Gene tap-1
tap-1
Species: C.elegans
Alias: tap-1
External Links:
Classification
Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.
Protein domain
Protein domains of tap-1.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit phosphatase group/family/subfamily, which is helpful to understand the relationship between phosphatases. Transmembrane region is predicted by TMHMM 2.0. Visualized by pviz.
Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking. View complete domain list.
| Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
|---|---|---|---|---|---|---|---|---|---|
| Phosphatase | tap-1.AA | PP2Cc | 11-325 | 19 | 2.2e-58 | 201.21 | SMART | 1-338 (338) | Show / Hide |
Range on Protein: 11-325 Range on HMM: 1-338/338 Sequence Identity: 19% (72 aa) PANTDAGIGTVHSC-RYSKQKNPVQNNDFLSCSMCIHNGPIKLYGIFSGFNGGDSTAKFVMNRLVYEIFGENPITPTLLPYQVVEEFKR--------KFE . .. ..| .... |.|...... |. .| ..|.| | ||...|......|. |.. |... .. .|.... . . . . HS-MGYNSGWRYGYMESSMQGWRHPMEDAHVCRP--------FFGVFDG-HGGHECAQYCRKHLH-EHLAEELQFHKDDDYKEND-E-MQDEPEMWWR-M NVAERYLLMNTDDLNNRLLKLEEQSETGNNAVSEINQKIRQGTTAIVVMIINQDLYVLNCGNSLAIAMNSEN----------VVQLNSNLHNNDNPLEIV . ....... .| | . |...|. .||.|. | ...||| |.| | |. ... | ..|| .. |. ||. |. W-HDKWFEDWEDALRKAFLRMDEEI-----------------CTAVVALIRGNKLYVANVGDSRAVLCRNGNDNWWGIRHYTAHQL-TEDHKPDNEDERR RIKGLG-------------------INPETV--LNPTRAIGDLQRT----------HLFEETEAFKNAKGPPVISTPDVQYTKI------DPSWRHLVLI ||...| . .. |...||.|| . ...... ....| |.||..|||..... .|... |.| RIEQAGGRVMPMHRQWVMNWNCDVWRVNGVPIPLAVSRAFGDHYYKWKEDEKIEWNRWYQMFDPRLPFKEPYVIAEPDVTHHELWQMTVPTPDDDFLILC SDGVVQNLKEVEVENIPTEVSVRLIEDHTVTSTAQALVDSFA-----RKHRDAYTMSDDKNFCISNHREEMTVIYV .||. .. . || | .. .. ... .|...||... . . .|| |.. ... | . |||| | CDGLWDVMSNQEVVDIVRKCLRKWHHK-PVKNQAQENA-H-MMRHRQKKHNDPMEAAKRLCDCAI--CDNMTVIVV |
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| Phosphatase | tap-1.AA | Subfamily.TAB1.PD | 15-324 | 36 | 9.3e-118 | 382.8 | In-house | 1-335 (336) | Show / Hide |
Range on Protein: 15-324
Range on HMM: 1-335/336
Sequence Identity: 36% (122 aa)
DAGIGTVHSCRYSKQKNPVQNNDFLSCSMCIHNGPIKLYGIFSGFNGgDSTAKFVMNRLVYEIF-----GENPITPTLLPYQVVEEFKRKF-----ENVA
|.|||.....||||.....................|.||..|.|..| ...|.||..|||.|.. .|....|.||..||.||..|||..||||. |
dsgiGisnneryskegsssedhenedkvfsrteddiilyavfdGydG-ekaaefveqrLvaelllgdlseeaeaepkllllqvieeverkffesiddava
ERYLLMNTDDLNNRLLKLEEQSETGNNAVSEINQKIRQGTTAIVVMIINQDLYVLNCGNSLAIAMNSE----NVVQLNSNlHNNDNPLEIVRIKGLGINP
..|.. ... ..|||..|. .|...|....|..||||.|..|.|..|||.|.|.|.||...|| .|.||... ||.||. |..|.|.||...|....
eradlkstlpkgvasyeleekyeekinrlkeleseisgGttavvalilnnkLyvaNvGdsrAilvesekdgikvkQLsvd-HnvdNedElkRlkdLGldi
ETVLN--------PTRAIGDLQRTHLFEETEAFKNAKGPPVISTPDVQYTKIDPSWR-HLVLISDGVVQNLkeVEVENIPT-EVSVRLI------EDHTV
.||.|||........|......|||.|.|.|||....|...... .|.|.|||....| .|..|.|| .||..|. ...|....||
eqikqnkrlgskeaTRsiGdykikkgykevdvlssAkgePiiatPdingpkdindlegfllLmSdGlykal--ieltnpptadvslallviqeaeksatl
TSTAQALVDSFARKHRDAYTMSDdKNFCISNHREEMTVIY
|.||...|||||.|..|. |...|...|..||.|.
ddvaqavvdrvkrkhrdvylssa-krsticrkrddmTliv
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| Phosphatase | tap-1.AA | PP2C | 46-295 | 19 | 4.3e-53 | 187.51 | Pfam | 1-284 (284) | Show / Hide |
Range on Protein: 46-295 Range on HMM: 1-284/284 Sequence Identity: 19% (56 aa) HNGPIKLYGIFSGFNGGDSTAKFVMNR--LVYEIFGENPITPTLLPYQVVEEFKRKFE---N--VAERYLLMNTD--DLNNRLLKLEEQSETGNNAVS-- . ... .. .. |. .. .....||. .. .. . . .|. . .. ... | ..||.... .. |....| | ....| .. | WDYGFCRMQGWRHFMEDAHHCYPNMNCSSSGKDSWHFFAVFDGHGGHQAAKYCRKHLHKAMNTILKERKSFPEGNPKDVEQALRKSFLECDTDMMFYSAP --EIN----QKIRQGTTAIVVMIINQD--LYVLNCGNSLAIAMNSENVV---QLNSNLHNNDNPLEIVRIKGLGINPETVLNPTRAIGD-LQRTHLFEET | | .....|.||....|.||. ||| ||| | |. . . |.. .. .. | .|..|. ||...| ... . .| | |. .. | . WHEQNVMHWECWHSGCTAVCAYIRNQKNILYVANCGDSRAVLCRNGNAHNWVHQLTYDHKPSNEDERRRIRQAGGWVMWW-GFWRVNGVWLAVSRAFGDF EAFKNA----KGPPVISTPDVQ-YTKIDPS-WRHLVLISDGVVQ-NLKEVEVENIPTEVS-----VRLIEDHTVTSTAQALVDSF . ..|. | .||...||.. ..||.|. . .|.| .||. . .. .. . ...| ...|.. .. |.. .|.. HYKPNHTCFPKEQPVTAEPDITPEHKITPDHDEFLILACDGLWDVMSDQEVCDIVRQCRSDWNDPMEACEKLVDYCIAYGSEDNI |
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| Phosphatase | tap-1.AA | Family.PPM.PD | 20-333 | 21 | 4.8e-39 | 123.9 | In-house | 14-292 (495) | Show / Hide |
Range on Protein: 20-333
Range on HMM: 14-292/495
Sequence Identity: 21% (71 aa)
TVHSCRYSKQKNPVQNNDFLSCSMCIHNG-PIKLYGIFSGFNgGDSTAKFVMNRLVYEIFGENPITPTLLPYQVVEEFKrkfeNVAERYLLMNTDDLNNR
. . .|.|.. ...| .. ....| .. |.|.| |.. |.. |.|. ..|. . . . . .. . |. . . .. | .. .|...|
glrygvasmqgwrsemeDahvvvenlennedfslfgvfDGhg-Gaeaaefaakklhkilkkqlekkddeksstsaessa----ekvkealrkafleldee
LLKLEEQSEtgnnavseinQKIRQGTTAIVVMIINQDLYVLNCGNSLAIAMNSENVVQLnSNLHNNDNPLEIVRIKGLG--INP-----ETVLNPTRAIG
. .... .. ..||||.||.| ...||| |.|.| |. ......|.| |. |. .|| | ||. .| .. . ||...||.||
lseelneks----------agkdsGtTAvvvlirgkklyvAnaGDsravLcrngkavel-skdHkpenpeEreRIekagGkvvirdgrvnGvlavsRalG
DlqrthlfeetEA------FknakgpPVISTPDVQYTKIDPS-WRHLVLISDGVVQNLKEVEVENIpteVSVRL-IEDHTVTSTAQALVDSFARKHRDay
. . |...||.. .|.... . ||| |||. . |.. || .. | .| .... .. |..|||. .|
d----------fdlkkeeqa------ivsaePditsvkltqeedeflvlasdGlWdvlsneevvel---vretleekeedleeiaeeLvdealakgsr--
tmsddknfcisnhrEEMTVIYVKLEEDYQA
. .||. |.|.|. .
--------------DNiTvlvvalyenikq
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| Phosphatase | tap-1.AA | Group.PPM.PD | 22-333 | 22 | 1.2e-37 | 119.4 | In-house | 39-327 (459) | Show / Hide |
Range on Protein: 22-333 Range on HMM: 39-327/459 Sequence Identity: 22% (71 aa) HSCRYSKQKNPVQNNDFLSCSMCIHNGPiKLYGIFSGfNGGDSTAKFVMNRLVYEIFGENPITPTLLPYQVVEEFKRKFE--NVAERYLLMNTDDLNNRL . | | . ...| .. ....| . ..|.| | .||.. |.|. ..|. . . . ... . |.. .. . . .. | . .|...| . rygvasmqgwrkemEDrhvivenfdnnd-sffgVfDG-HgGaeaaefaakkLpkilkkqlkkkkdevskksaeasldnddrgekvkkalrsafleldedl LKLEEQSEtgnnavseiNQKIRQGTTAIVVMIINQDLYVLNCGNSLAIAMNSENVVQLnSNLHNNDNPLEIVRIKGLG--INP----ETVLNPTRAIGDl ....| ..... ||||.|..| ...||| |.|.| |. . . ..|.| |. |. .|| | ||. .| .. . .|...||.|| seeaneke---------epgkdsGtTAvvalingkklyvANaGDSravLcrngkavpl-skdHkpenpeEreRIekagGsveidgRvnGilavsRalGd- qrtHLF-EeteA--FknakgppVISTPDVQYTKIDPSWRHLVLISDGVVQNLKEVEVENIPTEVSVR--LIEDHTVTSTAQALVDSFARKHrdaytmsdd | . . . . |...|||. |... . ||| |||. |.. || .. | . .... ...|..|||. .|... .... ---hdlkk---eeqm-------vsaePdvsvvklteedeflvlAsDGlWdvlsneevvefvretlekkkkelkkdleeiaerlvdealakg--------- KNfCISNHREEMTVIYVKLEEDYQA .||| |.|.. . st-gdgtscDNiTvivvtlndamrr |
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| Phosphatase | tap-1.AA | Subfamily.PPM1G2.PD | 14-295 | 24 | 1.4e-19 | 60.1 | In-house | 10-255 (275) | Show / Hide |
Range on Protein: 14-295 Range on HMM: 10-255/275 Sequence Identity: 24% (69 aa) TDAGIGTVHSCRYSKQKNPVQNNDFLSCSmciHNGPIKLYGIFSGFnGGDSTAKFVMNRLVYEIFGenpitptllpyqvveefKRKFE-NVAERYLLMNT . |.... | .. ...|..|. | . . |...| | ||.. ||.. ..|. | |..|. .|. | . iavgvssmqGyrlnmeDahilenelleks---ddkslalfavfDGh-GGakvakyagkklikkiak-----------------kksfkegaleqilkdaf DDLNNRLLKLeeqsetgnnavsEINQKIRQGTTAIVVMIINQDLYVLNCGNSLAIAMNSENVVQLnSNLHNNDNPLEIVRIKGLGI--NP---ETVLNPT ... ||| | .. |.||.||.|....||| |.|.| |.. .. || .| | | .. | ||. | . .| || letDeellkd------------eklkdesaGstavvvlikeeklyvanaGDsravlsskgnvkal-sfDhkPqeesekkriiaagGfvelnrvngnLals RAIGDLQRTHLFEeteafKNAKGPPVISTPDVQYTKIDPSWRHLVLISDGVVQNLKEVEVENIpteVSVRLIEDHTVTSTAQALVDSF .|| . . . |... | .||| .|.|... ||| ||. |.. || .. | || ..... . .. |.|. ralgDfefkknvk-----kkpeeqivtavPDvlvkkldeddeflvLaCDGiWDvltnkevvdl---vrerlvsgakldeiieelldkc |
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| Phosphatase | tap-1.AA | Subfamily.PPM1A.PD | 52-293 | 22 | 1.7e-16 | 50.1 | In-house | 43-260 (309) | Show / Hide |
Range on Protein: 52-293 Range on HMM: 43-260/309 Sequence Identity: 22% (56 aa) LYGIFSGFnGGDSTAKFVMNRLVYEIFGENPITptllpyqvveefkrkfENVAERYLLMNTDDLNNRLLKLEEQSEtGNNAVSEINQkiRQGTTAIVVMI ....| | .|.. .|. ..|. .| |. .. .. .. . . |.. .|.|.|. . ....|. .. .|.||.||.. ffavfDGH-aGskvskycakhlleaileeeefk----------------askeksskekvkealrkgfLelDekir-klvelskged--ksGsTavvvlv INQDLYVLNCGNSLAIAMNSENVvQLNSNLHNNDNPLEIVRIKGLG--INPE---TVLNPTRAIGDLQrthlFEETEAfKNAKGPPVISTPDVQYTKIDP .. ||. ||| | |. .. ..| . ... | .| | ||. | . . | .||.|| . . |.. |.|. |.. |.|. ...| . spkklylancGDsRavlsrngkv-vfateDHkpsdpkEkeRienAgGsvmikRvnGsLAvsRalGDyd----ykekpe-kkateqlvspepevtvierde SWRHLVLISDGVVQNLKEVEVENIpteVSVRLIEDHTVTSTAQALVD .||| .||. ... || .. | || . ... |..|.| edeflvlacDGiwDvmsneevaef---vksrlevtddleevanelld |
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| Phosphatase | tap-1.AA | Subfamily.PPM1E.PD | 136-293 | 27 | 1e-11 | 34.4 | In-house | 103-251 (269) | Show / Hide |
Range on Protein: 136-293 Range on HMM: 103-251/269 Sequence Identity: 27% (43 aa) INQKIRQGTTAIVVMIINQDLYVLNCGNSLAIAMNSENVVQLNsNLHNNDNPLEIVRIKGLGINPETVlNPTRAIGDLQRTHlfeeteAFKNAKGPP-VI ...|.. |.||.||.| .. ||| |.| |. .. ..||| . |. ... | ||. .| . . | | |. . |..| | |.. ereklksGstavvvliekdqlyvaWlGDsqallvrkgeavqlm-kpHkPeredEkkRieeagGlvvvi-gawRvnGvLsvsR------aiGDvklkpyvs STPDVQYTKIDPSWRHLVLISDGVVQNLKEVEVENIPTEVSVRlieDH-TVTSTAQALVD .|| ...| | |.| .||. ..| || .. .| . .. . .. |. ||. geadvaeveldgsedylilacDGlwDvvneeevvklveeflad---gaedlsevakllve |
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| Phosphatase | tap-1.AA | Subfamily.PPM1G.PD | 133-267 | 24 | 1.2e-11 | 34.3 | In-house | 298-432 (482) | Show / Hide |
Range on Protein: 133-267 Range on HMM: 298-432/482 Sequence Identity: 24% (34 aa) VSEINQKIRQGTTAIVVMIINQDLYVLNCGNSLAIAMNSENVVQLNSNlHNNDNPLEIVRIKGLG--INPE----TVLNPTRAIGDlqrtHLFEETEAFK ... .. ||||.| .. ...|.| | |.| .. .. . ..| . | ... | ||. | .. . || ||.|| |.. ..| gkseepGkdsGttavvaLvkgkklivanaGDsRcvlsrnGkaldlsiD-hkPeDeveleRiekaGGkvtldgRvnGGLnlsRalGD----haYktneeLp nAKGPPVISTPDVQYTKIDPSWRHLVLISDGVVQNLKEVEV |. . ||.. . . . ||| .||. .. || -aeeqmisalPDikklilteedeFlvlacDGiWnvmssqev |
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| Phosphatase | tap-1.AA | Subfamily.PDP.PD | 122-293 | 25 | 2.1e-10 | 30.3 | In-house | 144-344 (409) | Show / Hide |
Range on Protein: 122-293
Range on HMM: 144-344/409
Sequence Identity: 25% (47 aa)
LEEQSETGNNAVSEIN-QKIRQGTTAIVVMIINQDLYVLNCGNSLAIAMNSENV-----VQLnSNLHNNDNPLEIVRIKGLGINPET-----------VL
|| .... .. ..|. .. |..|....| ...|.| | | . |. .|. |.| |. .. ||. |. ||| . || |.|| ||..
lealkkleekvleeavlkvalsGacallaliegtelhvAntGDcravlgvqeeegsweavkL-skdqtadneeEveRikkeHPgeesktvirngRlLgeL
NPTRAIGDLQRT-------HLFEETE--AF---KNAKGPP-VISTPDVQYTKIDPSWRHLVLISDGVVQNLKEVEVENIPTEVSVRLIEDHTVTSTAQAL
...|.. . |. | || ....|.|.. |. .. . ||| .|| . |.. || .. .| .....|..... | .
aPlRAFGdvryKwskelqkkvlekllevkvvepkdyktPPYltaePevtshklrendkFLvlatDGLwdllsneevvslVgehlakkknkakvaaepakl
VD
kk
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| Phosphatase | tap-1.AA | Subfamily.ILKAP.PD | 140-270 | 27 | 1e-09 | 27.9 | In-house | 115-247 (298) | Show / Hide |
Range on Protein: 140-270 Range on HMM: 115-247/298 Sequence Identity: 27% (38 aa) IRQGTTAIVVMIINQDLYVLNCGNSLAIAMNSENVVQ----------LNSNLHNNDNPLEIVRIKGLGinpeTVLNPTRAIGDLQRTHLFEETEaFKNAK ..|.||.||..... ||| | |.| |. . .. . | |. |. . | ||. | .|.. | .| |. .. . ||.. WkdGstavvvlvvdnvlyvanlGDskavlaRakeegdkagestiasvlLskdHtpasyeerkriqkaG----gvvrdgRvlGvlevsRsiGDgr-fkelg gppVISTPDVQYTKIDPSWRHLVLISDGVVQNLKEVEVENI |||||||. ..... ...|| ||. .... || . ---vistPdvkkceLtenDlfvvlaCDGLwkvfeadevvkf |
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| Phosphatase | tap-1.AA | Subfamily.LRR-PP2C.PD | 132-269 | 25 | 7.6e-09 | 25.1 | In-house | 91-222 (257) | Show / Hide |
Range on Protein: 132-269 Range on HMM: 91-222/257 Sequence Identity: 25% (34 aa) AVSEINqkIRQGTTAIVVMIINQDLYVLNCGNSLAIAMNSENVVQLNSNLHNNDNPLEIVRIKGLGINPETVLNPTRAIGDLQRTHLFEetEAFKNakgP .|| .. ||||..|.||.. |. | |.| .. . . . . | |. .. | ||. || . . .| | | . ...| . | |.. qiserp--kfiGttaasvliiedkvyianvGdsrvvlcqkdgtakrlsldhkPseeseekriselGGtvvstvvtsrvnGtlavsralG--dsfle---P PVISTPDVQ-YTKIDPSWRHLVLISDGVVQNLKEVEVEN ||.. .| . ..|.| ||. . . | . fvvpdPdlsqsleiskkdkflilacdGiwdlisdeeave |
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| Phosphatase | tap-1.AA | Subfamily.PPM1L.PD | 46-266 | 20 | 8.4e-08 | 21.8 | In-house | 38-234 (273) | Show / Hide |
Range on Protein: 46-266 Range on HMM: 38-234/273 Sequence Identity: 20% (45 aa) HNGPIKLYGIFSGFnGGDSTAKFVMNRLVYEIFGENPITptllpyqvveefkrkfENVAERYLLmntddLNNRLLKLEEQSETGNNAVSEINQK-IRQGT .. ......| | ||. .|.|. ..|| .| . .. |. . .| | .| .. . ..... || nktgesffavfdGh-GGefaaefakdvlvkaiknkliel----------------dadkentvp-----infsklltdeilsvdekllekakraediaGt TAIVVMIINQDLYVLNCGNSLAIAMNSENVVQLNSNLHNNDNPLEIVRIKGLGINpETVLNPTRAIGDLQRTHLFEEtEAFKNAKgpPVISTPDVQYTKI ||.. .. ..|| | | |.| . .. . | | .. | ||| | . | | | . . . .|. . ||..||. .. talialvqesdlivanvGdsrGvlydkrGkaiplsfdhkpqqvkerkrikkaGGf-iafrGvwrvaGvlatsralGd-yplkdkn--lviadpdiltfdl DPS-WRHLVLISDGVVQNLKEVE | . |.| |||. . . . | ddhkpeflilasdGlwdtfsnee |
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| Phosphatase | tap-1.AA | Subfamily.PPM1H.PD | 138-181 | 32 | 2.5e-07 | 19.7 | In-house | 160-203 (402) | Show / Hide |
Range on Protein: 138-181 Range on HMM: 160-203/402 Sequence Identity: 32% (14 aa) QKIRQGTTAIVVMIINQDLYVLNCGNSLAIAMNSENVVQLNSNL .|. | ||.|...... ||| | |.| || ........| ... yrikGGCtalvalvllgklYvanaGDsRailvrkdeiiplsadf |
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| Phosphatase | tap-1.AA | Subfamily.PPM1D.PD | 138-197 | 30 | 1.2e-06 | 17.8 | In-house | 110-174 (311) | Show / Hide |
Range on Protein: 138-197 Range on HMM: 110-174/311 Sequence Identity: 30% (20 aa) QKIRQGTTAIVVMIINQDLYVLNCGNSLAIAMNSEN-----VVQLNSNLHNNDNPLEIVRIKGLG . |||| ||.| ...||| . |.| .. .|. . . . | ..| | ||. || llstaGttasvviirreklyvahvGDsgivlgvkepkekklrakeltkdHkPespeEkerieelG |
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