• Phosphatome.Net

Gene mpl1

mpl1
Species: D.discoideum
Alias: DDB_G0269918, mpl1
External Links:
Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Superfamily: Cx5R-I
Family: DSP
Subfamily: LRR-DSP
Protein domain

Protein domains of mpl1.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit phosphatase group/family/subfamily, which is helpful to understand the relationship between phosphatases. Transmembrane region is predicted by TMHMM 2.0. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking. View complete domain list.

Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Phosphatase mpl1.AA Family.DSP.PD 690-834 39 2.6e-35 112.7 In-house 101-249 (387) Show / Hide 
Range on Protein: 690-834
Range on HMM: 101-249/387
Sequence Identity: 39% (59 aa)

FWQSIVPDLIIDKLYLGCRECAMNKSWLKDNNVTHILTVANFKPL--YPDLFKYLIINIDDVDEANIYQYFKEMNTFIDEGR-EKGGVLIHCRAGVSRSA
. .   |  |...||||  . | |. |||...||.|. ..  ||   .   .||| |.|||  . .. ..| .   ||.||. .|| ||.|| ||..||.
rvengkpseilphlylgsllaaknlewlkelgvtkivnltddkpqftkelgikylripidDhnapplenlfekaidfieegndskgvVlVHCkaGkgRsg

TATIAYIMMKNSVKFQEAFDITIKGRS-RIYPNRGFLNQLKKFEKDLSK
| .|||.| .. ....||.|   . |.  | || ||| |||..|| ..|
tliiaYlmksegltleealdwvrskRpgvitpnqgflkqlkdlekeklk
Phosphatase mpl1.AA Subfamily.LRR-DSP.PD 695-831 84 2.5e-85 273.5 In-house 1-137 (137) Show / Hide 
Range on Protein: 695-831
Range on HMM: 1-137/137
Sequence Identity: 84% (116 aa)

VPDLIIDKLYLGCRECAMNKSWLKDNNVTHILTVANFKPLYPDLFKYLIINIDDVDEANIYQYFKEMNTFIDEGREKGGVLIHCRAGVSRSATATIAYIM
|||||||||||||||.|||||.||||||||||.||.||||||||||||||.|.|||||.|||.|||||.||||||||||||||||||||||||..|||.|
vpdliidklylgcresamnksilkdnnvthilavadfkplypdlfkyliidiedvdeadiyqhfkemnafidegrekggvlihcragvsrsatlviaylm

MKNSVKFQEAFDITIKGRSRIYPNRGFLNQLKKFEKD
.|||.||.||.|..||.|.|||||||||.||||||||
kknslkfkealdlvikkrpriypnrgfldqlkkfekd
Phosphatase mpl1.AA Subfamily.DSP19.PD 699-830 42 6.9e-43 136.1 In-house 5-138 (139) Show / Hide 
Range on Protein: 699-830
Range on HMM: 5-138/139
Sequence Identity: 42% (56 aa)

IIDKLYLGCRECAMNKSWLKDNNVTHILTVA-NFKPLYPDLFKYLIINIDDVDEANIYQYFKEMNTFIDEGREK-GGVLIHCRAGVSRSATATIAYIMMK
. ..||||  . |..|. || ...|||| || . . ..|. |.|. |.| |..|... .|.||.  ||.|.|.| | ||.||.|||||||.|||.| ...
vkprlylgsqdvaadkeilkklkitHilnvavgvpnvfpkdftyksieilDlpetkllsylkealdFieearskdgrvlvHCnAGvSRsasvviaylmkd

NSVKFQEAFDITIKGRSRIYPNRGFLNQLKKFEK
.....|..   . |  | || ||..|||..|.  
eelslekalekvrearpcikPneGFikqLkeyea
Phosphatase mpl1.AA Subfamily.DSP1.PD 696-830 44 6.5e-41 129.9 In-house 2-138 (139) Show / Hide 
Range on Protein: 696-830
Range on HMM: 2-138/139
Sequence Identity: 44% (61 aa)

PDLIIDKLYLGCRECAMNKSWLKDNNVTHILTVAN-FKPLYPDLFKYLIINIDDVDEANIYQYFKEMNTFIDEGREKGG-VLIHCRAGVSRSATATIAYI
|  |.| |||| .| | |.. ||. ..|..| |..  .  ...||||  |...| ..|.|...|.|.. |||. ..||| ||.||.||.|||||  .||.
pveildfLyLGsaehasnlqlLkelkitallnvsaelpnvfeelfkyksipvednkkadisslfeeaidfidsvkkkgGrvlvhCqaGisrsativlayL

MMKNSVKFQEAFDITIKGRSRIYPNRGFLNQLKKFEK
|... |...|||. . . || | || ||..|| .|||
mkekkvrleeafefvkqrrsiisPnfgfvgqLlefek
Phosphatase mpl1.AA Subfamily.DSP12.PD 699-830 38 2.4e-37 118.4 In-house 5-140 (143) Show / Hide 
Range on Protein: 699-830
Range on HMM: 5-140/143
Sequence Identity: 38% (52 aa)

IIDKLYLGCRECAMNKSWLKDNNVTHILTVANFK-PLYPDLFK--YLIINIDDVDEANIYQYFKEMNTFIDEGR-EKGGVLIHCRAGVSRSATATIAYIM
| ..|||| .| ..... ||. ..||.|.|.... | . .  .  .. |.|.| .|... ....|...||.||. ..| ||.|| ||||||.|. |||.|
ilpglylggleavqerellkelkithvlsvikeelpelqkekgvkskliqilDepeedlLshldeavrFieeglekegavlvHClagvSRSvtiviAYlm

MKNSVKFQEAFDITIKGRSRIYPNRGFLNQLKKFEK
 |. .....|...  . ...|.|| |||.||| |||
kkeklslekAlklvkekkkeiepNegFleQLklfek
Phosphatase mpl1.AA DSPc 695-831 33 7.8e-37 129.6 SMART 1-172 (172) Show / Hide 
Range on Protein: 695-831
Range on HMM: 1-172/172
Sequence Identity: 33% (57 aa)

VPDLIIDKLYLGCRECAM--NKSWLKDNNVTHILTVANFKP------------------LYPDLFKYLIIN-IDD-------VDEANIYQYFKEMNTFID
 |  |  .||||.  ..|  |.  || .|.||.. |....|                  . .  | |. |  |||        ...||.||| | . ||.
GPSEITPHLYLGSYPHHMEPNPCFLKKHNITHVINVTMECPWNFHHCQKNDMHYTNEWIYHNSHFQYMHIPMIDDIYYHIRWNHCTNISQYFPEVYDFIH

EGREKGG-VLIHCRAGVSRSATATIAYIMMKNSVKFQEAFDIT-----IKGR-SRIYPNRGFLNQLKKFEKD
. | ||| ||.||.||.||||| .|||.|.... . ..|...       . | . |.|| .|. ||. .|. 
DCRQKGGKVLVHCQAGISRSATLCIAYLMKYMNMSYNDAYHFVYIYHIKQRRCPIICPNFNFWHQLCEWERK
Phosphatase mpl1.AA Subfamily.DSP6.PD 698-830 39 1.8e-34 108.7 In-house 4-140 (141) Show / Hide 
Range on Protein: 698-830
Range on HMM: 4-140/141
Sequence Identity: 39% (53 aa)

LIIDKLYLGCRECAMNKSWLKDNNVTHILTVANF-KPLYP--DLFKYLIINIDDVDEANIYQYFKEMNTFIDEGREK-GGVLIHCRAGVSRSATATIAYI
|...||||... |.|   ||. .. ..| |..     .   . .||. | |.|. ..|. ..| |  .||||.|.|  .||.|| ||||||| |.||.| 
eilpllylGsakdasnlevlkklkikyvlnvtsnlpnkfeesgelkykqipiedhlsqnlakffPeaiefidearskkskvlvhclaGvsrsvtvtlayl

MMKNSVKFQEAFDITIKGRSRIYPNRGFLNQLKKFEK
|... ...|.|.  | .| | ||  |..||..||.  
mkklalslndaydlvkkkksnisPnfnfmgqlldfer
Phosphatase mpl1.AA Subfamily.DSP15.PD 699-830 39 3.6e-34 107.9 In-house 5-137 (138) Show / Hide 
Range on Protein: 699-830
Range on HMM: 5-137/138
Sequence Identity: 39% (53 aa)

IIDKLYLGCRECAMNKSWLKDNNVTHILTVA-NFKPLYPDlFKYLIINIDDVDEANIYQYFKEMNTFIDEGREKG-GVLIHCRAGVSRSATATIAYIMMK
..  ||.|  . | .|. |..|..||||..  . |||..| .||| |...|  . .. ..||| . || . | .|  ||.|| ||.||| |..||||   
vlpGlyvGnfrdakdkeqleenkithilsihdsakplled-ikylcikaadsPdqdlskffkesidfihkcrleggnvlvhclaGisrsvtlvvayimtv

NSVKFQEAFDITIKGRSRIYPNRGFLNQLKKFEK
......|. .   .||   || || .||..||| 
telswedalkavkaarsvanPnvGfrrqlqefek
Phosphatase mpl1.AA DSPc 703-831 33 7.7e-33 116.1 Pfam 1-151 (151) Show / Hide 
Range on Protein: 703-831
Range on HMM: 1-151/151
Sequence Identity: 33% (50 aa)

LYLGCRECAM-NKSWLKDNNVTHILTVANFKP----LYPDLFKYLIIN-IDD---------VDEANIYQYFKEMNTFIDEGREKGG-VLIHCRAGVSRSA
||||.  ..| ..  |. ...||.. ... .|      .  | |. |  ..|           ..||.||| .   |||  |.||| ||.||.||.||||
LYLGSYPHHMADPAFLQKHGITHVINCTMECPNNWFYHNSHFHYMWIPHVHDHIHYYHIHWNHCTNISQYFPMATDFIDDCRQKGGKVLVHCQAGISRSA

TATIAYIMMKNSVKFQEAFDIT-----IKGR-SRIYPNRGFLNQLKKFEKD
. .|||.|... .. .||.|.       . | . |.|| .|. ||  .|..
CLCIAYLMKYRNMSYNEAYDFVYIYHMKQRRCPMISPNMNFWRQLCEYERQ
Phosphatase mpl1.AA Subfamily.DSP10.PD 699-831 37 1.6e-31 99.3 In-house 5-141 (141) Show / Hide 
Range on Protein: 699-831
Range on HMM: 5-141/141
Sequence Identity: 37% (51 aa)

IIDKLYLGCRECAMNKSWLKDNNVTHILTVANFKPLYP---DLFKYLIINIDDVDEANIYQYFKEMNTFIDEGREKG-GVLIHCRAGVSRSATATIAYIM
|.  |.||  . | .|. |.  .....| |..  |..    .|..|  |.. | .. |. |.|.|   ||.| |..|  ||.||.||.||||| .|||.|
ilpflllGnekdaadkdaldrlgikyvlnvttsvPnffeekglvrykripvsdsgkqnlkqkfeealefieearkrgsrvlvhchaGisrsatvviayvm

MKNSVKFQEAFDITIKGRSRIYPNRGFLNQLKKFEKD
   |. ..||. .  . |  | || .|. || .|||.
khlslslseaykfvkekrPiisPnlnfmGqllefeke
Phosphatase mpl1.AA Subfamily.Slingshot.PD 698-829 42 2.6e-31 98.5 In-house 4-137 (139) Show / Hide 
Range on Protein: 698-829
Range on HMM: 4-137/139
Sequence Identity: 42% (57 aa)

LIIDKLYLGCRECAMNKSWLKDNNVTHILTVAN-FKPLYPDLFKYLIINIDDVDEANIYQYFKEMNTFIDEGREKG-GVLIHCRAGVSRSATATIAYIMM
| | ||||    | |   ||.|.|..|| |..  .  .|. |||| |.. | .|........|  .||.. .|||  ||.||. ||||||.. ||| | .
kifdhlylGsewnasnleelkengveyilnvtkeidnffpekfkylnirvydeeetdllkhwnetykfiekakekgskvlvhckmGvsrsastviayamk

KNSVKFQEAFDITIKGRSRIYPNRGFLNQLKKFE
 .....||..   . || | ||.|||.|||..| 
eyelsleealeyvkerrsiikpnkgflkqlkvye
Phosphatase mpl1.AA Subfamily.DSP3.PD 699-830 36 1.8e-30 96.0 In-house 5-147 (148) Show / Hide 
Range on Protein: 699-830
Range on HMM: 5-147/148
Sequence Identity: 36% (52 aa)

IIDKLYLGCRECAMNKSWLKDNNVTHILTVANFK---------PLYPD-LFKYLIINIDDVDEANIYQYFKEMNTFIDEG--REKGGVLIHCRAGVSRSA
. .|.|.| .. |..|. ||   .||.|  |. |           | |   ||| ....|| |... .||.|   ||||   ...| ||.||..|.||||
vypkvyvgdeavakdkekLkklGithvLnaaegkrllkvdtdaefYkdleikylGvevsDvpefdlskyfeeaadfidealsqkngkvlvhcvvGisRsa

TATIAYIMMKNSVKFQEAFDiTIKGRSRIYPNRGFLNQLKKFEK
|  .||.|...... .||   |.. .  |.||.|||.|| ....
tlvlayLmirrkltlkeaik-tvrkkreilPneGflkqLlelde
Phosphatase mpl1.AA Subfamily.DSP14.PD 699-830 36 4e-28 88.4 In-house 5-137 (138) Show / Hide 
Range on Protein: 699-830
Range on HMM: 5-137/138
Sequence Identity: 36% (49 aa)

IIDKLYLGcRECAMNKSWLKDNNVTHILTVANFKPLYP-DLFKYLIINIDDVDEANIYQYFKEMNTFIDEGREKGG-VLIHCRAGVSRSATATIAYIMMK
| ..|||.    |..|. || ...|.|. |.  .|  . . .|.. |...| .||.....|.|.   |.| ..||| .|.|| |||||||...||.|  .
itesLyls-gaaalkkeklkkkkitlivnvttelpetkledvktvkikveDkpeaklaehfdevadkieevkkkgGktlvhCvaGvsRsAslvlaylmky

NSVKFQEAFDITIKGRSRIYPNRGFLNQLKKFEK
..  .||. .. . |. | || || .|| ..|| 
eklsLreayklvksaRpiirPnvGFwkqlidyEk
Phosphatase mpl1.AA Subfamily.DSP8.PD 696-832 35 1.3e-27 86.8 In-house 2-142 (143) Show / Hide 
Range on Protein: 696-832
Range on HMM: 2-142/143
Sequence Identity: 35% (50 aa)

PDLIIDKLYLGCRECAMNKSWLKDNNVTHILTVANFKPLYPDLF---KYLIINIDDVDEANIYQYFKEMNTFIDEGREK-GGVLIHCRAGVSRSATATIA
|  |...||||... ..... ||.......| ...  |  ..|    ..| | . |  | .. ..|..   |||  |.. | ||.|| || |||||  ||
ptrilpnlylGsqkdsldeellkklgisyvlnisescpkdvellkesrflriPvkDkyeekllpwfdkalefidkarsangkvlvhclaGisrsatvaia

YIMMKNSVKFQEAFDITIKGRSRIYPNRGFLNQLKKFEKDL
||| . .....||.    . |. | ||  ||.|| ..||.|
yimktlemsldeayrfvkekrptispnlnflgqLleyekel
Phosphatase mpl1.AA Subfamily.STYX.PD 699-829 41 9.4e-27 83.9 In-house 5-144 (146) Show / Hide 
Range on Protein: 699-829
Range on HMM: 5-144/146
Sequence Identity: 41% (58 aa)

IIDKLYLGCRECAMNK--SWLKDNNVTHILTV-----AN-FKPLYPDLFKYLIINIDDVDEANIYQYFKEMNTFIDEGREKGG-VLIHCRAGVSRSATAT
|.  |.||   .||.     ||.. .|||. .     ||  || .|| |.||.... |    || .|. ....|||.  .||| ||.|  ||.||||.  
ilpglflgpysaamksklevlkehgithivcirqnieanlikpnfpdrfrylvldvadntveniirylptvkefiddslqkggkvlvhgnagisrsaalv

IAYIMMKNSVKFQEAFDITIKGRSRIYPNRGFLNQLKKFE
|||||    .|..|||    . |  | || || .|||..|
iayimetyglkyreafayvqerrfcinpnegfvsqlkeye
Phosphatase mpl1.AA Subfamily.STYXL1.PD 699-831 32 2.6e-25 79.6 In-house 6-143 (143) Show / Hide 
Range on Protein: 699-831
Range on HMM: 6-143/143
Sequence Identity: 32% (45 aa)

IIDKLYLGCRECAMNKSWLKDNNVTHILTVANF-KPLY---PDLFKYLIINIDDVDEANIYQYFKEMNTFIDEGREKG-GVLIHCRAGVSRSATATIAYI
. .|||||  . |.|..  ||  |   . |..  ..|.   .|  | | |...|..||.. . .||.  ||.. ...|  ||.    |.||||.. |||.
lPgklylGnykqaqnpaikkdlkvkahvnvssdaekliagladvakllhiavedeneadllerlkevvqfiekhkkegevvlvfsnkGisrsaaviiayl

MMKNSVKFQEAFDITIKGRSRIYPNRGFLNQLKKFEKD
| .. .....|..   | .. . |||.|..||...||.
myskkitlkkaykylkkckenvkPnrafveqlseWekq
Phosphatase mpl1.AA Subfamily.PTPMT1.PD 740-830 30 2.9e-14 43.3 In-house 54-145 (146) Show / Hide 
Range on Protein: 740-830
Range on HMM: 54-145/146
Sequence Identity: 30% (28 aa)

KYLIINIDDVDEANIYQYFKEMNTFIDEGREKG-GVLIHCRAGVSRSATATIAYIMMKNSVKFQEAFDITIKGRSRIYPNRGFLNQLKKFEK
..| . . |. ||   .. .|  .||.. ..||  | .||.|| .||||  ..|.|.|. .. .|| ..  | |. |  .   .. |..|..
eqlqlatvDfteapslekleegvefiekvaskgssvYvHCkAGrtRsatlvacylmkkkklspeeavkflkkkRpqirlkskqwralqefke
Phosphatase mpl1.AA Subfamily.PTEN.PD 757-808 26 2.6e-06 17.2 In-house 81-132 (305) Show / Hide 
Range on Protein: 757-808
Range on HMM: 81-132/305
Sequence Identity: 26% (13 aa)

YFKEMNTFIDEGREKgGVLIHCRAGVSRSATATIAYIMMKNSVKFQ-EAFDIT
........| ...  | .||.||  |. . . ||.....  | . || .|   
ivedvdkwLkedksn-VvavHCkaGkGRtGvmicayLlksgikksadealaiy
Phosphatase mpl1.AA Subfamily.CDC14.PD 769-803 25 6.2e-06 16.3 In-house 196-230 (258) Show / Hide 
Range on Protein: 769-803
Range on HMM: 196-230/258
Sequence Identity: 25% (9 aa)

REKGGVLIHCRAGVSRSATATIAYIMMKNSVKFQE
. .| . .||.||. | .|   .|.. .  .. .|
kaeGaiavhCkaGLGrtgtligcylikhyrftaae
Sequence
Name Sequence Type Origin Length Description Download
mpl1.AA Protein None 834 None Fasta, JSON
mpl1.NA RNA None 2505 None Fasta, JSON
mpl1.AA.PD_695-831 Protein Phosphatase Domain None 137 None Fasta, JSON