Gene scpl-2
scpl-2
Species: C.elegans
Alias: scpl-2
External Links:
Classification
Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.
Protein domain
Protein domains of scpl-2.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit phosphatase group/family/subfamily, which is helpful to understand the relationship between phosphatases. Transmembrane region is predicted by TMHMM 2.0. Visualized by pviz.
Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking. View complete domain list.
| Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
|---|---|---|---|---|---|---|---|---|---|
| Phosphatase | scpl-2.AA | Subfamily.DULLARD.PD | 56-227 | 71 | 1.6e-91 | 293.5 | In-house | 1-172 (172) | Show / Hide |
Range on Protein: 56-227 Range on HMM: 1-172/172 Sequence Identity: 71% (123 aa) KRKILVLDLDETLIHSHHDGVLRQTVKPGTPSDFTIRVVIDRHPVKFSVHERPHVDYFLSVVSQWYELVVFTASMEVYGTSVADRLDRGRGILKRRYFRQ |||.||||||||||||.||.| ..|||.||..||...|.|.|.||.|.|..|||||.||.|||.||.||.||||||.|...|.|.||.|||||||||.|| krktlvldldetlihsahdsvtkstvkegtapdfklkvlierepvlfyvykrPhvdlfldvvskWydlviftasmeeyaaavvdkldsgrgilkrryyrq HCTMEVGGYTKDLSAIHPDLSSICILDNSPGAYRKFPHNAIPIPSWFSDPNDTCLLNLLPFLDALRFTSDVR |||.|.|.||||||....||||..|||||| ||||.|.||||| ||.|||.||.||||||||||||||.||| hCtlesgkytkdlslvsedlssviilDnspvayrknpdnaipikswisdpsdtallnllPfldalrftkdvr |
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| Phosphatase | scpl-2.AA | CPDc | 56-208 | 41 | 8.7e-76 | 259.01 | SMART | 1-173 (173) | Show / Hide |
Range on Protein: 56-208 Range on HMM: 1-173/173 Sequence Identity: 41% (72 aa) KRKILVLDLDETLIHS------HHDGVLRQTVKPGTPSDFTIR----------VVIDRHPVKFSVHERPHVDYFLSVVSQWYELVVFTASMEVYGTSVAD |.|.||||||.||.|| ||. . ....|. |. ||... |.||.||. . |..||||..||. .|.|||..|||..|..|. |.| KKKTLVLDLDHTLVHSCMIPTLHHWMKYLRSFKEWTRRDFIWPQLKWFHMCMIVEIDGHPHQWYVKKRPHVHEFLKRCSKWYEMHVFTMGMRMYADPVLD RLDRGR-GILKRRYFRQHCTMEVGG-YTKD-LSAIH-PDLSSICILDNSPGAYRKFPHNAIPIPSWFSDPNDT .||..| ... ||..|.||. . |. |.|| || .. .|||...|.|.|| .....| |||||..||....|| MLDPKRKYFIYRRLYRDHCVYHKGKTYVKDTLSLVNRCDLSMVIIIDDSPDSWPWHPENAIPIKPWFYFMHDT |
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| Phosphatase | scpl-2.AA | NIF | 58-227 | 35 | 2e-72 | 251.72 | Pfam | 1-189 (189) | Show / Hide |
Range on Protein: 58-227 Range on HMM: 1-189/189 Sequence Identity: 35% (71 aa) KILVLDLDETLIHSH--HDGVLRQTVKPGTPSDFTIRVVIDRHPVKFSVHE-RPHVDYFLSVVSQWYELVVFTASMEVYGTSVADRLDRG-RGIL--KRR |.|||||||||.|. .. .. ..||....... ......|. ||..|.|| .|..||.|..||||..| | |..|. ... ..| KTLVLDLDETLVHCNPWWEPPN--------WHDFIVPIPFNGQNHQWYVYKPRPYCDEFLQHMSKYYEIVIWTASMKEYADPVIDYIDPKSKKYFDGHHR Y---FRQHCT-MEVGG-Y-T-KDLSAI--HP-DLSSICILDNSPGAYRKFPHNAIPIPS-WFS-----D-PND--TCLLNLLPFL-DALR-FT-SDVR . .|.||. .. || | . |||| . |||.. |.|||| .. |.|.||||. |.. | |.| ..||.||||| ..|. . .||| LICWYREHCWLYRNGGNYYVKKDLSILWYNRWDLSRVIIVDNSPHSW-LQPDNGIPIPPYWYGYHDDDDSPDDFWNELLDLLPFLIEYLALQCLDDVR |
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| Phosphatase | scpl-2.AA | Family.FCP.PD | 56-227 | 46 | 3.4e-60 | 191.7 | In-house | 1-164 (164) | Show / Hide |
Range on Protein: 56-227 Range on HMM: 1-164/164 Sequence Identity: 46% (80 aa) KRKILVLDLDETLIHShhdgvlrqTVKPGTPSDFTIRVVIDRHPVKFSVHERPHVDYFLSVVSQWYELVVFTASMEVYGTSVADRLDRGRGILKRRYFRQ |.|.|||||||||.|| ..|| . .||...| ||... .. |. |||.|.||. ||..||.|.||||.. | ||| ||. ....|.|..|. kkklLVlDLdetLvhs--------elkpknkpdfvvkveideleetvyvkkRPhldeFLekvselyeiviftastrkyadpvadiLDpekklfkkrllrd HCTMEVGGYTKDLSAIHPDLSSICILDNSPGAYRKFPHNAIPIPSWFSDPNDTCLLNLLPFLDALRFTSDVR .|... | |.||||... |||...|.|.|| .|. .|.|||...|...||.|| ||.|||||..|....||| ecvlvkgnyvkdLsklgrdlskviiiDdspdsyklnpdnaikvksfkedpkDteLldLlpfleslakeedvr |
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| Phosphatase | scpl-2.AA | Subfamily.SCP.PD | 57-226 | 45 | 2.1e-50 | 159.5 | In-house | 2-162 (163) | Show / Hide |
Range on Protein: 57-226 Range on HMM: 2-162/163 Sequence Identity: 45% (77 aa) RKILVLDLDETLIHShhdgvlrqTVKPGTPSDFTIRVVIDRHPVKFSVHERPHVDYFLSVVSQWYELVVFTASMEVYGTSVADRLDRGRgILKRRYFRQH .| |||||||||.|| ..|| . .||.. | || . | ||.|| ||. |.. .|.|.||||.. |. ||| ||. . ..|| ||..| kkclvldldetlvhs--------sfkpvenadfvvpveidgtvhqvyvlkrpfvdeflkkvgelfevvlftaslakyadpvadlldkkn-vikarlfres CTMEVGGYTKDLSAIHPDLSSICILDNSPGAYRKFPHNAIPIPSWFSDPNDTCLLNLLPFLDALRFTSDV . | | |||| . ||... |.|||| .| |.||.|. |||.|..|| ||.|||.|. |. ..|| cvfhkgnyvkdlsrlGrdlkkvvivdnspasyifhpdnavpveswfddeedtelldllplleelskvedv |
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| Phosphatase | scpl-2.AA | Group.HAD.PD | 57-227 | 29 | 5.4e-43 | 136.3 | In-house | 1-190 (190) | Show / Hide |
Range on Protein: 57-227 Range on HMM: 1-190/190 Sequence Identity: 29% (57 aa) RKILVLDLDETLI-HSHHDGVLRQTVKPGTPSDFTIrvviDRHPVKFSVHER------------PHVDYFLSVVSQWYELVVFTASMEVYGTSVADRLDR .. ||||||..|. |..... .| . . ..|. . .. .. ...| ||.|.|| |...||||||||... | ..|...| | kdtlvlDldgvlwlhgspepleglrskgkvlifltn----natksrlyllkrlallgflveevephldeflervgelyelvvftagtreyadpvvgavdv GRGILKRRYFRQHCTMEVGGYTK------DLSAIHPDLSSICILDNSPGAYRK--FPHNAIPIPSWFSDPNDTCLLNLLPFLDAL--RFTSDVR ......|..|..|.. | . . ||.|...||....|.||.| .. .| ||..| ....|..|. ||.|.|.|... ||..||. gdeafsyrklrdacvylkgpgalllatnrdlgalvrdlekvviidnkpsvfafecnpenalmigdfiddildaellglipdlenidvrfgkdvg |
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| Phosphatase | scpl-2.AA | Subfamily.HSPC129.PD | 58-227 | 41 | 6.5e-42 | 132.0 | In-house | 3-164 (164) | Show / Hide |
Range on Protein: 58-227 Range on HMM: 3-164/164 Sequence Identity: 41% (69 aa) KILVLDLDETLIHSHhdgvlrqtVKPGTPSDFTIRVVIDRHPVKFSVHERPHVDYFLSVVSQWYELVVFTASMEVYGTSVADRLDRGRGILKRRYFRQHC |||||||||.|. ... . .. .|. . . . |. ||.. .||. ||. .|...|||| .|| . | || ... | ||.|| fslvldldetlvhcs--------lakledatlsfkveyqdktyqvyvrlrpflreflervsklfevilftaskkvyadklldlldpekklvrhrlfrehc TMEVGGYTKDLSAIHPDLSSICILDNSPGAYRKFPHNAIPIPSWFSDPNDTCLLNLLPFLDALRFTSDVR | | |||| . ||| |.|||| |. .| ||| |||.| ||. ||.|||||..| ..||| vcvdgnyikdlsilGrdlsktiivdnspqafayqlenGipieswfadendsellkllpfleklaekedvr |
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| Phosphatase | scpl-2.AA | Subfamily.TIM50.PD | 103-222 | 31 | 1.8e-26 | 82.0 | In-house | 25-143 (150) | Show / Hide |
Range on Protein: 103-222 Range on HMM: 25-143/150 Sequence Identity: 31% (37 aa) SVHERPHVDYFLSVVSQWYELVVFTASMEVYGTSVADRLDRgRGILKRRYFRQHCTMEVGGYTKDLSAIHPDLSSICILDNSPGAYRKFPHNAIPIPSWF .. || ||.||. ... .|.||||.. .. . . |.|| ..... | ||.... | .|||| . ||| . ..| . .... |.||. . | rfkkrPgvdafleelaelfeivvftseqgltaaplidkldP-kqlimyrlfrdatkyvdGehvkdlsklnrdlskvivvdldkesvklqpenalalkkwk SDPNDTCLLNLLPFLDALRF ...|. ||.||.|| . Gnaddrelldllaflktiat |
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| Phosphatase | scpl-2.AA | Subfamily.FCP1.PD | 58-199 | 26 | 1.3e-19 | 60.0 | In-house | 3-141 (150) | Show / Hide |
Range on Protein: 58-199 Range on HMM: 3-141/150 Sequence Identity: 26% (37 aa) KILVLDLDETLIHSHHDGVLrQTVK--PGTPSDFTIrvviDRHPVKFSVHERPHVDYFLSVVSQWYELVVFTASMEVYGTSVADRLDRGRGILKRRYFRQ .||.|||.||||. .| . .. . . ||. ... . |. ||.. ||. .|. ||| ..| . | ...| || . ...| . lvLvvDlDqtlihttkdpti-evkeeklkdikkftl----peekevyyvklRpnlkeFleklsklyelhiytmgtraYaeqiakilDpekklFserilsr HCTMEVGGYTKDLSAIHPD-LSSICILDNSPGAYrKFPHNAIPIP ... ||.|... | | ..|.|. . .| .| | . dellnassktkklkklfptgdsmvviiDDredvW-nfaenlikvk |
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