Gene cele_TNS1
cele_TNS1
Species: C.elegans
Alias: cele_TNS1
External Links:
Classification
Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.
Protein domain
Protein domains of cele_TNS1.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit phosphatase group/family/subfamily, which is helpful to understand the relationship between phosphatases. Transmembrane region is predicted by TMHMM 2.0. Visualized by pviz.
Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking. View complete domain list.
| Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
|---|---|---|---|---|---|---|---|---|---|
| Phosphatase | cele_TNS1.AA | Subfamily.PTEN.PD | 34-198 | 23 | 4.2e-19 | 57.0 | In-house | 2-166 (305) | Show / Hide |
Range on Protein: 34-198 Range on HMM: 2-166/305 Sequence Identity: 23% (39 aa) VEYITSRLIVLSCTSETSERKFVESLLKASQQIQNAHNKHIRVWNVSQRRHDISSSLDA--IPFGWPSETAPSLEKLCTICKNLDQWMLEHPLNIAVIFC . || . ||||| || |. . . | . ... .... .. ... |.. .| .| . .. ..|.|| | .|....|.|. ||.... || | isyilvnlivlsypvetyekllyrnslddlillltvykgkgklrilnargekedsdfdgrvavypfdDhnpptleLleeivedvdkwLkedksnVvavHC KGGLERCAIVVNAFMRFNAISATDDSVDDRFSMQRFSERflGPDGPPSYKRYLGYFSSLLSGRISVN | ... |.. .. | . | . .. .|. .. || .||. |||.|. . . kaGkGRtGvmicayLlksgikksadealaiydekRtkdk--kGVtiPSQrRYvqYfsklvkssvpys |
|||||||||
| Phosphatase | cele_TNS1.AA | Subfamily.Tensin.PD | 94-322 | 37 | 2.5e-52 | 165.7 | In-house | 7-236 (237) | Show / Hide |
Range on Protein: 94-322 Range on HMM: 7-236/237 Sequence Identity: 37% (86 aa) PFGWPSETAPSLEKLCTICKNLDQWMLEHPLNIAVIFCKGGLERCAIVVNAFMRFNAISATDDSVDDRFSMQRFSERFLGPDGPPSYKRYLGYFSSLLSG .||| ||.|||||.|||.|. |. | |. |..|||| | ..|. |.|.. |||. |. |||...|| . . . || .||. |||.||||. dlGWPdllaPpleklcsickalesWlkadpqnvvvlhckGgkGrigvvisaymhyskisasadaaldrfalkrfyddkvsgvtqPsqrryveyfsgllsg RISVNSDPLYLHNIILTF---FEP---INVFLKIYERLVPVYQSKTVALN--KSSK--FEMDGSLKLRGDIFFKCIVAASsPGSSTRCLFTCQLNTCALE | .||.||.|| .|| |.. .. |||||. | .|| | .. .... ....| |.||.. ||... .| .|. |.|.. . siklnssplflhyvilhgipnfdskggcrpflkiyqalqlvytsgvynvagedterlcitiepalllkgdvlvkcyhkkl-rsttrdvvfrvqfhtgaik lhpinseGYSVVrLHKEELDLIFNDKKIDNRVTVELVVS ...| ..||.|| ..|... . |||| | -------dlklv-fekedldealkderfpeyakvelvfs |
|||||||||
| SH2 | cele_TNS1.AA | SH2 | 1231-1328 | 27 | 1.4e-23 | 85.6 | SMART | 1-87 (87) | Show / Hide |
Range on Protein: 1231-1328 Range on HMM: 1-87/87 Sequence Identity: 27% (28 aa) KYWYKPTISREQAINMLRD--KPPGTFVVRDSNSFPGAFGLALKVSTPPPGVNPGDGSELVRHFLIEPSP-KGVKLKGCNNEPVFGSLSALVYQHSITAL || ||||.| ..|. .|.|.|.|||| |.||.. | ... . |.|..|.... ... . .. ... | || || .. ..| QPWYHGNISREEAEQLLKNPGMPDGDFLVRDSESNPGDYVLSVRWK------------GKVKHYRIRRNDDGKYYIDET-WRRKFPSL-ELVNHYQHNPL A G |
|||||||||
| Phosphatase | cele_TNS1.AA | Family.DSP.PD | 49-308 | 15 | 7.1e-14 | 39.9 | In-house | 109-369 (387) | Show / Hide |
Range on Protein: 49-308 Range on HMM: 109-369/387 Sequence Identity: 15% (42 aa) ETSERKFVESLLKASQQIQNAHNKHIRVWNVSQRRHDI--SSSLDAIPFGWPSETAPSLEKLctICKNLDqWMLE--HPLNIAVIFCKGGLERCAIVVNA | .. .. |||.|.. . ..... .. |... .. . . . . .... .||.||.| ..| .| .. | . . ... ||.|. | ... |. eilphlylgsllaaknlewlkelgvtkivnltddkpqftkelgikylripidDhnapplenl--fekaid-fieegndskgvVlVHCkaGkgRsgtliia FMRFN-AISATddSVDDRFSMQRfserflgP-DGPPSYKrYLGYFSSLLSGRISVNSDPLYLHNIILTFFEP------INVFLKIYERLVPVYQS-KTVA . .. ... | .. .| | |... .| ... |.. ..|.| .. |. .| . ..|| . . .... |. Ylmksegltle--ealdwvrskR-------pgvitpnqg-flkqlkdlekeklkvssevmelrfvissivqnlgsvevsvsvlkkvatekakldrlkiLv LNKSSKF--EMDGSLKLRGDIFFKCIvAASSPGSSTRCLFTCQLNTCALELHPINSEGYSVVRLHKEELDLIFND .. |. . ..| | ||. ... . . . . . .. .| . . . . |||.. . .. | ideqekvvitikdglplsgDVkvelf-kknldkiirdiilntfFvtnyikdeslvlvkkeldelhkskifdvykd |
|||||||||
| Phosphatase | cele_TNS1.AA | Subfamily.TPIP.PD | 102-190 | 32 | 6.7e-13 | 36.8 | In-house | 15-106 (245) | Show / Hide |
Range on Protein: 102-190 Range on HMM: 15-106/245 Sequence Identity: 32% (29 aa) APSLEKLCTICKNLDQWMLEHPLNIAVIFCKGGLERCAIVVNAFMRFNAISATDDSVDDRFSMQR----FSERFLGPDGpPSYKRYLGYFSSL | ||.| ...|....|. . . |. .| |||| .| .| |.. | | . | |. .| |..| | . || .||.||.. vPtleelvvftkevkewlakdlenvvaihckGGkgrtGtivcalliaseifltaeesldyfgerrtdkthsnkfqGvet-Psqnryvgylaqv |
|||||||||
| Phosphatase | cele_TNS1.AA | PTEN_C2 | 197-323 | 22 | 4.9e-11 | 41.71 | Pfam | 1-141 (141) | Show / Hide |
Range on Protein: 197-323 Range on HMM: 1-141/141 Sequence Identity: 22% (34 aa) VNSDPLYLHNIILTFFEPI----------NVFLKIYERLVPV--YQSKTVALNKS-----SKFEMDGSLKLRGDIFFKCIVAA-SS-PGSSTRCLFTCQL .. ||.|| ||. ..| . ...|| . ..| . .| ..| .|. .. . . ||. ..|. | | .. | | ... PPPKPLFLHCIIM--DHGIPNFKQGGGCWRPYIQIYQNDQKVFYTCKKYWHCKKYKQQKCCIFKFPQPCPVQGDVKIQCYHKGPSDLPWMYEECMFRFWF NTCALELHPINSEGYSVVRLHKEELDLIFND---KKIDNRVTVELVVSH ||| .|. .. .... |.||| ..| |. .. ||.| | NTCFIEH------NNNRLTFPKNELDKAWKDKKWKRFPPDFKVEVVFSE |
|||||||||
| PTB | cele_TNS1.AA | PTB | 1355-1504 | 22 | 8.4e-36 | 126.18 | SMART | 1-155 (156) | Show / Hide |
Range on Protein: 1355-1504 Range on HMM: 1-155/156 Sequence Identity: 22% (37 aa) EQGAACNVVYVGSVDVESLT-------GNECVKRSIATCSQRAINGDSRAVSVHFKVSSQGVTLTDNTRKVFFRRHFNVQSVIFAGMDPIERRFENTRAL ..|...|| |.|.|.|.. . |...... ..... . . ...|...|..||.|.|. .| ....|.......|.. ||. | . || .. PWGCCFNVWYLGCVEVPHHRNSMAPGKGMQVCQECMRKIR----QHWKHWQKMHLHISVDGVKLIDPQTK-QVIHHHPIHRISFCAHDPY-R-W-NT-GG GFHDGCIAQARLFAFVARIPSSS-------ENACHVFAELEPE---QPGSAVVNFINKVMLAQKNRS | .| ...|.|....| |... ...|||| .|. .. .. .| .....||.|. --H-HCCDDDRCFGYICRHPNDRGSHRMTYWFRCHVFWCEDPHAEDIAQTIGQAFQVCYQQCQKQRC |
|||||||||
| SH2 | cele_TNS1.AA | SH2 | 1233-1322 | 30 | 1.4e-19 | 59.31 | Pfam | 1-81 (81) | Show / Hide |
Range on Protein: 1233-1322 Range on HMM: 1-81/81 Sequence Identity: 30% (28 aa) WYKPTISREQAINMLRD--KPPGTFVVRDSNSFPGAFGLALKVSTPPPGVNPGDGSELVRHFLIEPSPKGVKLKGCNNEPVFGSLSALVYQH || . |||..| ..|. .|.|||.||.| | || . | .. | .. |.|. | . | .. .. |.||. ||. . WYHGKISRQEAERLLMNPGNPDGTFLVRESESTPGDYTLSVRDDGP---------GDRVKHYRIQRTDNG-GYYITGRHK-FCSLQELVEHY |
|||||||||
| PTB | cele_TNS1.AA | PTB | 1359-1503 | 37 | 2e-66 | 231.76 | Pfam | 1-141 (141) | Show / Hide |
Range on Protein: 1359-1503 Range on HMM: 1-141/141 Sequence Identity: 37% (55 aa) ACNVVYVGSVDVESLTGNECVKRSIATCSQRAINGDSRAVSVHFKVSSQGVTLTDNTRKVFFRRHFNVQSVIFAGMDPIERRFENTRALGFHDGCIAQAR ...|... ..|..|.||..||...|.........|. .....||.||.|..|||||..| |||.|....|.... ..|...|...||. || ||. QYHVEHLMTCDMDSRTGMQCVEDCIRKLQMMDAQGRVWTQDMHFQVSDQHITLTDNETKEFFREHYPLNSIRHCQAVPNDCRWNSTRD---HD----QAK LFAFVARIP-SSSENACHVFA--ELEPEQPGSAVVNFINKVMLAQKNR .||||...| .|..|.||.|. ||..||| .....||.|.||..|.| IFAFVCQEPHQSKPNVCHFFQCDELDAEQPHEDIEKFIHKCMLGKKQR |
|||||||||
Sequence
| Name | Sequence Type | Origin | Length | Description | Download |
|---|---|---|---|---|---|
| cele_TNS1.AA | Protein | None | 1504 | None | Fasta, JSON |
| cele_TNS1.NA | RNA | None | 4512 | None | Fasta, JSON |