Gene C45E5.1
C45E5.1
Species: C.elegans
Alias: C45E5.1
External Links:
Classification
Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.
Protein domain
Protein domains of C45E5.1 .AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit phosphatase group/family/subfamily, which is helpful to understand the relationship between phosphatases. Transmembrane region is predicted by TMHMM 2.0. Visualized by pviz.
Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking. View complete domain list.
| Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
|---|---|---|---|---|---|---|---|---|---|
| Phosphatase | C45E5.1 .AA | Subfamily.PGP.PD | 15-265 | 49 | 2e-98 | 316.9 | In-house | 1-243 (243) | Show / Hide |
Range on Protein: 15-265 Range on HMM: 1-243/243 Sequence Identity: 49% (123 aa) FDTFVFDADGVLWTGDIPIPGAAEWINTLLDDpEKSVFITTNNSTKTLEQYMKKVKKMRFGRLGRENLLSPTIVLCDYFKQNSDKFENQYIYLIGVENLK |||..||.|||||.|. .||||.|..|.| .. .|.|...||||||| |.|.||.||..|. | .|..||...||.||.||...|.|....|||| |.|| fdtvlfDcdGVlWlgetaipgavevlnaLraa-gKkvlfvtNnstktreeylkkfkklgfkvlkkeeilssaavladylkqakakkekkkvyligeeglk KSLEEgGGVKCFGTGPDHKDNYTDGDFINEVDVKsKIPKAVVVSFDSHFSYPKLMKAANFLADPLVEFLVCNEDSTFPgPVPGMILPETGPWSAAIQNVS ..||| |....|.|||.... .|||....|... | ..||||.||.||||.||.||.|.|..| |.|...|||.|.| ..|....|.||...||....| eelee-lgieslgvgpdkledeldgdlaekvkle-kdvgaVvvgfdehfsyvklakAlnylqnpdvlfvatneDetlp-lnpevvipgtGslvaavetas GRKPdIVFGKPHEQLANFLKSRVqagKFNSERTVMFGDRLDTDMMFGKNNG ||.| .|.|||...|...|.... |...|||.|.|||||||..||||.| grep-lvvGKPskllldalleka---kidpertlmvGDrldtDilfgkncG |
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| Phosphatase | C45E5.1 .AA | Family.NagD.PD | 15-265 | 42 | 5.4e-89 | 286.1 | In-house | 1-239 (239) | Show / Hide |
Range on Protein: 15-265 Range on HMM: 1-239/239 Sequence Identity: 42% (105 aa) FDTFVFDADGVLWTGDIPIPGAAEWINTLLDDpEKSVFITTNNSTKTLEQYMKKVKKMRFGRlGRENLLSPTIVLCDYFKQNSDKFENQYIYLIGVENLK .||..||.|||||.|. .||||.|..|.| .. .|.|...||||||. |...||..|..|. .|...|......||.|....| ....|||||.||. idtvlfDcdGVLwlgekaipgavealnrLrqk-gkkvlfvTNnstksreellkklqklgfkv-seeeifssaaaaadylkkrkkkpfkkkvyligeeglk KSLEEgGGVKCFGTGPDHKDNYTDGDFinEVDVKSKIpKAVVVSFDSHFSYPKLMKAANFLADPLVEFLVCNEDSTFpgPVPGMILPETGPWSAAIQNVS .||| |....|||||......|||. |||..... .||||..|.||||.||.||...| .| |.|...|||.|. . |....|..|...||.. ..| eelee-lgieslgtgpdkledeldgdl--evdlekdv-gaVvvgadehfsyeklakAfryLqnpdvlfiatnedktl--kepevlipgaGsfvaaletat GRKPDIVfGKPHEQLANFLKSRVqagKFNSERTVMFGDRLDTDMMFGKNNG |....| |||...|...|.... ....|||||.||||.||..|....| grealvv-GKPskllfeallekl---gvdpertvmiGDrlntDilfaqkcG |
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| Phosphatase | C45E5.1 .AA | Group.HAD.PD | 63-265 | 12 | 6.4e-36 | 112.4 | In-house | 2-190 (190) | Show / Hide |
Range on Protein: 63-265 Range on HMM: 2-190/190 Sequence Identity: 12% (26 aa) EQYMKKVKKMRF---GRLGRENLLSPTIVLCDYFKqnsdKFENQYIYLIGVENLKKSLEEGGGvkcfgtgpDHKDNYTDGDF-INEVDVKSKIPKAVVVS .... ....... .. ..|.|.|...||..... .......||.....|...|.|... .|.|....... ..|..|... ..... . dtlvlDldgvlwlhgspepleglrskgkvlifltn----natksrlyllkrlallgflveeve--------phldeflervgelyelvvftagtreyadp FDSHFSYPKLMKAANFLADPLVEFLVCNEDSTFPGPVPGMILPETGPWSAAIQNVSGRKPDIvfgkpHEQLANFLKSRvqagKFNSERTVMFGDRLDTD- ............ ...|.|..|.. ........... .|.. ... ........ | ..... ... |...... ..........|...|.. vvgavdvgdeafsyrklrdacvylkgpgalllatnrdlgalvrdlekvviidnkpsvfafec-----npenalmigdf----iddildaellglipdlen --MMFGKNNG ..|||..| idvrfgkdvg |
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| Phosphatase | C45E5.1 .AA | Group.HAD.PD | 15-74 | 31 | 6.3e-11 | 30.9 | In-house | 1-54 (190) | Show / Hide |
Range on Protein: 15-74 Range on HMM: 1-54/190 Sequence Identity: 31% (19 aa) FDTFVFDADGVLWtgdipIPGAAEWINTLLDDPEKSVFITTnNSTKTLEQYMKKVKKMRF .||.|.| ||||| ..|..|... |. . .|.|. |.||. ...|. ....| kdtlvlDldgvlw-----lhgspepleglrskgkvlifltn-natksrlyllkrlallgf |
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| Phosphatase | C45E5.1 .AA | Hydrolase | 15-265 | 11 | 1.1e-10 | 38.05 | Pfam | 1-167 (167) | Show / Hide |
Range on Protein: 15-265
Range on HMM: 1-167/167
Sequence Identity: 11% (30 aa)
FDTFVFDADGVLWTGDIPIPGAAEWINTLLDDPEKSVFITTNNSTKTLEQYMKKVKKMRFGRLGRENLLSPTIVLCDYFKQNSDKFENQYIYLIGVENLK
....||| ||.|..| . |. .. .... .. .. . . ..... .... ..|. .|..
IKAVVFDKDGTLTDG--SEHPHAQAWVEAAREYGY---WPFEEVEYIWGRGI-GDRIIDWWRATDEHI--------------------------------
KSLEEGGGVKCFGTGPDHKDNYTDGDFINEVDVKSKIPKAVVVSFDSHFSYPKLMKAANFLADP-LVEFLVCNEDSTFPGPVPGMILPETGPWSAAIQNV
... | .| || ..| . | . . ... | . .. .| ... . . ..|
------------------------------------D-EYLGVIAD-DQPYPGAREALQALKRMGIKVAMITNDNR-NAQAVLE--HLGIA-YFDHIIDS
SGRKPDIVFGKPHEQLANFLKSRVQAGKF--NSERTVMFGDRLDTDMMFGKNNG
.... ..|||| . . . | . . ..|.||.. .| |. . |
DDVG---IVGKPHPEMYEKACQRLGVKPHECG---CMMVGDGINDDPMLAQ-AG
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| Phosphatase | C45E5.1 .AA | Subfamily.LHPP.PD | 147-259 | 24 | 5.6e-10 | 27.2 | In-house | 99-207 (213) | Show / Hide |
Range on Protein: 147-259 Range on HMM: 99-207/213 Sequence Identity: 24% (28 aa) VKSKIPKAVVVS-FDSHFSYPKLMKAANFLADPLVEFLVCNEDSTFPGPVPGMILpETGPWSAAIQNVSGRKPDIVfGKPHeqlANFLKSRVQAGKFNSE .. . |.|||.. . .|.| .| || . | . . |. . . . . |..| ..|.. .|.. . . .| |||. ..| .| .|. ... | idtdspnavviglapesfnyetlnkafrlllekkkkvLiaigkgkyykrkdglal-dvGafvkaLeyatdveaevv-GkPs---klfFesalqelgvdpe RTVMFGDRLDTDMM ..|| || . |. eavmiGDDvkdDvg |
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| Phosphatase | C45E5.1 .AA | Subfamily.LHPP.PD | 18-97 | 18 | 9.1e-08 | 20.0 | In-house | 4-81 (213) | Show / Hide |
Range on Protein: 18-97 Range on HMM: 4-81/213 Sequence Identity: 18% (15 aa) FVFDADGVLWTGDIPIPGAAEWINTLLDDPeKSVFITTNNSTKTLEQYMKKVKKMRFgRLGRENLLSPTIVLCDYFKQNS .. | |||.. . .|||..| .. | . | . ||.. .. .. ....... | . .|..... . ... |... vllDlsGvlyveeaaipgsveAlkrLkqsg-lkvrfvtnttkeskrelverLqrlgf-kveeeevftslpaarqllkkek |
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Sequence
| Name | Sequence Type | Origin | Length | Description | Download |
|---|---|---|---|---|---|
| C45E5.1 .AA | Protein | None | 303 | None | Fasta, JSON |
| C45E5.1 .NA | RNA | None | 912 | None | Fasta, JSON |
| C45E5.1 .AA.PD_15-265 | Protein Phosphatase Domain | None | 251 | None | Fasta, JSON |