cdc-25.2
Species: C.elegans
Alias: cdc-25.2
External Links:
Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Superfamily: Cx5R-II
Family: CDC25
Subfamily: CDC25
Protein domain

Protein domains of cdc-25.2.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit phosphatase group/family/subfamily, which is helpful to understand the relationship between phosphatases. Transmembrane region is predicted by TMHMM 2.0. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking. View complete domain list.

Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Rhodanese cdc-25.2.AA Rhodanese 227-343 20 1.2e-12 41.79 Pfam 1-102 (102) Show / Hide
Range on Protein: 227-343
Range on HMM: 1-102/102
Sequence Identity: 20% (25 aa)

TAETLRDIFFRLSEKEFDDKYILIDCRYPYEYNRGHIKNA-INHFDRVTVSKI--FYDENGRKRCNKIP-IFYCEFSQARGPKMAYALRQV-DRELNVNH
|.| |...         |..|..||.| |.||..|||..| . ....    ..  . .   . . .|   ..||  . .|.  .. .|..   ... .  
TPEWLKEMM-------NDPDYVIIDVRPPEEYEKGHIPGAHV-NIPW--LEEEHDLEELGIKLDKDKPIIVVYC--HGNRSG-AWACLVWWMLKAMGYP-

YPKCDYEEMYVLDLGYRNFFFA
       . |||| |.  .  .
------PNVYVLDGGWEAWKAE

Phosphatase cdc-25.2.AA Family.CDC25.PD 236-345 48 3.2e-46 144.0 In-house 4-116 (117) Show / Hide
Range on Protein: 236-345
Range on HMM: 4-116/117
Sequence Identity: 48% (55 aa)

FRLSEKEFDDKYILIDCRYPYEYNRGHIKNAINHFDRVTVSKIFYDENGRK---RCNKIPIFYCEFSQARGPKMAYALRQVDRELNVNHYPKCDYEEMYV
.. ..||. .|||.|||||||||..||||.|.|...| .....|..|. .|   ....|.||.||||. ||||.| .||.|||||| ..|||..|.|.|.
lkgetkeliekyiiiDcRypyeyegGHikgavnlysreeleeeflkepkvkaseekrtivifhCefSseRgPklarllrevdrelnkeeypkleypelyl

LDLGYRNFFFAAN
|. ||..|| ...
LegGykeffeeve

Phosphatase cdc-25.2.AA Group.Cx5R-II.PD 236-345 48 3.2e-46 144.0 In-house 4-116 (117) Show / Hide
Range on Protein: 236-345
Range on HMM: 4-116/117
Sequence Identity: 48% (55 aa)

FRLSEKEFDDKYILIDCRYPYEYNRGHIKNAINHFDRVTVSKIFYDENGRK---RCNKIPIFYCEFSQARGPKMAYALRQVDRELNVNHYPKCDYEEMYV
.. ..||. .|||.|||||||||..||||.|.|...| .....|..|. .|   ....|.||.||||. ||||.| .||.|||||| ..|||..|.|.|.
lkgetkeliekyiiiDcRypyeyegGHikgavnlysreeleeeflkepkvkaseekrtivifhCefSseRgPklarllrevdrelnkeeypkleypelyl

LDLGYRNFFFAAN
|. ||..|| ...
LegGykeffeeve

Phosphatase cdc-25.2.AA Subfamily.CDC25.PD 236-345 48 3.2e-46 144.0 In-house 4-116 (117) Show / Hide
Range on Protein: 236-345
Range on HMM: 4-116/117
Sequence Identity: 48% (55 aa)

FRLSEKEFDDKYILIDCRYPYEYNRGHIKNAINHFDRVTVSKIFYDENGRK---RCNKIPIFYCEFSQARGPKMAYALRQVDRELNVNHYPKCDYEEMYV
.. ..||. .|||.|||||||||..||||.|.|...| .....|..|. .|   ....|.||.||||. ||||.| .||.|||||| ..|||..|.|.|.
lkgetkeliekyiiiDcRypyeyegGHikgavnlysreeleeeflkepkvkaseekrtivifhCefSseRgPklarllrevdrelnkeeypkleypelyl

LDLGYRNFFFAAN
|. ||..|| ...
LegGykeffeeve

Rhodanese cdc-25.2.AA RHOD 233-346 25 7.8e-21 76.45 SMART 1-94 (94) Show / Hide
Range on Protein: 233-346
Range on HMM: 1-94/94
Sequence Identity: 25% (29 aa)

DIFFRLSEKEFDDKYILIDCRYPYEYNRGHIKNAINHFDRVTVSKIFYDENGRKRCNKIPIFYCEFSQARG-PKMAYALRQVDRELNVNHYPKCDYEEMY
    .. .... .....||||.||||..|||..|||      . .         . .|. |.|| .|. |. |..|..||  ...            ..|
V-PEWWKMLQN-EDCVIIDCRWPYEYEGGHIPGAINIPWDELLDR------LGIDKDKPVIVYC-RSGNRSAPRAAWWLREAGYK------------NVY

VLDLGYRNFFFAANE
.|| |.. .. |  .
ILDGGWKEWKRACPP

Sequence
Name Sequence Type Origin Length Description Download
cdc-25.2.AA Protein None 480 None Fasta, JSON
cdc-25.2.NA RNA None 1440 None Fasta, JSON
cdc-25.2.AA.PD_227-346 Protein Phosphatase Domain None 120 None Fasta, JSON