Gene pten
pten
Species: D.discoideum
Alias: pten, DDB_G0286557
External Links:
Classification
Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.
Protein domain
Protein domains of pten.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit phosphatase group/family/subfamily, which is helpful to understand the relationship between phosphatases. Transmembrane region is predicted by TMHMM 2.0. Visualized by pviz.
Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking. View complete domain list.
| Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
|---|---|---|---|---|---|---|---|---|---|
| Phosphatase | pten.AA | Subfamily.PTEN.PD | 24-235 | 38 | 3.9e-66 | 214.1 | In-house | 1-213 (305) | Show / Hide |
Range on Protein: 24-235 Range on HMM: 1-213/305 Sequence Identity: 38% (78 aa) DLAYITDNIVAMGFPSEKVEGVFRNPMKDVQRFLDQYHKDHFKVYNLCSERVYDHSKFYGRVGYYPFDDHNAPQFEMIDAFCRDVDAWMKEDSKNIAVIH |..|| |......| |..|..... ..|. ..|. .|.. |...|.... ...|.| ||| |||||||.|..|.. ...||| |.|||..|....| disyilvnlivlsypvetyekllyrnslddlillltvykgkgklrilnargekedsdfdgrvavypfdDhnpptleLleeivedvdkwLkedksnVvavH CKAGKGRTGLMICCWLMYCGMWKNTEDSLRFYAALRTYNQKGVTIPSQIRYVGYFGRSIRESIKYVPRNVTLKKIVLRPLPKEINLSEVQFNISVGKNCV |||||||||.|||..|.. |. |.....|..|. || ..|||||||| ||| || . .. |. | .. . .| .|| |. .||| ... |.| CkaGkGRtGvmicayLlksgikksadealaiydekRtkdkkGVtiPSQrRYvqYfsklvkssvpyskvslnvceirfsesscvqnlgmvecsisvlhdsa -FNSKEHNMNVVI .... tenakpdrlktlp |
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| Phosphatase | pten.AA | Subfamily.TPIP.PD | 83-230 | 31 | 2.1e-33 | 106.6 | In-house | 3-155 (245) | Show / Hide |
Range on Protein: 83-230 Range on HMM: 3-155/245 Sequence Identity: 31% (47 aa) GRVGYYPFDDHNAPQFEMIDAFCRDVDAWMKEDSKNIAVIHCKAGKGRTGLMICCWLMYCGMWKNTEDSLRFYAALRTYNQ-----KGVTIPSQIRYVGY || |||| |..| . |...|. |...| .|. .|||| |||||| ..|..|.. ......|.|| ... || .. .|| ||| |||||. nrvsrimiddhnvPtleelvvftkevkewlakdlenvvaihckGGkgrtGtivcalliaseifltaeesldyfgerrtdkthsnkfqGvetPsqnryvgy FGRSIRES-IKYVPRNV-TLKKIVLRPLPKEInlSEVQFNISVGKNCVFNSKEHN .. . || . .|.... . .. ... .. . |. ||.| laqvkhlynwnlpprrilfikrfiiysirgdv--cdlkvqvvmekkvvfsstslg |
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| Phosphatase | pten.AA | Family.DSP.PD | 31-233 | 24 | 5.3e-30 | 95.7 | In-house | 100-292 (387) | Show / Hide |
Range on Protein: 31-233 Range on HMM: 100-292/387 Sequence Identity: 24% (52 aa) NIVAMGFPSEKVEGVFRNPMKDVQRFLDQYHKDHFKVYNLCservYDHSKFYG--RVGY--YPFDDHNAPQFEMIdaFCRDVDaWMKE--DSKNIAVIHC . |. | ||| .... ...... . .. . |. ||. .|...|. . | .|.||||||..| . |....| ...| |||. ...|| ervengkpseilphlylgsllaaknlewlkelgvtkivnlt----ddkpqftkelgikylripidDhnapplenl--fekaid-fieegndskgvVlVHC KAGKGRTGLMICCWLMYCGMWKNTeDSLRFYAALRtynqKGVTIPSQIrYVGYFGRSIRESIKYVPRNVTLKKIVLRPLPkeiNLSEVQFNISVGKNCVF ||||||.| .|...||.. .. ..|.... | .||..|.| .. .. . | .| . . |... . || .|. .|| |. .. kaGkgRsgtliiaYlmksegltle-ealdwvrskR----pgvitpnqg-flkqlkdlekeklkvssevmelrfvissivq---nlgsvevsvsvlkkvat NSKEHNMNV .. . . ekakldrlk |
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| Phosphatase | pten.AA | Subfamily.Tensin.PD | 90-205 | 34 | 4.2e-24 | 76.0 | In-house | 10-127 (237) | Show / Hide |
Range on Protein: 90-205 Range on HMM: 10-127/237 Sequence Identity: 34% (41 aa) FDDHNAPQFEMIDAFCRDVDAWMKEDSKNIAVIHCKAGKGRTGLMICCWLMYCGMWKNTEDSLRFYAALRTYNQKG--VTIPSQIRYVGYFGRSIRESIK . |. || .| . . |. ...|.| | .|. |.||| ||||.|..|.... | . . .. .| .| | |..| || ||| ||| || . .||| WPdllaPpleklcsickalesWlkadpqnvvvlhckGgkGrigvvisaymhyskisasadaaldrfalkrfyddkvsgvtqPsqrryveyfsgllsgsik YVPRNVTLKKIVLRPLPK . . |. ..|. .|. lnssplflhyvilhgipn |
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| Phosphatase | pten.AA | PTEN_C2 | 188-405 | 15 | 2.9e-22 | 81.84 | Pfam | 1-141 (141) | Show / Hide |
Range on Protein: 188-405
Range on HMM: 1-141/141
Sequence Identity: 15% (37 aa)
YVPRNVTLKKIVL-RPLP--KEINLS-EVQFNISVGKNCVFNSKEHNMNVVISKKKKTVVDKNKKDPKKKLTKENSEKNIDSQQQQQSQSSLSQSQQGQS
. |. ..|..|.. ...| | . . .. | ....||
PPPKPLFLHCIIMDHGIPNFKQGGGCWRPYIQIYQNDQKVF-----------------------------------------------------------
SPNMQSLSASGTISSGSNVGTVNGNTLHQLGGSQFSLSDLADGNTIG-NDEYISFEIG-ALSLAGDIRIEFTNKQ--------DDRMFMFWVNTSFVQ--
. .. .... .. . |.. . ..||..|.. .|. .. || || ||.|..
-----------------------------------YTCKKYWHCKKYKQQKCCIFKFPQPCPVQGDVKIQCYHKGPSDLPWMYEECMFRFWFNTCFIEHN
-QLEIIPKSGLDKAHKDKNHKAFPEDFHVELTFDQ
. ..||. ||||.|||..| ||.||.||. |.
NNRLTFPKNELDKAWKDKKWKRFPPDFKVEVVFSE
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| Phosphatase | pten.AA | Subfamily.PRL.PD | 51-154 | 28 | 2.6e-12 | 37.4 | In-house | 12-116 (140) | Show / Hide |
Range on Protein: 51-154 Range on HMM: 12-116/140 Sequence Identity: 28% (30 aa) KDVQRFLDQYHKDHFKVYNLCSERVYDHSKF---YGRVGYYPFDDHNAPQFEMIDAFCRDVDAWMKEDSKNIAVIHCKAGKGRTGLMICCWLMYCGMwkN . |..|... .|.. | . | || .|. .| ..||| ..| |..| . . . . ||..|.. .|| || ||. .... |..|| .. etvekfieelkkenvkevvrvcepsydaeklkeegievldlafddGavPpkevvdeWlellkekfkeepkstvavhcvaGlGraPvlvalalieaGm--k TEDSLRF ||.. | yedavef |
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| Phosphatase | pten.AA | Subfamily.PTPDC1.PD | 87-178 | 28 | 7.7e-12 | 35.8 | In-house | 139-223 (229) | Show / Hide |
Range on Protein: 87-178 Range on HMM: 139-223/229 Sequence Identity: 28% (25 aa) YYPFDDHNAPQFEMIDAFCRDVDAWMkeDSKNIAvIHCKAGKGRTGLMICCWLMYCGMWKNtEDSLRFyaaLRTYNQKGVTIPSQIRYVGYF ....|.... | | . || . .|| .|| ||.||||..|.|.|.| . |..... .| | . .|.. || nfglkDygvasleriLdivkvvdfal--eegkia-vHCHAGlGRtGvliacylvyakrlta-eeaikl---vrskrpksiqtreqvelveeF |
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| Phosphatase | pten.AA | Subfamily.CDC14.PD | 54-142 | 26 | 8e-11 | 32.7 | In-house | 137-223 (258) | Show / Hide |
Range on Protein: 54-142 Range on HMM: 137-223/258 Sequence Identity: 26% (24 aa) QRFLDQYHKDHFKVYNLCSERVYDHSKFYgRVGY----YPFDDHNAPQFEMIDAFCRdvdawMKEDSKNIAVIHCKAGKGRTGLMICCWLMYC ...|. ..| . ...||..|| |. | | |. ... | . . |... ...||||| |||| .| |.|.. eklleyfrknnvttivrLnkklYdakkft-daGfahlDlffiDGtvPsdailkkfle-----itekaeGaiavhCkaGLGrtgtligcylikh |
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| Phosphatase | pten.AA | Subfamily.DSP11.PD | 73-161 | 24 | 2.6e-10 | 30.9 | In-house | 32-124 (141) | Show / Hide |
Range on Protein: 73-161 Range on HMM: 32-124/141 Sequence Identity: 24% (22 aa) ERVYDHSKFYGR-VGYYPF--DDHNAPQFEMIDAFCRDVDAWM--KEDSKNIAVIHCKAGKGRTGLMICCWLMYCGMWKnTEDSLRFYAALRTY .| |..... . | |. . |. |. |... |.. |. .. ..|.... .|| | ||| .|| .|. . .. .||... .| . dryykkkeltdegvkykklncpGhevpekedvkkfkeavkefleknkdndkligvhCthGvnrtGyliCrylidvegys-pedaieafeearGh |
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| Phosphatase | pten.AA | Family.DSP.PD | 258-404 | 18 | 5.3e-10 | 29.8 | In-house | 225-378 (387) | Show / Hide |
Range on Protein: 258-404 Range on HMM: 225-378/387 Sequence Identity: 18% (30 aa) NSEKNIDSQQQqqSQSSLSQSQQGQSSPNMQSLSASGTISSG-SNVGTVNGNT--LHQLGGSQFSLSdlaDGNTIGNDEYISFEI---GALSLAGDIRIE . ..| .|. . |.. .. ..... . . |||. |.| |.. |.. ... .| . .. || .. | ..| | ||...|. kRpgvitpnqg--flkqlkdlekeklkvssevmelrfvissivqnlgsvevsvsvlkkvatekakld---rlkiLvideqekvvitikdglplsgDVkve FTNKQDD-----RMFMFWVNTSFVQQ-LEIIPKSGLDKAHKDKNHKAFPEDFHVELTFD ..| | .. .. .|..... ..| ||..||.| . ... ..||. .. lfkknldkiirdiilntfFvtnyikdeslvlvkkeldelhkskifdvykdseaveisee |
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| Phosphatase | pten.AA | Subfamily.PTPMT1.PD | 91-157 | 22 | 1.1e-09 | 28.9 | In-house | 62-125 (146) | Show / Hide |
Range on Protein: 91-157 Range on HMM: 62-125/146 Sequence Identity: 22% (15 aa) DDHNAPQFEMIDAFCRDVDAWMKedSKNIAVIHCKAGKGRTGLMICCWLMYCGMWKNtEDSLRFYAA | .||..| . . .. .. .. .|||||..| . .. |.||. .. |.. .| .. Dfteapslekleegvefiekvas--kgssvYvHCkAGrtRsatlvacylmkkkklsp-eeavkflkk |
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| Phosphatase | pten.AA | Subfamily.RNGTT.PD | 94-159 | 27 | 1.3e-09 | 28.6 | In-house | 56-120 (140) | Show / Hide |
Range on Protein: 94-159 Range on HMM: 56-120/140 Sequence Identity: 27% (18 aa) NAPQFEMIDAFCRDVDAWMKEDSKNIAVIHCKAGKGRTGLMICCWLMYCGMWkNTEDSLRFYAALR .||. | .. | . |. ..|. ... .|| | |||..|...|. | . |... .| | eaPtkeqtklfiklvkeflkkkPdevigvhCthGfnrtGflivayLvekedw-sveaavalfakar |
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| Phosphatase | pten.AA | Subfamily.TPIP.PD | 354-404 | 41 | 1.5e-09 | 28.5 | In-house | 193-244 (245) | Show / Hide |
Range on Protein: 354-404 Range on HMM: 193-244/245 Sequence Identity: 41% (21 aa) NKQDDRMFMFWVNTSFVQQLE-IIPKSGLDKAHKDKNHKAFPEDFHVELTFD . |. |.||.||||.|. ..|.. ||. ||.| .| .| .| ||. | kyydncpfffwfntsfiqnnrlclprneldnphkqkawkiyppefaveilfg |
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| Phosphatase | pten.AA | Subfamily.RK.PD | 67-161 | 18 | 1.7e-09 | 27.9 | In-house | 146-241 (267) | Show / Hide |
Range on Protein: 67-161 Range on HMM: 146-241/267 Sequence Identity: 18% (18 aa) VYNLCS-ERVYDHSKFYGRVGYYPFDDH-NAPQFE-MIDAFCRDVDAWMKEDSKNIAVIHCKAGKGRTGLMICCWLMyCGMWKNtEDSLRFYAALRTY ..... | .. . .. . . .. . |. . . .. | |... .|... |.|| || ||.| | . . . | .. |. . . |.| ifrveklargqeeirevrqfqflgWpeyrdvPvskrsllklirrvkksqeeeeeGrivvhClaGaGrsGtfiaidiv-lemier-egvvdvfnavktl |
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| Phosphatase | pten.AA | Subfamily.DSP23.PD | 90-140 | 30 | 1.5e-08 | 25.5 | In-house | 41-89 (128) | Show / Hide |
Range on Protein: 90-140 Range on HMM: 41-89/128 Sequence Identity: 30% (15 aa) FDDHNAPQFEMIDAFCRDVDAWMKedSKNIAVIHCKAGKGRTGLMICCWLM .|. | | .. . | |. | ... .|| | |||| .. |.|. ipdfcPPaleqvarlvriveeaek--keeavgvhcalGlGrtGtllacylv |
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| Phosphatase | pten.AA | Subfamily.N20.PD | 73-149 | 28 | 5.2e-08 | 23.5 | In-house | 147-221 (257) | Show / Hide |
Range on Protein: 73-149 Range on HMM: 147-221/257 Sequence Identity: 28% (21 aa) ERVYDHSKFYGRVGYYPFDDHNAPQfeMIDAFCRDVDAWMKEDSKNIAVIHCKAGKGRTGLMICCWLMYCGMWKNTE |. |. .. . . || .| |.| . . | |.|| || ||||...| ...| . || ekstgtshsvkqlqftkwpdhgtpa--sadsfikyiryarkshltgpmvvhcsagigrtgvflcvdvvfcaivkncs |
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| Phosphatase | pten.AA | Subfamily.RB.PD | 60-137 | 25 | 5.4e-08 | 23.2 | In-house | 135-213 (261) | Show / Hide |
Range on Protein: 60-137 Range on HMM: 135-213/261 Sequence Identity: 25% (20 aa) YHKDHFKVYNLCSERvYDHSKFYGRVGYYPFDDHNAPQF-EMIDAFCRDVDAWMKED-SKNIAVIHCKAGKGRTGLMICC ..|.. . .. |. .... .. . . ||. |. . . .|.| |. ..... ||. |.|| || |||| | keldewvirefkiek-gkekrkvrqyhftsWpdhgvPektktlldfvrtvreaiekkaskkPivvHCsaGvGRtGtfial |
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| Phosphatase | pten.AA | Subfamily.PTEN.PD | 341-404 | 30 | 1.3e-07 | 21.9 | In-house | 227-304 (305) | Show / Hide |
Range on Protein: 341-404 Range on HMM: 227-304/305 Sequence Identity: 30% (24 aa) ALSLAGDIRIEFTNKQDDRMF-MFWVNTSFVQQ-------------LEIIPKSGLDKAHKDKNHKAFPEDFHVELTFD .. ..||...|.|.| |.. ||.|| ||.. . . || .| ||| .|| | |.|.. . |. sipvsgdvkfeltkkspdkiichfwlntffvrnyspcesdgtvnkyihtlskseiddvhkdsehkrfseefkisivfe |
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| Phosphatase | pten.AA | Subfamily.R_Anemone_2.PD | 88-140 | 30 | 3e-07 | 20.9 | In-house | 164-217 (262) | Show / Hide |
Range on Protein: 88-140 Range on HMM: 164-217/262 Sequence Identity: 30% (16 aa) YPFDDHNAPQF--EMIDaFCRDVDAWMKEDSKNIAVIHCKAGKGRTGLMICCWLM . |...|. ...| . |.|... .| .... |.|| || |||| | . tsWpdegvpesgaslld-lvrqvekaqqesgagpivvhcsaGvGrtGvfiavdil |
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| Phosphatase | pten.AA | Subfamily.N5_RR.PD | 58-140 | 21 | 3.4e-07 | 20.6 | In-house | 135-220 (265) | Show / Hide |
Range on Protein: 58-140 Range on HMM: 135-220/265 Sequence Identity: 21% (18 aa) DQYHKDHFKVYNLCSERVYDHSKFYGRVGYYPFDDHNAPQ-FEMIDAFCRDVDAWMKEDSKN--IAVIHCKAGKGRTGLMICCWLM . ......| .| . . . .. | . ||..|. . . ....|. .|.... |.|| || |||| .|. . eiverndysvrklvlkylerversvkhywytdWPdhksPddintlldlvleveesreeenaklaPvvvhcsaGiGrtGcfiaisia |
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| Phosphatase | pten.AA | Subfamily.N12.PD | 61-147 | 22 | 5.3e-07 | 19.7 | In-house | 144-229 (270) | Show / Hide |
Range on Protein: 61-147 Range on HMM: 144-229/270 Sequence Identity: 22% (20 aa) HKDHFKVYNLCSERVyDHSKFYGRVGYYPFDDHNAPQ-FEMIDAFCRDVDAWMKEDSKNIaVIHCKAGKGRTGLMICCWLMYCGMWKN .| | . | |. ..|. . | . ||. |. . . .. ..| ..... . |.|| || |||| .| ... . .. vdddflirtLkveaq-kesrkvyqfhytaWPDhgvPssaksllelielvrelqesedaPl-vvhCsaGvGrtGtiiaidyvrellkae |
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| Phosphatase | pten.AA | Subfamily.R_Sponge_2.PD | 69-170 | 19 | 6.6e-07 | 19.7 | In-house | 145-245 (262) | Show / Hide |
Range on Protein: 69-170 Range on HMM: 145-245/262 Sequence Identity: 19% (20 aa) NLCSERVYDHSKFYGRVGYYPFDDHNAPQFE--MIDaFCRDV-DAWMKEDSKNIaVIHCKAGKGRTGLMICCWLMYCGMwkNTEDSLRFYAALRTYNQKG .|..|. .... . . . .|. |... ... . ..| | .|. .| | ...|..| |||| |. . . ..|... . |.| | klskekssegeadvtqfhfvaWpehevPkdatslle-likrvlraqkksgnkai-tvvCsdgvgrtGtfialdsvlerl--kaeeeidvfevlktlrtkr VTIPS . . . iglvq |
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| Phosphatase | pten.AA | Subfamily.N_Choan_1.PD | 84-136 | 37 | 1.6e-06 | 18.4 | In-house | 159-212 (262) | Show / Hide |
Range on Protein: 84-136 Range on HMM: 159-212/262 Sequence Identity: 37% (20 aa) RVGYYPFDDHNAPQ--FEMIDaFCRDVDAWMKEDSKNIAVIHCKAGKGRTGLMIC .. | . || .|. |... | ..| |...| |||| || |||| | qlaytaWPdhGvPattkelle-frkavlkatkkktkaplvihCsaGvGrtGtyia |
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| Phosphatase | pten.AA | Subfamily.N14.PD | 99-149 | 30 | 2.4e-06 | 17.6 | In-house | 187-239 (275) | Show / Hide |
Range on Protein: 99-149 Range on HMM: 187-239/275 Sequence Identity: 30% (16 aa) EMIDAFCRDVDAWMK--EDSKNIAVIHCKAGKGRTGLMICCWLMYCGMWKNTE |.... .| .. .. ..|| ..|| || |||| .| |. . .| | eevqsvrrktnsevesvkeskPPvlvhCsaGvGrtGvlilsdlliatlehnee |
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| Phosphatase | pten.AA | Subfamily.N_Choan_2.PD | 103-175 | 28 | 2.4e-06 | 17.6 | In-house | 183-257 (266) | Show / Hide |
Range on Protein: 103-175 Range on HMM: 183-257/266 Sequence Identity: 28% (21 aa) AFCRDVDAWMKEDSKN-IAVIHCKAGKGRTGLMICCWLMYCGMWKN-TEDSLRFYAALRTYNQKGVTIPSQIRYV . |.| .. || .|. ..|| || ||||..| . . . .. | |. ..|| . . | | | ... kmlravrrvrkeldkaePllvHcsaGvgRtGtliaiDiavrlLeetkkvdvlaiieelRkdRmalvqhpeqyell |
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| Phosphatase | pten.AA | Subfamily.N13.PD | 78-139 | 29 | 4.8e-06 | 16.9 | In-house | 153-213 (259) | Show / Hide |
Range on Protein: 78-139 Range on HMM: 153-213/259 Sequence Identity: 29% (18 aa) HSKFYGRVGYYPFDDHNAPQF--EMIdAFCRDVDAwMKEDSKNIaVIHCKAGKGRTGLMICCWL .|. .. . . ||. |. |.. | ..| ...|. | |.|| || ||.| .|. esrevahlnfvkwPdhgvPssaaelv-qfvaevrl-lqtdagPi-vvhcsaGiGrsGvlitidv |
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| Phosphatase | pten.AA | Subfamily.N3.PD | 84-147 | 24 | 4.8e-06 | 16.6 | In-house | 160-223 (261) | Show / Hide |
Range on Protein: 84-147 Range on HMM: 160-223/261 Sequence Identity: 24% (16 aa) RVGYYPFDDHNAPQFE-MIDAFCRDVDAwMKEDSKNIAVIHCKAGKGRTGLMICCWLMYCGMWKN .. | . ||. |. . . | . | . ... ... |.|| || ||||..| . . . .. qlqylaWpdhgvPddsadflefvervrk-lrsgkeePvvvhCsaGigrtGvlilletalalieaa |
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| Phosphatase | pten.AA | Subfamily.Laforin.PD | 118-146 | 39 | 5.5e-06 | 16.8 | In-house | 105-133 (165) | Show / Hide |
Range on Protein: 118-146 Range on HMM: 105-133/165 Sequence Identity: 39% (11 aa) NIAVIHCKAGKGRTGLMICCWLMYCGMWK | .||.|| ||. ..| .|.| |. hivyvhcnagvgrstaivcgflqyvlgws |
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