Gene lip-1
lip-1
Species: C.elegans
Alias: lip-1
External Links:
Classification
Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.
Protein domain
Protein domains of lip-1.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit phosphatase group/family/subfamily, which is helpful to understand the relationship between phosphatases. Transmembrane region is predicted by TMHMM 2.0. Visualized by pviz.
Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking. View complete domain list.
| Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
|---|---|---|---|---|---|---|---|---|---|
| Phosphatase | lip-1.AA | Family.DSP.PD | 127-337 | 30 | 5.3e-41 | 132.0 | In-house | 51-259 (387) | Show / Hide |
Range on Protein: 127-337 Range on HMM: 51-259/387 Sequence Identity: 30% (65 aa) SQFPTLRDAADENWNTtfQMNSMPGQASGQQASSGPLLNLNQLRLEGEDQGGKQRAEFPVKLTNFLYLGNAETAKNRDVLKKYSISHVINVTSNlPNTFE ..| .|||.... ... .. . ..|| . .. .. |. |.. . . |.. . .||||....|||.. ||.. .....|.| . .. |. pkfapfrdasyapvla--klhvryvisgakqaelngfidvhtfdldtydhfervengkpseilphlylgsllaaknlewlkelgvtkivnltdd-kpqft EDPNMRYLRISADDNASHNLTKFFPEAISFIDDARRNDSACLVHCLAGISRSVTICLAYLMKTEMCTLDSAYEWVQKRNA-SIAPNFHFMGQLTDYEKML .. ...||||. ||. . .| ..| .|| ||...... . |||| ||..|| |.. ||||| | .||. |..||... .| ||..|. || |.||.. kelgikylripidDhnapplenlfekaidfieegndskgvVlVHCkaGkgRsgtliiaYlmksegltleealdwvrskRpgvitpnqgflkqlkdlekek GLNSNRVGVSRQ |..| . |. lkvssevmelrf |
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| Phosphatase | lip-1.AA | Subfamily.DSP6.PD | 184-324 | 56 | 6.2e-72 | 230.7 | In-house | 1-141 (141) | Show / Hide |
Range on Protein: 184-324 Range on HMM: 1-141/141 Sequence Identity: 56% (79 aa) FPVKLTNFLYLGNAETAKNRDVLKKYSISHVINVTSNLPNTFEEDPNMRYLRISADDNASHNLTKFFPEAISFIDDARRNDSACLVHCLAGISRSVTICL .||.....||||.|..|.|..||||..|..|.||||||||.|||.....|..|...|..|.||.|||||||.|||.||...|..|||||||.|||||..| lpveilpllylGsakdasnlevlkklkikyvlnvtsnlpnkfeesgelkykqipiedhlsqnlakffPeaiefidearskkskvlvhclaGvsrsvtvtl AYLMKTEMCTLDSAYEWVQKRNASIAPNFHFMGQLTDYEKM |||||.....|..||..|.|....|.|||.|||||.|.|.. aylmkklalslndaydlvkkkksnisPnfnfmgqlldfers |
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| Phosphatase | lip-1.AA | DSPc | 184-324 | 36 | 1.1e-54 | 188.96 | SMART | 1-172 (172) | Show / Hide |
Range on Protein: 184-324 Range on HMM: 1-172/172 Sequence Identity: 36% (62 aa) FPVKLTNFLYLGNAETAK--NRDVLKKYSISHVINVTSNLPNTFEED---------------PNMRYLRIS-ADD-------NASHNLTKFFPEAISFID |.. |. ||||.. .. | . |||. | |||||| . |..|. . ....|..| || | . |....|||.. ||. GPSEITPHLYLGSYPHHMEPNPCFLKKHNITHVINVTMECPWNFHHCQKNDMHYTNEWIYHNSHFQYMHIPMIDDIYYHIRWNHCTNISQYFPEVYDFIH DARRNDSACLVHCLAGISRSVTICLAYLMKTEMCTLDSAYEWV------QKRNASIAPNFHFMGQLTDYEKM |.|.. .||||.||||||.|.| |||||.. .....||. | |.|. .| |||.|..|| ..|.. DCRQKGGKVLVHCQAGISRSATLCIAYLMKYMNMSYNDAYHFVYIYHIKQRRCPIICPNFNFWHQLCEWERK |
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| Phosphatase | lip-1.AA | Subfamily.DSP10.PD | 187-323 | 45 | 2e-49 | 157.9 | In-house | 4-140 (141) | Show / Hide |
Range on Protein: 187-323 Range on HMM: 4-140/141 Sequence Identity: 45% (62 aa) KLTNFLYLGNAETAKNRDVLKKYSISHVINVTSNLPNTFEEDPNMRYLRISADDNASHNLTKFFPEAISFIDDARRNDSACLVHCLAGISRSVTICLAYL .. ||.||| . |...|.|....|..|.|||...||.|||. .|| || . |. .|| . | ||. ||..||...|. |||| ||||||.|. .||. silpflllGnekdaadkdaldrlgikyvlnvttsvPnffeekglvrykripvsdsgkqnlkqkfeealefieearkrgsrvlvhchaGisrsatvviayv MKTEMCTLDSAYEWVQKRNASIAPNFHFMGQLTDYEK || .| ||..|... |.||. ||||| ..|| mkhlslslseaykfvkekrPiisPnlnfmGqllefek |
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| Phosphatase | lip-1.AA | DSPc | 192-324 | 36 | 3.9e-49 | 172.76 | Pfam | 1-151 (151) | Show / Hide |
Range on Protein: 192-324 Range on HMM: 1-151/151 Sequence Identity: 36% (55 aa) LYLGNAETAK-NRDVLKKYSISHVINVTSNLPNTFE-EDPNMRYLRIS-ADD---------NASHNLTKFFPEAISFIDDARRNDSACLVHCLAGISRSV ||||.. ... . . |.|..|.||||.| ..||... ... .|..| .| | . |....||.|..||||.|.. .||||.||||||. LYLGSYPHHMADPAFLQKHGITHVINCTMECPNNWFYHNSHFHYMWIPHVHDHIHYYHIHWNHCTNISQYFPMATDFIDDCRQKGGKVLVHCQAGISRSA TICLAYLMKTEMCTLDSAYEWV-----QKRN-ASIAPNFHFMGQLTDYEKM ..|.|||||. .... ||. | ..| .| ||..|..|| .||.. CLCIAYLMKYRNMSYNEAYDFVYIYHMKQRRCPMISPNMNFWRQLCEYERQ |
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| Phosphatase | lip-1.AA | Subfamily.DSP1.PD | 185-323 | 47 | 1e-47 | 152.5 | In-house | 2-138 (139) | Show / Hide |
Range on Protein: 185-323 Range on HMM: 2-138/139 Sequence Identity: 47% (66 aa) PVKLTNFLYLGNAETAKNRDVLKKYSISHVINVTSNLPNTFEEdpNMRYLRISADDNASHNLTKFFPEAISFIDDARRNDSACLVHCLAGISRSVTICLA ||.. .||||| || | |...||. |....||...|||.||| ..| .| .|| . .....| ||| |||...... |||| |||||| ||.|| pveildfLyLGsaehasnlqlLkelkitallnvsaelpnvfee--lfkyksipvednkkadisslfeeaidfidsvkkkgGrvlvhCqaGisrsativla YLMKTEMCTLDSAYEWVQKRNASIAPNFHFMGQLTDYEK ||||.. ..|. |.|.|..| . |.||| |.||| .|| yLmkekkvrleeafefvkqrrsiisPnfgfvgqLlefek |
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| Phosphatase | lip-1.AA | Subfamily.DSP8.PD | 186-325 | 42 | 2.5e-45 | 144.8 | In-house | 3-142 (143) | Show / Hide |
Range on Protein: 186-325 Range on HMM: 3-142/143 Sequence Identity: 42% (59 aa) VKLTNFLYLGNAETAKNRDVLKKYSISHVINVTSNLPNTFEEDPNMRYLRISADDNASHNLTKFFPEAISFIDDARRNDSACLVHCLAGISRSVTICLAY .....|||| . . ....|||. ||.|.|.... | . |. .. |.||| |. . .| .|..|..||| ||.... .||||||||||| |. .||. trilpnlylGsqkdsldeellkklgisyvlnisescpkdvellkesrflriPvkDkyeekllpwfdkalefidkarsangkvlvhclaGisrsatvaiay LMKTEMCTLDSAYEWVQKRNASIAPNFHFMGQLTDYEKML ||| .||.||..|... ..| ||. |.||| .||| | imktlemsldeayrfvkekrptispnlnflgqLleyekel |
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| Phosphatase | lip-1.AA | Subfamily.DSP19.PD | 187-323 | 39 | 4.4e-39 | 124.4 | In-house | 4-138 (139) | Show / Hide |
Range on Protein: 187-323 Range on HMM: 4-138/139 Sequence Identity: 39% (54 aa) KLTNFLYLGNAETAKNRDVLKKYSISHVINVTSNLPNTFEEDpnMRYLRISADDNASHNLTKFFPEAISFIDDARRNDSACLVHCLAGISRSVTICLAYL .....|||| ..|.....||| | |..||. ..||.| .| ..|. |. |. ..|.....||. ||..||..| . |||| ||.|||... .||| evkprlylgsqdvaadkeilkklkitHilnvavgvpnvfpkd--ftyksieilDlpetkllsylkealdFieearskdgrvlvHCnAGvSRsasvviayl MKTEMCTLDSAYEWVQKRNASIAPNFHFMGQLTDYEK ||.| .| .|.| |.. .| || |. ||..||. mkdeelslekalekvrearpcikPneGFikqLkeyea |
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| Phosphatase | lip-1.AA | Subfamily.DSP12.PD | 188-324 | 37 | 5.1e-39 | 124.5 | In-house | 5-141 (143) | Show / Hide |
Range on Protein: 188-324 Range on HMM: 5-141/143 Sequence Identity: 37% (51 aa) LTNFLYLGNAETAKNRDVLKKYSISHVINVTSNLPNTFEEDPNMRYLRISADDNASHNLTKFFPEAISFIDDARRNDSACLVHCLAGISRSVTICLAYLM ... ||||..|....|. ||...|.||. |... ......... .. |...|. . .| ....||..||.... .. | |||||||.||||||..|||| ilpglylggleavqerellkelkithvlsvikeelpelqkekgvkskliqilDepeedlLshldeavrFieeglekegavlvHClagvSRSvtiviAYlm KTEMCTLDSAYEWVQKRNASIAPNFHFMGQLTDYEKM |.| . |..|.. |.. . .| || |. || .||| kkeklslekAlklvkekkkeiepNegFleQLklfekm |
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| Phosphatase | lip-1.AA | Subfamily.DSP14.PD | 187-323 | 37 | 6.9e-38 | 120.7 | In-house | 4-137 (138) | Show / Hide |
Range on Protein: 187-323 Range on HMM: 4-137/138 Sequence Identity: 37% (51 aa) KLTNFLYLGnAETAKNRDVLKKYSISHVINVTSNLPNTFeeDPNMRYLRISADDNASHNLTKFFPEAISFIDDARRNDSACLVHCLAGISRSVTICLAYL ..|. |||. . .|.....||| |....||| .||.| .......| .|. ...|...| |. |....... ..|||| ||.||| ...|||| eitesLyls-gaaalkkeklkkkkitlivnvttelpetk--ledvktvkikveDkpeaklaehfdevadkieevkkkgGktlvhCvaGvsRsAslvlayl MKTEMCTLDSAYEWVQKRNASIAPNFHFMGQLTDYEK || | .| ||..|... . | || | || |||| mkyeklsLreayklvksaRpiirPnvGFwkqlidyEk |
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| Phosphatase | lip-1.AA | Subfamily.DSP15.PD | 188-323 | 36 | 6.2e-36 | 114.2 | In-house | 5-137 (138) | Show / Hide |
Range on Protein: 188-323
Range on HMM: 5-137/138
Sequence Identity: 36% (49 aa)
LTNFLYLGNAETAKNRDVLKKYSISHVINVTSNLPNTFEEdpnMRYLRISADDNASHNLTKFFPEAISFIDDARRNDSACLVHCLAGISRSVTICLAYLM
. . ||.|| . ||... |... |.|.. . . .|. ..||.|.|.| . .|.||| |.| || .| .....|||||||||||||.. ||.|
vlpGlyvGnfrdakdkeqleenkithilsihdsakplled---ikylcikaadsPdqdlskffkesidfihkcrleggnvlvhclaGisrsvtlvvayim
KTEMCTLDSAYEWVQKRNASIAPNFHFMGQLTDYEK
. . | . |. . ||. | ||...||
tvtelswedalkavkaarsvanPnvGfrrqlqefek
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| Phosphatase | lip-1.AA | Subfamily.Slingshot.PD | 186-323 | 38 | 3.4e-35 | 111.7 | In-house | 3-138 (139) | Show / Hide |
Range on Protein: 186-323 Range on HMM: 3-138/139 Sequence Identity: 38% (51 aa) VKLTNFLYLGNAETAKNRDVLKKYSISHVINVTSNLPNTFEEdpNMRYLRISADDNASHNLTKFFPEAISFIDDARRNDSACLVHCLAGISRSVTICLAY |. ..|||| | | . ||. ......||| .. | |.| ...||.|. |. ...| |.. |. .||. |....| .|||||.||| .. .|| || skifdhlylGsewnasnleelkengveyilnvtkeidnffpe--kfkylnirvydeeetdllkhwnetykfiekakekgskvlvhckmGvsrsastviay LMKTEMCTLDSAYEWVQKRNASIAPNFHFMGQLTDYEK . ..|..|.|.|..| | || |. ||. || amkeyelsleealeyvkerrsiikpnkgflkqlkvyeg |
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| Phosphatase | lip-1.AA | Subfamily.DSP3.PD | 190-323 | 35 | 3.2e-30 | 95.8 | In-house | 7-147 (148) | Show / Hide |
Range on Protein: 190-323 Range on HMM: 7-147/148 Sequence Identity: 35% (51 aa) NFLYLGNAETAKNRDVLKKYSISHVINVTSNL-------PNTFEEDPNMRYLRISADDNASHNLTKFFPEAISFIDDARRN-DSACLVHCLAGISRSVTI . .|.|....||... ||| | ||.| . . . | .| ...|| . ..| . .| |.| || |||.| .. .. |||| .||||| |. pkvyvgdeavakdkekLkklGithvLnaaegkrllkvdtdaefYkdleikylGvevsDvpefdlskyfeeaadfidealsqkngkvlvhcvvGisRsatl CLAYLMKTEMCTLDSAYEWVQKRnASIAPNFHFMGQLTDYEK ||||| .. || .| . |.|. .| || |. ||..... vlayLmirrkltlkeaiktvrkk-reilPneGflkqLlelde |
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| Phosphatase | lip-1.AA | Subfamily.LRR-DSP.PD | 186-323 | 34 | 6.4e-30 | 94.6 | In-house | 3-136 (137) | Show / Hide |
Range on Protein: 186-323 Range on HMM: 3-136/137 Sequence Identity: 34% (47 aa) VKLTNFLYLGNAETAKNRDVLKKYSISHVINVTSNLPnTFEEdpNMRYLRISADDNASHNLTKFFPEAISFIDDARRnDSACLVHCLAGISRSVTICLAY .. . |||| |.|.|. .||. ...|.. |. | . . ..|| | ..| .. ..| | .|||. |. . |.|| ||.||| |. .||| dliidklylgcresamnksilkdnnvthilavadfkp-lypd--lfkyliidiedvdeadiyqhfkemnafidegre-kggvlihcragvsrsatlviay LMKTEMCTLDSAYEWVQKRNASIAPNFHFMGQLTDYEK || . .. |.. |.|. . | || |. || .|| lmkknslkfkealdlvikkrpriypnrgfldqlkkfek |
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| Phosphatase | lip-1.AA | Subfamily.STYXL1.PD | 188-324 | 30 | 3.1e-27 | 86.4 | In-house | 6-143 (143) | Show / Hide |
Range on Protein: 188-324 Range on HMM: 6-143/143 Sequence Identity: 30% (42 aa) LTNFLYLGNAETAKNRDVLKKYSISHVINVTSNLPNTFEEDPN-MRYLRISADDNASHNLTKFFPEAISFIDDARRNDSACLVHCLAGISRSVTICLAYL | ..||||| . |.|. . | . ..||.|. . .. ... . |.|. .|. .| ... |...||.. ...... || |||||... .||| lPgklylGnykqaqnpaikkdlkvkahvnvssdaekliagladvakllhiavedeneadllerlkevvqfiekhkkegevvlvfsnkGisrsaaviiayl MKTEMCTLDSAYEWVQKRNASIAPNFHFMGQLTDYEKM | . || .||. ..| . || |. ||...||. myskkitlkkaykylkkckenvkPnrafveqlseWekq |
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| Phosphatase | lip-1.AA | Subfamily.STYX.PD | 192-323 | 34 | 3.5e-24 | 76.2 | In-house | 9-145 (146) | Show / Hide |
Range on Protein: 192-323 Range on HMM: 9-145/146 Sequence Identity: 34% (46 aa) LYLGNAETAKN--RDVLKKYSISHVINVTSNLPNTFEE---DPNMRYLRISADDNASHNLTKFFPEAISFIDDARRNDSACLVHCLAGISRSVTICLAYL |.|| .|.. .|||. |.|.. . |. .. . ..||| . ||. |. ...|.. .||||. .. ||| ||||||.. .||.| lflgpysaamksklevlkehgithivcirqnieanlikpnfpdrfrylvldvadntveniirylptvkefiddslqkggkvlvhgnagisrsaalviayi MKTEMCTLDSAYEWVQKRNASIAPNFHFMGQLTDYEK .| .|. .||.| |.|| |. ||..|| metyglkyreafayvqerrfcinpnegfvsqlkeyea |
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| Phosphatase | lip-1.AA | Subfamily.PTPMT1.PD | 224-321 | 24 | 1.5e-14 | 44.9 | In-house | 44-143 (146) | Show / Hide |
Range on Protein: 224-321 Range on HMM: 44-143/146 Sequence Identity: 24% (24 aa) TFEE--DPNMRYLRISADDNASHNLTKFFPEAISFIDDARRNDSACLVHCLAGISRSVTICLAYLMKTEMCTLDSAYEWVQKRNASIAPNFHFMGQLTDY . || . ...|... | . .. |...||.. . . |. ||| || .|| |. .||||.. .. ..| . ..|. | .. . |. . steewkklGveqlqlatvDfteapslekleegvefiekvaskgssvYvHCkAGrtRsatlvacylmkkkklspeeavkflkkkRpqirlkskqwralqef |
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| Phosphatase | lip-1.AA | Subfamily.DSP23.PD | 206-309 | 26 | 1.7e-10 | 31.9 | In-house | 9-112 (128) | Show / Hide |
Range on Protein: 206-309 Range on HMM: 9-112/128 Sequence Identity: 26% (27 aa) LKKYSISHVINVTSNLPNTFEEDPNMRYLRISADDNASHNLTKfFPEAISFIDDARRNDSACLVHCLAGISRSVTICLAYLMKTEMCTLDSAY-EWVQKR | | .....| . .. | |.. . ||. .| | . . . ...| ... | |||. |. |. |. ||.|.| . || | ..|. ladqGirvlvslttegapyseaapsltlrridipdfcPPaleq-varlvriveeaekkeeavgvhcalGlGrtGtllacylvkeeglaaddaiaevrkrr NASIA || kGsie |
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| Phosphatase | lip-1.AA | Subfamily.PTEN.PD | 265-302 | 31 | 4.4e-06 | 17.1 | In-house | 95-133 (305) | Show / Hide |
Range on Protein: 265-302 Range on HMM: 95-133/305 Sequence Identity: 31% (11 aa) SACLVHCLAGISRSVTICLAYLMKTEMCTLD-SAYEWVQ ||| || |. .. |||.|. ... | .. . nVvavHCkaGkGRtGvmicayLlksgikksadealaiyd |
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| Phosphatase | lip-1.AA | Subfamily.Laforin.PD | 227-305 | 21 | 4.9e-06 | 17.2 | In-house | 67-146 (165) | Show / Hide |
Range on Protein: 227-305 Range on HMM: 67-146/165 Sequence Identity: 21% (17 aa) EDPNMRYLRISADDNASHNLTKFFPEAISFIDDARRNDSACLVHCLAGISRSVTICLAYLMKTEMCTLD-SAYEWVQKRN . . |. . .| .. . . .|.|. .. . ||| ||. || .| .|. .| | . || keeglayiwlptedlstesrvenlpqavyllhallekghivyvhcnagvgrstaivcgflqyvlgwslakvqyfllakrp |
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| Phosphatase | lip-1.AA | Subfamily.R_Nematode_3.PD | 245-286 | 33 | 5.1e-06 | 16.8 | In-house | 179-220 (267) | Show / Hide |
Range on Protein: 245-286 Range on HMM: 179-220/267 Sequence Identity: 33% (14 aa) NLTKFFPEAISFIDDARRNDSACLVHCLAGISRSVTICLAYL | . ||.. |. .. . . .||| .||||| |. . | napeepkealelikfveksktpvvVHCsdGisRsatlaaiel |
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