mtm-5
Species: C.elegans
Alias: mtm-5
External Links:
Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Superfamily: Cx5R-I
Family: Myotubularin
Subfamily: MTMR5
Protein domain

Protein domains of mtm-5.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit phosphatase group/family/subfamily, which is helpful to understand the relationship between phosphatases. Transmembrane region is predicted by TMHMM 2.0. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking. View complete domain list.

Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
UDENN mtm-5.AA uDENN 9-92 15 1.2e-16 62.54 SMART 1-114 (114) Show / Hide
Range on Protein: 9-92
Range on HMM: 1-114/114
Sequence Identity: 15% (18 aa)

SGPICDTVAVIVLEESDD-------------------------ENALPDVLHEVQSPHTSDNIPTSSIKKFARPRGWYN-----QSVSSPSEFFYQILTT
.....|...|. .. . .                         .  .| .|.   .....|...  .| .|. |.||.      ........||  .|| 
PHRLFDYFCVCGCPKDPGWWPDMHYACYQWEAPGRTGCFCPLQRSYKPEILYQYPEKDWWDFPFPDMIPMFCFPMGWDWCTWPRKTDRPDPQFFTFVLTD

ERGTRRIAYVLSTW
| |.||..... ..
EDGSRRYGFCRRFY

DENN mtm-5.AA DENN 101-278 21 7.6e-53 182.79 SMART 1-204 (204) Show / Hide
Range on Protein: 101-278
Range on HMM: 1-204/204
Sequence Identity: 21% (44 aa)

FKAVSI-VLISQNFHPKAFKEILLEISNDLR--TPEFSSSS-ELIRFLTYEL---VEEGSTIE------IRTK-TLHVE----LGFELIPISPVTG--KD
.   .| ..||.. .. .|...| |..  ..  ... ..    .|. ..|.    .. .|  .      .  .  ....    . ...    |...   |
WTPKCIHCIISHHPWFNWFRKWLNELYRYWQSDHNQHLFHHEFMIYLCHYPVPLPPPGKSIVFMSIVSYFQFHPPGNYYQPIEFCRPDDNRLPHIDENWD

VAMLFKMLGFQNVIKIIHALLSDCRIVLASSSLMRLSRCQNAILSLLYPFEYVHSCVTILPDSLAEVLESPTPFLIGVLSEFVTSFGDE------NIVVY
...||..|| .|..... ..|  .||.. ||....||.|  |...|||||.. | ...||| |....|..|.|...|..|.. ... .|       .|| 
LHELFECLGVENIMQLFCCILLERRIIFHSSNYQMLSMCCHAFVALLYPFQWQHIYIPILPASMLDYLCAPMPYIMGCHSSYFEEVKPEPDEEDDVVVVD

LDNG
.|..
IDTN

DENN mtm-5.AA DENN 174-278 31 2.5e-23 81.78 Pfam 97-207 (207) Show / Hide
Range on Protein: 174-278
Range on HMM: 97-207/207
Sequence Identity: 31% (35 aa)

SPV-TGKDVAMLFKMLGFQNVIKIIHALLSDCRIVLASSSLMRLSRCQNAILSLLYPFEYVHSCVTILPDSLAEVLESPTPFLIGVLSEFVT---SFGDE
.|| .. |. .||. || .|.. .. ..|.  ||.. ||.. .|. |  |...||||| . |  . |.| .|...|..|.||..||.| . .      ..
HPVWEHIDFHPLFRCLGPENCLHLFCCVLTEHRIIFHSSHYAMLTLCCHAVVALLYPFQWQHIYIPICPARLLDYLCAPCPFIMGVHSRYFDSKLLYDPP

N--IVVYLDNG
.  ..| ||..
DDVVCVDLDTN

DDENN mtm-5.AA dDENN 331-405 21 1.9e-16 61.9 SMART 1-84 (84) Show / Hide
Range on Protein: 331-405
Range on HMM: 1-84/84
Sequence Identity: 21% (18 aa)

LDKKLR-ACFIYYF--AELLYG--YQYYIL--YTRIKGNFEKKLTTSLTFHVGAFRGFRKLT--DMMSSSLLKSVYFQTFILTR
|....| |||  .|  ..|...  |..|.   ... ... .|.  .. ||.  .|.. |  .    . ...... .|..||  |
LNDQIREACFLRFFNYVQLFGHVDYRNYLRHHMIQQAYTWRKHPEPHITFNKESFLKSRPSHHMRPFLKMFCETQMFSQFIEER

SBF2 mtm-5.AA SBF2 501-710 36 1.2e-105 354.93 Pfam 1-233 (233) Show / Hide
Range on Protein: 501-710
Range on HMM: 1-233/233
Sequence Identity: 36% (86 aa)

AMLPVVN-------THAEYHANQFEAYA---HRIEALRNCLAAIFEGKVAFASKSLDAVKSSMRFAPLRIELCRLLNQKCSHDKL---TDKQFEDIALLM
.|.| ||       .. |.|...|. .|   .|.|.||||   ||..| ..|.|...|| ........||.|||.||. | . .    ...|| .....|
PMGPPVNTIVPGSMSIMEKHSGMFHNSALMLRRLEVLRNCISYIFDNKILEAKKMFPAVLRALKGRAARICLCRELNLHCQQNRHFVLDHQQFDMVVRMM

NAALQAECEEDKDGVVRSLMYLSNVYSRKVAQGMQQYMYTAVQEHKVWKNQRFWTSCFYYEVHEMLFSEML--QKDRKITESLWCHTLRPCAMEMI----
|.||| .|..|..||.. |..|| ...|| ..| .|..|| ||.|.|||||.||..|||..|........|   .|.. |.|.|||...|||||..    
NCALQDCCSMDEYGVAAALLPLSTAFCRKLCPGVHQFAYTCVQDHPVWKNQQFWEACFYQDVQNHIRELYLNMHHDEQKTWSDWCHKQEPCAMEIAAEQM

----NTDDTDQEELVKQENEMIQAQAKHFANIL
     .|...|.|||..|......||.|.|| .
RLWPTMDKEKQQELVQKEESTVYSQAIHYANRM

DDENN mtm-5.AA dDENN 331-405 21 3e-06 25.12 Pfam 1-77 (77) Show / Hide
Range on Protein: 331-405
Range on HMM: 1-77/77
Sequence Identity: 21% (17 aa)

LDKKLRACFIYYFAELLYGYQYYILYTRI-KGNFEKKLTTSLTFHVGAFRGF-RKLT-DMMSSSLLKS--VYFQTFILTR
... .|..|  .||.|...|. .. | |. . .. .   .. ||.  ||.   |  .   . ......   .| .||  |
HNQQVREAFLRFFAQLFGHYRNFLRYIRQHPRPW-T--DQMYTFQKEAFLKSRRPKSHRPFLKQFMETQVQMFAQFIQER

GRAM mtm-5.AA GRAM 783-872 19 2e-18 68.87 Pfam 1-78 (78) Show / Hide
Range on Protein: 783-872
Range on HMM: 1-78/78
Sequence Identity: 19% (18 aa)

EHLKKGNFDPVLAHGEFLISD---PIDCYLLTSIEESEMSLNRLENLLPADGSLFLTNYRVIFKGKSVDINATNGTIVQTIPLYSMESFKKLT
|...  .|...| ..|.|| |   ...|.| ...           ...|. | ...||..|.|... .. ..   ... .||...... .| .
EKFR-KHFKDPLPPNEKLIMDCNVTYSCCLWRPF-----------TKIPVQGRMYITNHHVCFYSDKFGWET---YYKMVIPWNDITRVEKMQ

mtm-5.AA Myotub-related 1027-1131 26 1.3e-33 122.77 Pfam 1-121 (121) Show / Hide
Range on Protein: 1027-1131
Range on HMM: 1-121/121
Sequence Identity: 26% (34 aa)

YTICPSYPGNFIVPSETNESELAKVAKGFVEHRLPVVVWMN-ENGALLVRAS--------AFTSID--MVKKLKK------------VVNYRRNASKLTG
|.|||.||....||......|| |||| ....|.||..|.. ||||...|.|        .....|  .|....|            .|..|....... 
YEICPTYPAKLVVPKSISDDELKKVAKFRSWGRFPVLCWRHQENGAVICRCSQPLVGWWGWRCKEDEKLVQAIMKANADMIQSRKMYIVDARPYTNAMAN

SMTGSQQTLHSKASSNEESSSNIVAGAE
 ..|       ... |||. .|..  . 
RAKG-------GGYENEEHYPNWEFVFM

GRAM mtm-5.AA GRAM 783-872 18 5.5e-17 63.67 SMART 1-80 (80) Show / Hide
Range on Protein: 783-872
Range on HMM: 1-80/80
Sequence Identity: 18% (18 aa)

EHLKKGNFDPVLAHGEFLISDP-----IDCYLLTSIEESEMSLNRLENLLPADGSLFLTNYRVIFKGKSVDINATNGTIVQTIPLYSMESFKKLT
|...   |.  |...|.|| |.       |||....             .|. | ....|....|...  . ..........||. ......|.|
EKFR-QHFK--LPPNEKLINDCKKEVTYSCYLWRTY------------DIPVQGHMYISNNHICFCSNMFGWMTCPQYYKVVIPWADITRIEKMT

Phosphatase mtm-5.AA Subfamily.MTMR1.PD 1242-1363 37 7.8e-27 82.1 In-house 11-142 (149) Show / Hide
Range on Protein: 1242-1363
Range on HMM: 11-142/149
Sequence Identity: 37% (47 aa)

NRTSFLESWNASNWPQCVSRMIELSNSIVALMNLYNSSVAICLEAGRSITTILSSLSQLLSDPYYRTCDGFQVLVEKEWLAFGHYFHK-----DTE----
. . .|.. ....| . .  ... .  |.  ..  ..|| .    |   |. |.||. || |.||||  ||.||.|||||.||| |..| .      || 
deskwlsaleetkwlehiklilagavriadkvesektsvvvhcsdgwdrtaqltslamllldsyyrtikgfevliekewlsfghkfaerighgdknhada

TSSPSFICFLDCVYQISQQYPTAFEFSYFY-I
|. |.|||.|...|.||||||.  . |     
drspvflqfidcvwqvtrqfptafefneefli

Phosphatase mtm-5.AA Family.Myotubularin.PD 1243-1369 37 3.5e-33 102.6 In-house 4-139 (141) Show / Hide
Range on Protein: 1243-1369
Range on HMM: 4-139/141
Sequence Identity: 37% (51 aa)

RTSFLESWNASNWPQCVSRMIELSNSIVALMNLYNSSVAICLEAGRSITTILSSLSQLLSDPYYRTCDGFQVLVEKEWLAFGHYFHKDT---------ET
...|.. ....| . .. ... . .||  ..  ..|| .    |   |. |.||.||| |||||| .||.||.|||||.||| |.. .         |  
ekkwlselestkWlehiklllkaavkivekvekektsvlvhcsdGWdrtaqltslaqllldpyyrtieGfevliekeWlsfGhkfaerlghgdkseseee

SSPSFICFLDCVYQISQQYPTAFEFSYFYISFLAYH
|| |. |.|||||...|.||||||.  ... .. | 
rsPvflqfidcvyqltkqfptafefnesflikildh

Phosphatase mtm-5.AA Subfamily.C2-MTMR1.PD 1252-1370 38 3e-29 90.1 In-house 12-136 (137) Show / Hide
Range on Protein: 1252-1370
Range on HMM: 12-136/137
Sequence Identity: 38% (47 aa)

ASNWPQCVSRMIELSNSIVALMNLYNSSVAICLEAGRSITTILSSLSQLLSDPYYRTCDGFQVLVEKEWLAFGHYFHKD-----T-ETSSPSFICFLDCV
...|   .. ... ...|   ..    |  .    |   |. | .|.||| |||||| ||..||.||||||||| |..      .|| |. ||||.||..
stqwlayikavlkaaraiarkveklavsalvhcsdgwdrtsqlvllaqllldpyyrtidglivliekewlafghkfderlggadsvserspiflqfldcl

YQISQQYPTAFEFSYFYISFLAYHS
.|.|.|||..  .. .|| .|    
yqvtkqfpsafeytarlllkladys

Phosphatase mtm-5.AA Subfamily.MTMR3.PD 1249-1370 37 2e-28 87.3 In-house 4-134 (135) Show / Hide
Range on Protein: 1249-1370
Range on HMM: 4-134/135
Sequence Identity: 37% (45 aa)

SWNASNWPQCVSRMIELSNSIVALMNLYNSSVAICLEAGRSITTILSSLSQLLSDPYYRTCDGFQVLVEKEWLAFGHYFHK---------DTETSSPSFI
. ....| | .| ... .  .|  ..  .  | .    |   |. . .|..|| |||||| .||.||||.||| ||| ||..  .| |. .||||.|...
alektkwlqhlsvllkaavkvvnavdkegrpvlvhcsdgwdrtpqivalakllldpyyrtlegfkvlverewldfghkfadrcghgedsddlnercpvfl

CFLDCVYQISQQYPTAFEFSYFYISFLAYHS
|.||.|||.  ..  |. |.           
qwldcvhqlkkqfptsfefneaflvklvqht

PH mtm-5.AA PH 1644-1743 26 1.1e-12 48.41 Pfam 1-92 (92) Show / Hide
Range on Protein: 1644-1743
Range on HMM: 1-92/92
Sequence Identity: 26% (27 aa)

PLCTGYLSKRGAKLKLWVPRFFVLYPDSPKVYYYEDFENWKTAEKPSGCIDLVDFKSFNLEQTG-RRGLIELHMKNK-THRLLSENINEAIRWKECIEQV
. . |.|.|.| |.| | .|.||| .   ..|||.|       ..| |.|.| |  ..    .. |.  ..... .. |. .  |.  |. .| ..|...
VIKEGWLHKKG-KRKSWKKRWFVLFN--NCLYYYKDDK-----YRPKGSIPLSDC-QVTKVPDNKRPHCFQIRT-DRRTYYFQAESEEEMNDWMQAIQSA

IR
.|
CR

PH mtm-5.AA PH 1644-1744 25 7.7e-11 43.25 SMART 1-81 (82) Show / Hide
Range on Protein: 1644-1744
Range on HMM: 1-81/82
Sequence Identity: 25% (26 aa)

PLCTGYLSKRGAKLKLWVPRFFVLYPDSPKVYYYEDFENWKTAEKPSGCIDLVDFKSFNLEQTGRRGLIELHMKNKTHRLLSENINEAIRWKECIEQVIR
... |.|.|..  .  | .|.|||..    .|||.|        ||.|.|.| |  ...         .|.|. ..|. .  |.  |. .| ..|...|.
VIKEGWLYKKS--K-RWKKRWFVLFN--DCLYYYKDK-------KPKGSIPLSDC-TVRE-P-----CFEIHH-DRTYYFQCESEEEMQEWMQAIQKAIH

D
.
N

Sequence
Name Sequence Type Origin Length Description Download
mtm-5.AA Protein None 1744 None Fasta, JSON
mtm-5.NA RNA None 5232 None Fasta, JSON