scpl-4
Species: C.elegans
Alias: scpl-4
External Links:
Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Superfamily: HAD
Family: FCP
Subfamily: TIM50
Protein domain

Protein domains of scpl-4.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit phosphatase group/family/subfamily, which is helpful to understand the relationship between phosphatases. Transmembrane region is predicted by TMHMM 2.0. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking. View complete domain list.

Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Phosphatase scpl-4.AA Subfamily.TIM50.PD 246-396 61 1.1e-73 235.0 In-house 1-150 (150) Show / Hide
Range on Protein: 246-396
Range on HMM: 1-150/150
Sequence Identity: 61% (93 aa)

PKYTIVIELKNILVHPEWTYKTGYRFLKRPALDYFLDVIGyPNFEVVIYSSESMMTAAPVVDSFDPKQRIMYKLFRDCTKYMNGHHVKDLSKLNRDLSKV
|.||.|.|||..|||||||||||.|| |||..|.||. .. ..||.|...||...||||..|..|||| |||.||||.|||..|.|||||||||||||||
ppytlvlelkdvlvhpewtyktGwrfkkrPgvdafleela-elfeivvftseqgltaaplidkldPkqlimyrlfrdatkyvdGehvkdlsklnrdlskv

IYIDFDAKSGQLNPENMLRVPEWKGNMDDTSLVDLAELLKTIHLSDAEDVR
|..|.|..| .|.|||.|.. .||||.||..|.||...||||. |..||||
ivvdldkesvklqpenalalkkwkGnaddrelldllaflktiatsevedvr

Phosphatase scpl-4.AA CPDc 246-375 29 1e-53 185.71 SMART 1-173 (173) Show / Hide
Range on Protein: 246-375
Range on HMM: 1-173/173
Sequence Identity: 29% (52 aa)

PKYTIVIELKNILVHP-----------------EWTYK----------------------TGYRFLKRPALDYFLDVIGYPNFEVVIYSSESMMTAAPVV
.|.|.|..|.. |||.                 |||..                      ......||| ...||. ..  ..|.........|.| ||.
KKKTLVLDLDHTLVHSCMIPTLHHWMKYLRSFKEWTRRDFIWPQLKWFHMCMIVEIDGHPHQWYVKKRPHVHEFLKRCS-KWYEMHVFTMGMRMYADPVL

DSFDPKQ-RIMYK-LFRDCTKYMNGH-HVKD-LSKLNR-DLSKVIYIDFDAKSGQLNPENMLRVPEWKGNMDDT
|  |||. ...|. |.||...|..|. .||| ||..|| |||.|| || . .|  ..|||.. .. |...|.||
DMLDPKRKYFIYRRLYRDHCVYHKGKTYVKDTLSLVNRCDLSMVIIIDDSPDSWPWHPENAIPIKPWFYFMHDT

Phosphatase scpl-4.AA NIF 248-396 30 5.8e-50 177.11 Pfam 1-189 (189) Show / Hide
Range on Protein: 248-396
Range on HMM: 1-189/189
Sequence Identity: 30% (58 aa)

YTIVIELKNILVHPE--WTYK---------------TGYRFLK-RPALDYFLDVIGYPNFEVVIYSSESMMTAAPVVDSFDP--KQRI--MYKL---FRD
.|.|. | . ||| .  |...               ..... | || .|.||. .   ..|.||... ....| ||.|  ||  |. .   ..|   .|.
KTLVLDLDETLVHCNPWWEPPNWHDFIVPIPFNGQNHQWYVYKPRPYCDEFLQHM-SKYYEIVIWTASMKEYADPVIDYIDPKSKKYFDGHHRLICWYRE

CTK-YMNG-HH-V-KDLSKL--NR-DLSKVIYIDFDAKSGQLNPENMLRVPE-WKG-----N-MDD--TSLVDLAELL-KTIHLSDA-EDVR
 .. | || .. | ||||.|  || |||.||..| .. |  |.|.| . .|  |.|     .  ||  . | || ..| . .  . . .|||
HCWLYRNGGNYYVKKDLSILWYNRWDLSRVIIVDNSPHSW-LQPDNGIPIPPYWYGYHDDDDSPDDFWNELLDLLPFLIEYLA-LQCLDDVR

Phosphatase scpl-4.AA Family.FCP.PD 246-396 36 1.2e-42 134.4 In-house 1-164 (164) Show / Hide
Range on Protein: 246-396
Range on HMM: 1-164/164
Sequence Identity: 36% (61 aa)

PKYTIVIELKNILVHPEWT---------------YKTGYRFLKRPALDYFLDVIGyPNFEVVIYSSESMMTAAPVVDSFDP-KQRIMYKLFRDCTKYMNG
.|...|..|...||| |..               ... ....||| ||.||. .. . .|.||........|.||.|  || |. ....|.|| .....|
kkklLVlDLdetLvhselkpknkpdfvvkveideleetvyvkkRPhldeFLekvs-elyeiviftastrkyadpvadiLDpekklfkkrllrdecvlvkg

HHVKDLSKLNRDLSKVIYIDFDAKSGQLNPENMLRVPEWKGNMDDTSLVDLAELLKTIHlSDaEDVR
..|||||||.||||||| || . .| .|||.|...|...|....||.|.||...|.... .  ||||
nyvkdLsklgrdlskviiiDdspdsyklnpdnaikvksfkedpkDteLldLlpflesla-ke-edvr

Phosphatase scpl-4.AA Subfamily.SCP.PD 271-395 41 2.1e-26 81.2 In-house 41-162 (163) Show / Hide
Range on Protein: 271-395
Range on HMM: 41-162/163
Sequence Identity: 41% (51 aa)

FLKRPALDYFLDVIGYpNFEVVIYSSESMMTAAPVVDSFDPKQRIMYKLFRDCTKYMNGHHVKDLSKLNRDLSKVIYIDFDAKSGQLNPENMLRVPEWKG
|||| .| ||. .|   ||||....     | ||.| .|.|. | ..|||.   ...| .|||||.| |||.||. .|   .|  ..|.| .|  |  ..
vlkrpfvdeflkkvge-lfevvlftaslakyadpvadlldkknvikarlfrescvfhkgnyvkdlsrlGrdlkkvvivdnspasyifhpdnavpveswfd

NMDDTSLVDLAELLKTIhlSDAEDV
.|| | ||  ||...  |..|||  
deedtelldllplleel--skvedv

Phosphatase scpl-4.AA Group.HAD.PD 247-396 25 9.5e-26 79.8 In-house 1-190 (190) Show / Hide
Range on Protein: 247-396
Range on HMM: 1-190/190
Sequence Identity: 25% (48 aa)

KYTIVIELKNILV-HPEWTYKTGYRFLKR-------------------------------PALDYFLDVIGYPnFEVVIYSSESMMTAAPVVDSFDP-KQ
|.|.|. |.  |. |.......| |....                               |.||.||. .|   .|.|.........| |||. .|... 
kdtlvlDldgvlwlhgspepleglrskgkvlifltnnatksrlyllkrlallgflveevephldeflervgel-yelvvftagtreyadpvvgavdvgde

RIMYKLFRDCTKYMNGHHVK------DLSKLNRDLSKVIYIDFDAKSGQL--NPENMLRVPEWKGNMDDTSLVDLAELLKTIHLSDAEDVR
..|...|| . | .|....      ||. |.|||.||. ||  ...  .  |||| | .  .. ...|. |..| . |..|  ....||. 
afsyrklrdacvylkgpgalllatnrdlgalvrdlekvviidnkpsvfafecnpenalmigdfiddildaellglipdlenidvrfgkdvg

Phosphatase scpl-4.AA Subfamily.DULLARD.PD 267-390 30 3.6e-23 70.8 In-house 45-168 (172) Show / Hide
Range on Protein: 267-390
Range on HMM: 45-168/172
Sequence Identity: 30% (38 aa)

TGYRFLKRPALDYFLDVIGYpNFEVVIYSSESMMTAAPVVDSFDPKQRIMY-KLFRDCTKYMNGHHVKDLSKLNRDLSKVIYIDFDAKSGQLNPENMLRV
. ..  ||| .|.||||.    ...||. .   . ||.||| .|  . |.  ...|.     .|...|||| .. |||.|| .|  .... ||.| ... 
vlfyvykrPhvdlfldvvsk-WydlviftasmeeyaaavvdkldsgrgilkrryyrqhCtlesgkytkdlslvsedlssviilDnspvayrknpdnaipi

PEWKGNMDDTSLVDLAELLKTIHLS
 |  . .||.|..|  .| ..  . 
kswisdpsdtallnllPfldalrft

Phosphatase scpl-4.AA Subfamily.HSPC129.PD 273-396 31 2.8e-19 58.2 In-house 43-164 (164) Show / Hide
Range on Protein: 273-396
Range on HMM: 43-164/164
Sequence Identity: 31% (39 aa)

KRPALDYFLDVIGYpNFEVVIYSSESMMTAAPVVDSFDPK-QRIMYKLFRDCTKYMNGHHVKDLSKLNRDLSKVIYIDFDAKSGQLNPENMLRVPEWKGN
|| | .||. .    |||.....   . |  ..| .||. . . ..|||.    ..| ..|||| | ||||| | .|  ...  .. || . .  |  . 
lrpflreflervsk-lfevilftaskkvyadklldlldpekklvrhrlfrehcvcvdgnyikdlsilGrdlsktiivdnspqafayqlenGipieswfad

MDDTSLVDLAELLKTIhlSDAEDVR
.|. |..| ..|...   . |||| 
endsellkllpflekl--aekedvr

Sequence
Name Sequence Type Origin Length Description Download
scpl-4.AA Protein None 452 None Fasta, JSON
scpl-4.NA RNA None 1356 None Fasta, JSON
scpl-4.AA.PD_246-396 Protein Phosphatase Domain None 151 None Fasta, JSON