Gene scpl-3
scpl-3
Species: C.elegans
Alias: scpl-3
External Links:
Classification
Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.
Protein domain
Protein domains of scpl-3.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit phosphatase group/family/subfamily, which is helpful to understand the relationship between phosphatases. Transmembrane region is predicted by TMHMM 2.0. Visualized by pviz.
Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking. View complete domain list.
| Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
|---|---|---|---|---|---|---|---|---|---|
| Phosphatase | scpl-3.AA | Subfamily.HSPC129.PD | 63-227 | 69 | 2e-93 | 299.8 | In-house | 1-164 (164) | Show / Hide |
Range on Protein: 63-227 Range on HMM: 1-164/164 Sequence Identity: 69% (115 aa) PEYTLVLDLDETLVHCSLTPLDNATMVFPVVFQNITYQVYVRLRPHLRTFLSRMAKTFEIIIFTASKKVYANKLCDILDPRKNHIRHRLFREHCVCVFGN ||..||||||||||||||..|..||..|.|..|..||||||||||.||.||.|..|.||.|.|||||||||.||.|.|||.|...|||||||||||| || pefslvldldetlvhcslakledatlsfkveyqdktyqvyvrlrpflreflervsklfevilftaskkvyadklldlldpekklvrhrlfrehcvcvdgn YVKDLTILGRDPSKTMILDNAVQSFAYQLDNGIPIESWFHDRNDTELLKLCSFLEAIPTLgRDVR |.|||.||||| |||.|.||..|.|||||.|||||||||.|.||.|||||..|||.. .. .||| yikdlsilGrdlsktiivdnspqafayqlenGipieswfadendsellkllpfleklaek-edvr |
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| Phosphatase | scpl-3.AA | NIF | 65-227 | 42 | 4.3e-75 | 260.57 | Pfam | 1-189 (189) | Show / Hide |
Range on Protein: 65-227 Range on HMM: 1-189/189 Sequence Identity: 42% (81 aa) YTLVLDLDETLVHCS--LTPLDNATMVFPVVFQNITYQVYVRL-RPHLRTFLSRMAKTFEIIIFTASKKVYANKLCDILDPR-KNHI--RHRL---FREH .|||||||||||||. .| .. ...|..|.....|.||.. ||... || .|.| .||.|.|||.|.||....|..|| |. . .||| .||| KTLVLDLDETLVHCNPWWEPPNWHDFIVPIPFNGQNHQWYVYKPRPYCDEFLQHMSKYYEIVIWTASMKEYADPVIDYIDPKSKKYFDGHHRLICWYREH CV-CVFG-NY-V-KDLTIL--GR-DPSKTMILDNAVQSFAYQLDNGIPIES-WFH-----D-RND--TELLKLCSFL-EAIP-TLGRDVR |. .. | || | |||.|| .| | |.. |.||. .|. .| ||||||.. |. | .| .|||.| || |.. . ||| CWLYRNGGNYYVKKDLSILWYNRWDLSRVIIVDNSPHSW-LQPDNGIPIPPYWYGYHDDDDSPDDFWNELLDLLPFLIEYLALQCLDDVR |
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| Phosphatase | scpl-3.AA | CPDc | 63-207 | 34 | 1.1e-69 | 238.68 | SMART | 1-173 (173) | Show / Hide |
Range on Protein: 63-207 Range on HMM: 1-173/173 Sequence Identity: 34% (60 aa) PEYTLVLDLDETLVHC--------------SLTPLDNATMVFP----------VVFQNITYQVYVRLRPHLRTFLSRMAKTFEIIIFTASKKVYANKLCD . .|||||||.||||. |. . .. ...| |.......|.||..|||.. ||.|..| .|...||.....|| ...| KKKTLVLDLDHTLVHSCMIPTLHHWMKYLRSFKEWTRRDFIWPQLKWFHMCMIVEIDGHPHQWYVKKRPHVHEFLKRCSKWYEMHVFTMGMRMYADPVLD ILDPRK-NHIRHRLFREHCVCVFGN-YVKD-LTILGR-DPSKTMILDNAVQSFAYQLDNGIPIESWFHDRNDT .||| . |..||.|.|||...|. |||| | ...| |.|...|.|. .|.... .|.|||..|| ...|| MLDPKRKYFIYRRLYRDHCVYHKGKTYVKDTLSLVNRCDLSMVIIIDDSPDSWPWHPENAIPIKPWFYFMHDT |
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| Phosphatase | scpl-3.AA | Subfamily.SCP.PD | 66-220 | 51 | 2e-63 | 202.0 | In-house | 4-157 (163) | Show / Hide |
Range on Protein: 66-220 Range on HMM: 4-157/163 Sequence Identity: 51% (79 aa) TLVLDLDETLVHCSLTPLDNATMVFPVVFQNITYQVYVRLRPHLRTFLSRMAKTFEIIIFTASKKVYANKLCDILDPrKNHIRHRLFREHCVCVFGNYVK .|||||||||||.|. |..|| .|.|| ......|||| ||.. ||......||...|||| . ||... |.||. || |..|||||.||. |||||| clvldldetlvhssfkpvenadfvvpveidgtvhqvyvlkrpfvdeflkkvgelfevvlftaslakyadpvadlldk-knvikarlfrescvfhkgnyvk DLTILGRDPSKTMILDNAVQSFAYQLDNGIPIESWFHDRNDTELLKLCSFLEAIP |. |||| .|..|.||. .|.... ||..|.||||.|..|||||.| .|| . dlsrlGrdlkkvvivdnspasyifhpdnavpveswfddeedtelldllplleels |
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| Phosphatase | scpl-3.AA | Family.FCP.PD | 64-227 | 47 | 7.9e-62 | 197.2 | In-house | 2-164 (164) | Show / Hide |
Range on Protein: 64-227 Range on HMM: 2-164/164 Sequence Identity: 47% (78 aa) EYTLVLDLDETLVHCSLTPLDNATMVFPVVFQNITYQVYVRLRPHLRTFLSRMAKTFEIIIFTASKKVYANKLCDILDPRKNHIRHRLFREHCVCVFGNY ...|||||||||||..|.| .....|..| ..... .|||. ||||..||..... .||.|||||.. ||....|||||.|. ...||.|..||.||||| kklLVlDLdetLvhselkpknkpdfvvkveideleetvyvkkRPhldeFLekvselyeiviftastrkyadpvadiLDpekklfkkrllrdecvlvkgny VKDLTILGRDPSKTMILDNAVQSFAYQLDNGIPIESWFHDRNDTELLKLCSFLEAIPTLgRDVR |||..|||| ||..|.|. .|.... ||.|...|...| .|||||.|..|||.. . .||| vkdLsklgrdlskviiiDdspdsyklnpdnaikvksfkedpkDteLldLlpfleslake-edvr |
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| Phosphatase | scpl-3.AA | Subfamily.DULLARD.PD | 66-220 | 37 | 2.8e-45 | 143.1 | In-house | 4-166 (172) | Show / Hide |
Range on Protein: 66-220 Range on HMM: 4-166/172 Sequence Identity: 37% (61 aa) TLVLDLDETLVHC--------SLTPLDNATMVFPVVFQNITYQVYVRLRPHLRTFLSRMAKTFEIIIFTASKKVYANKLCDILDPRKNHIRHRLFREHCV ||||||||||.| .... . ... |. .. ..|| |||. ||....| ....||||| ..||... | || .....|..|.||. tlvldldetlihsahdsvtkstvkegtapdfklkvlierepvlfyvykrPhvdlfldvvskWydlviftasmeeyaaavvdkldsgrgilkrryyrqhCt CVFGNYVKDLTILGRDPSKTMILDNAVQSFAYQLDNGIPIESWFHDRNDTELLKLCSFLEAIP .|.|.|||... | |...||||. .... ..||.|||.||. | .||.||.| ||.|. lesgkytkdlslvsedlssviilDnspvayrknpdnaipikswisdpsdtallnllPfldalr |
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| Phosphatase | scpl-3.AA | Group.HAD.PD | 65-219 | 30 | 7.9e-42 | 132.7 | In-house | 2-181 (190) | Show / Hide |
Range on Protein: 65-219 Range on HMM: 2-181/190 Sequence Identity: 30% (55 aa) YTLVLDLDETLV-HCSLTPLDNATMVFPVVFQNIT----YQVYVRLR------------PHLRTFLSRMAKTFEIIIFTASKKVYANKLCDILDPRKNHI .|||||||..|. |.| .||... . .| ... . ..|.. | |||. || |. . .|...|||. . ||. .....|. .... dtlvlDldgvlwlhgspepleglrskgkvlifltnnatksrlyllkrlallgflveevephldeflervgelyelvvftagtreyadpvvgavdvgdeaf RHRLFREHCVCVFGNYVK------DLTILGRDPSKTMILDNAVQSFAY--QLDNGIPIESWFHDRNDTELLKLCSFLEAI ..|..|..||.. |.... ||. |.||..|. |.|| ..|| . .|...|.... | .|.|||.| ..||.| syrklrdacvylkgpgalllatnrdlgalvrdlekvviidnkpsvfafecnpenalmigdfiddildaellglipdleni |
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| Phosphatase | scpl-3.AA | Subfamily.TIM50.PD | 63-221 | 36 | 3.6e-32 | 100.6 | In-house | 1-143 (150) | Show / Hide |
Range on Protein: 63-221 Range on HMM: 1-143/150 Sequence Identity: 36% (58 aa) PEYTLVLDLDETLVHCSLTpldnatmvfpvvfQNITYQvyVRLRPHLRTFLSRMAKTFEIIIFTASKKVYANKLCDILDPrKNHIRHRLFREHCVCVFGN |.|||||.|...||| | .. .. .. || . .||...|..|||..||... ..| .| | ||| |. |..||||... | |. ppytlvlelkdvlvhpewt-------------yktGwr--fkkrPgvdafleelaelfeivvftseqgltaaplidkldP-kqlimyrlfrdatkyvdGe YVKDLTILGRDPSKTMILDNAVQSFAYQLDNGIPIESWFHDRNDTELLKLCSFLEAIPT ||||. | || || ...| .|. | .| . .. | . .|.|||.| .||. | | hvkdlsklnrdlskvivvdldkesvklqpenalalkkwkGnaddrelldllaflktiat |
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| Phosphatase | scpl-3.AA | Subfamily.FCP1.PD | 66-188 | 26 | 3.2e-21 | 65.4 | In-house | 4-132 (150) | Show / Hide |
Range on Protein: 66-188 Range on HMM: 4-132/150 Sequence Identity: 26% (34 aa) TLVLDLDETLVHCSLTPL-----DNATMVFPVVFQNITYQVYVRLRPHLRTFLSRMAKTFEIIIFTASKKVYANKLCDILDPRKNHIRHRLF-REHCVCV .||.|||.||.|.. | . . . ... ||.|||.|. ||....|..|. |.| ... ||... |||| |. .|.|. .. . vLvvDlDqtlihttkdptievkeeklkdikkftlpeekevyyvklRpnlkeFleklsklyelhiytmgtraYaeqiakilDpekklFserilsrdellna FGNYVKDLTILGRDPSKTMILDNAVQSFA . | ... .. | .|.|. . . ssktkklkklfptgdsmvviiDDredvWn |
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