Gene daf-18
daf-18
Species: C.elegans
Alias: daf-18
External Links:
Classification
Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.
Protein domain
Protein domains of daf-18.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit phosphatase group/family/subfamily, which is helpful to understand the relationship between phosphatases. Transmembrane region is predicted by TMHMM 2.0. Visualized by pviz.
Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking. View complete domain list.
| Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
|---|---|---|---|---|---|---|---|---|---|
| Phosphatase | daf-18.AA | Subfamily.PTEN.PD | 68-235 | 43 | 2.5e-57 | 185.4 | In-house | 1-167 (305) | Show / Hide |
Range on Protein: 68-235 Range on HMM: 1-167/305 Sequence Identity: 43% (72 aa) DCAYITDRIIAIGYPATGIEAN-FRNSKVQTQQFLTRRHGKGNVKVFNLRGGyyYDADNFDGNVICFDMTDHHPPSLELMAPFCREAKEWLEADDKHVIA | .|| .|...||. .| .|||. . . .||. .|||.....| || .. .|||.|......||.||.|||. ..... ..||..|...|.| disyilvnlivlsypvetyekllyrnslddlillltvykgkgklrilnarge--kedsdfdgrvavypfdDhnpptleLleeivedvdkwLkedksnVva VHCKAGKGRTGVMICALLIYINFYPSPRQILDYYSIIRTKNNKGVTIPSQRRYIYYYHKLRERELNYLP |||||||||||||||| |.. . ..|... |..|. |||..|||||||||||..|..|| . . | vHCkaGkGRtGvmicayLlksgikksadealaiydekRtkdkkGVtiPSQrRYvqYfsklvkssvpysk |
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| Phosphatase | daf-18.AA | Subfamily.TPIP.PD | 128-287 | 33 | 5.8e-30 | 95.6 | In-house | 3-166 (245) | Show / Hide |
Range on Protein: 128-287 Range on HMM: 3-166/245 Sequence Identity: 33% (54 aa) GNVICFDMTDHHPPSLELMAPFCREAKEWLEADDKHVIAVHCKAGKGRTGVMICALLIYINFYPSPRQILDYYSIIRTKNN-----KGVTIPSQRRYIYY .| . || | || . |..|.||||..| ..|.|.||| |||||| ..|||||. . . .. |||.. ||... .|| |||.||. |. nrvsrimiddhnvPtleelvvftkevkewlakdlenvvaihckGGkgrtGtivcalliaseifltaeesldyfgerrtdkthsnkfqGvetPsqnryvgy YHKLRER-ELNYLPLRMQLIGVYVERppKTWGGGSKIKVEVGNGSTILFKPDPLIISKSNHQRERA .... . | | |. .| .. | .||.| ..| | |. | laqvkhlynwnlpprrilfikrfiiy--sirgdvcdlkvqvvmekkvvfsstslgncsilhdietd |
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| Phosphatase | daf-18.AA | PTEN_C2 | 233-530 | 11 | 2.2e-29 | 107.24 | Pfam | 1-141 (141) | Show / Hide |
Range on Protein: 233-530
Range on HMM: 1-141/141
Sequence Identity: 11% (35 aa)
YLPLRMQLIGVYV-ERPP--KTWGGGS-KIKVEVGNGSTILFKPDPLIISKSNHQRERATWLNNCDTPNEFDTGEQKYHGFVSKRAYCFMVPEDAPVFVE
. | . .|..... ...| |..| |. ...... .. ...| .|. .. . . |...|... ...|..|.
PPPKPLFLHCIIMDHGIPNFKQGG-GCWRPYIQIYQNDQKVF-----------------------YTCKKYWHCKKY------KQQKCCIFKFPQPCPVQ
GDVRIDIREIG-F-LKKFSDGKIGHVWFNTMFACDGGLNGGHFEYVDKTQPYIGDDTSIGRKNGMRRNETPMRKIDPETGNEFESPWQIVNPPGLEKHIT
|||.| . .| . |..... .. ..||||.| ..
GDVKIQCYHKGPSDLPWMYEECMFRFWFNTCFIEH-----------------------------------------------------------------
EEQAMENYTNYGMIPPRYTISKILHEKHEKGIVKDDYNDRKLPMGDKSYTESGKSGDIRGVGGPFEIPYKAEEHVLTFPVYEMDRALKS---KDLNNGMK
....|||| .|.|.| | | ...|
-----------------------------------------------------------------------NNNRLTFPKNELDKAWKDKKWKRFPPDFK
LHVVLRC
..||. .
VEVVFSE
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| Phosphatase | daf-18.AA | Family.DSP.PD | 108-238 | 28 | 3.5e-26 | 83.3 | In-house | 132-252 (387) | Show / Hide |
Range on Protein: 108-238 Range on HMM: 132-252/387 Sequence Identity: 28% (39 aa) GNVKVFNLRggyyYDADNFDG----NVICFDMTDHHPPSLELMapFCREAKeWLEA--DDKHVIAVHCKAGKGRTGVMICALLIYINFYPSPrQILDYYS | |. || .| ..|. ..... . ||..|.||.. |.. . ..| |.|.|..|||||||||.|..|.| |.. . . . . ||... gvtkivnlt----ddkpqftkelgikylripidDhnapplenl--fekaid-fieegndskgvVlVHCkaGkgRsgtliiaYlmksegltle-ealdwvr IIRtknnKGVTIPSQRryiyYYHKLRERELNYLPLRM . | .||..|.|. . ..| . | ..|... skR----pgvitpnqg----flkqlkdlekeklkvss |
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| Phosphatase | daf-18.AA | Subfamily.Tensin.PD | 129-230 | 37 | 1.9e-25 | 80.6 | In-house | 4-107 (237) | Show / Hide |
Range on Protein: 129-230 Range on HMM: 4-107/237 Sequence Identity: 37% (39 aa) NVICFDMTDHHPPSLELMAPFCREAKEWLEADDKHVIAVHCKAGKGRTGVMICALLIYINFYPSPRQILDYYSIIRTKNNK--GVTIPSQRRYIYYYHKL .| . |.. |.|| .. |.. . ||.|| ..|...||| ||||.||.|.| . | . |. . || ... | ..| ||| ||||||. |. .| kvldlGWPdllaPpleklcsickalesWlkadpqnvvvlhckGgkGrigvvisaymhyskisasadaaldrfalkrfyddkvsgvtqPsqrryveyfsgl RERE . . lsgs |
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| Phosphatase | daf-18.AA | Subfamily.PTPDC1.PD | 111-195 | 29 | 7.1e-12 | 36.2 | In-house | 115-199 (229) | Show / Hide |
Range on Protein: 111-195 Range on HMM: 115-199/229 Sequence Identity: 29% (25 aa) KVFNLRGGYYYDADNFDGNVIC---FDMTDHHPPSLELMAPFCREAKEWLeadDKHVIAVHCKAGKGRTGVMICALLIYINFYPSPRQ . . |. || ... . | | ..|. .||| . . .. | . ||||| ||.|||||.|.. |.| . . . . GagleesGfsYdpeelmrqgiyfynfglkDygvasleriLdivkvvdfal---eegkiavHCHAGlGRtGvliacylvyakrltaeea |
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| Phosphatase | daf-18.AA | Subfamily.DSP11.PD | 120-199 | 30 | 9.6e-10 | 29.4 | In-house | 34-117 (141) | Show / Hide |
Range on Protein: 120-199 Range on HMM: 34-117/141 Sequence Identity: 30% (26 aa) YYDADNFDGNVICF---DMTDHHPPSLELMAPFCREAKEWLE--ADDKHVIAVHCKAGKGRTGVMICALLIYINFYpSPRQILDY ||. ... . . . .. |. |. | . |... ||.|| .|....|.||| | ||| .|| || . | || . .. yykkkeltdegvkykklncpGhevpekedvkkfkeavkefleknkdndkligvhCthGvnrtGyliCrylidvegy-spedaiea |
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| Phosphatase | daf-18.AA | Subfamily.DSP23.PD | 130-188 | 30 | 1.2e-09 | 29.3 | In-house | 36-92 (128) | Show / Hide |
Range on Protein: 130-188 Range on HMM: 36-92/128 Sequence Identity: 30% (18 aa) VICFDMTDHHPPSLELMAPFCREAKEWLEADdkHVIAVHCKAGKGRTGVMICALLIYIN . . |. |..||.|| .| . | .| . . ..||| | |||| .. |. . lrridipdfcPPaleqvarlvriveeaekke--eavgvhcalGlGrtGtllacylvkee |
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| Phosphatase | daf-18.AA | Subfamily.RNGTT.PD | 119-186 | 32 | 1.1e-08 | 25.8 | In-house | 32-103 (140) | Show / Hide |
Range on Protein: 119-186 Range on HMM: 32-103/140 Sequence Identity: 32% (23 aa) YYYDADNFDGN-V--ICFDMTDH-HPPSLELMAPFCREAKEWLEADDKHVIAVHCKAGKGRTGVMICALLIY |||..... . | | ... . |. | . | . ||.|. ..||.||| | ||| .|.| |. ryydkeelekegvkyiklqcrGrGeaPtkeqtklfiklvkeflkkkPdevigvhCthGfnrtGflivayLve |
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| Phosphatase | daf-18.AA | Subfamily.RK.PD | 140-224 | 25 | 1.8e-08 | 24.8 | In-house | 177-260 (267) | Show / Hide |
Range on Protein: 140-224 Range on HMM: 177-260/267 Sequence Identity: 25% (22 aa) PPSLELMAPFCREAKEWLEADDKHVIAVHCKAGKGRTGVMiCALLIYINFYPSpRQILDYYSIIRTK-NNKGVTIPSQRRYIYYYH | | . . . |. |.. | ... | ||| || ||.|. .|. | .. ....| . ...| |.| . . .|.. | PvskrsllklirrvkksqeeeeeGrivvhClaGaGrsGtf-iaidivlemier-egvvdvfnavktlrnrkvnmveteeqykfvyd |
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| Phosphatase | daf-18.AA | Subfamily.CDC14.PD | 141-220 | 30 | 2.8e-08 | 24.6 | In-house | 182-251 (258) | Show / Hide |
Range on Protein: 141-220 Range on HMM: 182-251/258 Sequence Identity: 30% (24 aa) PSLELMAPFCREAKEWleaddKHVIAVHCKAGKGRTGVMICALLIYINFYpSPRQILDYYSIIRTknnkGVTIPSQRRYI || ... | . . . . |||||||| ||||..| . ||. . . ... . |.| | | |. |. Psdailkkfleiteka-----eGaiavhCkaGLGrtgtligcylikhyrf-taaetiawlriarP----Gsvigpqqtyl |
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| Phosphatase | daf-18.AA | Subfamily.R_Anemone_2.PD | 146-227 | 21 | 3.1e-08 | 24.4 | In-house | 178-258 (262) | Show / Hide |
Range on Protein: 146-227 Range on HMM: 178-258/262 Sequence Identity: 21% (18 aa) MAPFCREAKEWLEADDKHVIAVHCKAGKGRTGVMiCALLIYINFYPSPrQILDYYSIIRT-KNNKGVTIPSQRRYIYYYHKLR . . |..... . ....|.||| || ||||| .|. | .. ...| . .... .... . . . .|.. |. | lldlvrqvekaqqesgagpivvhcsaGvGrtGvf-iavdillerikae-alvdvfqtvkqlreqrnlmvqtkdqyefiydvll |
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| Phosphatase | daf-18.AA | PTPc_motif | 126-228 | 19 | 4.2e-08 | 34.15 | SMART | 1-92 (92) | Show / Hide |
Range on Protein: 126-228 Range on HMM: 1-92/92 Sequence Identity: 19% (21 aa) FDGNVICFDMTDH-----HPPSLELMAPFCREAKEWLEADDKHVIAVHCKAGKGRTGVMICALLIYINFYPSPRQILDYYSIIRTKNNKGVTIPSQRRYI . . . . || . |. . . |.|. .. | ||| || ||||..... ... . |... .| . . . . || TVHHYHYTNWPDHVEKDSGVPE-DSILEFIRHVRK--------PIVVHCSAGCGRTGTFCAIDMMMQQ-----VDIFQTVKEMR--KQRPGMVQTEEQYI YYYHKLRE . |. . | FCYRCILE |
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| Phosphatase | daf-18.AA | Subfamily.PRL.PD | 120-188 | 30 | 4.9e-08 | 23.8 | In-house | 36-107 (140) | Show / Hide |
Range on Protein: 120-188 Range on HMM: 36-107/140 Sequence Identity: 30% (21 aa) YYDADNF---DGNVICFDMTDHHPPSLELMAPFCREAKEWLEADDKHVIAVHCKAGKGRTGVMICALLIYIN |||... . .|. . . | .|. |.. . . || . ..|...|||| || ||. |... || sydaeklkeegievldlafddGavPpkevvdeWlellkekfkeepkstvavhcvaGlGraPvlvalalieaG |
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| Phosphatase | daf-18.AA | Subfamily.RB.PD | 137-224 | 24 | 3.2e-07 | 20.9 | In-house | 166-254 (261) | Show / Hide |
Range on Protein: 137-224 Range on HMM: 166-254/261 Sequence Identity: 24% (22 aa) DHH-PPSLELMAPFCREAKEWLEAD-DKHVIAVHCKAGKGRTGVMICALLIYINFYPspRQILDYYSIIRT-KNNKGVTIPSQRRYIYYYH || | . . . |.|. .|..|.. |. | ||| || ||||. | . . ....| .... .... . . ....||. .. dhgvPektktlldfvrtvreaiekkaskkPivvHCsaGvGRtGtfialdrllqaiee--ndyvdvfgvvaelReeRnllvqtekqyifihe |
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| Phosphatase | daf-18.AA | Subfamily.N12.PD | 142-205 | 24 | 9.3e-07 | 19.2 | In-house | 180-243 (270) | Show / Hide |
Range on Protein: 142-205 Range on HMM: 180-243/270 Sequence Identity: 24% (16 aa) SLELMAPFCREAKEWLEaDDKHVIAVHCKAGKGRTGVmICALLIYINFYPS-PR-QILDYYSIIRT | . . . ....| | .... ..||| || ||||. |.|. . . . . || .... . saksllelielvrelqe-sedaPlvvhCsaGvGrtGt-iiaidyvrellkaekipeeldvfdlvle |
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| Phosphatase | daf-18.AA | Subfamily.N13.PD | 136-223 | 24 | 1.2e-06 | 19.2 | In-house | 166-251 (259) | Show / Hide |
Range on Protein: 136-223 Range on HMM: 166-251/259 Sequence Identity: 24% (22 aa) TDHHPPSL-ELMAPFCREAKEWLEadDKHVIAVHCKAGKGRTGVMICALLIyINFYPS--PRQILDYYSIIRTKNNkgVTIPSQRRYIYYY || || . . | .| .. . |. |.||| || ||.||.|. . .. . .. . .| . . . .. .||. | PdhgvPssaaelvqfvaevrllqt--dagPivvhcsaGiGrsGvlitidvv-lglierdkefdvkeivrklreqrq--gvvqtkdqyifvy |
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| Phosphatase | daf-18.AA | Subfamily.RA.PD | 152-228 | 26 | 1.4e-06 | 18.8 | In-house | 188-263 (266) | Show / Hide |
Range on Protein: 152-228 Range on HMM: 188-263/266 Sequence Identity: 26% (21 aa) EAKEWLEADDKHVIAVHCKAGKGRTGVMIcALLIYINFYPSpRQILDYYSII-RTKNNKGVTIPSQRRYIYYYHKLRE . |. . .| |.||| || |||| .| .| .. . ..|| . .. | .... . .. .| . |. |.| kvkklqqqsanhpivvhcsaGvGrtGtfi-vldavlervka-erkldvfeavkrlrlqrpqmvqtleqyefiykvlle |
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| Phosphatase | daf-18.AA | Subfamily.PTPMT1.PD | 159-188 | 30 | 3e-06 | 18.0 | In-house | 83-112 (146) | Show / Hide |
Range on Protein: 159-188 Range on HMM: 83-112/146 Sequence Identity: 30% (9 aa) ADDKHVIAVHCKAGKGRTGVMICALLIYIN |.... . ||||||..| . .. . |.. . askgssvYvHCkAGrtRsatlvacylmkkk |
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| Phosphatase | daf-18.AA | Subfamily.N14.PD | 147-187 | 40 | 5.5e-06 | 16.7 | In-house | 190-233 (275) | Show / Hide |
Range on Protein: 147-187 Range on HMM: 190-233/275 Sequence Identity: 40% (16 aa) APFCREAKEWLE--ADDKHVIAVHCKAGKGRTGVMICAL-LIYI .|.... | . | . ||| || |||||.| . ||. qsvrrktnsevesvkeskPPvlvhCsaGvGrtGvlilsdlliat |
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| Phosphatase | daf-18.AA | Subfamily.N_Choan_1.PD | 146-224 | 21 | 6.7e-06 | 16.6 | In-house | 177-255 (262) | Show / Hide |
Range on Protein: 146-224 Range on HMM: 177-255/262 Sequence Identity: 21% (17 aa) MAPFCREAKEWLEADDKHVIAVHCKAGKGRTGVMIcALLIYINFYPSPRQILDYYSIIRT-KNNKGVTIPSQRRYIYYYH . | .. .. . . |. . .|| || ||||. | || ... . .. || .... .... . . . .| . |. llefrkavlkatkkktkaplvihCsaGvGrtGtyi-alDrlvkaveekaealdvkavvaelrkernlmvqtlvqyefvyk |
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| Phosphatase | daf-18.AA | Subfamily.N_Fungi_PTP1.PD | 153-181 | 42 | 7.6e-06 | 16.0 | In-house | 251-279 (343) | Show / Hide |
Range on Protein: 153-181 Range on HMM: 251-279/343 Sequence Identity: 42% (12 aa) AKEWLEADDKHVIAVHCKAGKGRTGVMIC |...|. . | ||| || ||||... aeshldnarsspilvhCsaGvGrtGtlvt |
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| Phosphatase | daf-18.AA | Subfamily.N5_RR.PD | 137-186 | 31 | 8.8e-06 | 16.2 | In-house | 169-221 (265) | Show / Hide |
Range on Protein: 137-186 Range on HMM: 169-221/265 Sequence Identity: 31% (16 aa) DHHPP-SLELMAPFCREAKEWLEADDKH--VIAVHCKAGKGRTGVMICALLIY ||. | . . . ...| .| |..... . ||| || ||||..|.... dhksPddintlldlvleveesreeenaklaPvvvhcsaGiGrtGcfiaisiav |
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