Gene mpl3
mpl3
Species: D.discoideum
Alias: DDB_G0278445, mpl3
External Links:
Classification
Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.
Protein domain
Protein domains of mpl3.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit phosphatase group/family/subfamily, which is helpful to understand the relationship between phosphatases. Transmembrane region is predicted by TMHMM 2.0. Visualized by pviz.
Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking. View complete domain list.
| Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
|---|---|---|---|---|---|---|---|---|---|
| Phosphatase | mpl3.AA | Family.DSP.PD | 626-780 | 40 | 1e-37 | 121.0 | In-house | 100-256 (387) | Show / Hide |
Range on Protein: 626-780 Range on HMM: 100-256/387 Sequence Identity: 40% (62 aa) MTLVTSIPSEIIPGIFLGGLDSANNAPILQTLGITHILLAIGDcEPFFPK--TFKYYSIdDARDAPQYDISQHFEQTNCFIESGR-KSGGVLVHCRAGIS . . ||||.|...||.|. |.| . |..||.|.|. . | .| | | .||. | | .. .....||. |||.|. ..| |||||||..|| ervengkpseilphlylgsllaaknlewlkelgvtkivnltdd-kpqftkelgikylri-pidDhnapplenlfekaidfieegndskgvVlVHCkaGkg RSSTLVISYLMKYQRMTFKQAMDLVQSKRP-QIQPNPGFKDQLLKYEAKLFCTNILNIS ||.| ||||....|...|.|.|.|||| .|.|| ||. || ..| .. .. . RsgtliiaYlmksegltleealdwvrskRpgvitpnqgflkqlkdlekeklkvssevme |
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| Phosphatase | mpl3.AA | Subfamily.LRR-DSP.PD | 632-770 | 52 | 8.1e-76 | 243.0 | In-house | 1-137 (137) | Show / Hide |
Range on Protein: 632-770 Range on HMM: 1-137/137 Sequence Identity: 52% (73 aa) IPSEIIPGIFLGGLDSANNAPILQTLGITHIlLAIGDCEPFFPKTFKYYSIdDARDAPQYDISQHFEQTNCFIESGRKSGGVLVHCRAGISRSSTLVISY .|..||....||...||.|..||.....||| ||..|..|..|..|||..| |..|....||.|||...|.||..||..||||.|||||.|||.||||.| vpdliidklylgcresamnksilkdnnvthi-lavadfkplypdlfkylii-diedvdeadiyqhfkemnafidegrekggvlihcragvsrsatlviay LMKYQRMTFKQAMDLVQSKRPQIQPNPGFKDQLLKYEAK |||.....||.|.|||..|||.|.||.||.|||.|.|.. lmkknslkfkealdlvikkrpriypnrgfldqlkkfekd |
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| Phosphatase | mpl3.AA | DSPc | 632-770 | 33 | 1.4e-42 | 148.65 | SMART | 1-172 (172) | Show / Hide |
Range on Protein: 632-770 Range on HMM: 1-172/172 Sequence Identity: 33% (58 aa) IPSEIIPGIFLGGLDSAN--NAPILQTLGITHILLAIGDCEP-----------------FFPKTFKYYSIDDARD-------APQYDISQHFEQTNCFIE |||| |...||. ... |.. |. ..|||.. .. |.. ... | | .| | .. .|||.|.... ||. GPSEITPHLYLGSYPHHMEPNPCFLKKHNITHVINVTMECPWNFHHCQKNDMHYTNEWIYHNSHFQYMHIPMIDDIYYHIRWNHCTNISQYFPEVYDFIH SGRKSGG-VLVHCRAGISRSSTLVISYLMKYQRMTFKQAMDLV-----QSKR-PQIQPNPGFKDQLLKYEAK . |..|| |||||.|||||| ||.| |||||. |. |...| ...| |.|.|| .|. ||. .| | DCRQKGGKVLVHCQAGISRSATLCIAYLMKYMNMSYNDAYHFVYIYHIKQRRCPIICPNFNFWHQLCEWERK |
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| Phosphatase | mpl3.AA | Subfamily.DSP19.PD | 635-769 | 42 | 8.2e-42 | 132.9 | In-house | 4-138 (139) | Show / Hide |
Range on Protein: 635-769 Range on HMM: 4-138/139 Sequence Identity: 42% (58 aa) EIIPGIFLGGLDSANNAPILQTLGITHILLAIGDCEPFFPKTFKYYSIDdARDAPQYDISQHFEQTNCFIESGRKS-GGVLVHCRAGISRSSTLVISYLM |. | ..|| |.|.. ||..|.||||| . . .||| |.| ||. | |. .. ...... |||..|.. | |||||.||.|||...||.||| evkprlylgsqdvaadkeilkklkitHilnvavgvpnvfpkdftyksie-ilDlpetkllsylkealdFieearskdgrvlvHCnAGvSRsasvviaylm KYQRMTFKQAMDLVQSKRPQIQPNPGFKDQLLKYEA | .......|.. |...|| |.|| || || .||| kdeelslekalekvrearpcikPneGFikqLkeyea |
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| Phosphatase | mpl3.AA | Subfamily.DSP1.PD | 633-769 | 43 | 5.8e-41 | 130.4 | In-house | 2-138 (139) | Show / Hide |
Range on Protein: 633-769 Range on HMM: 2-138/139 Sequence Identity: 43% (59 aa) PSEIIPGIFLGGLDSANNAPILQTLGITHILLAIGDCEPFFPKTFKYYSIDdARDAPQYDISQHFEQTNCFIESGRKSGG-VLVHCRAGISRSSTLVISY |.||.. ..||. .| | .|..|.||..| .... |...|||.|| | .. |||..||. . ||.| .|.|| |||||.||||||.|.|. | pveildfLyLGsaehasnlqlLkelkitallnvsaelpnvfeelfkyksip-vednkkadisslfeeaidfidsvkkkgGrvlvhCqaGisrsativlay LMKYQRMTFKQAMDLVQSKRPQIQPNPGFKDQLLKYEA ||| .......| . |...| |.|| || |||..| LmkekkvrleeafefvkqrrsiisPnfgfvgqLlefek |
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| Phosphatase | mpl3.AA | Subfamily.DSP12.PD | 635-769 | 41 | 7.2e-38 | 120.5 | In-house | 4-140 (143) | Show / Hide |
Range on Protein: 635-769 Range on HMM: 4-140/143 Sequence Identity: 41% (57 aa) EIIPGIFLGGLDSANNAPILQTLGITHILLAIGDCEPFFPKTFKYYS-IDDARDAPQYDISQHFEQTNCFIESGR-KSGGVLVHCRAGISRSSTLVISYL || ||..||||. ... |..| |||.| | | . |. .. | .. | |. |. .|..... |||.|. | | ||||| ||.|||.|.|| || eilpglylggleavqerellkelkithvlsvikeelpelqkekgvkskliqilDepeedlLshldeavrFieeglekegavlvHClagvSRSvtiviAYl MKYQRMTFKQAMDLVQSKRPQIQPNPGFKDQLLKYEA ||.... ...|..||..|...|.|| || .|| .|. mkkeklslekAlklvkekkkeiepNegFleQLklfek |
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| Phosphatase | mpl3.AA | Subfamily.DSP10.PD | 634-769 | 39 | 6.5e-35 | 110.7 | In-house | 3-140 (141) | Show / Hide |
Range on Protein: 634-769 Range on HMM: 3-140/141 Sequence Identity: 39% (54 aa) SEIIPGIFLGGLDSANNAPILQTLGITHILLAIGDCEPFFPKTFKY-YSIDDARDAPQYDISQHFEQTNCFIESGRKSG-GVLVHCRAGISRSSTLVISY |.|.| ..|| |.. .|. |||...| . || . . | ...|... ...|.||.. ||| || | |||||.||||||.|.||.| ssilpflllGnekdaadkdaldrlgikyvlnvttsvPnffeekglvrykripvsdsgkqnlkqkfeealefieearkrgsrvlvhchaGisrsatvviay LMKYQRMTFKQAMDLVQSKRPQIQPNPGFKDQLLKYEA .||. ......| .|..||| | || .| |||..| vmkhlslslseaykfvkekrPiisPnlnfmGqllefek |
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| Phosphatase | mpl3.AA | DSPc | 640-770 | 35 | 8.9e-35 | 122.85 | Pfam | 1-151 (151) | Show / Hide |
Range on Protein: 640-770 Range on HMM: 1-151/151 Sequence Identity: 35% (54 aa) IFLGGLDSAN-NAPILQTLGITHILLAIGDCEP---FFPKTFKYYSIDDARD---------APQYDISQHFEQTNCFIESGRKSGG-VLVHCRAGISRSS ..||. ... . ..|| .||||.. .. | . . .. | | .| | .. .|||.|.. ||.. |..|| |||||.|||||| LYLGSYPHHMADPAFLQKHGITHVINCTMECPNNWFYHNSHFHYMWIPHVHDHIHYYHIHWNHCTNISQYFPMATDFIDDCRQKGGKVLVHCQAGISRSA TLVISYLMKYQRMTFKQAMDLV-----QSKR-PQIQPNPGFKDQLLKYEAK .|.| |||||..|. . |.|.| ...| |.| ||..|. ||. || . CLCIAYLMKYRNMSYNEAYDFVYIYHMKQRRCPMISPNMNFWRQLCEYERQ |
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| Phosphatase | mpl3.AA | Subfamily.DSP15.PD | 635-769 | 37 | 3.9e-34 | 108.1 | In-house | 4-137 (138) | Show / Hide |
Range on Protein: 635-769 Range on HMM: 4-137/138 Sequence Identity: 37% (50 aa) EIIPGIFLGGLDSANNAPILQTLGITHILLAIGDCEPFFPKtFKYYSIDdARDAPQYDISQHFEQTNCFIESGRK-SGGVLVHCRAGISRSSTLVISYLM ...||...|.. |... |. ||||| . .|.... .|| | | |.|. |.|..|.... || . | | ||||| |||||||||..|.| kvlpGlyvGnfrdakdkeqleenkithilsihdsakplled-ikylcik-aadsPdqdlskffkesidfihkcrleggnvlvhclaGisrsvtlvvayim KYQRMTFKQAMDLVQSKRPQIQPNPGFKDQLLKYEA .....|. |.. |. .|| ||. || ..| tvtelswedalkavkaarsvanPnvGfrrqlqefek |
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| Phosphatase | mpl3.AA | Subfamily.DSP3.PD | 635-769 | 37 | 5e-33 | 104.7 | In-house | 4-147 (148) | Show / Hide |
Range on Protein: 635-769 Range on HMM: 4-147/148 Sequence Identity: 37% (55 aa) EIIPGIFLGGLDSANNAPILQTLGITHILLAIGDCE--------PFFPK-TFKYYSIdDARDAPQYDISQHFEQTNCFIESG--RKSGGVLVHCRAGISR |. |....|. ..|.. |..|||||.| | ... |. . || . ...|.|. |.|..||. ||.. .|.| |||||..|||| evypkvyvgdeavakdkekLkklGithvLnaaegkrllkvdtdaefYkdleikylGv-evsDvpefdlskyfeeaadfidealsqkngkvlvhcvvGisR SSTLVISYLMKYQRMTFKQAMDLVQSKRpQIQPNPGFKDQLLKYEA |.|||..||| ....| |.|. |..|| .|.|| || |||... satlvlayLmirrkltlkeaiktvrkkr-eilPneGflkqLlelde |
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| Phosphatase | mpl3.AA | Subfamily.DSP14.PD | 634-770 | 37 | 9.1e-33 | 103.8 | In-house | 3-138 (138) | Show / Hide |
Range on Protein: 634-770 Range on HMM: 3-138/138 Sequence Identity: 37% (52 aa) SEIIPGIFLGgLDSANNAPILQTLGITHILLAIGDCEPFFPKTFKYYSIDdARDAPQYDISQHFEQTNCFIESGRKSGG-VLVHCRAGISRSSTLVISYL ||| . ..|. .|.. |. .||.|. .. . . .|. | .|.|. ....||... ||. .|.|| .|||| ||.||| .||. || seitesLyls-gaaalkkeklkkkkitlivnvttelpetkledvktvkik-veDkpeaklaehfdevadkieevkkkgGktlvhCvaGvsRsAslvlayl MKYQRMTFKQAMDLVQSKRPQIQPNPGFKDQLLKYEAK |||.... ..| ||.|.||.|.||.|| || .|| | mkyeklsLreayklvksaRpiirPnvGFwkqlidyEkk |
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| Phosphatase | mpl3.AA | Subfamily.DSP6.PD | 633-769 | 35 | 8.1e-32 | 100.4 | In-house | 2-140 (141) | Show / Hide |
Range on Protein: 633-769 Range on HMM: 2-140/141 Sequence Identity: 35% (49 aa) PSEIIPGIFLGGLDSANNAPILQTLGITHILLAIGDCEPFFPK--TFKYYSIDdARDAPQYDISQHFEQTNCFIESGRK-SGGVLVHCRAGISRSSTLVI | ||.| ..|| ..|.| .|. |.| ..| . . .| . .||. | ..| . .....| .. ||. .|. . .||||| ||.||| |... pveilpllylGsakdasnlevlkklkikyvlnvtsnlpnkfeesgelkykqip-iedhlsqnlakffPeaiefidearskkskvlvhclaGvsrsvtvtl SYLMKYQRMTFKQAMDLVQSKRPQIQPNPGFKDQLLKYEA .||||.. .....| |||..|...| || | .|||..| aylmkklalslndaydlvkkkksnisPnfnfmgqlldfer |
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| Phosphatase | mpl3.AA | Subfamily.Slingshot.PD | 633-768 | 37 | 8.7e-32 | 100.4 | In-house | 2-137 (139) | Show / Hide |
Range on Protein: 633-768 Range on HMM: 2-137/139 Sequence Identity: 37% (51 aa) PSEIIPGIFLGGLDSANNAPILQTLGITHILLAIGDCEPFFPKTFKYYSIDdARDAPQYDISQHFEQTNCFIESGRKSG-GVLVHCRAGISRSSTLVISY .|.| ..|| | | |. |...|| ... |||..|||..| | .. |. .|...| ||| ...| |||||.|.|||.. ||.| askifdhlylGsewnasnleelkengveyilnvtkeidnffpekfkylnir-vydeeetdllkhwnetykfiekakekgskvlvhckmGvsrsastviay LMKYQRMTFKQAMDLVQSKRPQIQPNPGFKDQLLKYE || ......|.. |...| |.|| || .|| .|| amkeyelsleealeyvkerrsiikpnkgflkqlkvye |
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| Phosphatase | mpl3.AA | Subfamily.STYX.PD | 635-769 | 39 | 5.8e-29 | 91.4 | In-house | 4-145 (146) | Show / Hide |
Range on Protein: 635-769 Range on HMM: 4-145/146 Sequence Identity: 39% (56 aa) EIIPGIFLGGLDSANN--APILQTLGITHILLAIGDC-----EPFFPKTFKYYSIDDArDAPQYDISQHFEQTNCFIESGRKSGG-VLVHCRAGISRSST ||.||.||| .| . ..|. |||||. . | ||..|.| .| | |.. .| ... ... ||.. ..|| ||||||||||..|| eilpglflgpysaamksklevlkehgithivcirqnieanlikpnfpdrfrylvldva-dntveniirylptvkefiddslqkggkvlvhgnagisrsaa LVISYLMKYQRMTFKQAMDLVQSKRPQIQPNPGFKDQLLKYEA |.|.|. . ...|. || .| |.|| || .|| .||| lviayimetyglkyreafayvqerrfcinpnegfvsqlkeyea |
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| Phosphatase | mpl3.AA | Subfamily.DSP8.PD | 633-771 | 35 | 1e-27 | 87.4 | In-house | 2-142 (143) | Show / Hide |
Range on Protein: 633-771 Range on HMM: 2-142/143 Sequence Identity: 35% (51 aa) PSEIIPGIFLGGLDSANNAPILQTLGITHILLAIGDCE--PFFPKTFKYYSIDdARDAPQYDISQHFEQTNCFIESGRKS-GGVLVHCRAGISRSSTLVI | .|.| ..|| . . .|. |||...| . |. . . |. .. | .| . .....|... ||. |.. | ||||| ||||||.|..| ptrilpnlylGsqkdsldeellkklgisyvlnisescpkdvellkesrflriP-vkDkyeekllpwfdkalefidkarsangkvlvhclaGisrsatvai SYLMKYQRMTFKQAMDLVQSKRPQIQPNPGFKDQLLKYEAKL .|.||. .|.. .| |..||| |.|| | .|||.|| .| ayimktlemsldeayrfvkekrptispnlnflgqLleyekel |
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| Phosphatase | mpl3.AA | Subfamily.STYXL1.PD | 633-769 | 29 | 3e-21 | 66.7 | In-house | 2-142 (143) | Show / Hide |
Range on Protein: 633-769 Range on HMM: 2-142/143 Sequence Identity: 29% (41 aa) PSEIIPG-IFLGGLDSANNAPILQTLGITHILLAIGDCEPFFPKTFK---YYSIdDARDAPQYDISQHFEQTNCFIESGRKSG-GVLVHCRAGISRSSTL |.|..|| ..|| | | | . | . . |.|... . . | . .| .. |. ..... |||. .|.| |||||||| ...|.| PvevlPgklylGnykqaqnpaikkdlkvkahvnvssdaekliagladvakllhi-avedeneadllerlkevvqfiekhkkegevvlvfsnkGisrsaav VISYLMKYQRMTFKQAMDLVQSKRPQIQPNPGFKDQLLKYEA || ....|.|.|.. .. .. ..|| .| .|| ..| iiaylmyskkitlkkaykylkkckenvkPnrafveqlseWek |
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| Phosphatase | mpl3.AA | Subfamily.PTPMT1.PD | 681-768 | 33 | 6.2e-16 | 49.1 | In-house | 59-144 (146) | Show / Hide |
Range on Protein: 681-768 Range on HMM: 59-144/146 Sequence Identity: 33% (30 aa) SIDDARDAPQYDisqHFEQTNCFIESGRKSG-GVLVHCRAGISRSSTLVISYLMKYQRMTFKQAMDLVQSKRPQIQPNPGFKDQLLKYE .. | .||. . . |.. |||. .. | | |||.|| .||.|||..|||| .... ..|......|||||. . . | ... atvDfteapsle---kleegvefiekvaskgssvYvHCkAGrtRsatlvacylmkkkklspeeavkflkkkRpqirlkskqwralqefk |
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| Phosphatase | mpl3.AA | Subfamily.CDC14.PD | 709-752 | 37 | 6.2e-10 | 29.7 | In-house | 197-240 (258) | Show / Hide |
Range on Protein: 709-752 Range on HMM: 197-240/258 Sequence Identity: 37% (16 aa) KSGGVLVHCRAGISRSSTLVISYLMKYQRMTFKQAMDLVQSKRP .| . |||.||. | .||. .||.|..|.| .... .. || aeGaiavhCkaGLGrtgtligcylikhyrftaaetiawlriarP |
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| Phosphatase | mpl3.AA | Subfamily.PTPDC1.PD | 709-753 | 42 | 2.3e-09 | 27.6 | In-house | 165-209 (229) | Show / Hide |
Range on Protein: 709-753 Range on HMM: 165-209/229 Sequence Identity: 42% (19 aa) KSGGVLVHCRAGISRSSTLVISYLMKYQRMTFKQAMDLVQSKRPQ . | . ||| || | |. .||. .|.| ..|..||.||||. eegkiavHCHAGlGRtGvliacylvyakrltaeeaiklvrskrpk |
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| Phosphatase | mpl3.AA | Subfamily.PTEN.PD | 679-753 | 24 | 5.1e-08 | 23.2 | In-house | 64-138 (305) | Show / Hide |
Range on Protein: 679-753 Range on HMM: 64-138/305 Sequence Identity: 24% (18 aa) YYSIDDARDAPQYDISQHFEQTNCFIESGRkSGGVLVHCRAGISRSSTLVISYLMKYQRMTFK-QAMDLVQSKRPQ | .|| .. ... |. . .... . | | |||.|| |. ... .||.|.. .. . .|... ..|| . vypfdDhnpptleLleeivedvdkwLkedk-snVvavHCkaGkGRtGvmicayLlksgikksadealaiydekRtk |
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| Phosphatase | mpl3.AA | Subfamily.DSP23.PD | 701-752 | 30 | 1.1e-07 | 22.5 | In-house | 57-108 (128) | Show / Hide |
Range on Protein: 701-752 Range on HMM: 57-108/128 Sequence Identity: 30% (16 aa) NCFIESGRKSGGVLVHCRAGISRSSTLVISYLMKYQRMTFKQAMDLVQSKRP . |. .| . | ||| |. |. ||. ||.| .... ..|. |. .|. riveeaekkeeavgvhcalGlGrtGtllacylvkeeglaaddaiaevrkrrk |
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| Phosphatase | mpl3.AA | Subfamily.DSP11.PD | 689-751 | 21 | 6.9e-06 | 16.5 | In-house | 58-122 (141) | Show / Hide |
Range on Protein: 689-751 Range on HMM: 58-122/141 Sequence Identity: 21% (14 aa) PQYDISQHFE-QTNCFIESGRKSGG-VLVHCRAGISRSSTLVISYLMKYQRMTFKQAMDLVQSKR |. .. ..|. . . |.|. ... . ||| |. |. |. ||.. . . ..|.. .. | pekedvkkfkeavkefleknkdndkligvhCthGvnrtGyliCrylidvegyspedaieafeear |
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| Phosphatase | mpl3.AA | Subfamily.Laforin.PD | 709-753 | 28 | 8e-06 | 16.2 | In-house | 102-147 (165) | Show / Hide |
Range on Protein: 709-753 Range on HMM: 102-147/165 Sequence Identity: 28% (13 aa) KS-GGVLVHCRAGISRSSTLVISYLMKYQRMTFKQAMDLVQSKRPQ . | ||| ||. ||...| .|. .... . .||| ekghivyvhcnagvgrstaivcgflqyvlgwslakvqyfllakrpv |
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| Phosphatase | mpl3.AA | Subfamily.RNGTT.PD | 695-753 | 22 | 1e-05 | 15.8 | In-house | 64-122 (140) | Show / Hide |
Range on Protein: 695-753 Range on HMM: 64-122/140 Sequence Identity: 22% (13 aa) QHFEQTNCFIESGRKSGGVLVHCRAGISRSSTLVISYLMKYQRMTFKQAMDLVQSKRPQ ..| . . . . . . ||| | | |...||.. . .. ..|..| . ||. klfiklvkeflkkkPdevigvhCthGfnrtGflivayLvekedwsveaavalfakarpp |
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