Gene mtm-5
mtm-5
Species: C.elegans
Alias: mtm-5
External Links:
Classification
Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.
Protein domain
Protein domains of mtm-5.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit phosphatase group/family/subfamily, which is helpful to understand the relationship between phosphatases. Transmembrane region is predicted by TMHMM 2.0. Visualized by pviz.
Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking. View complete domain list.
| Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
|---|---|---|---|---|---|---|---|---|---|
| UDENN | mtm-5.AA | uDENN | 9-92 | 15 | 1.2e-16 | 62.54 | SMART | 1-114 (114) | Show / Hide |
Range on Protein: 9-92 Range on HMM: 1-114/114 Sequence Identity: 15% (18 aa) SGPICDTVAVIVLEESDD-------------------------ENALPDVLHEVQSPHTSDNIPTSSIKKFARPRGWYN-----QSVSSPSEFFYQILTT .....|...|. .. . . . .| .|. .....|... .| .|. |.||. ........|| .|| PHRLFDYFCVCGCPKDPGWWPDMHYACYQWEAPGRTGCFCPLQRSYKPEILYQYPEKDWWDFPFPDMIPMFCFPMGWDWCTWPRKTDRPDPQFFTFVLTD ERGTRRIAYVLSTW | |.||..... .. EDGSRRYGFCRRFY |
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| DENN | mtm-5.AA | DENN | 101-278 | 21 | 7.6e-53 | 182.79 | SMART | 1-204 (204) | Show / Hide |
Range on Protein: 101-278 Range on HMM: 1-204/204 Sequence Identity: 21% (44 aa) FKAVSI-VLISQNFHPKAFKEILLEISNDLR--TPEFSSSS-ELIRFLTYEL---VEEGSTIE------IRTK-TLHVE----LGFELIPISPVTG--KD . .| ..||.. .. .|...| |.. .. ... .. .|. ..|. .. .| . . . .... . ... |... | WTPKCIHCIISHHPWFNWFRKWLNELYRYWQSDHNQHLFHHEFMIYLCHYPVPLPPPGKSIVFMSIVSYFQFHPPGNYYQPIEFCRPDDNRLPHIDENWD VAMLFKMLGFQNVIKIIHALLSDCRIVLASSSLMRLSRCQNAILSLLYPFEYVHSCVTILPDSLAEVLESPTPFLIGVLSEFVTSFGDE------NIVVY ...||..|| .|..... ..| .||.. ||....||.| |...|||||.. | ...||| |....|..|.|...|..|.. ... .| .|| LHELFECLGVENIMQLFCCILLERRIIFHSSNYQMLSMCCHAFVALLYPFQWQHIYIPILPASMLDYLCAPMPYIMGCHSSYFEEVKPEPDEEDDVVVVD LDNG .|.. IDTN |
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| DENN | mtm-5.AA | DENN | 174-278 | 31 | 2.5e-23 | 81.78 | Pfam | 97-207 (207) | Show / Hide |
Range on Protein: 174-278 Range on HMM: 97-207/207 Sequence Identity: 31% (35 aa) SPV-TGKDVAMLFKMLGFQNVIKIIHALLSDCRIVLASSSLMRLSRCQNAILSLLYPFEYVHSCVTILPDSLAEVLESPTPFLIGVLSEFVT---SFGDE .|| .. |. .||. || .|.. .. ..|. ||.. ||.. .|. | |...||||| . | . |.| .|...|..|.||..||.| . . .. HPVWEHIDFHPLFRCLGPENCLHLFCCVLTEHRIIFHSSHYAMLTLCCHAVVALLYPFQWQHIYIPICPARLLDYLCAPCPFIMGVHSRYFDSKLLYDPP N--IVVYLDNG . ..| ||.. DDVVCVDLDTN |
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| DDENN | mtm-5.AA | dDENN | 331-405 | 21 | 1.9e-16 | 61.9 | SMART | 1-84 (84) | Show / Hide |
Range on Protein: 331-405 Range on HMM: 1-84/84 Sequence Identity: 21% (18 aa) LDKKLR-ACFIYYF--AELLYG--YQYYIL--YTRIKGNFEKKLTTSLTFHVGAFRGFRKLT--DMMSSSLLKSVYFQTFILTR |....| ||| .| ..|... |..|. ... ... .|. .. ||. .|.. | . . ...... .|..|| | LNDQIREACFLRFFNYVQLFGHVDYRNYLRHHMIQQAYTWRKHPEPHITFNKESFLKSRPSHHMRPFLKMFCETQMFSQFIEER |
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| SBF2 | mtm-5.AA | SBF2 | 501-710 | 36 | 1.2e-105 | 354.93 | Pfam | 1-233 (233) | Show / Hide |
Range on Protein: 501-710
Range on HMM: 1-233/233
Sequence Identity: 36% (86 aa)
AMLPVVN-------THAEYHANQFEAYA---HRIEALRNCLAAIFEGKVAFASKSLDAVKSSMRFAPLRIELCRLLNQKCSHDKL---TDKQFEDIALLM
.|.| || .. |.|...|. .| .|.|.|||| ||..| ..|.|...|| ........||.|||.||. | . . ...|| .....|
PMGPPVNTIVPGSMSIMEKHSGMFHNSALMLRRLEVLRNCISYIFDNKILEAKKMFPAVLRALKGRAARICLCRELNLHCQQNRHFVLDHQQFDMVVRMM
NAALQAECEEDKDGVVRSLMYLSNVYSRKVAQGMQQYMYTAVQEHKVWKNQRFWTSCFYYEVHEMLFSEML--QKDRKITESLWCHTLRPCAMEMI----
|.||| .|..|..||.. |..|| ...|| ..| .|..|| ||.|.|||||.||..|||..|........| .|.. |.|.|||...|||||..
NCALQDCCSMDEYGVAAALLPLSTAFCRKLCPGVHQFAYTCVQDHPVWKNQQFWEACFYQDVQNHIRELYLNMHHDEQKTWSDWCHKQEPCAMEIAAEQM
----NTDDTDQEELVKQENEMIQAQAKHFANIL
.|...|.|||..|......||.|.|| .
RLWPTMDKEKQQELVQKEESTVYSQAIHYANRM
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| DDENN | mtm-5.AA | dDENN | 331-405 | 21 | 3e-06 | 25.12 | Pfam | 1-77 (77) | Show / Hide |
Range on Protein: 331-405 Range on HMM: 1-77/77 Sequence Identity: 21% (17 aa) LDKKLRACFIYYFAELLYGYQYYILYTRI-KGNFEKKLTTSLTFHVGAFRGF-RKLT-DMMSSSLLKS--VYFQTFILTR ... .|..| .||.|...|. .. | |. . .. . .. ||. ||. | . . ...... .| .|| | HNQQVREAFLRFFAQLFGHYRNFLRYIRQHPRPW-T--DQMYTFQKEAFLKSRRPKSHRPFLKQFMETQVQMFAQFIQER |
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| GRAM | mtm-5.AA | GRAM | 783-872 | 19 | 2e-18 | 68.87 | Pfam | 1-78 (78) | Show / Hide |
Range on Protein: 783-872 Range on HMM: 1-78/78 Sequence Identity: 19% (18 aa) EHLKKGNFDPVLAHGEFLISD---PIDCYLLTSIEESEMSLNRLENLLPADGSLFLTNYRVIFKGKSVDINATNGTIVQTIPLYSMESFKKLT |... .|...| ..|.|| | ...|.| ... ...|. | ...||..|.|... .. .. ... .||...... .| . EKFR-KHFKDPLPPNEKLIMDCNVTYSCCLWRPF-----------TKIPVQGRMYITNHHVCFYSDKFGWET---YYKMVIPWNDITRVEKMQ |
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| Myotub-related | mtm-5.AA | Myotub-related | 1027-1131 | 26 | 1.3e-33 | 122.77 | Pfam | 1-121 (121) | Show / Hide |
Range on Protein: 1027-1131 Range on HMM: 1-121/121 Sequence Identity: 26% (34 aa) YTICPSYPGNFIVPSETNESELAKVAKGFVEHRLPVVVWMN-ENGALLVRAS--------AFTSID--MVKKLKK------------VVNYRRNASKLTG |.|||.||....||......|| |||| ....|.||..|.. ||||...|.| .....| .|....| .|..|....... YEICPTYPAKLVVPKSISDDELKKVAKFRSWGRFPVLCWRHQENGAVICRCSQPLVGWWGWRCKEDEKLVQAIMKANADMIQSRKMYIVDARPYTNAMAN SMTGSQQTLHSKASSNEESSSNIVAGAE ..| ... |||. .|.. . RAKG-------GGYENEEHYPNWEFVFM |
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| GRAM | mtm-5.AA | GRAM | 783-872 | 18 | 5.5e-17 | 63.67 | SMART | 1-80 (80) | Show / Hide |
Range on Protein: 783-872 Range on HMM: 1-80/80 Sequence Identity: 18% (18 aa) EHLKKGNFDPVLAHGEFLISDP-----IDCYLLTSIEESEMSLNRLENLLPADGSLFLTNYRVIFKGKSVDINATNGTIVQTIPLYSMESFKKLT |... |. |...|.|| |. |||.... .|. | ....|....|... . ..........||. ......|.| EKFR-QHFK--LPPNEKLINDCKKEVTYSCYLWRTY------------DIPVQGHMYISNNHICFCSNMFGWMTCPQYYKVVIPWADITRIEKMT |
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| Phosphatase | mtm-5.AA | Subfamily.MTMR1.PD | 1242-1363 | 37 | 7.8e-27 | 82.1 | In-house | 11-142 (149) | Show / Hide |
Range on Protein: 1242-1363 Range on HMM: 11-142/149 Sequence Identity: 37% (47 aa) NRTSFLESWNASNWPQCVSRMIELSNSIVALMNLYNSSVAICLEAGRSITTILSSLSQLLSDPYYRTCDGFQVLVEKEWLAFGHYFHK-----DTE---- . . .|.. ....| . . ... . |. .. ..|| . | |. |.||. || |.|||| ||.||.|||||.||| |..| . || deskwlsaleetkwlehiklilagavriadkvesektsvvvhcsdgwdrtaqltslamllldsyyrtikgfevliekewlsfghkfaerighgdknhada TSSPSFICFLDCVYQISQQYPTAFEFSYFY-I |. |.|||.|...|.||||||. . | drspvflqfidcvwqvtrqfptafefneefli |
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| Phosphatase | mtm-5.AA | Family.Myotubularin.PD | 1243-1369 | 37 | 3.5e-33 | 102.6 | In-house | 4-139 (141) | Show / Hide |
Range on Protein: 1243-1369 Range on HMM: 4-139/141 Sequence Identity: 37% (51 aa) RTSFLESWNASNWPQCVSRMIELSNSIVALMNLYNSSVAICLEAGRSITTILSSLSQLLSDPYYRTCDGFQVLVEKEWLAFGHYFHKDT---------ET ...|.. ....| . .. ... . .|| .. ..|| . | |. |.||.||| |||||| .||.||.|||||.||| |.. . | ekkwlselestkWlehiklllkaavkivekvekektsvlvhcsdGWdrtaqltslaqllldpyyrtieGfevliekeWlsfGhkfaerlghgdkseseee SSPSFICFLDCVYQISQQYPTAFEFSYFYISFLAYH || |. |.|||||...|.||||||. ... .. | rsPvflqfidcvyqltkqfptafefnesflikildh |
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| Phosphatase | mtm-5.AA | Subfamily.C2-MTMR1.PD | 1252-1370 | 38 | 3e-29 | 90.1 | In-house | 12-136 (137) | Show / Hide |
Range on Protein: 1252-1370 Range on HMM: 12-136/137 Sequence Identity: 38% (47 aa) ASNWPQCVSRMIELSNSIVALMNLYNSSVAICLEAGRSITTILSSLSQLLSDPYYRTCDGFQVLVEKEWLAFGHYFHKD-----T-ETSSPSFICFLDCV ...| .. ... ...| .. | . | |. | .|.||| |||||| ||..||.||||||||| |.. .|| |. ||||.||.. stqwlayikavlkaaraiarkveklavsalvhcsdgwdrtsqlvllaqllldpyyrtidglivliekewlafghkfderlggadsvserspiflqfldcl YQISQQYPTAFEFSYFYISFLAYHS .|.|.|||.. .. .|| .| yqvtkqfpsafeytarlllkladys |
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| Phosphatase | mtm-5.AA | Subfamily.MTMR3.PD | 1249-1370 | 37 | 2e-28 | 87.3 | In-house | 4-134 (135) | Show / Hide |
Range on Protein: 1249-1370 Range on HMM: 4-134/135 Sequence Identity: 37% (45 aa) SWNASNWPQCVSRMIELSNSIVALMNLYNSSVAICLEAGRSITTILSSLSQLLSDPYYRTCDGFQVLVEKEWLAFGHYFHK---------DTETSSPSFI . ....| | .| ... . .| .. . | . | |. . .|..|| |||||| .||.||||.||| ||| ||.. .| |. .||||.|... alektkwlqhlsvllkaavkvvnavdkegrpvlvhcsdgwdrtpqivalakllldpyyrtlegfkvlverewldfghkfadrcghgedsddlnercpvfl CFLDCVYQISQQYPTAFEFSYFYISFLAYHS |.||.|||. .. |. |. qwldcvhqlkkqfptsfefneaflvklvqht |
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| PH | mtm-5.AA | PH | 1644-1743 | 26 | 1.1e-12 | 48.41 | Pfam | 1-92 (92) | Show / Hide |
Range on Protein: 1644-1743 Range on HMM: 1-92/92 Sequence Identity: 26% (27 aa) PLCTGYLSKRGAKLKLWVPRFFVLYPDSPKVYYYEDFENWKTAEKPSGCIDLVDFKSFNLEQTG-RRGLIELHMKNK-THRLLSENINEAIRWKECIEQV . . |.|.|.| |.| | .|.||| . ..|||.| ..| |.|.| | .. .. |. ..... .. |. . |. |. .| ..|... VIKEGWLHKKG-KRKSWKKRWFVLFN--NCLYYYKDDK-----YRPKGSIPLSDC-QVTKVPDNKRPHCFQIRT-DRRTYYFQAESEEEMNDWMQAIQSA IR .| CR |
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| PH | mtm-5.AA | PH | 1644-1744 | 25 | 7.7e-11 | 43.25 | SMART | 1-81 (82) | Show / Hide |
Range on Protein: 1644-1744 Range on HMM: 1-81/82 Sequence Identity: 25% (26 aa) PLCTGYLSKRGAKLKLWVPRFFVLYPDSPKVYYYEDFENWKTAEKPSGCIDLVDFKSFNLEQTGRRGLIELHMKNKTHRLLSENINEAIRWKECIEQVIR ... |.|.|.. . | .|.|||.. .|||.| ||.|.|.| | ... .|.|. ..|. . |. |. .| ..|...|. VIKEGWLYKKS--K-RWKKRWFVLFN--DCLYYYKDK-------KPKGSIPLSDC-TVRE-P-----CFEIHH-DRTYYFQCESEEEMQEWMQAIQKAIH D . N |
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