Gene W09D10.4
W09D10.4
Species: C.elegans
Alias: W09D10.4
External Links:
Classification
Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.
Protein domain
Protein domains of W09D10.4.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit phosphatase group/family/subfamily, which is helpful to understand the relationship between phosphatases. Transmembrane region is predicted by TMHMM 2.0. Visualized by pviz.
Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking. View complete domain list.
| Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
|---|---|---|---|---|---|---|---|---|---|
| Phosphatase | W09D10.4.AA | Family.PPTC7.PD | 71-328 | 55 | 3.9e-117 | 380.6 | In-house | 1-261 (262) | Show / Hide |
Range on Protein: 71-328 Range on HMM: 1-261/262 Sequence Identity: 55% (144 aa) ASCAGFPKDMLNGPSTvlDKGVFGDDAWFISRFKNTFVVGVADGVGGWRKYGIDPSAFSRRLMKECEKRVQKGDFDPQKPESLLDYAFRASAEAPRPV-G |...||.||.|...|. ....||.||.|.|. |.. |.||||||||||.||.|.||||..|||.||..|....|.|.||..||..|... .|..|| || avkcgfakdllkqksk--krskfGeDayFvssnkvadvlgvADgvggwreygvdssafsselmkkcerlvkeskfkplkpkkllkaayaelleekvpvvG SSTACVLVVHQE--KLYSANLGDSGFMVVRNGKIVSKSREQVHYFNAPFQLTLPPEGYQG-FIGDKADMADKDEMAVKKGDIILLATDGVWDNLSEQQVL |||||.|...| ||.|||||||||.|||.||.|..|.||.||||.|.||..|||...| .| |....||. ...||||||||||||||.|||||.|.|. sstAcvvvldredkklesanlGDsgflvvRegkvvhrskeqqhyFntPyqLsipPeerdgkvisdspeaAdstsfevkkgDiillatDGvfDnlsedqil DQLKALDA-GKSNVQEVCNALALTARRLAFDSKHNSPFAMKAREHGFLAPGGKPDDITLVLLL .||.|.. .....|...|.||..||.|.||.|..||||.||...|. | ||||||||.|| eelkelkerdeeelqllanslaekareLsfdpkyespFaqkakkrglaasGGKpDDitvvlav |
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| Phosphatase | W09D10.4.AA | Subfamily.PPTC7.PD | 71-328 | 53 | 5.1e-114 | 370.4 | In-house | 2-262 (263) | Show / Hide |
Range on Protein: 71-328 Range on HMM: 2-262/263 Sequence Identity: 53% (141 aa) ASCAGFPKDMLNGPSTvlDKGVFGDDAWFISRFKNTFVVGVADGVGGWRKYGIDPSAFSRRLMKECEKRVQKGDFDPQKPESLLDYAFRASAEAPRPV-G ....||.||.|. .|. ... ||.||.|.|. |.. |.||||||||||.||||||.||..|||.||..|....|...||...|..|....|. .|| || svvcgfakdllkqksk--krskfGeDayFvssnkvadvlgVADgvggwreygidpsefskelmkkcerivkeskfkerkpkkileaayqelleekvpvvG SSTACVLVVHQE--KLYSANLGDSGFMVVRNGKIVSKSREQVHYFNAPFQLTLPPEGYQG-FIGDKADMADKDEMAVKKGDIILLATDGVWDNLSEQQVL ||||..|...| ||.|||||||||.||||||.|..|.||.||||.|.||..|||...| .| ||...||. ...|||||.||||||||.|||||...|. sstacivvldredkklesaNlGDSgflVvRngkvvhrskeqqhyFNtPyqLsipPeerdgkvildkpeaadstsfevkkgDlillatDGvfDNlsedeil DQLKALDA-GKSNVQEVCNALALTARRLAFDSKHNSPFAMKAREHGFLAPGGKPDDITLVLLL .||.|.. .....|...|.|| .||.|..|.|..||||.||...|. | ||||||||.|| | evlkelkerdeeelqllanslaekarelsldpkyespFakkakknglaasGGKpDDitvvlal |
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| Phosphatase | W09D10.4.AA | PP2Cc | 71-327 | 15 | 3.9e-42 | 147.22 | SMART | 1-338 (338) | Show / Hide |
Range on Protein: 71-327
Range on HMM: 1-338/338
Sequence Identity: 15% (55 aa)
ASCAGFPKDMLNGP--STVLDKGVFGDDAWFISRFKNTFVVGVADGVGGWRKYGIDPSAFSRRLMKECEKRVQKGDFDP---------------------
| .|..... .| |.. . . ||... ..||.|| | . . ..|. . |. .. . . |
HS-MGYNSGWRYGYMESSMQGWRHPMEDAHVCRP-----FFGVFDG-----HGGHECAQYCRKHLHEHLAEELQFHKDDDYKENDEMQDEPEMWWRMWHD
---QKPESLLDYAFRASAEAPRPVGSSTACVLVVHQEKLYSANLGDSGFMVVRNGK----------IVSKSREQVH------------------------
...| .|..||.. |. .||.|.... .||| ||.||| .. |||. .. .... .
KWFEDWEDALRKAFLRMDEEI-----CTAVVALIRGNKLYVANVGDSRAVLCRNGNDNWWGIRHYTAHQLTEDHKPDNEDERRRIEQAGGRVMPMHRQWV
--------YFNAP---FQLTLPPEGYQ--------------------------GFIGDKADMADKDEMA----VKKGDIILLATDGVWDNLSEQQVLDQL
..| ... .. .. | . . .. ....| ..|..||.||..|.|.| | .
MNWNCDVWRVNGVPIPLAVSRAFGDHYYKWKEDEKIEWNRWYQMFDPRLPFKEPYVIAEPDVTHHELWQMTVPTPDDDFLILCCDGLWDVMSNQEVVDIV
KALDAGKSNVQEVCNALALTARRLAFD----SKHNSPFAMKAREHGFLAPGGKPDDITLVLL
. .. .. .|.|.....| . . . .|||.| .. | . ... |..| ...
RKCLRKWHHK-PVKNQAQENA-H-M-MRHRQKKHNDPMEAAKRLCDCAI----CDNMTVIVV
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| Phosphatase | W09D10.4.AA | Group.PPM.PD | 95-206 | 26 | 3.2e-14 | 42.4 | In-house | 53-187 (459) | Show / Hide |
Range on Protein: 95-206 Range on HMM: 53-187/459 Sequence Identity: 26% (35 aa) DDAW-FISRFKN--TFvVGVADGVGGWRKYGIDPSAFSRRLMKECEKRVQKGD---------F--DPQKPESLLDYAF-------RASAEAPR---PVGS |.. ....|.| .| .|| || ||.. . . ... |.|...| .. . . ..|... |. || . .|. .. .||.|. EDrhvivenfdnndsf-fgVfDGHgGaeaaefaakkLpkilkkqlkkkkdevskksaeasldnddrgekvkkalrsafleldedlseeanekeepgkdsG STACVLVVHQEKLYSANLGDSGFMVVRNGKIVSKSR .. . ||| ||.||| ...||||.| |. tTAvvalingkklyvANaGDSravLcrngkavplsk |
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| Phosphatase | W09D10.4.AA | Group.PPM.PD | 247-327 | 19 | 3.6e-11 | 32.3 | In-house | 251-319 (459) | Show / Hide |
Range on Protein: 247-327 Range on HMM: 251-319/459 Sequence Identity: 19% (17 aa) DIILLATDGVWDNLSEQQVLDQLKALDAG-----KSNVQEVCNALALTARRLAfdskhnspfamkarehgflA--PGGKPDDITLVLL . . ||.||.|| ||...|.. ... . |.. .|....|. .|.. |...|.|| .. eflvlAsDGlWdvlsneevvefvretlekkkkelkkdleeiaerlvdealakg-------------------stgdgtscDNiTvivv |
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| Phosphatase | W09D10.4.AA | Family.PPM.PD | 150-206 | 32 | 1.1e-09 | 27.3 | In-house | 94-159 (495) | Show / Hide |
Range on Protein: 150-206 Range on HMM: 94-159/495 Sequence Identity: 32% (21 aa) PESLLDYAFRASAE-------A--PRPVGSSTACVLVVHQEKLYSANLGDSGFMVVRNGKIVSKSR .. |. || . | . . .||.|......||| ||.||| ...||||.| |. vkealrkafleldeelseelneksagkdsGtTAvvvlirgkklyvAnaGDsravLcrngkavelsk |
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| Phosphatase | W09D10.4.AA | Family.PPM.PD | 246-327 | 21 | 6.1e-09 | 24.8 | In-house | 225-284 (495) | Show / Hide |
Range on Protein: 246-327 Range on HMM: 225-284/495 Sequence Identity: 21% (18 aa) GDIILLATDGVWDNLSEQQVLDQLKALD-AGKSNVQEVCNALALTArrLAFDSKhnspfamkarehgflapggkpDDITLVLL . . ||.||.|| ||...|.. ... ... .|....| .| || .|. |.|| ... deflvlasdGlWdvlsneevvelvretleekeedleeiaeeLvdea--lakgsr---------------------DNiTvlvv |
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| Phosphatase | W09D10.4.AA | Subfamily.ILKAP.PD | 158-207 | 38 | 1.2e-07 | 21.4 | In-house | 104-155 (298) | Show / Hide |
Range on Protein: 158-207 Range on HMM: 104-155/298 Sequence Identity: 38% (20 aa) FRASAEAPRPV--GSSTACVLVVHQEKLYSANLGDSGFMVVRNGKIVSKSRE | . |.. .|| ||| |..| ...||.|||||| ...|. . .|. | flklaskakPvWkdGstavvvlvvdnvlyvanlGDskavlaRakeegdkage |
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| Phosphatase | W09D10.4.AA | Subfamily.PPM1H.PD | 158-207 | 40 | 2.3e-07 | 20.0 | In-house | 153-202 (402) | Show / Hide |
Range on Protein: 158-207 Range on HMM: 153-202/402 Sequence Identity: 40% (20 aa) FRASAEAPRPVGSSTACVLVVHQEKLYSANLGDSGFMVVRNGKIVSKSRE . || | | ||.| .| ..||| || ||| ..||...|. |.. iarereayrikGGCtalvalvllgklYvanaGDsRailvrkdeiiplsad |
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| Phosphatase | W09D10.4.AA | Subfamily.PPM1E.PD | 108-202 | 30 | 3.1e-07 | 19.9 | In-house | 49-142 (269) | Show / Hide |
Range on Protein: 108-202 Range on HMM: 49-142/269 Sequence Identity: 30% (30 aa) VVGVADGVGGwrkygIDPSAFSRRLMKECEKRVQKGDFDPQK----PESLLDYAFRASAEAPRPVGSSTACVLVVHQEKLYSANLGDSGFMVVRNGKIV . .| || || .. . .. . ..| . | .| ||.. |.| .| . || . . ||| | ......|| | |||| ..||.|..| ffavfDGHgG-----veaakyaaahlhellvrqeklkedpaealkeafkltDerflqkaereklksGstavvvliekdqlyvaWlGDsqallvrkgeav |
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| Phosphatase | W09D10.4.AA | Subfamily.PPM1A.PD | 245-290 | 30 | 4e-07 | 19.5 | In-house | 217-262 (309) | Show / Hide |
Range on Protein: 245-290 Range on HMM: 217-262/309 Sequence Identity: 30% (14 aa) KGDIILLATDGVWDNLSEQQVLDQLKALDAGKSNVQEVCNALALTA . . ..||.||.|| .|...| . .| . .....||.|.| |. edeflvlacDGiwDvmsneevaefvksrlevtddleevanelldtc |
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| Phosphatase | W09D10.4.AA | Subfamily.PPM1G.PD | 163-205 | 41 | 4.7e-07 | 19.3 | In-house | 301-343 (482) | Show / Hide |
Range on Protein: 163-205 Range on HMM: 301-343/482 Sequence Identity: 41% (18 aa) EAPRPVGSSTACVLVVHQEKLYSANLGDSGFMVVRNGKIVSKS | | .||.| .|...||. || ||| .. |||| . | eepGkdsGttavvaLvkgkklivanaGDsRcvlsrnGkaldls |
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| Phosphatase | W09D10.4.AA | Subfamily.PPM1A.PD | 170-205 | 51 | 4.8e-07 | 19.3 | In-house | 114-149 (309) | Show / Hide |
Range on Protein: 170-205 Range on HMM: 114-149/309 Sequence Identity: 51% (18 aa) SSTACVLVVHQEKLYSANLGDSGFMVVRNGKIVSKS ||| |..| ..||| ||.||| ...|||| | .. GsTavvvlvspkklylancGDsRavlsrngkvvfat |
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| Phosphatase | W09D10.4.AA | Subfamily.PPM1G2.PD | 244-287 | 25 | 5.7e-07 | 19.0 | In-house | 209-252 (275) | Show / Hide |
Range on Protein: 244-287 Range on HMM: 209-252/275 Sequence Identity: 25% (11 aa) KKGDIILLATDGVWDNLSEQQVLDQLKALDAGKSNVQEVCNALA .. . ..|| ||.|| |....|.| .. . . ...|... | eddeflvLaCDGiWDvltnkevvdlvrerlvsgakldeiieell |
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| Phosphatase | W09D10.4.AA | Subfamily.PPM1E.PD | 228-291 | 27 | 1.2e-06 | 17.9 | In-house | 192-254 (269) | Show / Hide |
Range on Protein: 228-291 Range on HMM: 192-254/269 Sequence Identity: 27% (18 aa) FIGDKADMADKDemAVKKGDIILLATDGVWDNLSEQQVLDQLK-ALDAGKSNVQEVCNALALTAR .. .||.|. . .. |...||.||.|| . |..|.. .. | |... .|| . | .|. yvsgeadvaeve--ldgsedylilacDGlwDvvneeevvklveefladgaedlsevakllveaak |
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| Phosphatase | W09D10.4.AA | PP2C_SIG | 95-329 | 12 | 2e-06 | 16.38 | SMART | 1-250 (250) | Show / Hide |
Range on Protein: 95-329 Range on HMM: 1-250/250 Sequence Identity: 12% (37 aa) DDAWFISRFKN--------------------TFVVGVADGVGGWRKYGIDPSAFSRRLMKECEKRVQKGDFDPQKPESLLDYAFRASAEA--PRPVGSST || |.|. . . .... ..|..| | |. .... .. . .. .. |...| . |. . .| DDHWDIYQYYEDATQVCGDWYDFWKIPEGQDRYFFVIGDVMG-WA-HGLPAALMMGMARTMMRTFWHE------SPPQILERCNRWIYQNNHEECGMFTT ACVLVV----HQEKLYSANLGDSGFMVVR--NGKIVSKSRE-------------------QVHYFNAPFQLTLPPEGYQGFIGDKADMADKDEMAVKKGD .|..|. . .|. .. |.| . ..| .|. | . . . .. . | . |. .| |. ...|| MCCCVYMPDFATHTLWYCHCGHSPPYLYRAMDGGRVEHTHDHYLVQHYVMRIIDEEDAKHHPWHNWTGPPLGMEPDYM----------YDVQEFQYEPGD IILLATDGVWDNLSEQQ----------VLDQLKALDAGKSNVQEVCN-----ALALTARRLAFDSKHNSPFAMKAREHGFLAPGGKPDDITLVLLLI .....||||... ..| .| .. . .||. . ........ .||.|.... RFVMCTDGVTEARNPQGEFFGEEWLQEILEEHQ-----CCCPQEIAQRIMQELMEHMGDHNG------------------------HDDMTVIVVKV |
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| Phosphatase | W09D10.4.AA | Subfamily.PPM1H.PD | 236-271 | 35 | 2.9e-06 | 16.4 | In-house | 316-351 (402) | Show / Hide |
Range on Protein: 236-271 Range on HMM: 316-351/402 Sequence Identity: 35% (12 aa) ADKDEMAVKKGDIILLATDGVWDNLSEQQVLDQLKA | ... .. |...|||||.|| ||...|. .. ldltqvesleDdvlilatDGLWdvlsneevaeivre |
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| Phosphatase | W09D10.4.AA | Subfamily.PPM1G2.PD | 168-201 | 41 | 9.8e-06 | 14.9 | In-house | 105-138 (275) | Show / Hide |
Range on Protein: 168-201 Range on HMM: 105-138/275 Sequence Identity: 41% (14 aa) VGSSTACVLVVHQEKLYSANLGDSGFMVVRNGKI . ||| | ....|||| || ||| .. .|.. saGstavvvlikeeklyvanaGDsravlsskgnv |
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Sequence
| Name | Sequence Type | Origin | Length | Description | Download |
|---|---|---|---|---|---|
| W09D10.4.AA | Protein | None | 330 | None | Fasta, JSON |
| W09D10.4.NA | RNA | None | 990 | None | Fasta, JSON |
| W09D10.4.AA.PD_71-329 | Protein Phosphatase Domain | None | 259 | None | Fasta, JSON |