Gene cel-1
cel-1
Species: C.elegans
Alias: cel-1
External Links:
Classification
Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.
Protein domain
Protein domains of cel-1.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit phosphatase group/family/subfamily, which is helpful to understand the relationship between phosphatases. Transmembrane region is predicted by TMHMM 2.0. Visualized by pviz.
Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking. View complete domain list.
| Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
|---|---|---|---|---|---|---|---|---|---|
| Phosphatase | cel-1.AA | Subfamily.RNGTT.PD | 52-189 | 52 | 1.7e-67 | 215.7 | In-house | 2-139 (140) | Show / Hide |
Range on Protein: 52-189 Range on HMM: 2-139/140 Sequence Identity: 52% (72 aa) RYQFHPAEVFSHPHLHGKKIGLWIDLTNTDRYYFREEVTEHECIYHKMKMAGRGVSPTQEDTDNFIKLVQEFHKKYPDRVVGVHCTHGFNRTGFLIAAYL ...|.|....|. . . .|.||.||||||.|||..||...... |.|....|||..||.|.|..|||||.||.||.||.|.|||||||||||||||.||| eeafepemlksylktlkvklglvidltntsryydkeelekegvkyiklqcrGrGeaPtkeqtklfiklvkeflkkkPdevigvhCthGfnrtGflivayL FQVEEYGLDAAIGEFAENRQKGIYKQDYIDDLFARYDP ...|.....||. .||..|..||||.||...||.||.. vekedwsveaavalfakarppGiykedylkelfkryed |
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| MRNA_cap_enzyme | cel-1.AA | mRNA_cap_enzyme | 289-479 | 41 | 2e-146 | 350.81 | Pfam | 1-213 (213) | Show / Hide |
Range on Protein: 289-479 Range on HMM: 1-213/213 Sequence Identity: 41% (88 aa) QPVSLSR-GNINLLEQESYMVSWKADGMRYIIYINDG-------DVYAFDRDNEVFEIENLDFVTKN-GAP------LMETLVDTEVIIDKVEINGAMCD ||||.|| |...|.|..|.|.||.|||||...|.| ..|..|||......||..|..|. ... ...||.|.|..||........|. QPVSMSRRENMKFLKQNYYYVCWKTDGMRYMMFITDHPEYGEFKGCYMIDRDMNYYHVENMRFPCKYNKWGESLDKHHHYTLLDGEMCIDTIPMQETQCQ QPRMLIYDIMRFNSVN-VMKEPFY--KRFEIIKTEIIDMRTAA--FKTGRLKHENQIMSVRRKDFYDLEATAKLF--GPKFVQHVGHEIDGLIFQPKKTK |||.||||....|... ||..||| ||.|.||.|||..|... |||..........|||.||..|.....||. ..||..|. |||||||||...|. QPRYLIYDCVAINGQCRVMQWPFYSRKRWEMIKREIIKPRNHNMKFKTHWYRYDMFPFSVRFKDMWDNWHSEKLVYYFHKFIPHLCHEIDGLIFQCWDTP YETGRCDKVLKWK |..|||....||| YVPGRCQNLFKWK |
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| Phosphatase | cel-1.AA | Subfamily.DSP11.PD | 54-184 | 43 | 1.4e-36 | 115.6 | In-house | 5-136 (141) | Show / Hide |
Range on Protein: 54-184 Range on HMM: 5-136/141 Sequence Identity: 43% (57 aa) QFHPAEVFSHPHLHGKKIGLWIDLTNTDRYYFREEVTEHECIYHKMKMAGRGVsPTQEDTDNFIKLVQEFH--KKYPDRVVGVHCTHGFNRTGFLIAAYL .| | ..... . ..||.|| |||||||||| ..|.|... |.|....|. | | .|| ..|.. |.|| .| |...||||||| ||||.|| || rfapedlleklqeknkklGLvidltntdryykkkeltdegvkykklncpGhev-pekedvkkfkeavkefleknkdndkligvhCthGvnrtGyliCryl FQVEEYGLDAAIGEFAENRQKGIYKQDYIDDLF .||.| . || | | | . ...|..|| idvegyspedaieafeearGhslerenyledLk |
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| Phosphatase | cel-1.AA | Family.DSP.PD | 61-187 | 24 | 6e-17 | 52.2 | In-house | 123-244 (387) | Show / Hide |
Range on Protein: 61-187 Range on HMM: 123-244/387 Sequence Identity: 24% (31 aa) FSHPHLHGKKIGLWIDLTnTDRYYFREevtEHECIYHKMKMAGRgVSPTQEDTdnFIKLVQeFHKK--YPDRVVGVHCTHGFNRTGFLIAAYLFQVEEYG ... |. ... ..|| .|. | . |.. |... . .|. | |.| .. | .. . || |||..| .|.| ||.||| .| . |. knlewlkelgvtkivnlt-ddkpqftk---elgikylripidDh-napplenl--fekaid-fieegndskgvVlVHCkaGkgRsgtliiaYlmkseglt LDAAIGEFAENRQ-KGIYKQDYIDDLFARY .|. ... |. . .| .. |.. . leealdwvrskRpgvitpnqgflkqlkdle |
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| Phosphatase | cel-1.AA | Subfamily.DSP23.PD | 106-174 | 38 | 1.6e-12 | 37.9 | In-house | 45-111 (128) | Show / Hide |
Range on Protein: 106-174 Range on HMM: 45-111/128 Sequence Identity: 38% (26 aa) VSPTQEDTDNFIKLVQEFHKKypDRVVGVHCTHGFNRTGFLIAAYLFQVEEYGLDAAIGEFAENRQKGI |. | ......|.| .|| . ||||| |. ||| |.| || . |.. | || | ..|. | cPPaleqvarlvriveeaekk--eeavgvhcalGlGrtGtllacylvkeeglaaddaiaevrkrrkGsi |
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| Phosphatase | cel-1.AA | Subfamily.PTPDC1.PD | 84-181 | 24 | 5e-11 | 32.7 | In-house | 125-218 (229) | Show / Hide |
Range on Protein: 84-181 Range on HMM: 125-218/229 Sequence Identity: 24% (24 aa) YFREEVTEHECIYHKMKMAGRGVSPTQEdTDNFIKLVQEFHkkyPDRVVGVHCTHGFNRTGFLIAAYLFQVEEYGLDAAIGEFAENRQKGIYKQDYID | ||. ... ..... .. || . .. . .|.|. . ..||| | ||| |||.|| ..... . || ..| ||. .. .. YdpeelmrqgiyfynfglkDygvasler-iLdivkvvdfal---eegkiavHCHAGlGRtGvliacylvyakrltaeeaiklvrskrpksiqtreqve |
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| Phosphatase | cel-1.AA | Subfamily.PTEN.PD | 108-172 | 33 | 2.5e-09 | 27.1 | In-house | 73-138 (305) | Show / Hide |
Range on Protein: 108-172 Range on HMM: 73-138/305 Sequence Identity: 33% (22 aa) PTQEDTDNFIKLVQEFHKKYPDRVVGVHCTHGFNRTGFLIAAYLFQVEEYGLD-AAIGEFAENRQK || | .... |... |. ..|| ||| | ||| .|.|||.. . |. ..|.| | ptleLleeivedvdkwLkedksnVvavHCkaGkGRtGvmicayLlksgikksadealaiydekRtk |
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| Phosphatase | cel-1.AA | Subfamily.PRL.PD | 89-173 | 25 | 8.5e-09 | 25.6 | In-house | 42-123 (140) | Show / Hide |
Range on Protein: 89-173 Range on HMM: 42-123/140 Sequence Identity: 25% (22 aa) VTEHECIYHKMKMAgRGVSPTQEDTDNFIKLVQEFHKKYPDRVVGVHCTHGFNRTGFLIAAYLFQVEEYGlDAAIgEFAENRQKG . |.. . .... | .|..| |....|..| .|. |. .|.||| |. |. |.| | . . |. || ....| lkeegievldlafd-dGavPpkevvdeWlellkekfkeepkstvavhcvaGlGraPvlvalalieaGmky-edav-efirekrrg |
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| Phosphatase | cel-1.AA | Subfamily.TPIP.PD | 108-157 | 38 | 7.7e-08 | 22.4 | In-house | 16-65 (245) | Show / Hide |
Range on Protein: 108-157 Range on HMM: 16-65/245 Sequence Identity: 38% (19 aa) PTQEDTDNFIKLVQEFHKKYPDRVVGVHCTHGFNRTGFLIAAYLFQVEEY || |. | | |.|. .| ...|| .|| | .||| .. |.| . | . PtleelvvftkevkewlakdlenvvaihckGGkgrtGtivcalliaseif |
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| Phosphatase | cel-1.AA | Subfamily.CDC14.PD | 83-161 | 24 | 1.3e-07 | 21.8 | In-house | 158-228 (258) | Show / Hide |
Range on Protein: 83-161 Range on HMM: 158-228/258 Sequence Identity: 24% (19 aa) YYFREEVTEhECIYHKMKMAGRGVSPTQEDTDNFIKLVQEFhkkypDRVVGVHCTHGFNRTGFLIAAYLFQveEYGLDA | ... |. . . |. . | |... .|...... . . ||| | ||| ||..|| . .|.. | lYdakkftd-aGfahlDlffiDGtvPsdailkkfleiteka-----eGaiavhCkaGLGrtgtligcylik--hyrfta |
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| Phosphatase | cel-1.AA | Subfamily.PTPMT1.PD | 101-172 | 20 | 7.7e-07 | 19.3 | In-house | 60-129 (146) | Show / Hide |
Range on Protein: 101-172 Range on HMM: 60-129/146 Sequence Identity: 20% (15 aa) MAGRGVSPTQEDTDNFIKLVQEFHKKypDRVVGVHCTHGFNRTGFLIAAYLFQVEEYGLDAAIGEFAENRQK . . .|..| . .........| | ||| | | . |.|.|| . ... . |. ... |.. tvDfteapslekleegvefiekvask--gssvYvHCkAGrtRsatlvacylmkkkklspeeavkflkkkRpq |
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| Phosphatase | cel-1.AA | Subfamily.DSP12.PD | 128-173 | 29 | 3e-06 | 17.6 | In-house | 80-125 (143) | Show / Hide |
Range on Protein: 128-173 Range on HMM: 80-125/143 Sequence Identity: 29% (13 aa) PDRVVGVHCTHGFNRTGFLIAAYLFQVEEYGLDAAIGEFAENRQKG .. | |||. | | ...||| . |. |. |. | ... kegavlvHClagvSRSvtiviAYlmkkeklslekAlklvkekkkei |
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| MRNA_cap_C | cel-1.AA | mRNA_cap_C | 482-585 | 38 | 2.9e-53 | 188.09 | Pfam | 1-138 (138) | Show / Hide |
Range on Protein: 482-585 Range on HMM: 1-138/138 Sequence Identity: 38% (53 aa) SHNSVDFLLKVEKKC---KEGML---PEWIGYL-FVQ----------NLSD-PF---------------GTMKATATLKKYHNKIIECTLLVDN--QGRP ..|.|||.||....| ..||| ..|.||| ... .... || ...|.|...|.|.|||.|||.|||| .||| EMNTVDFMLKMCFECIGGEDGMLDRFQQWRGYLDYMEMPNFQKGRWWGGYNCPFFCKMYVFNKMRIFDIEWEKWTNDEKPYNNKIVECTWLVDNKQKGRP KEWKFMRERTDKSLPNGLRTAENVVETMVNPVTETYLIE ||.|||.||||| ||...||..|.......||..||.| -EWVFMRFRTDKSNPNHINTARKVCYSIEDNVTKEYLFE |
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