K08B12.3
Species: C.elegans
Alias: K08B12.3
External Links:
Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Superfamily: HAD
Family: NagD
Subfamily: LHPP
Protein domain

Protein domains of K08B12.3.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit phosphatase group/family/subfamily, which is helpful to understand the relationship between phosphatases. Transmembrane region is predicted by TMHMM 2.0. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking. View complete domain list.

Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Phosphatase K08B12.3.AA Subfamily.LHPP.PD 4-216 61 1.2e-97 313.7 In-house 1-213 (213) Show / Hide
Range on Protein: 4-216
Range on HMM: 1-213/213
Sequence Identity: 61% (133 aa)

ISSVLIDLSGTIHIEEFAIPGAQTALELLRQHA-KVKFVTNTTKESKRLLHQRLINCGFKVEKEEIFTSLTAARDLIVKNQYRPFFIVDDRAMEDFEGIS
|..||.||||....|| ||||...||. |.|.. ||.||||||||||| |..||...|||||.||.||||.|||.|. |...|||..|.|.|.||||||.
ikgvllDlsGvlyveeaaipgsveAlkrLkqsglkvrfvtnttkeskrelverLqrlgfkveeeevftslpaarqllkkeklrpfllveddaredFegid

TDDPNAVVIGLAPEKFNDTTLTHAFRLIKEKKAS-LIAINKGRYHQTNAGLCLGPGTYVAGLEYSAGVEATIVGKPNKLFFESALQSLneNVDFSSAVMI
||.|||||||||||.||..||..||||..|||.. ||||.||.|.....||.|..|..|..|||...|||..||||.|||||||||.|  .||...||||
tdspnavviglapesfnyetlnkafrlllekkkkvLiaigkgkyykrkdglaldvGafvkaLeyatdveaevvGkPsklfFesalqel--gvdpeeavmi

GDDVNDDALGAIKIG
||||.||. ||.|.|
GDDvkdDvgGAqkvG

Phosphatase K08B12.3.AA Family.NagD.PD 5-216 35 2.1e-64 205.6 In-house 2-239 (239) Show / Hide
Range on Protein: 5-216
Range on HMM: 2-239/239
Sequence Identity: 35% (86 aa)

SSVLIDLSGTIHIEEFAIPGAQTALELLRQH-AKVKFVTNTTKESKRLLHQRLINCGFKVEKEEIFTSLTAARDLIVKNQYRPF-----FIVDDRAMEDF
..||.|..|... .| |||||. ||. |||.  ||.||||....|.. |...| ..||||..||||.|..||.|.. |.. .||     .|......|..
dtvlfDcdGVLwlgekaipgavealnrLrqkgkkvlfvTNnstksreellkklqklgfkvseeeifssaaaaadylkkrkkkpfkkkvyligeeglkeel

EG----------------------ISTDDPNAVVIGLAPEKFNDTTLTHAFRLIKEKKASLIAINKGRYHQTNAGLCLGPGTYVAGLEYSAGVEATIVGK
|                       .........|.. |.|.|. ..|..|||.........||.|........ .|..|.|..|| ||...|.||..|||
eelgieslgtgpdkledeldgdlevdlekdvgaVvvgadehfsyeklakAfryLqnpdvlfiatnedktlkepevlipgaGsfvaaletatgrealvvGK

PNKLFFESALQSLneNVDFSSAVMIGDDVNDDALGAIKIG
|.||.||..|..|  .|| ...|||||..|.| |.| |.|
Pskllfeallekl--gvdpertvmiGDrlntDilfaqkcG

Phosphatase K08B12.3.AA Group.HAD.PD 6-225 25 2.5e-27 84.4 In-house 3-182 (190) Show / Hide
Range on Protein: 6-225
Range on HMM: 3-182/190
Sequence Identity: 25% (54 aa)

SVLIDLSGTIHieefaIPGAQTALELLRQHAKVKF-VTNTTKESKRLLHQRLINCGFKVEKEEifTSLTAARDLIvkNQYrPFFIVDDRAMEDFegistD
....||.|...     ..|. ..|| ||...||.. .||....|.  |..|| ..||.||..|    | .  . .   .. .  .| . ... ..||...
tlvlDldgvlw-----lhgspepleglrskgkvlifltnnatksrlyllkrlallgflveeve--phldeflerv--gel-yelvvftagtrey-----a

DPNAVVIGLAPEKFNDTTLTHAFRLIKEKKASLIAINKgryhqtnaglclGPGTYVAGLEysAgvEATIVGKPNKLFFESalqslnenvDFSSAVMIGDD
... . | |. . |. |.. .|...| |.| |.            ..|  |..||  .   . | .||.  .||          . . |.||||.  || 
dpvvgavdvgdeafsyrklrdacvylkgpgalllatnr------------dlgalvrdle--k--vviidnkpsvfafec---------npenalmigdf

VnDDALGAIKIGMRAILVKTG
|.|...|..  | ...     
i-ddildaellglipdlenid

Phosphatase K08B12.3.AA Subfamily.PGP.PD 104-214 29 5.5e-18 53.4 In-house 133-241 (243) Show / Hide
Range on Protein: 104-214
Range on HMM: 133-241/243
Sequence Identity: 29% (32 aa)

DDPNAVVIGLApEKFNDTTLTHAFRLIKEKKASLIAINKGRYHQTNAGLCL-GPGTYVAGLEYSAGVEATIVGKPNKLFFESALQSLneNVDFSSAVMIG
|..|||.|.  |.|. . |..| . ...... ..| |. . ...| .... | |. || .| ..| |...||||.|| ... |..   ..|. ..|.|| 
kdvgaVvvgfd-ehfsyvklakAlnylqnpdvlfvatneDetlplnpevvipgtGslvaavetasgreplvvGKPskllldalleka--kidpertlmvG

DDVNDDALGAIK
.. | | . .  
DrldtDilfgkn

Phosphatase K08B12.3.AA Hydrolase 4-216 18 2.7e-14 50.38 Pfam 1-167 (167) Show / Hide
Range on Protein: 4-216
Range on HMM: 1-167/167
Sequence Identity: 18% (40 aa)

ISSVLIDLSGTIHIEEFAIPGAQTALELLRQHAKVKFVTNTTKESKRLLHQRLINCGFKVEKEEIFTSLTAARDLIVKNQYRPFFIVDDRAMEDFEGIST
|  |..|. ||.     . | ||.  |..|.. .           . . .  .  . .    ..|...  |....|                        
IKAVVFDKDGTLTDG-SEHPHAQAWVEAAREYGY--------WPFEEVEYIWGRGI-G----DRIIDWWRATDEHI------------------------

DDPNAVVIGLAPEKFNDTTLTHAFRLIKEKKAS---LIAINKGRYHQTNAGLCLGPGTYVAGLEYSAGVEATIVGKPNKLFFESALQSLNENVD--FSSA
     .   |. .   |. . .| ..... |.    .. |  . ...   . .|| . |......|..|.  |||||..  .| |.| |. ..   .  .
-----D-EYLGVIAD-DQPYPGAREALQALKRMGIKVAMITNDNRNAQAVLEHLGIA-YFDHIIDSDDVG--IVGKPHPEMYEKACQRLGVKPHECG--C

VMIGDDVNDDALGAIKIG
.|.||..|||. .|   |
MMVGDGINDDPMLAQ-AG

Phosphatase K08B12.3.AA Subfamily.PGP.PD 5-83 36 2.7e-13 38.1 In-house 2-82 (243) Show / Hide
Range on Protein: 5-83
Range on HMM: 2-82/243
Sequence Identity: 36% (29 aa)

SSVLIDLSGTIHIEEFAIPGAQTALELLRQHAK-VKFVTNTTKESKRLLHQRLINCGFKVEK-EEIFTSLTAARDLIVKNQ
.||.|  |... .| |||||  .|. ||.. | | ||||    ..  . ... . |||| | |||..| ... |.. ... 
dtvlfDcdGVlWlgetaipgavevlnaLraagKkvlfvtNnstktreeylkkfkklgfkvlkkeeilssaavladylkqak

Sequence
Name Sequence Type Origin Length Description Download
K08B12.3.AA Protein None 257 None Fasta, JSON
K08B12.3.NA RNA None 771 None Fasta, JSON
K08B12.3.AA.PD_4-216 Protein Phosphatase Domain None 213 None Fasta, JSON