Gene F43C1.1
F43C1.1
Species: C.elegans
Alias: F43C1.1
External Links:
Classification
Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.
Protein domain
Protein domains of F43C1.1.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit phosphatase group/family/subfamily, which is helpful to understand the relationship between phosphatases. Transmembrane region is predicted by TMHMM 2.0. Visualized by pviz.
Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking. View complete domain list.
| Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
|---|---|---|---|---|---|---|---|---|---|
| LRR | F43C1.1.AA | LRR_TYP | 265-288 | 45 | 2e-06 | 28.97 | SMART | 1-24 (24) | Show / Hide |
Range on Protein: 265-288 Range on HMM: 1-24/24 Sequence Identity: 45% (11 aa) LQNLQSLDISFNQFSQIPPCLFHL | ||..|| |.||....|| .|. LPNLRELDLSNNQLTHLPPGAFQG |
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| Phosphatase | F43C1.1.AA | Family.PPM.PD | 661-896 | 17 | 2.9e-22 | 68.1 | In-house | 91-285 (495) | Show / Hide |
Range on Protein: 661-896 Range on HMM: 91-285/495 Sequence Identity: 17% (44 aa) SegsqnlfgfqigvsgsrgmknkqcirqvrventfgfidggsnsymsssicrfmtsylkENVSMDIRSILLRCHCELGEEGE------RLGASVMIIRVH . |.|. .|. .|... || || . . |...... .. a----------------------------------------------------------ekvkealrkafleldeelseelneksagkdsGtTAvvvlir EKRLEIASTGTMSAAIARNQKLKMIINGRYEIDDDEYSRIREAHGFVDE-ENRINGVIGSSRQIGHFSTFP----VVLPTHSYRNIQLN-EQIEGLIVGN .|.| .| .| | . ||.| . . ...|..||..|.|.|. ..|.|||. || .|.|. . .| .. . ....|. |.| |.. . gkklyvAnaGDsravLcrngkavelskdHkpenpeEreRIekagGkvvirdgrvnGvlavsRalGdfdlkkeeqaivsaePditsvkltqeedeflvlas NMIWNMLSIDDLNSTFHNNR-----SPIVVAKKIQDQLQSYDYGGNSNILVLR .|..|| ... .. ... .. .|... |. ... . | .||. dGlWdvlsneevvelvretleekeedleeiaeeLvdealakgsrDNiTvlvva |
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| Phosphatase | F43C1.1.AA | Subfamily.PHLPP.PD | 663-895 | 40 | 2.3e-112 | 363.6 | In-house | 1-257 (257) | Show / Hide |
Range on Protein: 663-895 Range on HMM: 1-257/257 Sequence Identity: 40% (104 aa) GSQNLFG--FQIGVSGSRGMKNKQCIRQVRVEN-------TFGFIDGGSNSYMSSSICRFMTSYLKENVSMD------IRSILLRCHCELGEEGERLGAS |...|.. |..|.|...|.|||.|.....||| ..|.|||..||...|.....|...|||.|..| |..|||..|..|||.|..|||| gdaslasavfshGlseaaGvknklCvaalavenfaenveavyGlidGdrnselpsllqctmadvlkeevqkdkneevyianillvshrklGeaGqklGas VMIIRVHEKRLEIASTGTMSAAIARNQKLKMIINGR---------YEIDDDEYSRIREAHGFVDEENRINGVIGSSRQIGHFSTFPVVLPTHSYRNIQLN ...||..|.|..|||..|..||.....||..|.||. .||||.|..||.||.....|.|..||||.|.|..|....||||||....|...|. allirikedrvdiassftltaanvgkcklvlirnGkplplskvyileiddeelkrikeakaiitednkvnGviestrilGytflfPvvlPkphvrsvlLt EQIEGLIVGNNMIWNMLSIDDLNSTFHNNRSPIVVAKKIQDQLQSYDYGGNSNILVL ||.|.||.||...|..||||.......|...|.|.|||..|..|||........||. eqdEllilGnkalWevlsideaveavrnvedplvaAkklvdlaqsygaadsvsalvv |
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| Phosphatase | F43C1.1.AA | PP2Cc | 663-897 | 13 | 5e-31 | 110.31 | SMART | 1-338 (338) | Show / Hide |
Range on Protein: 663-897
Range on HMM: 1-338/338
Sequence Identity: 13% (47 aa)
GSQNLFGFQIGVSG--SRGMKNKQCIRQVRVENT-FGFIDGGSNSYMSSSICRFMTSYLKENVSMD---------------------------------I
| . .. .. .. |. ....... . | . || || .. . ... . ..|.|..... .
HS-MGYNSGWRYGYMESSMQGWRHPMEDAHVCRPFFGVFDGHGGHECAQYCRKHLHEHLAEELQFHKDDDYKENDEMQDEPEMWWRMWHDKWFEDWEDAL
RSILLRCHCELGEEGERLGASVMIIRVHEKRLEIASTGTMSAAIARNQK----------LKMIINGRYEIDDDEYSRIREAHG--------FVDEEN---
|. ||.. |. ... .. .....| .|..| | . ||.. .... . . ||..||..|.| .|. .|
RKAFLRMDEEI--------CTAVVALIRGNKLYVANVGDSRAVLCRNGNDNWWGIRHYTAHQLTEDHKPDNEDERRRIEQAGGRVMPMHRQWVMNWNCDV
-RINGV---IGSSRQIGHFSTF------------------------PVVLPTHSYRNIQL------NEQIEGLIVGNNMIWNMLSIDDLNSTFHNNR---
|.||| . ||..| . . | | .. ..| ... . || . .|...| ... . ....
WRVNGVPIPLAVSRAFGDHYYKWKEDEKIEWNRWYQMFDPRLPFKEPYVIAEPDVTHHELWQMTVPTPDDDFLILCCDGLWDVMSNQEVVDIVRKCLRKW
------------------------SPIVVAKKIQDQLQSYDYGGNSNILVLRR
.| .||.. |... |. |.
HHKPVKNQAQENAHMMRHRQKKHNDPMEAAKRLCDCAI------CDNMTVIVV
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| Phosphatase | F43C1.1.AA | Group.PPM.PD | 688-866 | 19 | 4.3e-19 | 57.8 | In-house | 118-275 (459) | Show / Hide |
Range on Protein: 688-866 Range on HMM: 118-275/459 Sequence Identity: 19% (37 aa) QvrventfgfidggsnsymsssicrfmtsylkENVSMDIRSILLRCHCELGEEGERL-------GASVMIIRVHEKRLEIASTGTMSAAIARNQKLKMII . |.|. .|| |... .| || .. |...... . .| | .| .| | . ||.| .. g-------------------------------ekvkkalrsafleldedlseeanekeepgkdsGtTAvvalingkklyvANaGDSravLcrngkavpls NGRYEIDDDEYSRIREAHGFVDEENRINGVIGSSRQIGHFSTFPV---VLPTHSYRNIQLNEQIEGLIVGNNMIWNMLSIDDLNSTFHN ...|..||..|.|.|. ..|.||... || .|.. | .. . ..|.|. | |... . .|..|| ... .. .. kdHkpenpeEreRIekagGsveidgRvnGilavsRalGdhdlkkeeqmvsaePdvsvvklteedeflvlAsDGlWdvlsneevvefvre |
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| Phosphatase | F43C1.1.AA | Subfamily.LRR-PP2C.PD | 703-894 | 20 | 1.2e-13 | 40.4 | In-house | 55-252 (257) | Show / Hide |
Range on Protein: 703-894 Range on HMM: 55-252/257 Sequence Identity: 20% (39 aa) NSYMSSSICRFMTSYLKENVS---MDIRSILLRCHCELGEEGERLGASVMIIRVHEKRLEIASTGTMSAAIA-RNQKLKMIINGRYEIDDDEYSRIREAH .. | . . ....|. | . .. . ..| . ..|.. . . . |.. || | . .. .. | ....| ||.|. |.| .. akfaseelykilaelldlnnanPlkslkkaykeistqiserpkfiGttaasvliiedkvyianvGdsrvvlcqkdgtakrlsldhkPseeseekriselG GFVDEE---NRINGVIGSSRQIGHFSTFPVVLPTHSYR-NIQLNEQIEGLIVGNNMIWNMLSIDDLNSTFHNNRSPIVVAKKIQDQlqSYDYGGNSNILV |.|| . || .| | |.| ... .. . ||. . ||...| .. .. . .||.|..|. .| | . || | GtvvstvvtsrvnGtlavsralGdsflePfvvpdPdlsqsleiskkdkflilacdGiwdlisdeeaveivagisdpekaaeklrdl--ayssGstdnisv |
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| Phosphatase | F43C1.1.AA | Subfamily.PPM1E.PD | 740-865 | 23 | 1.3e-12 | 36.9 | In-house | 105-232 (269) | Show / Hide |
Range on Protein: 740-865 Range on HMM: 105-232/269 Sequence Identity: 23% (29 aa) EGERLGASVMIIRVHEKRLEIASTGTMSAAIARNQKLKMIINGRYEIDDDEYSRIREAHGFVD--EENRINGVIGSSRQIGHFSTFPVVLPTHSYRNIQL |. . |. ... .....| .| | |.. |... .... ..|| .|| || |.| .. |.|||. || || .. | |...|... . | eklksGstavvvliekdqlyvaWlGDsqallvrkgeavqlmkpHkPeredEkkRieeagGlvvvigawRvnGvLsvsRaiGDvklkpyvsgeadvaevel NEQIEGLIVGNNMIWNMLSIDDLNSTFH |.. . .|... ... .. . dgsedylilacDGlwDvvneeevvklve |
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| Phosphatase | F43C1.1.AA | Subfamily.PPM1G.PD | 735-855 | 27 | 8.5e-10 | 27.7 | In-house | 298-427 (482) | Show / Hide |
Range on Protein: 735-855
Range on HMM: 298-427/482
Sequence Identity: 27% (35 aa)
CELGEEGERLGASVMIIRVHEKRLEIASTGTMSAAIARNQ-KLKMIINGRyEIDDDEYSRIREAHGFVDEENRINGVIGSSRQIG-HFSTFPVVLPTHSY
.. |.|. |. .. |..|.| .| | . ..|| | . |. . .|. | .||..| | |... |.|| . || .| |.. ||..
gkseepGkdsGttavvaLvkgkklivanaGDsRcvlsrnGkaldlsiDhk-PeDeveleRiekaGGkvtldgRvnGGLnlsRalGDhaYktneeLpaeeq
--------RNIQLNEQIEGLIVGNNMIWNML
.. |.|. | |.. . |||..
misalPDikklilteedeFlvlacDGiWnvm
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| Phosphatase | F43C1.1.AA | Subfamily.PPM1A.PD | 735-867 | 26 | 2.3e-09 | 26.2 | In-house | 104-244 (309) | Show / Hide |
Range on Protein: 735-867 Range on HMM: 104-244/309 Sequence Identity: 26% (34 aa) CELGEEGERLGASVMIIRVHEKRLEIASTGTMSAAIARNQKLKMIINGRYEIDDDEYSRIREAHGFVDeENRINGVIGSSRQIGHFST---------FPV || .. .. |. .. . | .| | .| | | ..||.| .. . .|..| ||..| |.| .|.|| . || .| ...| | . |. . velskgedksGsTavvvlvspkklylancGDsRavlsrngkvvfateDHkpsdpkEkeRienAgGsvm-ikRvnGsLAvsRalGDydykekpekkateql VLPTHSYRNIQLNEQIEGLIVGNNMIWNMLSIDDLNSTFHNN |. | |.. || ..| ... . ... vspepevtvierdeedeflvlacDGiwDvmsneevaefvksr |
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| Phosphatase | F43C1.1.AA | Subfamily.PPM1G2.PD | 717-821 | 25 | 2.7e-08 | 22.6 | In-house | 75-182 (275) | Show / Hide |
Range on Protein: 717-821 Range on HMM: 75-182/275 Sequence Identity: 25% (27 aa) YLKENVSMDIRSILLRCHCELGEE----GERLGASVMIIRVHEKRLEIASTGTMSAAIARNQKLKMIINGRYEIDDDEYSRIREAHGFVdEENRINGVIG . ..... .. .|.. || .. | |. ... ..|..| .| .| | .. . ..| . . .| .|| .| |||| ||.||.. fkegaleqilkdafletDeellkdeklkdesaGstavvvlikeeklyvanaGDsravlsskgnvkalsfDhkPqeesekkriiaagGfv-elnrvngnLa SSRQIGHFS || .| |. lsralgDfe |
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| Phosphatase | F43C1.1.AA | Subfamily.PPM1K.PD | 745-894 | 21 | 7.4e-08 | 21.3 | In-house | 107-261 (264) | Show / Hide |
Range on Protein: 745-894 Range on HMM: 107-261/264 Sequence Identity: 21% (32 aa) GASVMIIRvHEKRLEIASTGTMSAAIARNQKLKMIINGRYEIDDDEYSRIREAHGFVD----EENRINGVIGSSRQIGHFSTFP-VVLPTHSYRNIQLNE |.| ..| . . | .||.| | . || | | . . ..| ||..| |.|. .. ..|... .| .| . . |. |...... . . tatvsllr-dGnelvlaslGdsrailcrnGkakkltkdhdPerkeekerikaagGsvewnslgkplvnsrlamtrslGdldlkryGviatPetkslkvkh QIEGLIV-GNNMIWNMLSIDDLNSTFHNNRSPIVVAKKIQDQLQSYDYGGNSNILV ..| . | .... .| . . | |. . .| | |. ..| aadsflvlitdgisfvvnsqelcdlvrlchdpeeaahavteqalqygsednatavv |
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| Phosphatase | F43C1.1.AA | Subfamily.ILKAP.PD | 779-860 | 27 | 4.1e-07 | 18.9 | In-house | 172-244 (298) | Show / Hide |
Range on Protein: 779-860 Range on HMM: 172-244/298 Sequence Identity: 27% (20 aa) IingryeiddDEYSRIREAHGFVDeENRINGVIGSSRQIG--HFSTFPVVlPTHSYRNIQLNEQIEGLIVGNNMIWNMLSIDDL .| ||..| |.| ..|..||.. || || .| . |. | ....|.|. ... . .|. .. |. y---------eerkriqkaGgvvr-dgRvlGvlevsRsiGDgrfkelgvi-stPdvkkceLtenDlfvvlaCDGLwkvfeadev |
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| Phosphatase | F43C1.1.AA | PP2C | 787-829 | 32 | 5e-06 | 23.19 | Pfam | 163-217 (284) | Show / Hide |
Range on Protein: 787-829 Range on HMM: 163-217/284 Sequence Identity: 32% (18 aa) DDDEYSRIREAHGFVDE--ENRINGV-IGSSRQIGHFSTFP---------VVLPT ..||..|||.|.|.|. ..|.||| || .| | .| .| .. NEDERRRIRQAGGWVMWWGFWRVNGVWLAVSRAFGDFHYKPNHTCFPKEQPVTAE |
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Sequence
| Name | Sequence Type | Origin | Length | Description | Download |
|---|---|---|---|---|---|
| F43C1.1.AA | Protein | None | 1036 | None | Fasta, JSON |
| F43C1.1.NA | RNA | None | 3108 | None | Fasta, JSON |
| F43C1.1.AA.PD_663-897 | Protein Phosphatase Domain | None | 235 | None | Fasta, JSON |