Gene F28C6.8
F28C6.8
Species: C.elegans
Alias: F28C6.8
External Links:
Classification
Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.
Protein domain
Protein domains of F28C6.8.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit phosphatase group/family/subfamily, which is helpful to understand the relationship between phosphatases. Transmembrane region is predicted by TMHMM 2.0. Visualized by pviz.
Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking. View complete domain list.
| Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
|---|---|---|---|---|---|---|---|---|---|
| Phosphatase | F28C6.8.AA | Subfamily.PTPMT1.PD | 30-176 | 52 | 1e-66 | 214.2 | In-house | 1-145 (146) | Show / Hide |
Range on Protein: 30-176 Range on HMM: 1-145/146 Sequence Identity: 52% (77 aa) RVDETLILGAMPFRSMKDELIQKENVGGVVCCTEEFELKAAMNAMREvdWKNEGVEFFAVPMKDFTGTAPRAEINEAVEFIESVASKGKTVYVHCKAGRT |.|||.||||.||||...||..|||| .||...||.||||..|...| ||..|||.......|||... .....|.|||||.|||||..|||||||||| ridetvilGalPfrsltkeLvekenvkavvslneeyelkalanstee--wkklGveqlqlatvDfteapslekleegvefiekvaskgssvYvHCkAGrt RSATVATCYLMKSRNWMSNVAWEFLKDKRHQVLLRNAHWRTVNEYRR ||||...|||||........|..|||.||.|..|....||...|... RsatlvacylmkkkklspeeavkflkkkRpqirlkskqwralqefke |
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| Phosphatase | F28C6.8.AA | DSPc | 49-177 | 25 | 3.5e-47 | 165.99 | Pfam | 1-151 (151) | Show / Hide |
Range on Protein: 49-177 Range on HMM: 1-151/151 Sequence Identity: 25% (38 aa) LIQKENVGGV--VCCTEEFELKAAMNAMREVDW----KNEGVEFFAVP-MKD---------FTGTAPRAEINEAVEFIESVASKGKTVYVHCKAGRTRSA |.. . . ....... .. .|...|... .|.. ... .| ..| ...|. .....|..||.....||. |.|||.|| ||| LYLGSYPHHMADPAFLQKHGITHVINCTMECPNNWFYHNSHFHYMWIPHVHDHIHYYHIHWNHCTNISQYFPMATDFIDDCRQKGGKVLVHCQAGISRSA TVATCYLMKSRNWMSNVAWEFL-----KDKRHQVLLRN-AHWRTVNEYRRF ... .||||.||...| |..|. |..|... .| .||. .||.|. CLCIAYLMKYRNMSYNEAYDFVYIYHMKQRRCPMISPNMNFWRQLCEYERQ |
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| Phosphatase | F28C6.8.AA | DSPc | 40-177 | 22 | 1.2e-44 | 155.53 | SMART | 1-172 (172) | Show / Hide |
Range on Protein: 40-177 Range on HMM: 1-172/172 Sequence Identity: 22% (39 aa) MPFRSMKDELIQKENVGGV---VCCTEEFELKAAMNAMREVDW------------------KNEGVEFFAVP-MKD-------FTGTAPRAEINEAVEFI .|.. .. |.. . . . .|..... .. .|...|..| .| . ... .| . | ...|. ....|...|| GPSEITPH-LYLGSYPHHMEPNPCFLKKHNITHVINVTMECPWNFHHCQKNDMHYTNEWIYHNSHFQYMHIPMIDDIYYHIRWNHCTNISQYFPEVYDFI ESVASKGKTVYVHCKAGRTRSATVATCYLMKSRNWMSNVAWEFL-----KDKRHQVLLRN-AHWRTVNEYRRF .....||. |.|||.|| ||||.. .||||..|...| |..|. |..|.. ..| .|.. |..|. HDCRQKGGKVLVHCQAGISRSATLCIAYLMKYMNMSYNDAYHFVYIYHIKQRRCPIICPNFNFWHQLCEWERK |
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| Phosphatase | F28C6.8.AA | Family.DSP.PD | 30-176 | 22 | 9.8e-25 | 78.6 | In-house | 109-245 (387) | Show / Hide |
Range on Protein: 30-176 Range on HMM: 109-245/387 Sequence Identity: 22% (35 aa) RVDETLILGAMPFRSMKDELiQKENVGGVVCCTeefeL------KaamnamrevdwkNEGVEFFAVPMKDFTGTAPRAEINEAVEFIESVASKGKTVYVH .. . |.|| . . ...| .. .| .| .| | ..|... .|. |.. . . . .|..|||.. .....|.|| eilphlylgsllaaknlewl-kelgvtkivnlt----ddkpqftk------------elgikylripidDhnapplenlfekaidfieegndskgvVlVH CKAGRTRSATVATCYLMKSRNWMSNVAWEFLKDKRHQVLLRNAH-WRTVNEYRR ||||. ||.|. .|||||... . |......|| .|. | . .. . ... CkaGkgRsgtliiaYlmksegltleealdwvrskRpgvitpnqgflkqlkdlek |
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| Phosphatase | F28C6.8.AA | Subfamily.DSP8.PD | 43-161 | 31 | 2.1e-20 | 64.2 | In-house | 16-125 (143) | Show / Hide |
Range on Protein: 43-161 Range on HMM: 16-125/143 Sequence Identity: 31% (37 aa) RSMKDELIQKENVGGVVCCTEEFElkaamnamREVDWKNEgVEFFAVPMKDFTGTAPRAEINEAVEFIESVASKGKTVYVHCKAGRTRSATVATCYLMKS |...||..| ... |. .|. . .|. ..| ..|. .|.|| ...|.|||. . |. ..| ||| ||..|||||| .|.|| dsldeellkklgisyvlnisescp--------kdvellke-srflriPvkDkyeekllpwfdkalefidkarsangkvlvhclaGisrsatvaiayimkt RNWMSNVAWEFLKDKRHQV . .. |..|.|.||. . lemsldeayrfvkekrpti |
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| Phosphatase | F28C6.8.AA | Subfamily.DSP1.PD | 66-159 | 34 | 4.9e-19 | 59.7 | In-house | 27-121 (139) | Show / Hide |
Range on Protein: 66-159 Range on HMM: 27-121/139 Sequence Identity: 34% (33 aa) ELKAAMNAMREVDWK-NEGVEFFAVPMKDFTGTAPRAEINEAVEFIESVASKGKTVYVHCKAGRTRSATVATCYLMKSRNWMSNVAWEFLKDKRH .. | .| .|.. . .| .. .|..| . . . ..||..||.|| .|| |.|||.|| .||||. ||||.... . |.||.|..|. kitallnvsaelpnvfeelfkyksipvednkkadisslfeeaidfidsvkkkgGrvlvhCqaGisrsativlayLmkekkvrleeafefvkqrrs |
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| Phosphatase | F28C6.8.AA | Subfamily.DSP10.PD | 81-159 | 37 | 2.3e-18 | 57.4 | In-house | 45-123 (141) | Show / Hide |
Range on Protein: 81-159 Range on HMM: 45-123/141 Sequence Identity: 37% (29 aa) NEGVEFFAVPMKDFTGTAPRAEINEAVEFIESVASKGKTVYVHCKAGRTRSATVATCYLMKSRNWMSNVAWEFLKDKRH .. |.. .|..| . . . . .||.|||| . ..|..| |||.|| .|||||. |.|| . . |..|.|.|| kglvrykripvsdsgkqnlkqkfeealefieearkrgsrvlvhchaGisrsatvviayvmkhlslslseaykfvkekrP |
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| Phosphatase | F28C6.8.AA | Subfamily.DSP6.PD | 65-161 | 28 | 1.1e-17 | 55.0 | In-house | 26-125 (141) | Show / Hide |
Range on Protein: 65-161 Range on HMM: 26-125/141 Sequence Identity: 28% (29 aa) FELKAAMNAMREVD--W-KNEGVEFFAVPMKDFTGTAPRAEINEAVEFIESVASKGKTVYVHCKAGRTRSATVATCYLMKSRNWMSNVAWEFLKDKRHQV ...| .| ... . ... ... .|..| . . . ||.|||. || ..| ||| || .|| ||. .||||... | |....|.|. .. lkikyvlnvtsnlpnkfeesgelkykqipiedhlsqnlakffPeaiefidearskkskvlvhclaGvsrsvtvtlaylmkklalslndaydlvkkkksni |
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| Phosphatase | F28C6.8.AA | Subfamily.DSP12.PD | 87-163 | 32 | 1.2e-17 | 55.3 | In-house | 51-127 (143) | Show / Hide |
Range on Protein: 87-163 Range on HMM: 51-127/143 Sequence Identity: 32% (24 aa) FAVPMKDFTGTAPRAEINEAVEFIESVASKGKTVYVHCKAGRTRSATVATCYLMKSRNWMSNVAWEFLKDKRHQVLL ... | . ..|||.|||. .|...|.|||.|| ||.|. . ||||.... . | ...|.|.... kliqilDepeedlLshldeavrFieeglekegavlvHClagvSRSvtiviAYlmkkeklslekAlklvkekkkeiep |
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| Phosphatase | F28C6.8.AA | Subfamily.DSP19.PD | 84-174 | 30 | 3.8e-17 | 53.4 | In-house | 46-136 (139) | Show / Hide |
Range on Protein: 84-174 Range on HMM: 46-136/139 Sequence Identity: 30% (28 aa) VEFFAVPMKDFTGTAPRAEINEAVEFIESVASKGKTVYVHCKAGRTRSATVATCYLMKSRNWMSNVAWEFLKDKRHQVLLRNAHWRTVNEY ... ... | | . ..||..|||.. ||. .|.|||.||. |||.|. ||||... . | | ....| . . .. ..|| ftyksieilDlpetkllsylkealdFieearskdgrvlvHCnAGvSRsasvviaylmkdeelslekalekvrearpcikPneGFikqLkey |
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| Phosphatase | F28C6.8.AA | Subfamily.Slingshot.PD | 67-175 | 27 | 2.5e-16 | 50.7 | In-house | 28-137 (139) | Show / Hide |
Range on Protein: 67-175 Range on HMM: 28-137/139 Sequence Identity: 27% (30 aa) LKAAMNAMREVD-WKNEGVEFFAVPMKDFTGTAPRAEINEAVEFIESVASKGKTVYVHCKAGRTRSATVATCYLMKSRNWMSNVAWEFLKDKRHQVLLRN .. .| .|.| . .| .... . . | . | . ||. .||| . .|| | |||| | .|||.. | ||. .. . |.|..|..|. . . veyilnvtkeidnffpekfkylnirvydeeetdllkhwnetykfiekakekgskvlvhckmGvsrsastviayamkeyelsleealeyvkerrsiikpnk AHWRTVNEYR . .. ...|. gflkqlkvye |
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| Phosphatase | F28C6.8.AA | Subfamily.DSP14.PD | 70-174 | 26 | 4.2e-16 | 50.2 | In-house | 30-135 (138) | Show / Hide |
Range on Protein: 70-174 Range on HMM: 30-135/138 Sequence Identity: 26% (28 aa) AMNAMR-EVDWKNEGVEFFAVPMKDFTGTAPRAEINEAVEFIESVASKGKTVYVHCKAGRTRSATVATCYLMKSRNWMSNVAWEFLKDKRHQVLLRNAHW .|. . ... | |.|. ....| . . .|... ||.| .|| . |||.||. |||.... |||| .. . |....|..|.. . |. ivnvttelpetkledvktvkikveDkpeaklaehfdevadkieevkkkgGktlvhCvaGvsRsAslvlaylmkyeklsLreayklvksaRpiirPnvGFw RTVNEY . .| kqlidy |
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| Phosphatase | F28C6.8.AA | Subfamily.DSP3.PD | 56-159 | 27 | 5.1e-16 | 49.9 | In-house | 29-131 (148) | Show / Hide |
Range on Protein: 56-159
Range on HMM: 29-131/148
Sequence Identity: 27% (27 aa)
GGVVCCTEEfELKAAMNAMREVdWKNEGVEFFAVPMKDFTGTAPRAEINEAVEFIES-VASKGKTVYVHCKAGRTRSATVATCYLMKSRNWMSNVAWEFL
|. ..|. . . ... .|. .|. .... |...|. . .. .||..||.. ...|. |.|||..| ||||.. ||| .|.. | . ..||.
thvLnaaeg-krllkvdtdaef-YkdleikylGvevsDvpefdlskyfeeaadfidealsqkngkvlvhcvvGisRsatlvlayLmirrkltlkeaiktv
KDKRH
rkkre
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| Phosphatase | F28C6.8.AA | Subfamily.Laforin.PD | 73-164 | 27 | 1.3e-13 | 41.9 | In-house | 61-151 (165) | Show / Hide |
Range on Protein: 73-164 Range on HMM: 61-151/165 Sequence Identity: 27% (25 aa) AMREVdWKNEGVEFFAVPMKDFTGTAPRAEINEAVEFIESVASKGKTVYVHCKAGRTRSATVATCYLMKSRNWMSNVAWEFLKDKRHQVLLR ... . .|.||. . .|..|.. . . .|| .. .. ||. |||||.|| ||... .|. .| . || || |. tlkkl-ykeeglayiwlptedlstesrvenlpqavyllhallekghivyvhcnagvgrstaivcgflqyvlgwslakvqyfllakrpvvyid |
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| Phosphatase | F28C6.8.AA | Subfamily.PTPDC1.PD | 78-179 | 27 | 1.5e-13 | 41.7 | In-house | 129-228 (229) | Show / Hide |
Range on Protein: 78-179 Range on HMM: 129-228/229 Sequence Identity: 27% (26 aa) DWKNEGVEFFAVPMKDFtGTAPRAEINEAVEFIESVASKGKtVYVHCKAGRTRSATVATCYLMKSRNWMSNVAWEFLKDKRHQVLLRNAHWRTVNEYRRF . ...|. |. ...||. |.|. .| . | .... ..|| . ||| ||. | . .|||. ... .. | .....|| . ...|.|...|| elmrqgiyfynfglkDy-gvasleriLdivkvvdfaleegk-iavHCHAGlGRtGvliacylvyakrltaeeaiklvrskrpksiqtreqvelveeFalf LD lr |
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| Phosphatase | F28C6.8.AA | Subfamily.STYXL1.PD | 68-161 | 25 | 1.9e-13 | 41.8 | In-house | 30-127 (143) | Show / Hide |
Range on Protein: 68-161 Range on HMM: 30-127/143 Sequence Identity: 25% (25 aa) KAAMNAMRE----VDWKNEGVEFFAVPMKDFTGTAPRAEINEAVEFIESVASKGKTVYVHCKAGRTRSATVATCYLMKSRNWMSNVAWEFLKDKRHQV || .| . .. .. .. . ....| . ...|.|.|||. .|..| | . | .|||.|. .||| |... ..|...||. .. | kahvnvssdaekliagladvakllhiavedeneadllerlkevvqfiekhkkegevvlvfsnkGisrsaaviiaylmyskkitlkkaykylkkckenv |
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| Phosphatase | F28C6.8.AA | Subfamily.DSP15.PD | 82-155 | 25 | 1e-11 | 35.9 | In-house | 43-116 (138) | Show / Hide |
Range on Protein: 82-155 Range on HMM: 43-116/138 Sequence Identity: 25% (19 aa) EGVEFFAVPMKDFTGTAPRAEINEAVEFIESVASKGKTVYVHCKAGRTRSATVATCYLMKSRNWMSNVAWEFLK |.... .....| . .|...|| .. .|..|.||| || .|| |... |.| .. . | . .| edikylcikaadsPdqdlskffkesidfihkcrleggnvlvhclaGisrsvtlvvayimtvtelswedalkavk |
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| Phosphatase | F28C6.8.AA | Subfamily.DSP23.PD | 82-175 | 22 | 6.9e-11 | 33.3 | In-house | 32-124 (128) | Show / Hide |
Range on Protein: 82-175 Range on HMM: 32-124/128 Sequence Identity: 22% (21 aa) EGVEFFAVPMKDFTGTAPrAEINEAVEFIESVASKGKTVYVHCKAGRTRSATVATCYLMKSRNWMSNVAWEFLKDKRHQVLLRNAHWRTVNEYR ... . .. ..||. |. ... |. .| |...| ||| |. |. |. .|||.|... .. | .. .|. . . |..|. psltlrridipdfcPPal-eqvarlvriveeaekkeeavgvhcalGlGrtGtllacylvkeeglaaddaiaevrkrrkGsietveqekavkdye |
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| Phosphatase | F28C6.8.AA | Subfamily.LRR-DSP.PD | 101-162 | 35 | 5.1e-10 | 30.3 | In-house | 62-122 (137) | Show / Hide |
Range on Protein: 101-162 Range on HMM: 62-122/137 Sequence Identity: 35% (21 aa) AEINEAVEFIESVASKGkTVYVHCKAGRTRSATVATCYLMKSRNWMSNVAWEFLKDKRHQVL ..| ||.. || | .||.|| .||||.. .|||| .. . | .. ..|| .. qhfkemnafidegrekg-gvlihcragvsrsatlviaylmkknslkfkealdlvikkrpriy |
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| Phosphatase | F28C6.8.AA | Subfamily.CDC14.PD | 96-154 | 32 | 8e-10 | 29.8 | In-house | 179-235 (258) | Show / Hide |
Range on Protein: 96-154 Range on HMM: 179-235/258 Sequence Identity: 32% (19 aa) GTAPRAEINEavEFIESVASKGKTVYVHCKAGRTRSATVATCYLMKSRNWMSNVAWEFL || | .| . .|.| . . .. |||||| | .|. .|||.| . . . .| GtvPsdailk--kfleitekaeGaiavhCkaGLGrtgtligcylikhyrftaaetiawl |
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| Phosphatase | F28C6.8.AA | Subfamily.STYX.PD | 103-174 | 26 | 1.2e-09 | 29.2 | In-house | 72-143 (146) | Show / Hide |
Range on Protein: 103-174 Range on HMM: 72-143/146 Sequence Identity: 26% (19 aa) INEAVEFIESVASKGKTVYVHCKAGRTRSATVATCYLMKSRNWMSNVAWEFLKDKRHQVLLRNAHWRTVNEY . .. |||.. .|| | || .|| .|||.. .|.|.. |. .....| . . . ..|| lptvkefiddslqkggkvlvhgnagisrsaalviayimetyglkyreafayvqerrfcinpnegfvsqlkey |
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| Phosphatase | F28C6.8.AA | Subfamily.PTEN.PD | 74-159 | 28 | 4e-09 | 27.2 | In-house | 50-137 (305) | Show / Hide |
Range on Protein: 74-159 Range on HMM: 50-137/305 Sequence Identity: 28% (25 aa) MREVDWKNEGVEFFAVPMKDFTgtAPRAE-INEAVEFIESV--ASKGKTVYVHCKAGRTRSATVATCYLMKSRNWMSN-VAWEFLKDKRH .| . . .|..| . .|. | ..| || ... ..| . | ||||||. |. .. ..||.|| |. | .. ..|| rgekedsdfdgrvavypfdDhn--pptleLleeivedvdkwLkedksnVvavHCkaGkGRtGvmicayLlksgikksadealaiydekRt |
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| Phosphatase | F28C6.8.AA | Subfamily.R_Nematode_3.PD | 91-137 | 37 | 3.9e-07 | 20.6 | In-house | 172-218 (267) | Show / Hide |
Range on Protein: 91-137 Range on HMM: 172-218/267 Sequence Identity: 37% (17 aa) MKDFTGTAPRAEINEAVEFIESVASKGKTVYVHCKAGRTRSATVATC .|. . | .||.| |. | . ..| |||..| |||| | ykgWkelnapeepkealelikfveksktpvvVHCsdGisRsatlaai |
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| Phosphatase | F28C6.8.AA | Subfamily.DSP11.PD | 103-170 | 28 | 1.1e-06 | 19.5 | In-house | 66-134 (141) | Show / Hide |
Range on Protein: 103-170 Range on HMM: 66-134/141 Sequence Identity: 28% (19 aa) INEAV-EFIESVASKGKTVYVHCKAGRTRSATVATCYLMKSRNWMSNVAWEFLKDKRHQVLLRNAHWRT .||| ||.|. . ..| . ||| | |. . ||.. .. .. | | ... | | |... . fkeavkefleknkdndkligvhCthGvnrtGyliCrylidvegyspedaieafeearGhslerenyled |
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| Phosphatase | F28C6.8.AA | Subfamily.PRL.PD | 77-162 | 27 | 1.8e-06 | 18.8 | In-house | 40-125 (140) | Show / Hide |
Range on Protein: 77-162 Range on HMM: 40-125/140 Sequence Identity: 27% (24 aa) VDWKNEGVEFFAVPMKDftGTAPRAE-INEAVEFIESV--ASKGKTVYVHCKAGRTRSATVATCYLMKSrNWMSNVAWEFLKDKRHQVL |.||.| ....| |..| | ..| .| ... ....|| ||| || |. . . |. . .. | ||...||. . eklkeegievldlafdd--GavPpkevvdeWlellkekfkeepkstvavhcvaGlGraPvlvalaliea-Gmkyedavefirekrrgai |
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| Phosphatase | F28C6.8.AA | Subfamily.RNGTT.PD | 81-161 | 20 | 9.1e-06 | 16.4 | In-house | 41-123 (140) | Show / Hide |
Range on Protein: 81-161 Range on HMM: 41-123/140 Sequence Identity: 20% (17 aa) NEGVEFFAVPMKDfTGTAPRAE-INEAVEFIESVAS--KGKTVYVHCKAGRTRSATVATCYLMKSRNWMSNVAWEFLKDKRHQV .|||.. . .. | || | ... .. ... . .... ||| | | . .||.. .| . | . . |.. kegvkyiklqcrG-rGeaPtkeqtklfiklvkeflkkkPdevigvhCthGfnrtGflivayLvekedwsveaavalfakarppG |
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Sequence
| Name | Sequence Type | Origin | Length | Description | Download |
|---|---|---|---|---|---|
| F28C6.8.AA | Protein | None | 189 | None | Fasta, JSON |
| F28C6.8.NA | RNA | None | 567 | None | Fasta, JSON |
| F28C6.8.AA.PD_40-177 | Protein Phosphatase Domain | None | 138 | None | Fasta, JSON |