Gene DDB_G0269404
DDB_G0269404
Species: D.discoideum
Alias: DDB_G0269404
External Links:
Classification
Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.
Protein domain
Protein domains of DDB_G0269404.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit phosphatase group/family/subfamily, which is helpful to understand the relationship between phosphatases. Transmembrane region is predicted by TMHMM 2.0. Visualized by pviz.
Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking. View complete domain list.
| Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
|---|---|---|---|---|---|---|---|---|---|
| Phosphatase | DDB_G0269404.AA | Family.DSP.PD | 28-173 | 32 | 3.9e-35 | 112.9 | In-house | 103-253 (387) | Show / Hide |
Range on Protein: 28-173 Range on HMM: 103-253/387 Sequence Identity: 32% (49 aa) ICFDAQEVIPNLYIGSISAATCTTSLKEHKITHILSISTNPPKIKE---FTTLCINIEDESQKDISSYFQQCHGFIENGR-KLGGILVHCSAGVSRSASV . . .|..|.||.|| .||.... |||...|.|.......|.... .. |.|.|.| .. .....|... |||.|. . | .|||| ||..||.... engkpseilphlylgsllaaknlewlkelgvtkivnltddkpqftkelgikylripidDhnapplenlfekaidfieegndskgvVlVHCkaGkgRsgtl VISYLMSV-FFKPFwYCMQYLRNIRP-CIQPNTGFINQLINYEATILKNQNV | |||. .. .....| || .|.|| ||. || .| .|| .. iiaYlmksegltle-ealdwvrskRpgvitpnqgflkqlkdlekeklkvsse |
|||||||||
| Phosphatase | DDB_G0269404.AA | Subfamily.DSP19.PD | 32-165 | 45 | 2.4e-56 | 180.5 | In-house | 2-138 (139) | Show / Hide |
Range on Protein: 32-165 Range on HMM: 2-138/139 Sequence Identity: 45% (63 aa) AQEVIPNLYIGSISAATCTTSLKEHKITHILSISTNPPKI--KEFTTLCINIEDESQKDISSYFQQCHGFIENGRKL-GGILVHCSAGVSRSASVVISYL ..|| |.||.||...|.....||..||||||..... |.. |.||...|.| |...... ||..... |||..|. | .||||.|||||||||||.|| vaevkprlylgsqdvaadkeilkklkitHilnvavgvpnvfpkdftyksieilDlpetkllsylkealdFieearskdgrvlvHCnAGvSRsasvviayl MSVFFKPFWYCMQYLRNIRPCIQPNTGFINQLINYEA |. . ........|. ||||.||.|||.|| .||| mkdeelslekalekvrearpcikPneGFikqLkeyea |
|||||||||
| Phosphatase | DDB_G0269404.AA | Subfamily.LRR-DSP.PD | 33-165 | 39 | 6.4e-40 | 127.2 | In-house | 3-136 (137) | Show / Hide |
Range on Protein: 33-165
Range on HMM: 3-136/137
Sequence Identity: 39% (53 aa)
QEVIPNLYIGSISAATCTTSLKEHKITHILSISTNPP-KIKEFTTLCINIEDESQKDISSYFQQCHGFIENGRKLGGILVHCSAGVSRSASVVISYLMSV
...|..||.|. .|. . ||. ..||||... | . | | |.||| . ||. .|.. ||..||. ||.|.|| |||||||..||.|||
dliidklylgcresamnksilkdnnvthilavadfkplypdlfkyliidiedvdeadiyqhfkemnafidegrekggvlihcragvsrsatlviaylmkk
FFKPFWYCMQYLRNIRPCIQPNTGFINQLINYEA
| .. . || |.||.||..|| .|.
nslkfkealdlvikkrpriypnrgfldqlkkfek
|
|||||||||
| Phosphatase | DDB_G0269404.AA | DSPc | 31-166 | 28 | 5.6e-37 | 130.08 | SMART | 1-172 (172) | Show / Hide |
Range on Protein: 31-166 Range on HMM: 1-172/172 Sequence Identity: 28% (49 aa) DAQEVIPNLYIGSISAAT--CTTSLKEHKITHILSISTNPP------KI-------------KEFTTLCIN-IED-------ESQKDISSYFQQCHGFIE . .|. |.||.|| .... .||.|.|||... . . | .. ..|. ..| |.| . . .|| || .. ||. GPSEITPHLYLGSYPHHMEPNPCFLKKHNITHVINVTMECPWNFHHCQKNDMHYTNEWIYHNSHFQYMHIPMIDDIYYHIRWNHCTNISQYFPEVYDFIH NGRKLGG-ILVHCSAGVSRSASVVISYLMSVFFKPFWYCMQYL-----RNIR-PCIQPNTGFINQLINYEAT . |. || .|||| ||.||||...| |||. . .. .. .. . .| |.|.|| .|. ||. .| . DCRQKGGKVLVHCQAGISRSATLCIAYLMKYMNMSYNDAYHFVYIYHIKQRRCPIICPNFNFWHQLCEWERK |
|||||||||
| Phosphatase | DDB_G0269404.AA | Subfamily.DSP12.PD | 33-165 | 37 | 1.1e-36 | 117.1 | In-house | 3-140 (143) | Show / Hide |
Range on Protein: 33-165 Range on HMM: 3-140/143 Sequence Identity: 37% (52 aa) QEVIPNLYIGSISAATCTTSLKEHKITHILSISTNPP----KIKEFTTLCINIEDESQKDISSYFQQCHGFIENGR-KLGGILVHCSAGVSRSASVVISY .|. |.||.|...|.. ...||| ||||.||. ... |.|. ... |.| || ..|. |..... |||.|. | | .|||| ||||||...|| | seilpglylggleavqerellkelkithvlsvikeelpelqkekgvkskliqilDepeedlLshldeavrFieeglekegavlvHClagvSRSvtiviAY LMSVFFKPFWYCMQYLRNIRPCIQPNTGFINQLINYEA || .. .. ...... |.||.||..|| .|. lmkkeklslekAlklvkekkkeiepNegFleQLklfek |
|||||||||
| Phosphatase | DDB_G0269404.AA | Subfamily.DSP15.PD | 33-165 | 36 | 1.2e-35 | 113.5 | In-house | 3-137 (138) | Show / Hide |
Range on Protein: 33-165
Range on HMM: 3-137/138
Sequence Identity: 36% (49 aa)
QEVIPNLYIGSISAATCTTSLKEHKITHILSISTNP-PKIKEFTTLCINIEDESQKDISSYFQQCHGFIENGRKL-GGILVHCSAGVSRSASVVISYLMS
..|.| ||.|.. | .. |.|.|||||||| .. | ..... |||...| ..|.|..|... || . | | .|||| ||.|||..|..|.|.|
nkvlpGlyvGnfrdakdkeqleenkithilsihdsakplledikylcikaadsPdqdlskffkesidfihkcrleggnvlvhclaGisrsvtlvvayimt
VFFKPFWYCMQYLRNIRPCIQPNTGFINQLINYEA
. ... .. |.. .||.|| .|| ..|
vtelswedalkavkaarsvanPnvGfrrqlqefek
|
|||||||||
| Phosphatase | DDB_G0269404.AA | Subfamily.DSP1.PD | 33-165 | 38 | 4.1e-35 | 111.9 | In-house | 3-138 (139) | Show / Hide |
Range on Protein: 33-165
Range on HMM: 3-138/139
Sequence Identity: 38% (52 aa)
QEVIPNLYIGSISAATCTTSLKEHKITHILSISTNPPKI--KEFTTLCINIEDESQKDISSYFQQCHGFIENGRKLGG-ILVHCSAGVSRSASVVISYLM
|... ||.|| . |. . |||.|||..| .|.. |. . |. .|..||....||||.|.. ||.. .| || .|||| ||.||||..|. |||.
veildfLyLGsaehasnlqlLkelkitallnvsaelpnvfeelfkyksipvednkkadisslfeeaidfidsvkkkgGrvlvhCqaGisrsativlayLm
SVFFKPFWYCMQYLRNIRPCIQPNTGFINQLINYEA
. ..... | .|.|| ||..||...|
kekkvrleeafefvkqrrsiisPnfgfvgqLlefek
|
|||||||||
| Phosphatase | DDB_G0269404.AA | DSPc | 39-166 | 30 | 2.7e-32 | 114.24 | Pfam | 1-151 (151) | Show / Hide |
Range on Protein: 39-166 Range on HMM: 1-151/151 Sequence Identity: 30% (46 aa) LYIGSISAAT-CTTSLKEHKITHILSISTNPPK--I---KEFTTLCIN-IED---------ESQKDISSYFQQCHGFIENGRKLGG-ILVHCSAGVSRSA ||.|| .... |..|.|||... ... |. . ..|. ..| ..| . . .|| ||... ||.. |. || .|||| ||.|||| LYLGSYPHHMADPAFLQKHGITHVINCTMECPNNWFYHNSHFHYMWIPHVHDHIHYYHIHWNHCTNISQYFPMATDFIDDCRQKGGKVLVHCQAGISRSA SVVISYLMSVFFKPFWYCMQYL-----RNIR-PCIQPNTGFINQLINYEAT ...| |||. . . .. .. . | |.| ||..|. ||. || CLCIAYLMKYRNMSYNEAYDFVYIYHMKQRRCPMISPNMNFWRQLCEYERQ |
|||||||||
| Phosphatase | DDB_G0269404.AA | Subfamily.DSP14.PD | 33-165 | 38 | 3.1e-32 | 102.5 | In-house | 3-137 (138) | Show / Hide |
Range on Protein: 33-165 Range on HMM: 3-137/138 Sequence Identity: 38% (52 aa) QEVIPNLYIGsISAATCTTSLKEHKITHILSISTNPPKIK--EFTTLCINIEDESQKDISSYFQQCHGFIENGRKLGG-ILVHCSAGVSRSASVVISYLM |. ..||.. .||. . ||..|||.|. ..|. |. | .. |. |..||.........|.. ||. .| || .|||| ||||||||.|. ||| seitesLyls-gaaalkkeklkkkkitlivnvttelpetkledvktvkikveDkpeaklaehfdevadkieevkkkgGktlvhCvaGvsRsAslvlaylm SVFFKPFWYCMQYLRNIRPCIQPNTGFINQLINYEA . ..... || |.||.|| .|||.|| kyeklsLreayklvksaRpiirPnvGFwkqlidyEk |
|||||||||
| Phosphatase | DDB_G0269404.AA | Subfamily.DSP10.PD | 32-165 | 32 | 4.9e-32 | 101.8 | In-house | 2-140 (141) | Show / Hide |
Range on Protein: 32-165 Range on HMM: 2-140/141 Sequence Identity: 32% (45 aa) AQEVIPNLYIGSISAATCTTSLKEHKITHILSISTNPPKIKEFTTLC----INIEDESQKDISSYFQQCHGFIENGRKLG-GILVHCSAGVSRSASVVIS | ...| |..|. |. . .|. . |...| . |. |. | |. |...|....... .|.. |||. || | .|||| ||.|||| |||. assilpflllGnekdaadkdaldrlgikyvlnvttsvPnffeekglvrykripvsdsgkqnlkqkfeealefieearkrgsrvlvhchaGisrsatvvia YLMSVFFKPFWYCMQYLRNIRPCIQPNTGFINQLINYEA |.| . . ..... || | || .|. ||...| yvmkhlslslseaykfvkekrPiisPnlnfmGqllefek |
|||||||||
| Phosphatase | DDB_G0269404.AA | Subfamily.DSP6.PD | 34-165 | 32 | 8.8e-29 | 91.0 | In-house | 4-140 (141) | Show / Hide |
Range on Protein: 34-165 Range on HMM: 4-140/141 Sequence Identity: 32% (44 aa) EVIPNLYIGSISAATCTTSLKEHKITHILSISTNPPK----IKEFTTLCINIEDESQKDISSYFQQCHGFIENGRKL-GGILVHCSAGVSRSASVVISYL |..|.||.|| .|. . .||..|| ..| ...| |. .|.. . | |||. .......| . ||...|. ..|||| ||||||.|...||| eilpllylGsakdasnlevlkklkikyvlnvtsnlpnkfeesgelkykqipiedhlsqnlakffPeaiefidearskkskvlvhclaGvsrsvtvtlayl MSVFFKPFWYCMQYLRNIRPCIQPNTGFINQLINYEA . . ..... .. | || |..||...| mkklalslndaydlvkkkksnisPnfnfmgqlldfer |
|||||||||
| Phosphatase | DDB_G0269404.AA | Subfamily.Slingshot.PD | 33-164 | 34 | 2.7e-28 | 89.6 | In-house | 3-137 (139) | Show / Hide |
Range on Protein: 33-164 Range on HMM: 3-137/139 Sequence Identity: 34% (46 aa) QEVIPNLYIGSISAATCTTSLKEHKITHILSISTNPPKI--KEFTTLCINIEDESQKDISSYFQQCHGFIENGRKLG-GILVHCSAGVSRSASVVISYLM .. ||.|| |. |||.....|| .... . ..|. | |.. ||...|. ..... . |||. .. | .|||| |||||||.||.| | skifdhlylGsewnasnleelkengveyilnvtkeidnffpekfkylnirvydeeetdllkhwnetykfiekakekgskvlvhckmGvsrsastviayam SVFFKPFWYCMQYLRNIRPCIQPNTGFINQLINYE . . ...|... | .|.||.||..|| || keyelsleealeyvkerrsiikpnkgflkqlkvye |
|||||||||
| Phosphatase | DDB_G0269404.AA | Subfamily.DSP8.PD | 33-167 | 33 | 3.4e-28 | 89.4 | In-house | 3-142 (143) | Show / Hide |
Range on Protein: 33-167 Range on HMM: 3-142/143 Sequence Identity: 33% (47 aa) QEVIPNLYIGSISAATCTTSLKEHKITHILSISTNPPK----IKEFTTLCINIEDESQKDISSYFQQCHGFIENGRKLG-GILVHCSAGVSRSASVVISY ....||||.|| . . ||. |...| ||.. || .|| | | ..|. . ... .|... ||. |. .|||| || ||||.|.|.| trilpnlylGsqkdsldeellkklgisyvlnisescpkdvellkesrflriPvkDkyeekllpwfdkalefidkarsangkvlvhclaGisrsatvaiay LMSVFFKPFWYCMQYLRNIRPCIQPNTGFINQLINYEATI .| . . . ..... || |.|| |..||..|| .. imktlemsldeayrfvkekrptispnlnflgqLleyekel |
|||||||||
| Phosphatase | DDB_G0269404.AA | Subfamily.STYX.PD | 32-165 | 37 | 4.9e-28 | 88.9 | In-house | 2-145 (146) | Show / Hide |
Range on Protein: 32-165 Range on HMM: 2-145/146 Sequence Identity: 37% (53 aa) AQEVIPNLYIGSISAATCT--TSLKEHKITHILSISTNP-------PKIKEFTTLCINIEDESQKDISSYFQQCHGFIENGRKLGG-ILVHCSAGVSRSA ||..| |..| ||| . |||| ||||. | |. ..| | ... |.. ..| |. . ..||.. . || .|||||.||||..| mqeilpglflgpysaamksklevlkehgithivcirqnieanlikpnfpdrfrylvldvadntveniirylptvkefiddslqkggkvlvhgnagisrsa SVVISYLMSVFFKPFWYCMQYLRNIRPCIQPNTGFINQLINYEA |.|.| . . ...|... | ||.|| ||..|| .||| alviayimetyglkyreafayvqerrfcinpnegfvsqlkeyea |
|||||||||
| Phosphatase | DDB_G0269404.AA | Subfamily.DSP3.PD | 32-164 | 31 | 1.1e-24 | 78.1 | In-house | 2-146 (148) | Show / Hide |
Range on Protein: 32-164 Range on HMM: 2-146/148 Sequence Identity: 31% (46 aa) AQEVIPNLYIGSISAATCTTSLKEHKITHILSIS---------TNPPKIKE--FTTLCINIEDESQKDISSYFQQCHGFIENG--RKLGGILVHCSAGVS ..|| |..|.| ..|. .. ||. |||.| . |.. |. . | ....| . |.|.||.. ||.. .| | .|||| .|.| vdevypkvyvgdeavakdkekLkklGithvLnaaegkrllkvdtdaefYkdleikylGvevsDvpefdlskyfeeaadfidealsqkngkvlvhcvvGis RSASVVISYLMSVFFKPFWYCMQYLRNIRpCIQPNTGFINQLINYE ||| .|..||| .. |. | .|.||.||..||.... RsatlvlayLmirrkltlkeaiktvrkkr-eilPneGflkqLleld |
|||||||||
| Phosphatase | DDB_G0269404.AA | Subfamily.STYXL1.PD | 34-165 | 30 | 1.4e-20 | 64.9 | In-house | 4-142 (143) | Show / Hide |
Range on Protein: 34-165 Range on HMM: 4-142/143 Sequence Identity: 30% (42 aa) EVIPN-LYIGSISAATCTTSLKEHKITHILSISTNPPKIK----E-FTTLCINIEDESQKDISSYFQQCHGFIENGRKLG-GILVHCSAGVSRSASVVIS ||.|. ||.| . |. . |. |. . .|.. |. . | |..|||.. |. . ... |||. .| | .|| |.||||.|.|. evlPgklylGnykqaqnpaikkdlkvkahvnvssdaekliagladvakllhiavedeneadllerlkevvqfiekhkkegevvlvfsnkGisrsaaviia YLMSVFFKPFWYCMQYLRNIRPCIQPNTGFINQLINYEA ||| . ...||.. .. ..|| .|..|| ..| ylmyskkitlkkaykylkkckenvkPnrafveqlseWek |
|||||||||
| Phosphatase | DDB_G0269404.AA | Subfamily.PTPMT1.PD | 77-163 | 26 | 4.5e-10 | 30.5 | In-house | 56-143 (146) | Show / Hide |
Range on Protein: 77-163 Range on HMM: 56-143/146 Sequence Identity: 26% (23 aa) LCINIEDESQKDISSYFQQCHGFIENGRKLGG-ILVHCSAGVSRSASVVISYLMSVFFKPFWYCMQYLRNIRPCIQPNTGFINQLINY | . . | . . .. |||. ...| . ||| || .|||..|..||| ...|...|| |. .. .. | .. lqlatvDfteapslekleegvefiekvaskgssvYvHCkAGrtRsatlvacylmkkkklspeeavkflkkkRpqirlkskqwralqef |
|||||||||
| Phosphatase | DDB_G0269404.AA | Subfamily.CDC14.PD | 52-149 | 25 | 1.6e-08 | 25.6 | In-house | 142-241 (258) | Show / Hide |
Range on Protein: 52-149 Range on HMM: 142-241/258 Sequence Identity: 25% (24 aa) SLKEHKITHILSISTNPPKIKEFTTLCINIEDESQKDISSYFQQ-CHGFIENGRK-LGGILVHCSAGVSRSASVVISYLMSVFFKPFWYCMQYLRNIRPC .....|.|. . . . |.|| .. .| | . .. . |.| | | | ||| ||. | .... .||. . ...|| .|| yfrknnvttivrLnkklYdakkftdaGfahlDlffiDGtvPsdailkkfleitekaeGaiavhCkaGLGrtgtligcylikhyrftaaetiawlriarPG |
|||||||||
| Phosphatase | DDB_G0269404.AA | Subfamily.Laforin.PD | 96-137 | 35 | 4.4e-07 | 20.8 | In-house | 97-135 (165) | Show / Hide |
Range on Protein: 96-137 Range on HMM: 97-135/165 Sequence Identity: 35% (14 aa) CHGFIENGRKlggILVHCSAGVSRSASVVISYLMSVFFKPFW |...|.| . . ||| ||| ||...| .|. |. . lhallekghi---vyvhcnagvgrstaivcgflqyvlgwsla |
|||||||||
| Phosphatase | DDB_G0269404.AA | Subfamily.R_Nematode_3.PD | 105-126 | 47 | 2.6e-06 | 18.0 | In-house | 196-218 (267) | Show / Hide |
Range on Protein: 105-126 Range on HMM: 196-218/267 Sequence Identity: 47% (10 aa) KLG-GILVHCSAGVSRSASVVIS | ..||||.|.||||. . ksktpvvVHCsdGisRsatlaai |
|||||||||
| Phosphatase | DDB_G0269404.AA | Subfamily.N_Nematode_1.PD | 107-130 | 50 | 4.3e-06 | 17.2 | In-house | 197-221 (265) | Show / Hide |
Range on Protein: 107-130 Range on HMM: 197-221/265 Sequence Identity: 50% (12 aa) GGILVHCSAGVSRSASVV-ISYLMS | |.||||||. |. ..| |.|.. gPivvhCsaGiGrtGtivaieyild |
|||||||||
Sequence
| Name | Sequence Type | Origin | Length | Description | Download |
|---|---|---|---|---|---|
| DDB_G0269404.AA | Protein | None | 212 | None | Fasta, JSON |
| DDB_G0269404.NA | RNA | None | 639 | None | Fasta, JSON |
| DDB_G0269404.AA.PD_31-166 | Protein Phosphatase Domain | None | 136 | None | Fasta, JSON |