Gene mpl2
mpl2
Species: D.discoideum
Alias: mpl2, DDB_G0270688
External Links:
Classification
Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.
Protein domain
Protein domains of mpl2.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit phosphatase group/family/subfamily, which is helpful to understand the relationship between phosphatases. Transmembrane region is predicted by TMHMM 2.0. Visualized by pviz.
Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking. View complete domain list.
| Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
|---|---|---|---|---|---|---|---|---|---|
| Phosphatase | mpl2.AA | Family.DSP.PD | 494-693 | 28 | 4e-34 | 108.7 | In-house | 45-247 (387) | Show / Hide |
Range on Protein: 494-693 Range on HMM: 45-247/387 Sequence Identity: 28% (58 aa) QLPQSKPENEKLTNiPEQQQKQQQQQQQQEVQQPIITLTKSTSSKVEVEMIVPNQLIFWQSIVPDLIIDKLYLGCRECAMNKSWLKDNNVTHILTVANFK .| . ||.. .. . . ... . . ..... .. ....... ... .. . . | |...|||| . | |. |||...||.|. .. | cldtvkpkfapfrd-asyapvlaklhvryvisgakqaelngfidvhtfdldtydhfervengkpseilphlylgsllaaknlewlkelgvtkivnltddk PL--YPDLFKYLIINIEDVDEANIYQHFKEMNAFIDEGR-EKGGVLIHCRAGVSRSASATMAFIMMKNSLKFQEAFDITIKGRP-RIYPNIGFINQLKKF | . .||| |.|.| . .. ..| . ||.||. .|| ||.|| ||..||.. ..|..| .. |...||.| . || | || ||. |||.. pqftkelgikylripidDhnapplenlfekaidfieegndskgvVlVHCkaGkgRsgtliiaYlmksegltleealdwvrskRpgvitpnqgflkqlkdl EKDL || . ekek |
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| Phosphatase | mpl2.AA | Subfamily.LRR-DSP.PD | 556-692 | 84 | 2.7e-85 | 273.3 | In-house | 1-137 (137) | Show / Hide |
Range on Protein: 556-692 Range on HMM: 1-137/137 Sequence Identity: 84% (116 aa) VPDLIIDKLYLGCRECAMNKSWLKDNNVTHILTVANFKPLYPDLFKYLIINIEDVDEANIYQHFKEMNAFIDEGREKGGVLIHCRAGVSRSASATMAFIM |||||||||||||||.|||||.||||||||||.||.||||||||||||||.|||||||.|||||||||||||||||||||||||||||||||....|..| vpdliidklylgcresamnksilkdnnvthilavadfkplypdlfkyliidiedvdeadiyqhfkemnafidegrekggvlihcragvsrsatlviaylm MKNSLKFQEAFDITIKGRPRIYPNIGFINQLKKFEKD .||||||.||.|..||.|||||||.||..|||||||| kknslkfkealdlvikkrpriypnrgfldqlkkfekd |
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| Phosphatase | mpl2.AA | Subfamily.DSP19.PD | 560-691 | 43 | 2.8e-43 | 137.3 | In-house | 5-138 (139) | Show / Hide |
Range on Protein: 560-691 Range on HMM: 5-138/139 Sequence Identity: 43% (57 aa) IIDKLYLGCRECAMNKSWLKDNNVTHILTVA-NFKPLYPDLFKYLIINIEDVDEANIYQHFKEMNAFIDEGREK-GGVLIHCRAGVSRSASATMAFIMMK . ..|||| . |..|. || ...|||| || . . ..|. |.|. |.| |..|... ...||. ||.|.|.| | ||.||.||||||||.|..| ... vkprlylgsqdvaadkeilkklkitHilnvavgvpnvfpkdftyksieilDlpetkllsylkealdFieearskdgrvlvHCnAGvSRsasvviaylmkd NSLKFQEAFDITIKGRPRIYPNIGFINQLKKFEK |....|.. . || | || |||.|||..|. eelslekalekvrearpcikPneGFikqLkeyea |
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| Phosphatase | mpl2.AA | Subfamily.DSP1.PD | 557-691 | 42 | 1.1e-39 | 125.9 | In-house | 2-138 (139) | Show / Hide |
Range on Protein: 557-691 Range on HMM: 2-138/139 Sequence Identity: 42% (58 aa) PDLIIDKLYLGCRECAMNKSWLKDNNVTHILTVAN-FKPLYPDLFKYLIINIEDVDEANIYQHFKEMNAFIDEGREKGG-VLIHCRAGVSRSASATMAFI | |.| |||| .| | |.. ||. ..|..| |.. . ...|||| |..|| ..|.|...|.|.. |||. ..||| ||.||.||.||||. .|.. pveildfLyLGsaehasnlqlLkelkitallnvsaelpnvfeelfkyksipvednkkadisslfeeaidfidsvkkkgGrvlvhCqaGisrsativlayL MMKNSLKFQEAFDITIKGRPRIYPNIGFINQLKKFEK |... ....|||. . . | | ||.||..|| .||| mkekkvrleeafefvkqrrsiisPnfgfvgqLlefek |
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| Phosphatase | mpl2.AA | Subfamily.DSP12.PD | 560-691 | 36 | 1.5e-36 | 115.8 | In-house | 5-140 (143) | Show / Hide |
Range on Protein: 560-691 Range on HMM: 5-140/143 Sequence Identity: 36% (50 aa) IIDKLYLGCRECAMNKSWLKDNNVTHILTVANFK-PLYPDLFK--YLIINIEDVDEANIYQHFKEMNAFIDEGR-EKGGVLIHCRAGVSRSASATMAFIM | ..|||| .| ..... ||. ..||.|.|.... | . . . .. |.| | .|... .|..|...||.||. ..| ||.|| ||||||... .|..| ilpglylggleavqerellkelkithvlsvikeelpelqkekgvkskliqilDepeedlLshldeavrFieeglekegavlvHClagvSRSvtiviAYlm MKNSLKFQEAFDITIKGRPRIYPNIGFINQLKKFEK |. |....|... . ...|.|| ||..||| ||| kkeklslekAlklvkekkkeiepNegFleQLklfek |
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| Phosphatase | mpl2.AA | DSPc | 556-692 | 30 | 3.8e-36 | 127.31 | SMART | 1-172 (172) | Show / Hide |
Range on Protein: 556-692 Range on HMM: 1-172/172 Sequence Identity: 30% (53 aa) VPDLIIDKLYLGCRECAM--NKSWLKDNNVTHILTVANFKP------------------LYPDLFKYLIIN-IED-------VDEANIYQHFKEMNAFID | | .||||. ..| |. || .|.||.. |....| . . | |. | |.| ...||.|.| | ..||. GPSEITPHLYLGSYPHHMEPNPCFLKKHNITHVINVTMECPWNFHHCQKNDMHYTNEWIYHNSHFQYMHIPMIDDIYYHIRWNHCTNISQYFPEVYDFIH EGREKGG-VLIHCRAGVSRSASATMAFIMMKNSLKFQEAFDIT-----IKGR-PRIYPNIGFINQLKKFEKD . | ||| ||.||.||.||||. ..|..|...... ..|... . | | |.||..|. ||. .|. DCRQKGGKVLVHCQAGISRSATLCIAYLMKYMNMSYNDAYHFVYIYHIKQRRCPIICPNFNFWHQLCEWERK |
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| Phosphatase | mpl2.AA | Subfamily.DSP6.PD | 559-691 | 38 | 3.5e-33 | 104.4 | In-house | 4-140 (141) | Show / Hide |
Range on Protein: 559-691 Range on HMM: 4-140/141 Sequence Identity: 38% (52 aa) LIIDKLYLGCRECAMNKSWLKDNNVTHILTVANF-KPLYP--DLFKYLIINIEDVDEANIYQHFKEMNAFIDEGREK-GGVLIHCRAGVSRSASATMAFI |...||||... |.| ||. .. ..| |.. . . .||. | |||. ..|. ..| | .||||.|.| .||.|| ||||||. |.|..| eilpllylGsakdasnlevlkklkikyvlnvtsnlpnkfeesgelkykqipiedhlsqnlakffPeaiefidearskkskvlvhclaGvsrsvtvtlayl MMKNSLKFQEAFDITIKGRPRIYPNIGFINQLKKFEK |..| ...|.|. | .. | || |..||..||. mkklalslndaydlvkkkksnisPnfnfmgqlldfer |
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| Phosphatase | mpl2.AA | DSPc | 564-692 | 31 | 7.4e-33 | 116.17 | Pfam | 1-151 (151) | Show / Hide |
Range on Protein: 564-692 Range on HMM: 1-151/151 Sequence Identity: 31% (48 aa) LYLGCRECAM-NKSWLKDNNVTHILTVANFKP----LYPDLFKYLIIN-IED---------VDEANIYQHFKEMNAFIDEGREKGG-VLIHCRAGVSRSA ||||. ..| .. |. ...||.. ... .| . | |. | ..| ..||.|.| . .||| |.||| ||.||.||.|||| LYLGSYPHHMADPAFLQKHGITHVINCTMECPNNWFYHNSHFHYMWIPHVHDHIHYYHIHWNHCTNISQYFPMATDFIDDCRQKGGKVLVHCQAGISRSA SATMAFIMMKNSLKFQEAFDIT-----IKGR-PRIYPNIGFINQLKKFEKD . ..|..|... .. .||.|. . | | |.||..|. || .|.. CLCIAYLMKYRNMSYNEAYDFVYIYHMKQRRCPMISPNMNFWRQLCEYERQ |
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| Phosphatase | mpl2.AA | Subfamily.DSP15.PD | 560-691 | 38 | 1.3e-32 | 102.8 | In-house | 5-137 (138) | Show / Hide |
Range on Protein: 560-691 Range on HMM: 5-137/138 Sequence Identity: 38% (51 aa) IIDKLYLGCRECAMNKSWLKDNNVTHILTVA-NFKPLYPDlFKYLIINIEDVDEANIYQHFKEMNAFIDEGREKG-GVLIHCRAGVSRSASATMAFIMMK .. ||.| . | .|. |..|..||||.. . |||..| .||| |...| . .. ..||| . || . | .| ||.|| ||.||| ...|.|| vlpGlyvGnfrdakdkeqleenkithilsihdsakplled-ikylcikaadsPdqdlskffkesidfihkcrleggnvlvhclaGisrsvtlvvayimtv NSLKFQEAFDITIKGRPRIYPNIGFINQLKKFEK .|....|. . .|. ||.|| .||..||| telswedalkavkaarsvanPnvGfrrqlqefek |
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| Phosphatase | mpl2.AA | Subfamily.DSP10.PD | 560-692 | 36 | 5.3e-32 | 100.8 | In-house | 5-141 (141) | Show / Hide |
Range on Protein: 560-692 Range on HMM: 5-141/141 Sequence Identity: 36% (50 aa) IIDKLYLGCRECAMNKSWLKDNNVTHILTVANFKPLYP---DLFKYLIINIEDVDEANIYQHFKEMNAFIDEGREKG-GVLIHCRAGVSRSASATMAFIM |. |.|| . | .|. |. .....| |.. |.. .|..| |...| .. |. |.|.| .||.| |..| ||.||.||.|||| ..|..| ilpflllGnekdaadkdaldrlgikyvlnvttsvPnffeekglvrykripvsdsgkqnlkqkfeealefieearkrgsrvlvhchaGisrsatvviayvm MKNSLKFQEAFDITIKGRPRIYPNIGFINQLKKFEKD || ..||. . . || | ||..|. || .|||. khlslslseaykfvkekrPiisPnlnfmGqllefeke |
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| Phosphatase | mpl2.AA | Subfamily.Slingshot.PD | 559-690 | 42 | 3e-30 | 95.0 | In-house | 4-137 (139) | Show / Hide |
Range on Protein: 559-690 Range on HMM: 4-137/139 Sequence Identity: 42% (56 aa) LIIDKLYLGCRECAMNKSWLKDNNVTHILTVAN-FKPLYPDLFKYLIINIEDVDEANIYQHFKEMNAFIDEGREKG-GVLIHCRAGVSRSASATMAFIMM | | |||| | | ||.|.|..|| |.. . .|. |||| |.. | .|.....|..| ||.. .||| ||.||. |||||||. .|. | . kifdhlylGsewnasnleelkengveyilnvtkeidnffpekfkylnirvydeeetdllkhwnetykfiekakekgskvlvhckmGvsrsastviayamk KNSLKFQEAFDITIKGRPRIYPNIGFINQLKKFE .|...||.. . | | || ||..|||..| eyelsleealeyvkerrsiikpnkgflkqlkvye |
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| Phosphatase | mpl2.AA | Subfamily.DSP14.PD | 560-691 | 39 | 2.2e-29 | 92.5 | In-house | 5-137 (138) | Show / Hide |
Range on Protein: 560-691 Range on HMM: 5-137/138 Sequence Identity: 39% (53 aa) IIDKLYLGcRECAMNKSWLKDNNVTHILTVANFKPLYP-DLFKYLIINIEDVDEANIYQHFKEMNAFIDEGREKGG-VLIHCRAGVSRSASATMAFIMMK | ..|||. |..|. || ...|.|. |. .| . . .|.. |..|| .||....||.|. . |.| ..||| .|.|| ||||||||..|..| . itesLyls-gaaalkkeklkkkkitlivnvttelpetkledvktvkikveDkpeaklaehfdevadkieevkkkgGktlvhCvaGvsRsAslvlaylmky NSLKFQEAFDITIKGRPRIYPNIGFINQLKKFEK .| .||. .. . || | || || .|| ..|| eklsLreayklvksaRpiirPnvGFwkqlidyEk |
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| Phosphatase | mpl2.AA | Subfamily.DSP3.PD | 560-691 | 34 | 1.2e-27 | 86.8 | In-house | 5-147 (148) | Show / Hide |
Range on Protein: 560-691 Range on HMM: 5-147/148 Sequence Identity: 34% (49 aa) IIDKLYLGCRECAMNKSWLKDNNVTHILTVANFK---------PLYPD-LFKYLIINIEDVDEANIYQHFKEMNAFIDEG--REKGGVLIHCRAGVSRSA . .|.|.| .. |..|. || .||.| |. | | | ||| ....|| |... ..|.| |||| ...| ||.||..|.|||| vypkvyvgdeavakdkekLkklGithvLnaaegkrllkvdtdaefYkdleikylGvevsDvpefdlskyfeeaadfidealsqkngkvlvhcvvGisRsa SATMAFIMMKNSLKFQEAFDiTIKGRPRIYPNIGFINQLKKFEK .|..|....|. .|| |.. . |.|| ||..|| .... tlvlayLmirrkltlkeaik-tvrkkreilPneGflkqLlelde |
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| Phosphatase | mpl2.AA | Subfamily.DSP8.PD | 557-693 | 33 | 3.8e-27 | 85.2 | In-house | 2-142 (143) | Show / Hide |
Range on Protein: 557-693 Range on HMM: 2-142/143 Sequence Identity: 33% (47 aa) PDLIIDKLYLGCRECAMNKSWLKDNNVTHILTVANFKPLYPDLF---KYLIINIEDVDEANIYQHFKEMNAFIDEGREK-GGVLIHCRAGVSRSASATMA | |...||||... ..... ||.......| ... | ..| ..| | ..| | .. ..|.. ||| |.. | ||.|| || ||||. .| ptrilpnlylGsqkdsldeellkklgisyvlnisescpkdvellkesrflriPvkDkyeekllpwfdkalefidkarsangkvlvhclaGisrsatvaia FIMMKNSLKFQEAFDITIKGRPRIYPNIGFINQLKKFEKDL .|| . .....||. . || | ||. |..|| ..||.| yimktlemsldeayrfvkekrptispnlnflgqLleyekel |
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| Phosphatase | mpl2.AA | Subfamily.STYX.PD | 560-690 | 40 | 1.3e-25 | 80.2 | In-house | 5-144 (146) | Show / Hide |
Range on Protein: 560-690 Range on HMM: 5-144/146 Sequence Identity: 40% (56 aa) IIDKLYLGCRECAMNK--SWLKDNNVTHILTV-----AN-FKPLYPDLFKYLIINIEDVDEANIYQHFKEMNAFIDEGREKGG-VLIHCRAGVSRSASAT |. |.|| .||. ||.. .|||. . || || .|| |.||.... | || ... ....|||. .||| ||.| ||.||||. ilpglflgpysaamksklevlkehgithivcirqnieanlikpnfpdrfrylvldvadntveniirylptvkefiddslqkggkvlvhgnagisrsaalv MAFIMMKNSLKFQEAFDITIKGRPRIYPNIGFINQLKKFE .|.|| ||..||| . | | || ||..|||..| iayimetyglkyreafayvqerrfcinpnegfvsqlkeye |
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| Phosphatase | mpl2.AA | Subfamily.STYXL1.PD | 560-692 | 31 | 1.2e-23 | 74.1 | In-house | 6-143 (143) | Show / Hide |
Range on Protein: 560-692 Range on HMM: 6-143/143 Sequence Identity: 31% (43 aa) IIDKLYLGCRECAMNKSWLKDNNVTHILTVANF-KPLY---PDLFKYLIINIEDVDEANIYQHFKEMNAFIDEGREKG-GVLIHCRAGVSRSASATMAFI . .||||| . |.|.. || | . |.. ..|. .| | | |..||..||.. ...||. ||.. ...| ||. |.||||.. .|.. lPgklylGnykqaqnpaikkdlkvkahvnvssdaekliagladvakllhiavedeneadllerlkevvqfiekhkkegevvlvfsnkGisrsaaviiayl MMKNSLKFQEAFDITIKGRPRIYPNIGFINQLKKFEKD | .. .....|.. | .. . || .|..||...||. myskkitlkkaykylkkckenvkPnrafveqlseWekq |
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| Phosphatase | mpl2.AA | Subfamily.PTPMT1.PD | 601-691 | 30 | 7.4e-13 | 38.7 | In-house | 54-145 (146) | Show / Hide |
Range on Protein: 601-691 Range on HMM: 54-145/146 Sequence Identity: 30% (28 aa) KYLIINIEDVDEANIYQHFKEMNAFIDEGREKG-GVLIHCRAGVSRSASATMAFIMMKNSLKFQEAFDITIKGRPRIYPNIGFINQLKKFEK ..| . . |. || .. .| ||.. ..|| | .||.|| .|||. ...|.|. |. .|| .. | || | . .. |..|.. eqlqlatvDfteapslekleegvefiekvaskgssvYvHCkAGrtRsatlvacylmkkkklspeeavkflkkkRpqirlkskqwralqefke |
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