIGVHCTHGLNRTGYLICRYMIDVDNYSASDAISMF . | ..||| .. ..| . || . | .|. .|... ...|| . |||..|. |. |. |.. . .. .||.. fYkdleikylGvev--sDvp-efdlskyfeeaa-dfidealsqkngk-vlvhcvvGisRsatlvlayLmirrkltlkeaiktv |
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| Phosphatase | pir-1.AA | Subfamily.N3.PD | 101-190 | 22 | 8.7e-06 | 16.4 | In-house | 129-212 (261) | Show / Hide |
Range on Protein: 101-190 Range on HMM: 129-212/261 Sequence Identity: 22% (20 aa) ISLAQQANKQIGLVIDLTNTDRYYKKtEWADHGVKYLklNCPGHEVNEREDLVQDFINAVKEFvndKENDGKLIGVHCTHGLNRTGYLIC . . ...... .. .|. .|. |. | . ..|| . | |.| . .. . .|.. |.. .. . . . |||. |..||| || vrcekedetksyvlrelvlkdketke-erkilqlqyl--aWpdhgvPddsadflefvervrkl---rsgkeePvvvhCsaGigrtGvlil |
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| Phosphatase | pir-1.AA | Subfamily.N13.PD | 139-194 | 27 | 9.7e-06 | 16.6 | In-house | 163-214 (259) | Show / Hide |
Range on Protein: 139-194 Range on HMM: 163-214/259 Sequence Identity: 27% (15 aa) LNCPGHEVNEREDLVQDFINAVKEFVNDKendgKLIGVHCTHGLNRTGYLICRYMI . | |.| . . |. |... .|. | |||. |. |.| ||. ... vkwPdhgvPssaaelvqfvaevrllqtda----gPivvhcsaGiGrsGvlitidvv |
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| Phosphatase | pir-1.AA | Subfamily.DSP14.PD | 107-212 | 21 | 1e-05 | 16.9 | In-house | 23-119 (138) | Show / Hide |
Range on Protein: 107-212 Range on HMM: 23-119/138 Sequence Identity: 21% (23 aa) ANKQIGLVIDLTNtdryyKKTEWADHGVKYLKLNCPGHevnEREDLVQDFINAVKEFVNDKENDGKLIgVHCTHGLNRTGYLICRYMIDVDNYSASDAIS ..|.| |....| ...| ..||..|.. . ....| . | ..... . |...|| . |||. | | |. |.. .. | .| . kkkkitlivnvtt-----elpetkledvktvkikveDk---peaklaehfdevadkieevkkkgGktl-vhCvaGvsRsAslvlaylmkyeklsLreayk MFEYYR . . | lvksaR |
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