• Phosphatome.Net

Gene ZK757.2

ZK757.2
Species: C.elegans
Alias: ZK757.2
External Links:
Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Superfamily: Cx5R-I
Family: DSP
Subfamily: DSP14
Protein domain

Protein domains of ZK757.2.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit phosphatase group/family/subfamily, which is helpful to understand the relationship between phosphatases. Transmembrane region is predicted by TMHMM 2.0. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking. View complete domain list.

Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Phosphatase ZK757.2.AA Family.DSP.PD 10-150 28 2.3e-21 66.4 In-house 103-248 (387) Show / Hide 
Range on Protein: 10-150
Range on HMM: 103-248/387
Sequence Identity: 28% (43 aa)

EQRQCSQIRPYLYVSGLAALSPRVLS---RFCVCINLIpgfrL-----SAPPHMKVVHLPLQDNETTDLSPHWANVYKEIEEARKGAGRALLLCAMGISR
|....|.|.| ||. .| | . ..     .  . .||           .   ..|....|. |.....|. .. .... |||...  |..|  | .|..|
engkpseilphlylgsllaaknlewlkelgvtkivnlt----ddkpqftkelgikylripidDhnapplenlfekaidfieegndskgvVlVHCkaGkgR

SATFGIAYVMQYEKKTLHDSYKAVQLARN-IICPNVGFFQQLIDLEQKLR
|.|  ||| |..|. ||..... |. .|. .| || ||..|| |||....
sgtliiaYlmksegltleealdwvrskRpgvitpnqgflkqlkdlekekl
Phosphatase ZK757.2.AA Subfamily.DSP14.PD 13-148 39 1.3e-49 157.7 In-house 1-138 (138) Show / Hide 
Range on Protein: 13-148
Range on HMM: 1-138/138
Sequence Identity: 39% (55 aa)

QCSQIRPYLYVSGLAALSPRVLSR--FCVCINLIPGFRLSAPPHMKVVHLPLQDNETTDLSPHWANVYKEIEEARKGAGRALLLCAMGISRSATFGIAYV
|.|.|...||.|| |||....|..  .....|...       ...|.|.....|.....|..|...|...|||..| .|..|. |..|.||||.. .||.
qlseitesLylsgaaalkkeklkkkkitlivnvttelpetkledvktvkikveDkpeaklaehfdevadkieevkkkgGktlvhCvaGvsRsAslvlayl

MQYEKKTLHDSYKAVQLARNIICPNVGFFQQLIDLEQK
|.|||..|...||.|. ||.||.|||||..||||.|.|
mkyeklsLreayklvksaRpiirPnvGFwkqlidyEkk
Phosphatase ZK757.2.AA DSPc 13-148 28 7.1e-48 166.29 SMART 1-172 (172) Show / Hide 
Range on Protein: 13-148
Range on HMM: 1-172/172
Sequence Identity: 28% (49 aa)

QCSQIRPYLYVSGLAALS---PRVLS--RFCVCINLIPGFRL-----------------SAPPHMKVVHLP-LQD-------NETTDLSPHWANVYKEIE
..|.| |.||...  . .   |. |.   ....||.......                 ....|.  .|.| ..|       |..|..|... .||. |.
GPSEITPHLYLGSYPHHMEPNPCFLKKHNITHVINVTMECPWNFHHCQKNDMHYTNEWIYHNSHFQYMHIPMIDDIYYHIRWNHCTNISQYFPEVYDFIH

EARKGAGRALLLCAMGISRSATFGIAYVMQYEKKTLHDSYKAV-----QLAR-NIICPNVGFFQQLIDLEQK
..|.  |. |  |..|||||||. ||| |.|......|.| .|     . .| .|||||..|..||...|.|
DCRQKGGKVLVHCQAGISRSATLCIAYLMKYMNMSYNDAYHFVYIYHIKQRRCPIICPNFNFWHQLCEWERK
Phosphatase ZK757.2.AA Subfamily.DSP10.PD 17-147 32 6.5e-28 87.3 In-house 5-140 (141) Show / Hide 
Range on Protein: 17-147
Range on HMM: 5-140/141
Sequence Identity: 32% (44 aa)

IRPYLYV-SGLAALSPRVLSRFCV--CINLIPGFRLS--APPHMKVVHLPLQDNETTDLSPHWANVYKEIEEARKGAGRALLLCAMGISRSATFGIAYVM
| |.|.. ..  | .  .|.|. .   .|. .   .       ..  ..|..|.....|. .. . .. ||||||  .| |. |  |||||||  |||||
ilpflllGnekdaadkdaldrlgikyvlnvttsvPnffeekglvrykripvsdsgkqnlkqkfeealefieearkrgsrvlvhchaGisrsatvviayvm

QYEKKTLHDSYKAVQLARNIICPNVGFFQQLIDLEQ
.. . .|...|| |. .| ||.||..|  ||...|.
khlslslseaykfvkekrPiisPnlnfmGqllefek
Phosphatase ZK757.2.AA Subfamily.DSP1.PD 42-147 34 1.4e-25 79.9 In-house 33-138 (139) Show / Hide 
Range on Protein: 42-147
Range on HMM: 33-138/139
Sequence Identity: 34% (36 aa)

NLIPGFRLSAPPHMKVVHLPLQDNETTDLSPHWANVYKEIEEARKGAGRALLLCAMGISRSATFGIAYVMQYEKKTLHDSYKAVQLARNIICPNVGFFQQ
|.        . ..|  ..|..||...|.| .. .. . |....|  || |. |..|||||||. .||.|. .| .|..... |.  |.||||.|| .||
nvsaelpnvfeelfkyksipvednkkadisslfeeaidfidsvkkkgGrvlvhCqaGisrsativlayLmkekkvrleeafefvkqrrsiisPnfgfvgq

LIDLEQ
.  |. 
Llefek
Phosphatase ZK757.2.AA Subfamily.Slingshot.PD 54-143 40 4.3e-23 71.6 In-house 45-134 (139) Show / Hide 
Range on Protein: 54-143
Range on HMM: 45-134/139
Sequence Identity: 40% (36 aa)

HMKVVHLPLQDNETTDLSPHWANVYKEIEEARKGAGRALLLCAMGISRSATFGIAYVMQYEKKTLHDSYKAVQLARNIICPNVGFFQQLI
..| ... . |.|.||| .|| . || ||.|..   ..|. | ||.||||.  ||| |.  . .|..... |.  |.|| || ||..|| 
kfkylnirvydeeetdllkhwnetykfiekakekgskvlvhckmGvsrsastviayamkeyelsleealeyvkerrsiikpnkgflkqlk
Phosphatase ZK757.2.AA Subfamily.DSP19.PD 17-147 31 5.3e-23 71.3 In-house 5-138 (139) Show / Hide 
Range on Protein: 17-147
Range on HMM: 5-138/139
Sequence Identity: 31% (42 aa)

IRPYLYVSGL-AALSPRVLSRFCV--CINLIPGFRLSAPPHMKVVHLPLQDNETTDLSPHWANVYKEIEEARKGAGRALLLCAMGISRSATFGIAYVMQY
..|.||..   .| . ..|..  .   .|.  |     | ......... |.. |.|  .. .. . |||||.  || |. |  |.||||.. |||.|. 
vkprlylgsqdvaadkeilkklkitHilnvavgvpnvfpkdftyksieilDlpetkllsylkealdFieearskdgrvlvHCnAGvSRsasvviaylmkd

EKKTLHDSYKAVQLARNIICPNVGFFQQLIDLEQ
|...|..... |. ||  |.|| ||..|| ..|.
eelslekalekvrearpcikPneGFikqLkeyea
Phosphatase ZK757.2.AA Subfamily.DSP6.PD 53-147 31 6.9e-23 70.8 In-house 46-140 (141) Show / Hide 
Range on Protein: 53-147
Range on HMM: 46-140/141
Sequence Identity: 31% (30 aa)

PHMKVVHLPLQDNETTDLSPHWANVYKEIEEARKGAGRALLLCAMGISRSATFGIAYVMQYEKKTLHDSYKAVQLARNIICPNVGFFQQLIDLEQ
...| ...|..|. ...|. .. .  . |.|||.     |. |  |.||| |  .||.|.... .| |.|. |.  .  |.||  |..||.||. 
gelkykqipiedhlsqnlakffPeaiefidearskkskvlvhclaGvsrsvtvtlaylmkklalslndaydlvkkkksnisPnfnfmgqlldfer
Phosphatase ZK757.2.AA Subfamily.DSP8.PD 53-149 34 2.6e-22 69.2 In-house 46-142 (143) Show / Hide 
Range on Protein: 53-149
Range on HMM: 46-142/143
Sequence Identity: 34% (33 aa)

PHMKVVHLPLQDNETTDLSPHWANVYKEIEEARKGAGRALLLCAMGISRSATFGIAYVMQYEKKTLHDSYKAVQLARNIICPNVGFFQQLIDLEQKL
.. .....|..|. . .|.|.. . .. |. ||.  |. |. |  |||||||  |||.|.. . .| ..|. |.  |. | ||. | .||..|..| 
kesrflriPvkDkyeekllpwfdkalefidkarsangkvlvhclaGisrsatvaiayimktlemsldeayrfvkekrptispnlnflgqLleyekel
Phosphatase ZK757.2.AA Subfamily.DSP12.PD 50-142 34 1.4e-20 63.8 In-house 43-135 (143) Show / Hide 
Range on Protein: 50-142
Range on HMM: 43-135/143
Sequence Identity: 34% (32 aa)

SAPPHMKVVHLPLQDNETTDLSPHWANVYKEIEEARKGAGRALLLCAMGISRSATFGIAYVMQYEKKTLHDSYKAVQLARNIICPNVGFFQQL
.. ...|   ... |....||  |  .. . |||...  |  |  |..|.|||.|. |||.|..||  |.. .|.|. ... |.|| || .||
qkekgvkskliqilDepeedlLshldeavrFieeglekegavlvHClagvSRSvtiviAYlmkkeklslekAlklvkekkkeiepNegFleQL
Phosphatase ZK757.2.AA Subfamily.DSP3.PD 57-148 38 5.1e-20 61.8 In-house 57-148 (148) Show / Hide 
Range on Protein: 57-148
Range on HMM: 57-148/148
Sequence Identity: 38% (35 aa)

VVHLPLQDNETTDLSPHWANVYKEIEEARKG-AGRALLLCAMGISRSATFGIAYVMQYEKKTLHDSYKAVQLARNIiCPNVGFFQQLIDLEQK
. .. .|  ..||| .. .  . |.|| .   |. |. |..|||||||  .||.| ..| ||... |.|.  |.|  || ||..||..|..| 
ylGvevsDvpefdlskyfeeaadfidealsqkngkvlvhcvvGisRsatlvlayLmirrkltlkeaiktvrkkrei-lPneGflkqLleldek
Phosphatase ZK757.2.AA DSPc 21-148 24 2.1e-18 65.9 Pfam 1-151 (151) Show / Hide 
Range on Protein: 21-148
Range on HMM: 1-151/151
Sequence Identity: 24% (38 aa)

LYVSGLAALS--PRVLSR--FCVCINLI-----PGFRLSAPPHMKVVHLP-LQD---------NETTDLSPHWANVYKEIEEARKGAGRALLLCAMGISR
||...  . .  |. |.   . . ||..     .  ......|    ..| . |         |..|..|..   ... |. .|.  |. |  |..||||
LYLGSYPHHMADPAFLQKHGITHVINCTMECPNN--WFYHNSHFHYMWIPHVHDHIHYYHIHWNHCTNISQYFPMATDFIDDCRQKGGKVLVHCQAGISR

SATFGIAYVMQYEKKTLHDSYKAV-----QLAR-NIICPNVGFFQQLIDLEQK
||.. ||| |.| . .. . |  |     .  |  .|.||..|  ||...|..
SACLCIAYLMKYRNMSYNEAYDFVYIYHMKQRRCPMISPNMNFWRQLCEYERQ
Phosphatase ZK757.2.AA Subfamily.STYXL1.PD 55-147 34 2.5e-18 56.6 In-house 50-142 (143) Show / Hide 
Range on Protein: 55-147
Range on HMM: 50-142/143
Sequence Identity: 34% (31 aa)

MKVVHLPLQDNETTDLSPHWANVYKEIEEARKGAGRALLLCAMGISRSATFGIAYVMQYEKKTLHDSYKAVQLARNIICPNVGFFQQLIDLEQ
|..|....|.. .|| ..  .| . ||. .|     |.    ||||||.  |||.| ..| ||...|| ..  .. ..|| .| .|| .|.  
akllhiavedeneadllerlkevvqfiekhkkegevvlvfsnkGisrsaaviiaylmyskkitlkkaykylkkckenvkPnrafveqlseWek
Phosphatase ZK757.2.AA Subfamily.LRR-DSP.PD 47-147 32 7.9e-18 54.5 In-house 37-136 (137) Show / Hide 
Range on Protein: 47-147
Range on HMM: 37-136/137
Sequence Identity: 32% (32 aa)

FRLSAPPHMKVVHLPLQDNETTDLSPHWANVYKEIEEARKGAGrALLLCAMGISRSATFGIAYVMQYEKKTLHDSYKAVQLARNIICPNVGFFQQLIDLE
|.   |  .| . . ..| . .|.. |. ..   |.| |.  |  |. |  |.|||||  |||.|.... ......  |.  |. | |||| .||   |.
fkplypdlfkyliidiedvdeadiyqhfkemnafidegrekgg-vlihcragvsrsatlviaylmkknslkfkealdlvikkrpriypnrgfldqlkkfe

Q
 
k
Phosphatase ZK757.2.AA Subfamily.DSP15.PD 55-147 35 2.7e-17 52.9 In-house 45-137 (138) Show / Hide 
Range on Protein: 55-147
Range on HMM: 45-137/138
Sequence Identity: 35% (33 aa)

MKVVHLPLQDNETTDLSPHWANVYKEIEEARKGAGRALLLCAMGISRSATFGIAYVMQYEKKTLHDSYKAVQLARNIICPNVGFFQQLIDLEQ
.|   .. .|   .||| .. .  . | ..|   |  |. |. ||||| |  .||.|   . . .|. |||. || .  ||||| .|| .|. 
ikylcikaadsPdqdlskffkesidfihkcrleggnvlvhclaGisrsvtlvvayimtvtelswedalkavkaarsvanPnvGfrrqlqefek
Phosphatase ZK757.2.AA Subfamily.STYX.PD 55-146 30 7.9e-13 38.4 In-house 53-144 (146) Show / Hide 
Range on Protein: 55-146
Range on HMM: 53-144/146
Sequence Identity: 30% (28 aa)

MKVVHLPLQDNETTDLSPHWANVYKEIEEARKGAGRALLLCAMGISRSATFGIAYVMQYEKKTLHDSYKAVQLARNIICPNVGFFQQLIDLE
.. . | . || . ..  .  .| . |... .  |. |.    ||||||.. |||.|.       .... ||  |  | || || .|| . |
frylvldvadntveniirylptvkefiddslqkggkvlvhgnagisrsaalviayimetyglkyreafayvqerrfcinpnegfvsqlkeye
Phosphatase ZK757.2.AA Subfamily.PTPMT1.PD 60-135 21 1.4e-06 18.1 In-house 58-133 (146) Show / Hide 
Range on Protein: 60-135
Range on HMM: 58-133/146
Sequence Identity: 21% (16 aa)

LPLQDNETTDLSPHWANVYKEIEEARKGAGRALLLCAMGISRSATFGIAYVMQYEKKTLHDSYKAVQLARNIICPN
|.  |   .    . ..  . ||. ..   .  . |  | .||||  ..|.|. .| . ... |...  |..|  .
latvDfteapslekleegvefiekvaskgssvYvHCkAGrtRsatlvacylmkkkklspeeavkflkkkRpqirlk
Sequence
Name Sequence Type Origin Length Description Download
ZK757.2.AA Protein None 294 None Fasta, JSON
ZK757.2.NA RNA None 882 None Fasta, JSON
ZK757.2.AA.PD_13-148 Protein Phosphatase Domain None 136 None Fasta, JSON