tap-1
Species: C.elegans
Alias: tap-1
External Links:
Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Superfamily: PPM
Family: PPM
Subfamily: TAB1
Protein domain

Protein domains of tap-1.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit phosphatase group/family/subfamily, which is helpful to understand the relationship between phosphatases. Transmembrane region is predicted by TMHMM 2.0. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking. View complete domain list.

Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Phosphatase tap-1.AA PP2Cc 11-325 19 2.2e-58 201.21 SMART 1-338 (338) Show / Hide
Range on Protein: 11-325
Range on HMM: 1-338/338
Sequence Identity: 19% (72 aa)

PANTDAGIGTVHSC-RYSKQKNPVQNNDFLSCSMCIHNGPIKLYGIFSGFNGGDSTAKFVMNRLVYEIFGENPITPTLLPYQVVEEFKR--------KFE
.  .. ..| ....   |.|...... |. .|          ..|.| |  ||...|......|. |.. |... ..  .|.... . .        . .
HS-MGYNSGWRYGYMESSMQGWRHPMEDAHVCRP--------FFGVFDG-HGGHECAQYCRKHLH-EHLAEELQFHKDDDYKEND-E-MQDEPEMWWR-M

NVAERYLLMNTDDLNNRLLKLEEQSETGNNAVSEINQKIRQGTTAIVVMIINQDLYVLNCGNSLAIAMNSEN----------VVQLNSNLHNNDNPLEIV
. ....... .| | .  |...|.                  .||.|. | ...||| |.| | |. ... |          ..|| .. |. ||. |. 
W-HDKWFEDWEDALRKAFLRMDEEI-----------------CTAVVALIRGNKLYVANVGDSRAVLCRNGNDNWWGIRHYTAHQL-TEDHKPDNEDERR

RIKGLG-------------------INPETV--LNPTRAIGDLQRT----------HLFEETEAFKNAKGPPVISTPDVQYTKI------DPSWRHLVLI
||...|                     . ..  |...||.|| .             ...... ....| |.||..|||.....      .|... |.| 
RIEQAGGRVMPMHRQWVMNWNCDVWRVNGVPIPLAVSRAFGDHYYKWKEDEKIEWNRWYQMFDPRLPFKEPYVIAEPDVTHHELWQMTVPTPDDDFLILC

SDGVVQNLKEVEVENIPTEVSVRLIEDHTVTSTAQALVDSFA-----RKHRDAYTMSDDKNFCISNHREEMTVIYV
.||.  .. . ||  | ..  .. ... .|...||... . .     .|| |.. ...    |    .  |||| |
CDGLWDVMSNQEVVDIVRKCLRKWHHK-PVKNQAQENA-H-MMRHRQKKHNDPMEAAKRLCDCAI--CDNMTVIVV

Phosphatase tap-1.AA Subfamily.TAB1.PD 15-324 36 9.3e-118 382.8 In-house 1-335 (336) Show / Hide
Range on Protein: 15-324
Range on HMM: 1-335/336
Sequence Identity: 36% (122 aa)

DAGIGTVHSCRYSKQKNPVQNNDFLSCSMCIHNGPIKLYGIFSGFNGgDSTAKFVMNRLVYEIF-----GENPITPTLLPYQVVEEFKRKF-----ENVA
|.|||.....||||.....................|.||..|.|..| ...|.||..|||.|..     .|....|.||..||.||..|||..||||. |
dsgiGisnneryskegsssedhenedkvfsrteddiilyavfdGydG-ekaaefveqrLvaelllgdlseeaeaepkllllqvieeverkffesiddava

ERYLLMNTDDLNNRLLKLEEQSETGNNAVSEINQKIRQGTTAIVVMIINQDLYVLNCGNSLAIAMNSE----NVVQLNSNlHNNDNPLEIVRIKGLGINP
..|.. ... ..|||..|. .|...|....|..||||.|..|.|..|||.|.|.|.||...||    .|.||... ||.||. |..|.|.||...|....
eradlkstlpkgvasyeleekyeekinrlkeleseisgGttavvalilnnkLyvaNvGdsrAilvesekdgikvkQLsvd-HnvdNedElkRlkdLGldi

ETVLN--------PTRAIGDLQRTHLFEETEAFKNAKGPPVISTPDVQYTKIDPSWR-HLVLISDGVVQNLkeVEVENIPT-EVSVRLI------EDHTV
        .||.|||........|......|||.|.|.|||....|...... .|.|.|||....|  .|..|.|| .||..|.      ...|....||
eqikqnkrlgskeaTRsiGdykikkgykevdvlssAkgePiiatPdingpkdindlegfllLmSdGlykal--ieltnpptadvslallviqeaeksatl

TSTAQALVDSFARKHRDAYTMSDdKNFCISNHREEMTVIY
|.||...|||||.|..|. |...|...|..||.|.     
ddvaqavvdrvkrkhrdvylssa-krsticrkrddmTliv

Phosphatase tap-1.AA PP2C 46-295 19 4.3e-53 187.51 Pfam 1-284 (284) Show / Hide
Range on Protein: 46-295
Range on HMM: 1-284/284
Sequence Identity: 19% (56 aa)

HNGPIKLYGIFSGFNGGDSTAKFVMNR--LVYEIFGENPITPTLLPYQVVEEFKRKFE---N--VAERYLLMNTD--DLNNRLLKLEEQSETGNNAVS--
. ...  .. .. |. .. .....||.    .. ..   .    . .|. . .. ...   |  ..||.... ..  |....| |  ....| ..  |  
WDYGFCRMQGWRHFMEDAHHCYPNMNCSSSGKDSWHFFAVFDGHGGHQAAKYCRKHLHKAMNTILKERKSFPEGNPKDVEQALRKSFLECDTDMMFYSAP

--EIN----QKIRQGTTAIVVMIINQD--LYVLNCGNSLAIAMNSENVV---QLNSNLHNNDNPLEIVRIKGLGINPETVLNPTRAIGD-LQRTHLFEET
  | |    .....|.||....|.||.  ||| ||| | |. . . |..   .. .. |  .|..|. ||...|   ... . .|  |  |. .. |  .
WHEQNVMHWECWHSGCTAVCAYIRNQKNILYVANCGDSRAVLCRNGNAHNWVHQLTYDHKPSNEDERRRIRQAGGWVMWW-GFWRVNGVWLAVSRAFGDF

EAFKNA----KGPPVISTPDVQ-YTKIDPS-WRHLVLISDGVVQ-NLKEVEVENIPTEVS-----VRLIEDHTVTSTAQALVDSF
. ..|.    | .||...||.. ..||.|. . .|.| .||. .   ..  .. . ...|      ...|..  .. |.. .|..
HYKPNHTCFPKEQPVTAEPDITPEHKITPDHDEFLILACDGLWDVMSDQEVCDIVRQCRSDWNDPMEACEKLVDYCIAYGSEDNI

Phosphatase tap-1.AA Family.PPM.PD 20-333 21 4.8e-39 123.9 In-house 14-292 (495) Show / Hide
Range on Protein: 20-333
Range on HMM: 14-292/495
Sequence Identity: 21% (71 aa)

TVHSCRYSKQKNPVQNNDFLSCSMCIHNG-PIKLYGIFSGFNgGDSTAKFVMNRLVYEIFGENPITPTLLPYQVVEEFKrkfeNVAERYLLMNTDDLNNR
.  . .|.|..  ...|  .. ....|  .. |.|.| |.. |.. |.|. ..|.  .  .   . . .. .  |. .    .  .. | ..  .|...|
glrygvasmqgwrsemeDahvvvenlennedfslfgvfDGhg-Gaeaaefaakklhkilkkqlekkddeksstsaessa----ekvkealrkafleldee

LLKLEEQSEtgnnavseinQKIRQGTTAIVVMIINQDLYVLNCGNSLAIAMNSENVVQLnSNLHNNDNPLEIVRIKGLG--INP-----ETVLNPTRAIG
 .  ....          .. ..||||.||.| ...||| |.|.| |. ......|.| |. |. .|| |  ||. .|  ..      . ||...||.||
lseelneks----------agkdsGtTAvvvlirgkklyvAnaGDsravLcrngkavel-skdHkpenpeEreRIekagGkvvirdgrvnGvlavsRalG

DlqrthlfeetEA------FknakgpPVISTPDVQYTKIDPS-WRHLVLISDGVVQNLKEVEVENIpteVSVRL-IEDHTVTSTAQALVDSFARKHRDay
           .      .       |...||.. .|....  . ||| |||. . |.. || ..   |  .|  .... .. |..|||.  .|      
d----------fdlkkeeqa------ivsaePditsvkltqeedeflvlasdGlWdvlsneevvel---vretleekeedleeiaeeLvdealakgsr--

tmsddknfcisnhrEEMTVIYVKLEEDYQA
             . .||. |.|.|. .  
--------------DNiTvlvvalyenikq

Phosphatase tap-1.AA Group.PPM.PD 22-333 22 1.2e-37 119.4 In-house 39-327 (459) Show / Hide
Range on Protein: 22-333
Range on HMM: 39-327/459
Sequence Identity: 22% (71 aa)

HSCRYSKQKNPVQNNDFLSCSMCIHNGPiKLYGIFSGfNGGDSTAKFVMNRLVYEIFGENPITPTLLPYQVVEEFKRKFE--NVAERYLLMNTDDLNNRL
.  | | .  ...|  .. ....| .  ..|.| | .||.. |.|. ..|.  .  . .   ...  .  |.. .. .  .  .. | .   .|...| .
rygvasmqgwrkemEDrhvivenfdnnd-sffgVfDG-HgGaeaaefaakkLpkilkkqlkkkkdevskksaeasldnddrgekvkkalrsafleldedl

LKLEEQSEtgnnavseiNQKIRQGTTAIVVMIINQDLYVLNCGNSLAIAMNSENVVQLnSNLHNNDNPLEIVRIKGLG--INP----ETVLNPTRAIGDl
 ....|         ..... ||||.|..| ...||| |.|.| |. . . ..|.| |. |. .|| |  ||. .|  ..     . .|...||.||   
seeaneke---------epgkdsGtTAvvalingkklyvANaGDSravLcrngkavpl-skdHkpenpeEreRIekagGsveidgRvnGilavsRalGd-

qrtHLF-EeteA--FknakgppVISTPDVQYTKIDPSWRHLVLISDGVVQNLKEVEVENIPTEVSVR--LIEDHTVTSTAQALVDSFARKHrdaytmsdd
 | . .   .  .       |...|||.  |...  . ||| |||.   |.. || ..  | .      .... ...|..|||.  .|...   ....  
---hdlkk---eeqm-------vsaePdvsvvklteedeflvlAsDGlWdvlsneevvefvretlekkkkelkkdleeiaerlvdealakg---------

KNfCISNHREEMTVIYVKLEEDYQA
.||| |.|..  .            
st-gdgtscDNiTvivvtlndamrr

Phosphatase tap-1.AA Subfamily.PPM1G2.PD 14-295 24 1.4e-19 60.1 In-house 10-255 (275) Show / Hide
Range on Protein: 14-295
Range on HMM: 10-255/275
Sequence Identity: 24% (69 aa)

TDAGIGTVHSCRYSKQKNPVQNNDFLSCSmciHNGPIKLYGIFSGFnGGDSTAKFVMNRLVYEIFGenpitptllpyqvveefKRKFE-NVAERYLLMNT
.  |....   | ..    ...|..|. |    .  . |...| |  ||.. ||.. ..|.  |                   |..|. .|. |     .
iavgvssmqGyrlnmeDahilenelleks---ddkslalfavfDGh-GGakvakyagkklikkiak-----------------kksfkegaleqilkdaf

DDLNNRLLKLeeqsetgnnavsEINQKIRQGTTAIVVMIINQDLYVLNCGNSLAIAMNSENVVQLnSNLHNNDNPLEIVRIKGLGI--NP---ETVLNPT
... |||             |  ..   |.||.||.|....||| |.|.| |.. .. || .| |  |  ..  |  ||.  |   .      .|   ||
letDeellkd------------eklkdesaGstavvvlikeeklyvanaGDsravlsskgnvkal-sfDhkPqeesekkriiaagGfvelnrvngnLals

RAIGDLQRTHLFEeteafKNAKGPPVISTPDVQYTKIDPSWRHLVLISDGVVQNLKEVEVENIpteVSVRLIEDHTVTSTAQALVDSF
.|| .  .  .     |...   |  .|||  .|.|...  |||  ||.   |.. || ..   |  || ..... . .. |.|.   
ralgDfefkknvk-----kkpeeqivtavPDvlvkkldeddeflvLaCDGiWDvltnkevvdl---vrerlvsgakldeiieelldkc

Phosphatase tap-1.AA Subfamily.PPM1A.PD 52-293 22 1.7e-16 50.1 In-house 43-260 (309) Show / Hide
Range on Protein: 52-293
Range on HMM: 43-260/309
Sequence Identity: 22% (56 aa)

LYGIFSGFnGGDSTAKFVMNRLVYEIFGENPITptllpyqvveefkrkfENVAERYLLMNTDDLNNRLLKLEEQSEtGNNAVSEINQkiRQGTTAIVVMI
....| |  .|.. .|.  ..|. .|  |. ..                ..  ..   .  . |.. .|.|.|. .  ....|. ..  .|.||.||.. 
ffavfDGH-aGskvskycakhlleaileeeefk----------------askeksskekvkealrkgfLelDekir-klvelskged--ksGsTavvvlv

INQDLYVLNCGNSLAIAMNSENVvQLNSNLHNNDNPLEIVRIKGLG--INPE---TVLNPTRAIGDLQrthlFEETEAfKNAKGPPVISTPDVQYTKIDP
.. ||. ||| | |. .. ..| . ... |   .| |  ||.  |  .  .     |  .||.|| .    . |..  |.|.   |.. |.|. ...| .
spkklylancGDsRavlsrngkv-vfateDHkpsdpkEkeRienAgGsvmikRvnGsLAvsRalGDyd----ykekpe-kkateqlvspepevtvierde

SWRHLVLISDGVVQNLKEVEVENIpteVSVRLIEDHTVTSTAQALVD
  .||| .||.   ... || ..   |  ||   . ... |..|.| 
edeflvlacDGiwDvmsneevaef---vksrlevtddleevanelld

Phosphatase tap-1.AA Subfamily.PPM1E.PD 136-293 27 1e-11 34.4 In-house 103-251 (269) Show / Hide
Range on Protein: 136-293
Range on HMM: 103-251/269
Sequence Identity: 27% (43 aa)

INQKIRQGTTAIVVMIINQDLYVLNCGNSLAIAMNSENVVQLNsNLHNNDNPLEIVRIKGLGINPETVlNPTRAIGDLQRTHlfeeteAFKNAKGPP-VI
...|.. |.||.||.| .. |||   |.| |. ..  ..|||  . |. ... |  ||. .|     . .  |  | |. .       |..|  | |.. 
ereklksGstavvvliekdqlyvaWlGDsqallvrkgeavqlm-kpHkPeredEkkRieeagGlvvvi-gawRvnGvLsvsR------aiGDvklkpyvs

STPDVQYTKIDPSWRHLVLISDGVVQNLKEVEVENIPTEVSVRlieDH-TVTSTAQALVD
.||  ...| |   |.| .||.   ..| || .. .|   .   .. . .. |. ||.  
geadvaeveldgsedylilacDGlwDvvneeevvklveeflad---gaedlsevakllve

Phosphatase tap-1.AA Subfamily.PPM1G.PD 133-267 24 1.2e-11 34.3 In-house 298-432 (482) Show / Hide
Range on Protein: 133-267
Range on HMM: 298-432/482
Sequence Identity: 24% (34 aa)

VSEINQKIRQGTTAIVVMIINQDLYVLNCGNSLAIAMNSENVVQLNSNlHNNDNPLEIVRIKGLG--INPE----TVLNPTRAIGDlqrtHLFEETEAFK
... ..    ||||.| .. ...|.| | |.| ..  .. . ..|  . |  ... |  ||.  |  .. .      ||  ||.||    |.. ..|   
gkseepGkdsGttavvaLvkgkklivanaGDsRcvlsrnGkaldlsiD-hkPeDeveleRiekaGGkvtldgRvnGGLnlsRalGD----haYktneeLp

nAKGPPVISTPDVQYTKIDPSWRHLVLISDGVVQNLKEVEV
 |.   .   ||.. . . .    ||| .||.   ..  ||
-aeeqmisalPDikklilteedeFlvlacDGiWnvmssqev

Phosphatase tap-1.AA Subfamily.PDP.PD 122-293 25 2.1e-10 30.3 In-house 144-344 (409) Show / Hide
Range on Protein: 122-293
Range on HMM: 144-344/409
Sequence Identity: 25% (47 aa)

LEEQSETGNNAVSEIN-QKIRQGTTAIVVMIINQDLYVLNCGNSLAIAMNSENV-----VQLnSNLHNNDNPLEIVRIKGLGINPET-----------VL
|| .... .. ..|.  ..   |..|....| ...|.| | | . |.   .|.      |.| |. .. ||. |. |||    . || |.|| ||..   
lealkkleekvleeavlkvalsGacallaliegtelhvAntGDcravlgvqeeegsweavkL-skdqtadneeEveRikkeHPgeesktvirngRlLgeL

NPTRAIGDLQRT-------HLFEETE--AF---KNAKGPP-VISTPDVQYTKIDPSWRHLVLISDGVVQNLKEVEVENIPTEVSVRLIEDHTVTSTAQAL
      ...|..    .   |. | || ....|.|.. |. .. . ||| .||  . |.. || .. .|   .....|..... | .             
aPlRAFGdvryKwskelqkkvlekllevkvvepkdyktPPYltaePevtshklrendkFLvlatDGLwdllsneevvslVgehlakkknkakvaaepakl

VD
  
kk

Phosphatase tap-1.AA Subfamily.ILKAP.PD 140-270 27 1e-09 27.9 In-house 115-247 (298) Show / Hide
Range on Protein: 140-270
Range on HMM: 115-247/298
Sequence Identity: 27% (38 aa)

IRQGTTAIVVMIINQDLYVLNCGNSLAIAMNSENVVQ----------LNSNLHNNDNPLEIVRIKGLGinpeTVLNPTRAIGDLQRTHLFEETEaFKNAK
..|.||.||..... ||| | |.| |. .  ..  .          | |. |.  .  |  ||.  |    .|..  | .| |.    .. . ||..   
WkdGstavvvlvvdnvlyvanlGDskavlaRakeegdkagestiasvlLskdHtpasyeerkriqkaG----gvvrdgRvlGvlevsRsiGDgr-fkelg

gppVISTPDVQYTKIDPSWRHLVLISDGVVQNLKEVEVENI
 |||||||. .....  ...||  ||. ....  || .   
---vistPdvkkceLtenDlfvvlaCDGLwkvfeadevvkf

Phosphatase tap-1.AA Subfamily.LRR-PP2C.PD 132-269 25 7.6e-09 25.1 In-house 91-222 (257) Show / Hide
Range on Protein: 132-269
Range on HMM: 91-222/257
Sequence Identity: 25% (34 aa)

AVSEINqkIRQGTTAIVVMIINQDLYVLNCGNSLAIAMNSENVVQLNSNLHNNDNPLEIVRIKGLGINPETVLNPTRAIGDLQRTHLFEetEAFKNakgP
.||    .. ||||..|.||..  |. | |.| ..  . . . .  |  |.  .. |  ||. || .  .    .|  | |  .  ...| .   | |..
qiserp--kfiGttaasvliiedkvyianvGdsrvvlcqkdgtakrlsldhkPseeseekriselGGtvvstvvtsrvnGtlavsralG--dsfle---P

PVISTPDVQ-YTKIDPSWRHLVLISDGVVQNLKEVEVEN
 ||..   .|  . ..|.|  ||.   . . |  .    
fvvpdPdlsqsleiskkdkflilacdGiwdlisdeeave

Phosphatase tap-1.AA Subfamily.PPM1L.PD 46-266 20 8.4e-08 21.8 In-house 38-234 (273) Show / Hide
Range on Protein: 46-266
Range on HMM: 38-234/273
Sequence Identity: 20% (45 aa)

HNGPIKLYGIFSGFnGGDSTAKFVMNRLVYEIFGENPITptllpyqvveefkrkfENVAERYLLmntddLNNRLLKLEEQSETGNNAVSEINQK-IRQGT
..  ......| |  ||. .|.|. ..|| .|  .                    ..  |. .      .|   |  .|     .. . .....    ||
nktgesffavfdGh-GGefaaefakdvlvkaiknkliel----------------dadkentvp-----infsklltdeilsvdekllekakraediaGt

TAIVVMIINQDLYVLNCGNSLAIAMNSENVVQLNSNLHNNDNPLEIVRIKGLGINpETVLNPTRAIGDLQRTHLFEEtEAFKNAKgpPVISTPDVQYTKI
||.. .. ..|| | | |.|  . .. .      |  |   .. |  |||  |    .     |  | |  .  . .   .|. .   ||..||.   ..
talialvqesdlivanvGdsrGvlydkrGkaiplsfdhkpqqvkerkrikkaGGf-iafrGvwrvaGvlatsralGd-yplkdkn--lviadpdiltfdl

DPS-WRHLVLISDGVVQNLKEVE
|    . |.| |||. . . . |
ddhkpeflilasdGlwdtfsnee

Phosphatase tap-1.AA Subfamily.PPM1H.PD 138-181 32 2.5e-07 19.7 In-house 160-203 (402) Show / Hide
Range on Protein: 138-181
Range on HMM: 160-203/402
Sequence Identity: 32% (14 aa)

QKIRQGTTAIVVMIINQDLYVLNCGNSLAIAMNSENVVQLNSNL
.|. | ||.|...... ||| | |.| || ........| ... 
yrikGGCtalvalvllgklYvanaGDsRailvrkdeiiplsadf

Phosphatase tap-1.AA Subfamily.PPM1D.PD 138-197 30 1.2e-06 17.8 In-house 110-174 (311) Show / Hide
Range on Protein: 138-197
Range on HMM: 110-174/311
Sequence Identity: 30% (20 aa)

QKIRQGTTAIVVMIINQDLYVLNCGNSLAIAMNSEN-----VVQLNSNLHNNDNPLEIVRIKGLG
.    |||| ||.| ...||| . |.| ..   .|.     . .   . |  ..| |  ||. ||
llstaGttasvviirreklyvahvGDsgivlgvkepkekklrakeltkdHkPespeEkerieelG

Sequence
Name Sequence Type Origin Length Description Download
tap-1.AA Protein None 386 None Fasta, JSON
tap-1.NA RNA None 1158 None Fasta, JSON
tap-1.AA.PD_11-325 Protein Phosphatase Domain None 315 None Fasta, JSON