Gene fcp-1
fcp-1
Species: C.elegans
Alias: fcp-1
External Links:
Classification
Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.
Protein domain
Protein domains of fcp-1.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit phosphatase group/family/subfamily, which is helpful to understand the relationship between phosphatases. Transmembrane region is predicted by TMHMM 2.0. Visualized by pviz.
Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking. View complete domain list.
| Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
|---|---|---|---|---|---|---|---|---|---|
| Phosphatase | fcp-1.AA | Subfamily.FCP1.PD | 142-288 | 59 | 1.1e-66 | 212.8 | In-house | 1-150 (150) | Show / Hide |
Range on Protein: 142-288 Range on HMM: 1-150/150 Sequence Identity: 59% (89 aa) RKLVLLVDLDQTIIHTSDKPM-TVDTENHKDITKYNL--HSRVYTTKLRPHTTEFLNKMSNMYEMHIVTYGQRQYAHRIAQILDPDARLFEQRILSRDEL |||||.||||||.|||...|. .|..|..|||.|..| ...||..||||...|||.|.|..||.||.|.|.|.||..||.||||...||..|||||||| rklvLvvDlDqtlihttkdptievkeeklkdikkftlpeekevyyvklRpnlkeFleklsklyelhiytmgtraYaeqiakilDpekklFserilsrdel FSAQHKTNNLKALFPCGDNLVVIIDDRSDVWMYSEALIQIKPYRFFKEVG ..|..||..||.|||.||..|||||||.|||...|.||..|||.|||.|| lnassktkklkklfptgdsmvviiDDredvWnfaenlikvkpykfFkgvg |
|||||||||
| Phosphatase | fcp-1.AA | CPDc | 142-288 | 28 | 8.5e-52 | 179.32 | SMART | 1-173 (173) | Show / Hide |
Range on Protein: 142-288 Range on HMM: 1-173/173 Sequence Identity: 28% (49 aa) RKLVLLVDLDQTIIHT----------SDKPMTVDTENHKDITK------------YNLHSRVYTTKLRPHTTEFLNKMSNMYEMHIVTYGQRQYAHRIAQ .|..| .|||.|..|. ... . ....| . .. |.. . .|.||| .||| ..| .||||. | |.| ||. ... KKKTLVLDLDHTLVHSCMIPTLHHWMKYLRSFKEWTRRDFIWPQLKWFHMCMIVEIDGHPHQWYVKKRPHVHEFLKRCSKWYEMHVFTMGMRMYADPVLD ILDPDARLFEQRILSRDELFSAQHKTNN--LKALFPC-GDNLVVIIDDRSDVWMYSE-ALIQIKPYRFFKEVG .|||. ..| |.|.||. .. ..|| . . |... .. |.||||..|.| . .|.|||...|.. . MLDPKRKYFIYRRLYRDHCVYHKGKTYVKDTLSLVNRCDLSMVIIIDDSPDSWPWHPENAIPIKPWFYFMHDT |
|||||||||
| Phosphatase | fcp-1.AA | Family.FCP.PD | 142-282 | 33 | 8.5e-39 | 122.1 | In-house | 1-139 (164) | Show / Hide |
Range on Protein: 142-282 Range on HMM: 1-139/164 Sequence Identity: 33% (47 aa) RKLVLLVDLDQTIIHTSDKPMtVDTENHKDITKYNlHSRVYTTKLRPHTTEFLNKMSNMYEMHIVTYGQRQYAHRIAQILDPDARLFEQRILsRDEL-FS .|..|..|||.|..|.. ||. ... ..... . .. ...| |||..|||.|.|..||..| | ..|.||...|.||||. .||..|.| |||. . kkklLVlDLdetLvhselkpk-nkpdfvvkveide-leetvyvkkRPhldeFLekvselyeiviftastrkyadpvadiLDpekklfkkrll-rdecvlv AQHKTNNLKALfPCGDNLVVIIDDRSDVWMYSE-ALIQIKPYR .....|..| ..... |.||||..|.. . . .|..|... kgnyvkdLskl-grdlskviiiDdspdsyklnpdnaikvksfk |
|||||||||
| Phosphatase | fcp-1.AA | Group.HAD.PD | 144-285 | 23 | 2.5e-22 | 68.9 | In-house | 2-164 (190) | Show / Hide |
Range on Protein: 144-285 Range on HMM: 2-164/190 Sequence Identity: 23% (38 aa) LVLLVDLDQTII-HTSDKPMTVDTENHKDITKYNL---HSRVYTTKL-R----------PHTTEFLNKMSNMYEMHIVTYGQRQYAHRIAQILDPDARLF .|..|||.... |.| .|.. . | . .. ||.| .| . ||. |||......||... | |.|.||.... ..|... | dtlvlDldgvlwlhgspepleglrskgkvlifltnnatksrlyllkrlallgflveevephldeflervgelyelvvftagtreyadpvvgavdvgdeaf EQRILSRDELFSAQhKTNNL-----KALFPCGDNL-VVIIDDRSDVWM---YSEALIQIKPYrfFK |.| .. . . ....| ... | |||||....|.. | . |... . syrklrdacvylkg-pgalllatnrdlgalvrdlekvviidnkpsvfafecnpenalmigdf--id |
|||||||||
| Phosphatase | fcp-1.AA | NIF | 144-284 | 24 | 6.3e-21 | 77.93 | Pfam | 1-153 (189) | Show / Hide |
Range on Protein: 144-284 Range on HMM: 1-153/189 Sequence Identity: 24% (38 aa) LVLLVDLDQTIIHTS--DKPMTVDTENHKDITKYNL--HSRVYTTKL-RPHTTEFLNKMSNMYEMHIVTYGQRQYAHRIAQILDPD-ARLF-EQRIL--- ..| ||| |..|.. .|. .| | .... . . . ... ||. |||..||..||..| | ... || . ...||. ..| ...| KTLVLDLDETLVHCNPWWEPPN----WHDFIVPIPFNGQNHQWYVYKPRPYCDEFLQHMSKYYEIVIWTASMKEYADPVIDYIDPKSKKYFDGHHRLICW SRDEL--FSAQ-HK-TN-NLKALFPCG-D-NLVVIIDDRSDVWMYSEALIQIKPYRFF .|.. . . .. . .| |... | . |.|.|.....|.. . .|.|.|| .. YREHCWLYRNGGNYYVKKDLSILWYNRWDLSRVIIVDNSPHSWLQPDNGIPIPPY-WY |
|||||||||
| Phosphatase | fcp-1.AA | Subfamily.SCP.PD | 143-271 | 29 | 1.5e-18 | 56.0 | In-house | 2-126 (163) | Show / Hide |
Range on Protein: 143-271 Range on HMM: 2-126/163 Sequence Identity: 29% (39 aa) KLVLLVDLDQTIIHTSDKPMTvDTENHKDITKYNLHSRVYTTKlRPHTTEFLNKMSNMYEMHIVTYGQRQYAHRIAQILDPDaRLFEQRILsRDElfSAQ | |..|||.|..|.| ||.. ... . . . .|| .| ||. |||.|.....|. . | . .||...|..||. . ...|. |.. kkclvldldetlvhssfkpve-nadfvvpveidgtvhqvyvlk-rpfvdeflkkvgelfevvlftaslakyadpvadlldkk-nvikarlf-res--cvf HKTNNLKALFPCGDNL--VVIIDDRSDVWMY ||.| .| | | .| |||.|. ... hkgnyvkdlsrlGrdlkkvvivdnspasyif |
|||||||||
| Phosphatase | fcp-1.AA | Subfamily.HSPC129.PD | 144-264 | 28 | 2.8e-17 | 51.9 | In-house | 3-120 (164) | Show / Hide |
Range on Protein: 144-264 Range on HMM: 3-120/164 Sequence Identity: 28% (34 aa) LVLLVDLDQTIIHTSDKPMTVDTENhKDITKYNLHSRVYtTKLRPHTTEFLNKMSNMYEMHIVTYGQRQYAHRIAQILDPDARLFEQRILsRDELFSAQh |..|||.|..|.| ... | . .. . .|| .|||. |||...|...|. . | .. ||... ..|||. .|.. |.|. . .| fslvldldetlvhcslakledatls-fkveyqdktyqvy-vrlrpflreflervsklfevilftaskkvyadklldlldpekklvrhrlf-rehcvcvd- kTNNLKALFPCGDNL--VVIIDD .| | | .| .|.|. -gnyikdlsilGrdlsktiivdn |
|||||||||
| Phosphatase | fcp-1.AA | Subfamily.DULLARD.PD | 144-281 | 22 | 2.1e-16 | 49.0 | In-house | 3-146 (172) | Show / Hide |
Range on Protein: 144-281 Range on HMM: 3-146/172 Sequence Identity: 22% (32 aa) LVLLVDLDQTIIHTSDKPMTVDTENH---KDITKYNLHS---RVYTTKLRPHTTEFLNKMSNMYEMHIVTYGQRQYAHRIAQILDPDARLFEQRILSRDE .|..|||.|.||. . .| | .. .|.. . | . .. ||| .||...|. |.. | | . ..||. ... || .....| . . . ktlvldldetlihsahdsvtkstvkegtapdfklkvlierepvlfyvykrPhvdlfldvvskWydlviftasmeeyaaavvdkldsgrgilkrryyrqhC LFSAQHKTNNLKALFPCGDNLVvIIDD-RSDVWMYSEALIQIKPY .. | .| .. . .... |.|. .. .. . |.|| . tlesgkytkdlslvsedlssvi-ilDnspvayrknpdnaipiksw |
|||||||||
| BRCT | fcp-1.AA | BRCT | 351-430 | 19 | 4.4e-13 | 50.83 | Pfam | 1-84 (84) | Show / Hide |
Range on Protein: 351-430 Range on HMM: 1-84/84 Sequence Identity: 19% (17 aa) ERHKVLDGCVIVFSGIVPMGEKLERTDIYRLCTQFGAVIVPDVTDDVTHVV--GARY---GTQK-VYQANRLNKFVVTVQWVYACV . .|.. ||.... | .. .. | .. ..|. ....|....|||. . .|.| . .| ..|...|. .|...|. H-EKPFKGCTFCITGGFDNMNRDEIH-WQEMIEKHGGKVTDSVSKQTTHVIPWVGEPHCTRTKKFYWKAKEWNIPIVHPDWIWDCI |
|||||||||
| Phosphatase | fcp-1.AA | Subfamily.TIM50.PD | 181-281 | 21 | 1.9e-08 | 23.4 | In-house | 23-122 (150) | Show / Hide |
Range on Protein: 181-281 Range on HMM: 23-122/150 Sequence Identity: 21% (21 aa) VYTTKLRPHTTEFLNKMSNMYEMHIVTYGQRQYAHRIAQILDPDArLFEQRILSRDELFSAQHKTNNLKALFPCGDNLVVIIDDRSDVWMYSEALIQIKP . .| || ||.......|. . | | .|... . |||.. | . |.. . ... .|. | . ..|. |.. | .| ...|.. GwrfkkrPgvdafleelaelfeivvftseqgltaaplidkldPkq-limyrlfrdatkyvdGehvkdlsklnrdlskvivvdldkesvklqpenalalkk Y w |
|||||||||
| BRCT | fcp-1.AA | BRCT | 353-433 | 19 | 6.9e-21 | 76.63 | SMART | 1-93 (93) | Show / Hide |
Range on Protein: 353-433 Range on HMM: 1-93/93 Sequence Identity: 19% (19 aa) HKVLDGCVIVFSG--IVPMGEKLERTDIYRLCTQFGAVIVPDVTD----DVTHVVGARYGTQKVY----------QANRLNKFVVTVQWVYACVEKW .|...||.....| |. . . | .. .. ..|. .. .|. |.|||.. . ...|.. .| .... .|. .|...|..|| MKPFKGCTFCITGDDIEGNFD-M-RDELKEMIEMHGGKVT-SVSRKRCPDTTHVIC-SPENPKYETWNRMMTKYMKAIAWGIWIVHPDWIWDCIKKW |
|||||||||