Gene ZK757.2
ZK757.2
Classification
Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.
Protein domain
Protein domains of ZK757.2.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit phosphatase group/family/subfamily, which is helpful to understand the relationship between phosphatases. Transmembrane region is predicted by TMHMM 2.0. Visualized by pviz.
Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking. View complete domain list.
Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
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Phosphatase | ZK757.2.AA | Family.DSP.PD | 10-150 | 28 | 2.3e-21 | 66.4 | In-house | 103-248 (387) | Show / Hide |
Range on Protein: 10-150 Range on HMM: 103-248/387 Sequence Identity: 28% (43 aa) EQRQCSQIRPYLYVSGLAALSPRVLS---RFCVCINLIpgfrL-----SAPPHMKVVHLPLQDNETTDLSPHWANVYKEIEEARKGAGRALLLCAMGISR |....|.|.| ||. .| | . .. . . .|| . ..|....|. |.....|. .. .... |||... |..| | .|..| engkpseilphlylgsllaaknlewlkelgvtkivnlt----ddkpqftkelgikylripidDhnapplenlfekaidfieegndskgvVlVHCkaGkgR SATFGIAYVMQYEKKTLHDSYKAVQLARN-IICPNVGFFQQLIDLEQKLR |.| ||| |..|. ||..... |. .|. .| || ||..|| |||.... sgtliiaYlmksegltleealdwvrskRpgvitpnqgflkqlkdlekekl |
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Phosphatase | ZK757.2.AA | Subfamily.DSP14.PD | 13-148 | 39 | 1.3e-49 | 157.7 | In-house | 1-138 (138) | Show / Hide |
Range on Protein: 13-148 Range on HMM: 1-138/138 Sequence Identity: 39% (55 aa) QCSQIRPYLYVSGLAALSPRVLSR--FCVCINLIPGFRLSAPPHMKVVHLPLQDNETTDLSPHWANVYKEIEEARKGAGRALLLCAMGISRSATFGIAYV |.|.|...||.|| |||....|.. .....|... ...|.|.....|.....|..|...|...|||..| .|..|. |..|.||||.. .||. qlseitesLylsgaaalkkeklkkkkitlivnvttelpetkledvktvkikveDkpeaklaehfdevadkieevkkkgGktlvhCvaGvsRsAslvlayl MQYEKKTLHDSYKAVQLARNIICPNVGFFQQLIDLEQK |.|||..|...||.|. ||.||.|||||..||||.|.| mkyeklsLreayklvksaRpiirPnvGFwkqlidyEkk |
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Phosphatase | ZK757.2.AA | DSPc | 13-148 | 28 | 7.1e-48 | 166.29 | SMART | 1-172 (172) | Show / Hide |
Range on Protein: 13-148 Range on HMM: 1-172/172 Sequence Identity: 28% (49 aa) QCSQIRPYLYVSGLAALS---PRVLS--RFCVCINLIPGFRL-----------------SAPPHMKVVHLP-LQD-------NETTDLSPHWANVYKEIE ..|.| |.||... . . |. |. ....||....... ....|. .|.| ..| |..|..|... .||. |. GPSEITPHLYLGSYPHHMEPNPCFLKKHNITHVINVTMECPWNFHHCQKNDMHYTNEWIYHNSHFQYMHIPMIDDIYYHIRWNHCTNISQYFPEVYDFIH EARKGAGRALLLCAMGISRSATFGIAYVMQYEKKTLHDSYKAV-----QLAR-NIICPNVGFFQQLIDLEQK ..|. |. | |..|||||||. ||| |.|......|.| .| . .| .|||||..|..||...|.| DCRQKGGKVLVHCQAGISRSATLCIAYLMKYMNMSYNDAYHFVYIYHIKQRRCPIICPNFNFWHQLCEWERK |
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Phosphatase | ZK757.2.AA | Subfamily.DSP10.PD | 17-147 | 32 | 6.5e-28 | 87.3 | In-house | 5-140 (141) | Show / Hide |
Range on Protein: 17-147 Range on HMM: 5-140/141 Sequence Identity: 32% (44 aa) IRPYLYV-SGLAALSPRVLSRFCV--CINLIPGFRLS--APPHMKVVHLPLQDNETTDLSPHWANVYKEIEEARKGAGRALLLCAMGISRSATFGIAYVM | |.|.. .. | . .|.|. . .|. . . .. ..|..|.....|. .. . .. |||||| .| |. | ||||||| ||||| ilpflllGnekdaadkdaldrlgikyvlnvttsvPnffeekglvrykripvsdsgkqnlkqkfeealefieearkrgsrvlvhchaGisrsatvviayvm QYEKKTLHDSYKAVQLARNIICPNVGFFQQLIDLEQ .. . .|...|| |. .| ||.||..| ||...|. khlslslseaykfvkekrPiisPnlnfmGqllefek |
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Phosphatase | ZK757.2.AA | Subfamily.DSP1.PD | 42-147 | 34 | 1.4e-25 | 79.9 | In-house | 33-138 (139) | Show / Hide |
Range on Protein: 42-147 Range on HMM: 33-138/139 Sequence Identity: 34% (36 aa) NLIPGFRLSAPPHMKVVHLPLQDNETTDLSPHWANVYKEIEEARKGAGRALLLCAMGISRSATFGIAYVMQYEKKTLHDSYKAVQLARNIICPNVGFFQQ |. . ..| ..|..||...|.| .. .. . |....| || |. |..|||||||. .||.|. .| .|..... |. |.||||.|| .|| nvsaelpnvfeelfkyksipvednkkadisslfeeaidfidsvkkkgGrvlvhCqaGisrsativlayLmkekkvrleeafefvkqrrsiisPnfgfvgq LIDLEQ . |. Llefek |
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Phosphatase | ZK757.2.AA | Subfamily.Slingshot.PD | 54-143 | 40 | 4.3e-23 | 71.6 | In-house | 45-134 (139) | Show / Hide |
Range on Protein: 54-143 Range on HMM: 45-134/139 Sequence Identity: 40% (36 aa) HMKVVHLPLQDNETTDLSPHWANVYKEIEEARKGAGRALLLCAMGISRSATFGIAYVMQYEKKTLHDSYKAVQLARNIICPNVGFFQQLI ..| ... . |.|.||| .|| . || ||.|.. ..|. | ||.||||. ||| |. . .|..... |. |.|| || ||..|| kfkylnirvydeeetdllkhwnetykfiekakekgskvlvhckmGvsrsastviayamkeyelsleealeyvkerrsiikpnkgflkqlk |
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Phosphatase | ZK757.2.AA | Subfamily.DSP19.PD | 17-147 | 31 | 5.3e-23 | 71.3 | In-house | 5-138 (139) | Show / Hide |
Range on Protein: 17-147 Range on HMM: 5-138/139 Sequence Identity: 31% (42 aa) IRPYLYVSGL-AALSPRVLSRFCV--CINLIPGFRLSAPPHMKVVHLPLQDNETTDLSPHWANVYKEIEEARKGAGRALLLCAMGISRSATFGIAYVMQY ..|.||.. .| . ..|.. . .|. | | ......... |.. |.| .. .. . |||||. || |. | |.||||.. |||.|. vkprlylgsqdvaadkeilkklkitHilnvavgvpnvfpkdftyksieilDlpetkllsylkealdFieearskdgrvlvHCnAGvSRsasvviaylmkd EKKTLHDSYKAVQLARNIICPNVGFFQQLIDLEQ |...|..... |. || |.|| ||..|| ..|. eelslekalekvrearpcikPneGFikqLkeyea |
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Phosphatase | ZK757.2.AA | Subfamily.DSP6.PD | 53-147 | 31 | 6.9e-23 | 70.8 | In-house | 46-140 (141) | Show / Hide |
Range on Protein: 53-147 Range on HMM: 46-140/141 Sequence Identity: 31% (30 aa) PHMKVVHLPLQDNETTDLSPHWANVYKEIEEARKGAGRALLLCAMGISRSATFGIAYVMQYEKKTLHDSYKAVQLARNIICPNVGFFQQLIDLEQ ...| ...|..|. ...|. .. . . |.|||. |. | |.||| | .||.|.... .| |.|. |. . |.|| |..||.||. gelkykqipiedhlsqnlakffPeaiefidearskkskvlvhclaGvsrsvtvtlaylmkklalslndaydlvkkkksnisPnfnfmgqlldfer |
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Phosphatase | ZK757.2.AA | Subfamily.DSP8.PD | 53-149 | 34 | 2.6e-22 | 69.2 | In-house | 46-142 (143) | Show / Hide |
Range on Protein: 53-149 Range on HMM: 46-142/143 Sequence Identity: 34% (33 aa) PHMKVVHLPLQDNETTDLSPHWANVYKEIEEARKGAGRALLLCAMGISRSATFGIAYVMQYEKKTLHDSYKAVQLARNIICPNVGFFQQLIDLEQKL .. .....|..|. . .|.|.. . .. |. ||. |. |. | ||||||| |||.|.. . .| ..|. |. |. | ||. | .||..|..| kesrflriPvkDkyeekllpwfdkalefidkarsangkvlvhclaGisrsatvaiayimktlemsldeayrfvkekrptispnlnflgqLleyekel |
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Phosphatase | ZK757.2.AA | Subfamily.DSP12.PD | 50-142 | 34 | 1.4e-20 | 63.8 | In-house | 43-135 (143) | Show / Hide |
Range on Protein: 50-142 Range on HMM: 43-135/143 Sequence Identity: 34% (32 aa) SAPPHMKVVHLPLQDNETTDLSPHWANVYKEIEEARKGAGRALLLCAMGISRSATFGIAYVMQYEKKTLHDSYKAVQLARNIICPNVGFFQQL .. ...| ... |....|| | .. . |||... | | |..|.|||.|. |||.|..|| |.. .|.|. ... |.|| || .|| qkekgvkskliqilDepeedlLshldeavrFieeglekegavlvHClagvSRSvtiviAYlmkkeklslekAlklvkekkkeiepNegFleQL |
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Phosphatase | ZK757.2.AA | Subfamily.DSP3.PD | 57-148 | 38 | 5.1e-20 | 61.8 | In-house | 57-148 (148) | Show / Hide |
Range on Protein: 57-148 Range on HMM: 57-148/148 Sequence Identity: 38% (35 aa) VVHLPLQDNETTDLSPHWANVYKEIEEARKG-AGRALLLCAMGISRSATFGIAYVMQYEKKTLHDSYKAVQLARNIiCPNVGFFQQLIDLEQK . .. .| ..||| .. . . |.|| . |. |. |..||||||| .||.| ..| ||... |.|. |.| || ||..||..|..| ylGvevsDvpefdlskyfeeaadfidealsqkngkvlvhcvvGisRsatlvlayLmirrkltlkeaiktvrkkrei-lPneGflkqLleldek |
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Phosphatase | ZK757.2.AA | DSPc | 21-148 | 24 | 2.1e-18 | 65.9 | Pfam | 1-151 (151) | Show / Hide |
Range on Protein: 21-148 Range on HMM: 1-151/151 Sequence Identity: 24% (38 aa) LYVSGLAALS--PRVLSR--FCVCINLI-----PGFRLSAPPHMKVVHLP-LQD---------NETTDLSPHWANVYKEIEEARKGAGRALLLCAMGISR ||... . . |. |. . . ||.. . ......| ..| . | |..|..|.. ... |. .|. |. | |..|||| LYLGSYPHHMADPAFLQKHGITHVINCTMECPNN--WFYHNSHFHYMWIPHVHDHIHYYHIHWNHCTNISQYFPMATDFIDDCRQKGGKVLVHCQAGISR SATFGIAYVMQYEKKTLHDSYKAV-----QLAR-NIICPNVGFFQQLIDLEQK ||.. ||| |.| . .. . | | . | .|.||..| ||...|.. SACLCIAYLMKYRNMSYNEAYDFVYIYHMKQRRCPMISPNMNFWRQLCEYERQ |
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Phosphatase | ZK757.2.AA | Subfamily.STYXL1.PD | 55-147 | 34 | 2.5e-18 | 56.6 | In-house | 50-142 (143) | Show / Hide |
Range on Protein: 55-147 Range on HMM: 50-142/143 Sequence Identity: 34% (31 aa) MKVVHLPLQDNETTDLSPHWANVYKEIEEARKGAGRALLLCAMGISRSATFGIAYVMQYEKKTLHDSYKAVQLARNIICPNVGFFQQLIDLEQ |..|....|.. .|| .. .| . ||. .| |. ||||||. |||.| ..| ||...|| .. .. ..|| .| .|| .|. akllhiavedeneadllerlkevvqfiekhkkegevvlvfsnkGisrsaaviiaylmyskkitlkkaykylkkckenvkPnrafveqlseWek |
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Phosphatase | ZK757.2.AA | Subfamily.LRR-DSP.PD | 47-147 | 32 | 7.9e-18 | 54.5 | In-house | 37-136 (137) | Show / Hide |
Range on Protein: 47-147 Range on HMM: 37-136/137 Sequence Identity: 32% (32 aa) FRLSAPPHMKVVHLPLQDNETTDLSPHWANVYKEIEEARKGAGrALLLCAMGISRSATFGIAYVMQYEKKTLHDSYKAVQLARNIICPNVGFFQQLIDLE |. | .| . . ..| . .|.. |. .. |.| |. | |. | |.||||| |||.|.... ...... |. |. | |||| .|| |. fkplypdlfkyliidiedvdeadiyqhfkemnafidegrekgg-vlihcragvsrsatlviaylmkknslkfkealdlvikkrpriypnrgfldqlkkfe Q k |
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Phosphatase | ZK757.2.AA | Subfamily.DSP15.PD | 55-147 | 35 | 2.7e-17 | 52.9 | In-house | 45-137 (138) | Show / Hide |
Range on Protein: 55-147 Range on HMM: 45-137/138 Sequence Identity: 35% (33 aa) MKVVHLPLQDNETTDLSPHWANVYKEIEEARKGAGRALLLCAMGISRSATFGIAYVMQYEKKTLHDSYKAVQLARNIICPNVGFFQQLIDLEQ .| .. .| .||| .. . . | ..| | |. |. ||||| | .||.| . . .|. |||. || . ||||| .|| .|. ikylcikaadsPdqdlskffkesidfihkcrleggnvlvhclaGisrsvtlvvayimtvtelswedalkavkaarsvanPnvGfrrqlqefek |
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Phosphatase | ZK757.2.AA | Subfamily.STYX.PD | 55-146 | 30 | 7.9e-13 | 38.4 | In-house | 53-144 (146) | Show / Hide |
Range on Protein: 55-146 Range on HMM: 53-144/146 Sequence Identity: 30% (28 aa) MKVVHLPLQDNETTDLSPHWANVYKEIEEARKGAGRALLLCAMGISRSATFGIAYVMQYEKKTLHDSYKAVQLARNIICPNVGFFQQLIDLE .. . | . || . .. . .| . |... . |. |. ||||||.. |||.|. .... || | | || || .|| . | frylvldvadntveniirylptvkefiddslqkggkvlvhgnagisrsaalviayimetyglkyreafayvqerrfcinpnegfvsqlkeye |
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Phosphatase | ZK757.2.AA | Subfamily.PTPMT1.PD | 60-135 | 21 | 1.4e-06 | 18.1 | In-house | 58-133 (146) | Show / Hide |
Range on Protein: 60-135 Range on HMM: 58-133/146 Sequence Identity: 21% (16 aa) LPLQDNETTDLSPHWANVYKEIEEARKGAGRALLLCAMGISRSATFGIAYVMQYEKKTLHDSYKAVQLARNIICPN |. | . . .. . ||. .. . . | | .|||| ..|.|. .| . ... |... |..| . latvDfteapslekleegvefiekvaskgssvYvHCkAGrtRsatlvacylmkkkklspeeavkflkkkRpqirlk |
Sequence
Name | Sequence Type | Origin | Length | Description | Download |
---|---|---|---|---|---|
ZK757.2.AA | Protein | None | 294 | None | Fasta, JSON |
ZK757.2.NA | RNA | None | 882 | None | Fasta, JSON |
ZK757.2.AA.PD_13-148 | Protein Phosphatase Domain | None | 136 | None | Fasta, JSON |