• Phosphatome.Net

Gene cdc-25.3

cdc-25.3
Species: C.elegans
Alias: cdc-25.3
External Links:
Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Superfamily: Cx5R-II
Family: CDC25
Subfamily: CDC25
Protein domain

Protein domains of cdc-25.3.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit phosphatase group/family/subfamily, which is helpful to understand the relationship between phosphatases. Transmembrane region is predicted by TMHMM 2.0. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking. View complete domain list.

Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Rhodanese cdc-25.3.AA RHOD 126-239 26 5.6e-23 83.58 SMART 1-94 (94) Show / Hide 
Range on Protein: 126-239
Range on HMM: 1-94/94
Sequence Identity: 26% (30 aa)

EIMQKLSQIEFMQKYILIDCRYDYEYNGGHIKGAQSLFNPETAADFFFNKDGSKKINRIPIFYCEYSQKRG-PTMANNLREVDRKLNSNIYPRCDYEEIY
   ... .... .....||||. |||.||||.||  .  .|  ..       .   ... |.|| .|. |. |..|  ||| ..|            ..|
V-PEWWKMLQN-EDCVIIDCRWPYEYEGGHIPGAINIPWDELLDR------LGIDKDKPVIVYC-RSGNRSAPRAAWWLREAGYK------------NVY

LLEGGYKNFYAFTRG
.|.||.| ...  . 
ILDGGWKEWKRACPP
Phosphatase cdc-25.3.AA Family.CDC25.PD 127-236 49 6.7e-47 146.2 In-house 2-114 (117) Show / Hide 
Range on Protein: 127-236
Range on HMM: 2-114/117
Sequence Identity: 49% (55 aa)

IMQKLSQIEFMQKYILIDCRYDYEYNGGHIKGAQSLFNPETAADFFFNKDGSK---KINRIPIFYCEYSQKRGPTMANNLREVDRKLNSNIYPRCDYEEI
...| .. |...|||.|||||.|||.|||||||..|.. |.....|.... .|   . ..|.||.||.|..|||..|. ||||||.||.. ||...|.|.
allkgetkeliekyiiiDcRypyeyegGHikgavnlysreeleeeflkepkvkaseekrtivifhCefSseRgPklarllrevdrelnkeeypkleypel

YLLEGGYKNFYAF
||||||||.|.. 
ylLegGykeffee
Phosphatase cdc-25.3.AA Group.Cx5R-II.PD 127-236 49 6.7e-47 146.2 In-house 2-114 (117) Show / Hide 
Range on Protein: 127-236
Range on HMM: 2-114/117
Sequence Identity: 49% (55 aa)

IMQKLSQIEFMQKYILIDCRYDYEYNGGHIKGAQSLFNPETAADFFFNKDGSK---KINRIPIFYCEYSQKRGPTMANNLREVDRKLNSNIYPRCDYEEI
...| .. |...|||.|||||.|||.|||||||..|.. |.....|.... .|   . ..|.||.||.|..|||..|. ||||||.||.. ||...|.|.
allkgetkeliekyiiiDcRypyeyegGHikgavnlysreeleeeflkepkvkaseekrtivifhCefSseRgPklarllrevdrelnkeeypkleypel

YLLEGGYKNFYAF
||||||||.|.. 
ylLegGykeffee
Phosphatase cdc-25.3.AA Subfamily.CDC25.PD 127-236 49 6.7e-47 146.2 In-house 2-114 (117) Show / Hide 
Range on Protein: 127-236
Range on HMM: 2-114/117
Sequence Identity: 49% (55 aa)

IMQKLSQIEFMQKYILIDCRYDYEYNGGHIKGAQSLFNPETAADFFFNKDGSK---KINRIPIFYCEYSQKRGPTMANNLREVDRKLNSNIYPRCDYEEI
...| .. |...|||.|||||.|||.|||||||..|.. |.....|.... .|   . ..|.||.||.|..|||..|. ||||||.||..||...|.|.|
allkgetkeliekyiiiDcRypyeyegGHikgavnlysreeleeeflkepkvkaseekrtivifhCefSseRgPklarllrevdrelnkeeypkleypel

YLLEGGYKNFYAF
|||||||.|..  
ylLegGykeffee
Phosphatase cdc-25.3.AA Rhodanese 138-236 20 2.5e-10 34.42 Pfam 12-102 (102) Show / Hide 
Range on Protein: 138-236
Range on HMM: 12-102/102
Sequence Identity: 20% (22 aa)

QKYILIDCRYDYEYNGGHIKGA-QSLFNPETAADFFF--NKDGSKKINRIP---IFYCEYSQKRGPTMANNLREV-DRKLNSNIYPRCDYE-EIYLLEGG
..|..||.| ..||..|||.||  ..              ..  .|...     ..||  . .|.  .. .|..   ...         |. ..|.|.||
PDYVIIDVRPPEEYEKGHIPGAHVNIPW-----LEEEHDLEELGIKLDKDKPIIVVYC--HGNRSG-AWACLVWWMLKAM--------GYPPNVYVLDGG

YKNFYAF
.. ..| 
WEAWKAE
Sequence
Name Sequence Type Origin Length Description Download
cdc-25.3.AA Protein None 316 None Fasta, JSON
cdc-25.3.NA RNA None 948 None Fasta, JSON
cdc-25.3.AA.PD_126-239 Protein Phosphatase Domain None 114 None Fasta, JSON