Gene cnrN
cnrN
Species: D.discoideum
Alias: DDB_G0287969, cnrN
External Links:
Classification
Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.
Protein domain
Protein domains of cnrN.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit phosphatase group/family/subfamily, which is helpful to understand the relationship between phosphatases. Transmembrane region is predicted by TMHMM 2.0. Visualized by pviz.
Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking. View complete domain list.
| Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
|---|---|---|---|---|---|---|---|---|---|
| Phosphatase | cnrN.AA | Subfamily.PTEN.PD | 30-193 | 41 | 1.5e-60 | 195.6 | In-house | 1-165 (305) | Show / Hide |
Range on Protein: 30-193 Range on HMM: 1-165/305 Sequence Identity: 41% (67 aa) DLSYITDNILAMGFPGTGLEASWRNSIDDVCELLKQKHHGKYMIWNLS-ERVYDYSKLNNQILEFPFLDHHPPPLSLLFEIVNSLSNWLKADAENVAVVH |.||| |......| .| ... ..|. ||. ...||. . .|. .. ...|...... ..|| ||.||.|.|| |||.....|||.|.||..||| disyilvnlivlsypvetyekllyrnslddlillltvykgkgklrilnargekedsdfdgrvavypfdDhnpptleLleeivedvdkwLkedksnVvavH CKGGKGRTGTIICCYLYYSCQFEIMDDAKNHFAEKRSKMKKGVTQPSQQRYINYFKEIVSGSHMV | ||||||..||.||..|.... .|.| ....|||.|.||||| |||.||..||...| | CkaGkGRtGvmicayLlksgikksadealaiydekRtkdkkGVtiPSQrRYvqYfsklvkssvpy |
|||||||||
| Phosphatase | cnrN.AA | Subfamily.Tensin.PD | 86-193 | 46 | 1.6e-30 | 96.7 | In-house | 1-110 (237) | Show / Hide |
Range on Protein: 86-193 Range on HMM: 1-110/237 Sequence Identity: 46% (51 aa) LNNQILEFPFLDHHPPPLSLLFEIVNSLSNWLKADAENVAVVHCKGGKGRTGTIICCYLYYSCQFEIMDDAKNHFAEKR--SKMKKGVTQPSQQRYINYF ||...|.. . |.. ||| | |...| ||||| .|| |.||||||||.| .|..|. || . | | ..|| || . .|||||||.||..|| lnekvldlGWPdllaPpleklcsickalesWlkadpqnvvvlhckGgkGrigvvisaymhyskisasadaaldrfalkrfyddkvsgvtqPsqrryveyf KEIVSGSHMV ....||| . sgllsgsikl |
|||||||||
| Phosphatase | cnrN.AA | Family.DSP.PD | 68-204 | 27 | 4.6e-29 | 92.3 | In-house | 131-261 (387) | Show / Hide |
Range on Protein: 68-204 Range on HMM: 131-261/387 Sequence Identity: 27% (40 aa) HGKYMIWNLS-------ErvydysKLNNQILEFPFLDHHPPPLSLLfeIVNSLSnWLKA--DAENVAVVHCKGGKGRTGTIICCYLYYSCQFEIMdDAKN .| .| ||. . .|. ..|..|. ||..|||..| ..... ... |...|..||||.||||.||.|..|| .| ....| .... lgvtkivnltddkpqftk------elgikylripidDhnapplenl--fekaid-fieegndskgvVlVHCkaGkgRsgtliiaYlmksegltle-eald HFAEKRskmkKGVTQPSQQrYINYFKEIVSGSHMVEEFVLTFRSIE .|| .||..|.|. .. ..|. . |.. |. .| .. wvrskR----pgvitpnqg-flkqlkdlekeklkvssevmelrfvi |
|||||||||
| Phosphatase | cnrN.AA | Subfamily.TPIP.PD | 87-187 | 37 | 1.7e-28 | 90.3 | In-house | 2-107 (245) | Show / Hide |
Range on Protein: 87-187 Range on HMM: 2-107/245 Sequence Identity: 37% (39 aa) NNQILEFPFLDHHPPPLSLLFEIVNSLSNWLKADAENVAVVHCKGGKGRTGTIICCYLYYSCQFEIMDDAKNHFAEKRS-----KMKKGVTQPSQQRYIN .|.. || | |. |. . . . .||..| ||| ..||||||||||||.|..| .| .|. ... ..|.|.| .. .|||||.||..|. hnrvsrimiddhnvPtleelvvftkevkewlakdlenvvaihckGGkgrtGtivcalliaseifltaeesldyfgerrtdkthsnkfqGvetPsqnryvg YFKEIV ... ylaqvk |
|||||||||
| Phosphatase | cnrN.AA | Subfamily.PTPMT1.PD | 73-171 | 23 | 4.7e-13 | 39.6 | In-house | 38-134 (146) | Show / Hide |
Range on Protein: 73-171 Range on HMM: 38-134/146 Sequence Identity: 23% (23 aa) IWNLSERVYDYSKLNNQILEFPFLDHHP-PPLSLLFEIVNSLSNWLKaDaENVAVVHCKGGKGRTGTIICCYLYYSCQFEiMDDAKNHFAEKRSKMKKGV . .|.. . ...|| . |... |. | | |.| |. ... . . .. |||| |..| .|.. ||| .. .. ..|......||..... lkalansteewkklGveqlqlatvDfteapslekleegvefiekvas-k-gssvYvHCkAGrtRsatlvacylmkkkkls-peeavkflkkkRpqirlks |
|||||||||
| Phosphatase | cnrN.AA | Subfamily.PTPDC1.PD | 54-185 | 25 | 7.7e-13 | 38.8 | In-house | 97-225 (229) | Show / Hide |
Range on Protein: 54-185 Range on HMM: 97-225/229 Sequence Identity: 25% (35 aa) NSIDDVCELLKQKHHGKYMIW-NLSERVYDYSKLNN---QILEFPFLDHHPPPLSLLFEIVNSLSNWLkaDAENVAvVHCKGGKGRTGTIICCYLYYSCQ . |. | | .. | . . | || .| . . |.. |. ..| . .|| .. | ..| ||| |.|||| .|.||| |. . sGikavinLqeagehahCGagleesGfsYdpeelmrqgiyfynfglkDygvasleriLdivkvvdfal--eegkia-vHCHAGlGRtGvliacylvyakr FEimddAKNHFAEKRSKMKKGVTQPSQQRYINYFKE .. |.. ||| | . .| . .. |.. lt----aeeaiklvrskrpksiqtreqvelveeFal |
|||||||||
| Phosphatase | cnrN.AA | Subfamily.DSP23.PD | 93-185 | 29 | 5.4e-11 | 33.1 | In-house | 39-125 (128) | Show / Hide |
Range on Protein: 93-185 Range on HMM: 39-125/128 Sequence Identity: 29% (26 aa) FPFLDHHPPPLSLLFEIVNSLSNwLKADAENVAvVHCKGGKGRTGTIICCYLYYSCQFEimddAKNHFAEKRSKMKKGVTQPSQQRYINYFKE |..|| | . ..|. . . .. | |. ||| | |||||.. ||| . .. |.. || | . | . |.. .. ..| idipdfcPPaleqvarlvrivee-aekkeeavg-vhcalGlGrtGtllacylvkeegla----addaiaevrkrrkGsietveqekavkdyee |
|||||||||
| Phosphatase | cnrN.AA | Subfamily.CDC14.PD | 69-151 | 29 | 3.5e-10 | 30.4 | In-house | 147-227 (258) | Show / Hide |
Range on Protein: 69-151 Range on HMM: 147-227/258 Sequence Identity: 29% (25 aa) GKYMIWNLSERVYDYSKLNNQILE---FPFLDHHPPPLSLLFEIVNSLSNWlkadaENVAVVHCKGGKGRTGTIICCYLYYSCQFE . | | ...|| .| ... .. | | |. ..| . .. . . | ..|||| | |||||.| ||| . .|. nvttivrLnkklYdakkftdaGfahlDlffiDGtvPsdailkkfleiteka-----eGaiavhCkaGLGrtgtligcylikhyrft |
|||||||||
| Phosphatase | cnrN.AA | Subfamily.RNGTT.PD | 113-166 | 32 | 3.5e-09 | 26.9 | In-house | 70-122 (140) | Show / Hide |
Range on Protein: 113-166 Range on HMM: 70-122/140 Sequence Identity: 32% (17 aa) LSNWLKADAENVAVVHCKGGKGRTGTIICCYLYYSCQFEImDDAKNHFAEKRSK ...|| ..| ||| | ||| .|..|| .... ..| . ||. | . vkeflkkkPdevigvhCthGfnrtGflivayLvekedwsv-eaavalfakarpp |
|||||||||
| Phosphatase | cnrN.AA | Subfamily.DSP11.PD | 78-165 | 26 | 3.3e-08 | 23.9 | In-house | 32-123 (141) | Show / Hide |
Range on Protein: 78-165 Range on HMM: 32-123/141 Sequence Identity: 26% (24 aa) ERVYDYSKLNNQILEFPFL---DHHPPPLSLLFEIVNSLSNWLK--ADAENVAVVHCKGGKGRTGTIICCYLYYSCQFEiMDDAKNHFAEKRS .| |. ..|... ... | |. | . . . ....|. .| ... ||| | ||| .|| || . .. .|| . | || dryykkkeltdegvkykklncpGhevpekedvkkfkeavkefleknkdndkligvhCthGvnrtGyliCrylidvegys-pedaieafeearG |
|||||||||
| Phosphatase | cnrN.AA | Subfamily.PRL.PD | 54-145 | 25 | 2.9e-07 | 20.8 | In-house | 12-104 (140) | Show / Hide |
Range on Protein: 54-145 Range on HMM: 12-104/140 Sequence Identity: 25% (23 aa) NSIDDVCELLKQKHHgkYMIWNLSERVYDYSKLN---NQILEFPFLDHHPPPLSLLFEIVNSLSNWLKADAENVAVVHCKGGKGRTGTIICCYLY ..... | ||... . | || .||. ..|...| | .|| ... | .. | . | . ... ||| | ||. ...| etvekfieelkkenv--kevvrvcepsydaeklkeegievldlafddGavPpkevvdeWlellkekfkeepkstvavhcvaGlGraPvlvalali |
|||||||||
| Phosphatase | cnrN.AA | Subfamily.N12.PD | 69-142 | 29 | 1.1e-06 | 18.4 | In-house | 146-219 (270) | Show / Hide |
Range on Protein: 69-142 Range on HMM: 146-219/270 Sequence Identity: 29% (21 aa) GKYMIWNLSERVYDYSKLNNQILEFPFLDHHPP-PLSLLFEIVNSLSNWLKADAeNVAVVHCKGGKGRTGTIICC ..| | .. . |. .|. . || | . |.|..... . .... . |||| | ||||||| ddflirtLkveaqkesrkvyqfhytaWPDhgvPssaksllelielvrelqesed-aPlvvhCsaGvGrtGtiiai |
|||||||||
| Phosphatase | cnrN.AA | Subfamily.DSP1.PD | 72-165 | 23 | 1.3e-06 | 18.9 | In-house | 30-121 (139) | Show / Hide |
Range on Protein: 72-165 Range on HMM: 30-121/139 Sequence Identity: 23% (22 aa) MIWNLSERVYDYSKLNNQILEFPFLDHHPPPLSLLFEIVNSLSNWLKADAENVaVVHCKGGKGRTGTIICCYLYYSCQFEiMDDAKNHFAEKRS . |.|... .. . . . | |.. .| ||| .. ...|. | .|||. | |. ||. || . ... ...| .. ..|| allnvsaelpnvfeelfkyksipvednkkadisslfeeaidfidsvkkkgGrv-lvhCqaGisrsativlayLmkekkvr-leeafefvkqrrs |
|||||||||
| Phosphatase | cnrN.AA | Subfamily.DSP8.PD | 85-173 | 20 | 1.7e-06 | 18.5 | In-house | 45-131 (143) | Show / Hide |
Range on Protein: 85-173 Range on HMM: 45-131/143 Sequence Identity: 20% (18 aa) KLNNQILEFPFLDHHPPPLSLLFEIVNSLSNWLKADAENVaVVHCKGGKGRTGTIICCYLYYSCQFEiMDDAKNHFAEKRSKMKKGVTQ . ....| | |.. |. |. . . .. .| .||| |. |. |.. .|. ... .|.| .. |||. ... . lkesrflriPvkDkyeekllpwfdkalefidkarsangkv-lvhclaGisrsatvaiayimktlems-ldeayrfvkekrptispnlnf |
|||||||||
| Phosphatase | cnrN.AA | Subfamily.R_Anemone_2.PD | 104-142 | 32 | 2.4e-06 | 17.8 | In-house | 176-214 (262) | Show / Hide |
Range on Protein: 104-142 Range on HMM: 176-214/262 Sequence Identity: 32% (12 aa) SLLFEIVNSLSNWLKADAENVAVVHCKGGKGRTGTIICC . |...|.. ... . ... |||| .| ||||. | aslldlvrqvekaqqesgagpivvhcsaGvGrtGvfiav |
|||||||||
| Phosphatase | cnrN.AA | Subfamily.RK.PD | 98-143 | 28 | 2.7e-06 | 17.2 | In-house | 175-220 (267) | Show / Hide |
Range on Protein: 98-143 Range on HMM: 175-220/267 Sequence Identity: 28% (13 aa) HHPPPLSLLFEIVNSLSNWLKADAENVAVVHCKGGKGRTGTIICCY . | |.... . .. . . | |||| | ||.|| | . dvPvskrsllklirrvkksqeeeeeGrivvhClaGaGrsGtfiaid |
|||||||||
| Phosphatase | cnrN.AA | Subfamily.N20.PD | 119-170 | 35 | 4.2e-06 | 17.0 | In-house | 186-241 (257) | Show / Hide |
Range on Protein: 119-170 Range on HMM: 186-241/257 Sequence Identity: 35% (20 aa) ADAENVAVVHCKGGKGRTGTIIC-----CYLYYSCQFEIMDDAkNHFAEKRSKMKKG . |||| | |||| ..| | . | |.||| .. |.|| | . shltgpmvvhcsagigrtgvflcvdvvfcaivkncsfnimdiv-aqmreqrsgmvqt |
|||||||||
| Phosphatase | cnrN.AA | Subfamily.N13.PD | 97-185 | 28 | 5.7e-06 | 16.5 | In-house | 167-253 (259) | Show / Hide |
Range on Protein: 97-185 Range on HMM: 167-253/259 Sequence Identity: 28% (27 aa) DHHPPPLSL-LFEIVNSLSNwLKADAENVaVVHCKGGKGRTGTIICCYLYyscqFEIMD-----DAKNHFaEKRSKMKKGVTQPSQQrYINYFKE || | . | ..| . . |. || . |||| | ||.|..|. . ..... | |. .| . ..|| | ..| || .| dhgvPssaaelvqfvaevrl-lqtdagPi-vvhcsaGiGrsGvlitidvv----lglierdkefdvkeiv-rklreqrqgvvqtkdq-yifvyka |
|||||||||