Gene mkpA
mkpA
Species: D.discoideum
Alias: mkpA, DDB_G0288249
External Links:
Classification
Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.
Protein domain
Protein domains of mkpA.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit phosphatase group/family/subfamily, which is helpful to understand the relationship between phosphatases. Transmembrane region is predicted by TMHMM 2.0. Visualized by pviz.
Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking. View complete domain list.
| Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
|---|---|---|---|---|---|---|---|---|---|
| Phosphatase | mkpA.AA | Family.DSP.PD | 1036-1209 | 28 | 6e-35 | 111.5 | In-house | 86-258 (387) | Show / Hide |
Range on Protein: 1036-1209 Range on HMM: 86-258/387 Sequence Identity: 28% (50 aa) IDQCQEEFQHLSQKELIlfFEPTLNRIVDELYLGSRIPASNLQLLKGEGITHILNCAGMvCPNHFQ-DHFVYKTLFISDGNGEDISCLFYEILDFIQDAT || .. . ... ..| . . ..| ..||||| |.||. || |.|.|.|.. .|.. . .. | ..|.|.| .... || ...|||... idvhtfdldtydhferv--engkpseilphlylgsllaaknlewlkelgvtkivnltdd-kpqftkelgikylripidDhnapplenlfekaidfieegn KTNGKVYIHCHQGISRSSAFVILYLMWINKWSFQQAHEFTKKRRY-ISNPNPGFTGQLMYWNKFLLKHLQHPSVKE ...|.|..||..|..|| .| ||| .......| .. ...| . .|| || ||. . | .|| ... ... dskgvVlVHCkaGkgRsgtliiaYlmksegltleealdwvrskRpgvitpnqgflkqlkdlekeklkvssevmelr |
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| Phosphatase | mkpA.AA | Subfamily.DSP1.PD | 1059-1196 | 47 | 3.1e-60 | 192.5 | In-house | 2-138 (139) | Show / Hide |
Range on Protein: 1059-1196 Range on HMM: 2-138/139 Sequence Identity: 47% (65 aa) LNRIVDELYLGSRIPASNLQLLKGEGITHILNCAGMvCPNHFQDHFVYKTLFISDGNGEDISCLFYEILDFIQDATKTNGKVYIHCHQGISRSSAFVILY ...|.|.|||||.. |||||||| ..||..||.... .||.|...| ||.....| . .|||.||.|..|||....|..|.|..||..|||||...|..| pveildfLyLGsaehasnlqlLkelkitallnvsae-lpnvfeelfkyksipvednkkadisslfeeaidfidsvkkkgGrvlvhCqaGisrsativlay LMWINKWSFQQAHEFTKKRRYISNPNPGFTGQLMYWNK ||. .|.....|.||.|.||.|..|| ||.|||....| LmkekkvrleeafefvkqrrsiisPnfgfvgqLlefek |
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| Phosphatase | mkpA.AA | Subfamily.DSP19.PD | 1060-1193 | 39 | 1.6e-35 | 112.2 | In-house | 3-135 (139) | Show / Hide |
Range on Protein: 1060-1193 Range on HMM: 3-135/139 Sequence Identity: 39% (52 aa) NRIVDELYLGSRIPASNLQLLKGEGITHILNCAgMVCPNHFQDHFVYKTLFISDGNGEDISCLFYEILDFIQDATKTNGKVYIHCHQGISRSSAFVILYL .. ..||||| |.... || ..|||||| | . ||.| ..| ||.. | | . ... . |.||||..| ...| |..||. |.|||...|| ||| aevkprlylgsqdvaadkeilkklkitHilnva-vgvpnvfpkdftyksieilDlpetkllsylkealdFieearskdgrvlvHCnAGvSRsasvviayl MWINKWSFQQAHEFTKKRRYISNPNPGFTGQLMY .. |...| | .. | .|| ||. || mkdeelslekalekvrearpcikPneGFikqLke |
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| Phosphatase | mkpA.AA | DSPc | 1058-1197 | 32 | 1.4e-34 | 122.11 | SMART | 1-172 (172) | Show / Hide |
Range on Protein: 1058-1197 Range on HMM: 1-172/172 Sequence Identity: 32% (57 aa) TLNRIVDELYLGSRIPAS--NLQLLKGEGITHILNCAGMVCPNHFQ-----------------DHFVYKTLF-ISD-------GNGEDISCLFYEILDFI .| .||||| .. |. .|| .|||..|.. |.||..| || |. . |.| ...|| | | ||| GPSEITPHLYLGSYPHHMEPNPCFLKKHNITHVINVT-MECPWNFHHCQKNDMHYTNEWIYHNSHFQYMHIPMIDDIYYHIRWNHCTNISQYFPEVYDFI QDATKTNGKVYIHCHQGISRSSAFVILYLMWINKWSFQQAHEFT-----KKRR-YISNPNPGFTGQLMYWNKF .|... .|||..|| ||||| ...| |||. ...| . | .| |.|| | .|| .|..||. |... HDCRQKGGKVLVHCQAGISRSATLCIAYLMKYMNMSYNDAYHFVYIYHIKQRRCPIICPNFNFWHQLCEWERK |
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| Phosphatase | mkpA.AA | Subfamily.Slingshot.PD | 1061-1194 | 39 | 5.7e-33 | 103.9 | In-house | 4-136 (139) | Show / Hide |
Range on Protein: 1061-1194 Range on HMM: 4-136/139 Sequence Identity: 39% (52 aa) RIVDELYLGSRIPASNLQLLKGEGITHILNCAGmVCPNHFQDHFVYKTLFISDGNGEDISCLFYEILDFIQDATKTNGKVYIHCHQGISRSSAFVILYLM .| | ||||| ||||. || .|...||| . . |.|...| |... . | . .|. . | .||. | ... || .|||.|||.. || | | kifdhlylGsewnasnleelkengveyilnvtk-eidnffpekfkylnirvydeeetdllkhwnetykfiekakekgskvlvhckmGvsrsastviayam WINKWSFQQAHEFTKKRRYISNPNPGFTGQLMYW ..|...|.|. |.|| | .|| ||. || . keyelsleealeyvkerrsiikpnkgflkqlkvy |
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| Phosphatase | mkpA.AA | Subfamily.DSP10.PD | 1061-1195 | 35 | 9.7e-33 | 103.3 | In-house | 4-139 (141) | Show / Hide |
Range on Protein: 1061-1195 Range on HMM: 4-139/141 Sequence Identity: 35% (49 aa) RIVDELYLGSRIPASNLQLLKGEGITHILNCAGmVCPNHFQ--DHFVYKTLFISDGNGEDISCLFYEILDFIQDATKTNGKVYIHCHQGISRSSAFVILY .|. |.||. |.. ..|. ||...|| . ..||.|. . . || . .|| . .... | | |.||..| |....| .||| |||||.. || | silpflllGnekdaadkdaldrlgikyvlnvtt-svPnffeekglvrykripvsdsgkqnlkqkfeealefieearkrgsrvlvhchaGisrsatvviay LMWINKWSFQQAHEFTKKRRYISNPNPGFTGQLMYWN .| . |...|..| |..| | || .| |||. .. vmkhlslslseaykfvkekrPiisPnlnfmGqllefe |
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| Phosphatase | mkpA.AA | DSPc | 1066-1197 | 34 | 4.8e-32 | 113.36 | Pfam | 1-151 (151) | Show / Hide |
Range on Protein: 1066-1197 Range on HMM: 1-151/151 Sequence Identity: 34% (52 aa) LYLGSRIPAS-NLQLLKGEGITHILNCAGMVCPNHFQ---DHFVYKTLF-ISD---------GNGEDISCLFYEILDFIQDATKTNGKVYIHCHQGISRS ||||| .. ....|. ||||..||. | |||.. || |. . . | ...|| | .. |||.|... .|||..|| ||||| LYLGSYPHHMADPAFLQKHGITHVINCT-MECPNNWFYHNSHFHYMWIPHVHDHIHYYHIHWNHCTNISQYFPMATDFIDDCRQKGGKVLVHCQAGISRS SAFVILYLMWINKWSFQQAHEFT-----KKRR-YISNPNPGFTGQLMYWNKF ...| |||. ...| . | .| |.|| . .||..|..||. .... ACLCIAYLMKYRNMSYNEAYDFVYIYHMKQRRCPMISPNMNFWRQLCEYERQ |
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| Phosphatase | mkpA.AA | Subfamily.DSP12.PD | 1060-1197 | 32 | 7e-32 | 100.7 | In-house | 3-141 (143) | Show / Hide |
Range on Protein: 1060-1197 Range on HMM: 3-141/143 Sequence Identity: 32% (45 aa) NRIVDELYLGSRIPASNLQLLKGEGITHILNCAGMVCPNHFQD-HFVYKTLFISDGNGEDISCLFYEILDFIQDATKTNGKVYIHCHQGISRSSAFVILY ..| ..||||.. .. . .||| |||.| . . |.. .. . ..|.. | | . ||. . |...||... ...|.|..||. |.|||...|| | seilpglylggleavqerellkelkithvlsvikeelpelqkekgvkskliqilDepeedlLshldeavrFieeglekegavlvHClagvSRSvtiviAY LMWINKWSFQQAHEFTKKRRYISNPNPGFTGQLMYWNKF || .|.|...|... |. . .|| || || ..| lmkkeklslekAlklvkekkkeiepNegFleQLklfekm |
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| Phosphatase | mkpA.AA | Subfamily.LRR-DSP.PD | 1061-1195 | 38 | 1.7e-29 | 92.7 | In-house | 4-135 (137) | Show / Hide |
Range on Protein: 1061-1195 Range on HMM: 4-135/137 Sequence Identity: 38% (52 aa) RIVDELYLGSRIPASNLQLLKGEGITHILNCAGmvCPNHFQDHFVYKTLFISDGNGEDISCLFYEILDFIQDAtKTNGKVYIHCHQGISRSSAFVILYLM |.|.||||.| | | .|| ..|||| | . . | | | .. |.| . ||. | |. ||.. . .| | ||| |.|||.. || ||| liidklylgcresamnksilkdnnvthilavad--fkplypdlfkyliidiedvdeadiyqhfkemnafideg-rekggvlihcragvsrsatlviaylm WINKWSFQQAHEFTKKRRYISNPNPGFTGQLMYWN |. |..| ....|.| .||.|| || .. kknslkfkealdlvikkrpriypnrgfldqlkkfe |
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| Phosphatase | mkpA.AA | Subfamily.DSP6.PD | 1061-1195 | 35 | 1.1e-28 | 89.9 | In-house | 4-139 (141) | Show / Hide |
Range on Protein: 1061-1195 Range on HMM: 4-139/141 Sequence Identity: 35% (48 aa) RIVDELYLGSRIPASNLQLLKGEGITHILNCAGMvCPNHFQD--HFVYKTLFISDGNGEDISCLFYEILDFIQDATKTNGKVYIHCHQGISRSSAFVILY .|.. |||||. ||||..|| .| ..|| . || |.. .. || . |.| .... .| | ..||..| ... || .||. |.||| . .. | eilpllylGsakdasnlevlkklkikyvlnvtsn-lpnkfeesgelkykqipiedhlsqnlakffPeaiefidearskkskvlvhclaGvsrsvtvtlay LMWINKWSFQQAHEFTKKRRYISNPNPGFTGQLMYWN || .. |...|... ||.. || | |||. .. lmkklalslndaydlvkkkksnisPnfnfmgqlldfe |
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| Phosphatase | mkpA.AA | Subfamily.DSP3.PD | 1060-1195 | 34 | 3.2e-28 | 88.7 | In-house | 3-146 (148) | Show / Hide |
Range on Protein: 1060-1195 Range on HMM: 3-146/148 Sequence Identity: 34% (50 aa) NRIVDELYLGSRIPASNLQLLKGEGITHILNCAGMV-------CPNHFQD-HFVYKTLFISDGNGEDISCLFYEILDFIQDATKT-NGKVYIHCHQGISR . . ...|.| . |.. . || ||||.||.| .. ..| . | . .|| |.| |.| |||..| .. ||||..||..|||| devypkvyvgdeavakdkekLkklGithvLnaaegkrllkvdtdaefYkdleikylGvevsDvpefdlskyfeeaadfidealsqkngkvlvhcvvGisR SSAFVILYLMWINKWSFQQAHEFTKKRRYIsNPNPGFTGQLMYWN |.. |. ||| .| . ..| . .|.| | || || ||. . satlvlayLmirrkltlkeaiktvrkkrei-lPneGflkqLleld |
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| Phosphatase | mkpA.AA | Subfamily.DSP8.PD | 1059-1197 | 35 | 9.7e-28 | 87.2 | In-house | 2-141 (143) | Show / Hide |
Range on Protein: 1059-1197 Range on HMM: 2-141/143 Sequence Identity: 35% (49 aa) LNRIVDELYLGSRIPASNLQLLKGEGITHILNCAgMVCPN--HFQDHFVYKTLFISDGNGEDISCLFYEILDFIQDATKTNGKVYIHCHQGISRSSAFVI ..||.. |||||.. . . .||| ||...|| . . || ..... . . . | . |... | . |.||. | ..|||| .||.|||||.. .| ptrilpnlylGsqkdsldeellkklgisyvlnis-escpkdvellkesrflriPvkDkyeekllpwfdkalefidkarsangkvlvhclaGisrsatvai LYLMWINKWSFQQAHEFTKKRRYISNPNPGFTGQLMYWNKF |.| . |...|..| |..| .|| | |||. ..| ayimktlemsldeayrfvkekrptispnlnflgqLleyeke |
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| Phosphatase | mkpA.AA | Subfamily.DSP14.PD | 1059-1194 | 31 | 1.3e-27 | 86.7 | In-house | 2-135 (138) | Show / Hide |
Range on Protein: 1059-1194 Range on HMM: 2-135/138 Sequence Identity: 31% (43 aa) LNRIVDELYLGsRIPASNLQLLKGEGITHILNCAGmVCPNHFQDHFVYKTLFISDGNGEDISCLFYEILDFIQDATKTNGKVYIHCHQGISRSSAFVILY |..| ..|||. |.. . || ..||.|.| . |. ... . . ..| . .... | |. | |....|..||. .|| .|.||| ..|. | lseitesLyls-gaaalkkeklkkkkitlivnvtt-elpetkledvktvkikveDkpeaklaehfdevadkieevkkkgGktlvhCvaGvsRsAslvlay LMWINKWSFQQAHEFTKKRRYISNPNPGFTGQLMYW || .| | ..|....|..| | .||.|| ||. . lmkyeklsLreayklvksaRpiirPnvGFwkqlidy |
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| Phosphatase | mkpA.AA | Subfamily.DSP15.PD | 1059-1196 | 33 | 1.4e-27 | 86.5 | In-house | 2-137 (138) | Show / Hide |
Range on Protein: 1059-1196 Range on HMM: 2-137/138 Sequence Identity: 33% (46 aa) LNRIVDELYLGSRIPASNLQLLKGEGITHILNCAGMVCPnHFQDhFVYKTLFISDGNGEDISCLFYEILDFIQDATKTNGKVYIHCHQGISRSSAFVILY .|... ||.|. . |.. ..|. . ||||| | ...| . |... ..| |.| | | ||| . .|.|..|| ||||| . |. | mnkvlpGlyvGnfrdakdkeqleenkithilsihdsakp-lled-ikylcikaadsPdqdlskffkesidfihkcrleggnvlvhclaGisrsvtlvvay LMWINKWSFQQAHEFTKKRRYISNPNPGFTGQLMYWNK .| . ..|...| . | | ..||| || ||. ..| imtvtelswedalkavkaarsvanPnvGfrrqlqefek |
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| Phosphatase | mkpA.AA | Subfamily.STYX.PD | 1060-1195 | 36 | 9.3e-26 | 80.7 | In-house | 3-144 (146) | Show / Hide |
Range on Protein: 1060-1195 Range on HMM: 3-144/146 Sequence Identity: 36% (52 aa) NRIVDELYLGSRIPA--SNLQLLKGEGITHILNC-----AGMVCPNhFQDHFVYKTLFISDGNGEDISCLFYEILDFIQDATKTNGKVYIHCHQGISRSS . |. |.|| | |.|. || .|||||. | .. || |.|.| | | ..| |.| . .. .||.|. .. ||| .| |||||. qeilpglflgpysaamksklevlkehgithivcirqnieanlikpn-fpdrfrylvldvadntveniirylptvkefiddslqkggkvlvhgnagisrsa AFVILYLMWINKWSFQQAHEFTKKRRYISNPNPGFTGQLMYWN |.|| |.| ...|. . ..||. ||| ||. ||. .. alviayimetyglkyreafayvqerrfcinpnegfvsqlkeye |
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| Phosphatase | mkpA.AA | Subfamily.STYXL1.PD | 1108-1196 | 32 | 7e-17 | 52.2 | In-house | 54-142 (143) | Show / Hide |
Range on Protein: 1108-1196 Range on HMM: 54-142/143 Sequence Identity: 32% (29 aa) TLFISDGNGEDISCLFYEILDFIQDATKTNGKVYIHCHQGISRSSAFVILYLMWINKWSFQQAHEFTKKRRYISNPNPGFTGQLMYWNK .. ..| | |. . |. .||.. |.. | . ..||||| | .| |||. .|.....|... || . .|| .| || |.| hiavedeneadllerlkevvqfiekhkkegevvlvfsnkGisrsaaviiaylmyskkitlkkaykylkkckenvkPnrafveqlseWek |
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| Phosphatase | mkpA.AA | Subfamily.PTPMT1.PD | 1126-1179 | 38 | 3.7e-13 | 39.8 | In-house | 75-128 (146) | Show / Hide |
Range on Protein: 1126-1179 Range on HMM: 75-128/146 Sequence Identity: 38% (20 aa) ILDFIQDATKTNGKVYIHCHQGISRSSAFVILYLMWINKWSFQQAHEFTKKRRY ..||.. .. . .||.|| | .||.. |. ||| .|.| ..|..| ||.| gvefiekvaskgssvYvHCkAGrtRsatlvacylmkkkklspeeavkflkkkRp |
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| GEL | mkpA.AA | GEL | 1212-1307 | 22 | 1.7e-07 | 32.19 | SMART | 1-102 (102) | Show / Hide |
Range on Protein: 1212-1307 Range on HMM: 1-102/102 Sequence Identity: 22% (24 aa) LLYRMVQLLDGLIVPKRVQTVSYLSLDARCCFILRVT-DCIYIWSGEGCVGKLGDLFLESAKLAISRFQRYENDS------------TNIIELRQGHEDD . . .. . |. .|. ||. ..|.|| . . ||.| |... . | |.. | | . | .....|||| . YRLFCWHVKGKKNVRVPEVPFSQGSLNSGDCYILDCGNHHIYVWIGKQSS-------QDEKKKAMQMAQEYDDMMRMEGPPAHRPRWTQVRVVDQGHEPP KFWDHLGGE ||. .|| HFWQYFGGW |
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| Phosphatase | mkpA.AA | Subfamily.PTPDC1.PD | 1130-1178 | 24 | 1.8e-07 | 21.1 | In-house | 160-207 (229) | Show / Hide |
Range on Protein: 1130-1178 Range on HMM: 160-207/229 Sequence Identity: 24% (12 aa) IQDATkTNGKVYIHCHQGISRSSAFVILYLMWINKWSFQQAHEFTKKRR .. | ..||. .||| | | . ||.. .. . ..| .. ...| vdfal-eegkiavHCHAGlGRtGvliacylvyakrltaeeaiklvrskr |
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| Phosphatase | mkpA.AA | Subfamily.Laforin.PD | 1138-1177 | 33 | 2.1e-07 | 21.0 | In-house | 105-144 (165) | Show / Hide |
Range on Protein: 1138-1177 Range on HMM: 105-144/165 Sequence Identity: 33% (13 aa) GKVYIHCHQGISRSSAFVILYLMWINKWSFQQAHEFTKKR .||.|| |. ||.| | .|... .||... | . hivyvhcnagvgrstaivcgflqyvlgwslakvqyfllak |
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| Phosphatase | mkpA.AA | Subfamily.CDC14.PD | 1043-1168 | 20 | 1.3e-06 | 18.5 | In-house | 107-229 (258) | Show / Hide |
Range on Protein: 1043-1168 Range on HMM: 107-229/258 Sequence Identity: 20% (26 aa) FQHLSQKELILFFEPTLNRIVDELYlGSRIPASNLQLLKGEGITHILNCAG-MVCPNHFQDH-FVYKTLFISDGNGEDISCLfyeiLDFIQDATKTNGKV | . ...| . | .. |.. | . | . |. . ...|.|. . ..|.|. | .. || || . . | |.. . |..|.. fttiipnkfialagphnkskvedGy-tllaPeklleyfrknnvttivrLnkklYdakkftdaGfahlDlffiDGtvPsdail----kkfleitekaeGai YIHCHQGISRSSAFVILYLMWINKWSFQ .||. |. | .... ||. . . . avhCkaGLGrtgtligcylikhyrftaa |
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| Phosphatase | mkpA.AA | Subfamily.DSP23.PD | 1124-1178 | 24 | 4.5e-06 | 17.0 | In-house | 53-107 (128) | Show / Hide |
Range on Protein: 1124-1178 Range on HMM: 53-107/128 Sequence Identity: 24% (13 aa) YEILDFIQDATKTNGKVYIHCHQGISRSSAFVILYLMWINKWSFQQAHEFTKKRR ... ...| | .. | .|| .|. |. ... ||. .. . ..| ..||| arlvriveeaekkeeavgvhcalGlGrtGtllacylvkeeglaaddaiaevrkrr |
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