pten
Species: D.discoideum
Alias: pten, DDB_G0286557
External Links:
Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Superfamily: Cx5R-I
Family: DSP
Subfamily: PTEN
Protein domain

Protein domains of pten.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit phosphatase group/family/subfamily, which is helpful to understand the relationship between phosphatases. Transmembrane region is predicted by TMHMM 2.0. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking. View complete domain list.

Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Phosphatase pten.AA Subfamily.PTEN.PD 24-235 38 3.9e-66 214.1 In-house 1-213 (305) Show / Hide
Range on Protein: 24-235
Range on HMM: 1-213/305
Sequence Identity: 38% (78 aa)

DLAYITDNIVAMGFPSEKVEGVFRNPMKDVQRFLDQYHKDHFKVYNLCSERVYDHSKFYGRVGYYPFDDHNAPQFEMIDAFCRDVDAWMKEDSKNIAVIH
|..||  |......| |..|..... ..|. ..|.  .|.. |...|.... ...|.| |||  |||||||.|..|..  ...||| |.|||..|....|
disyilvnlivlsypvetyekllyrnslddlillltvykgkgklrilnargekedsdfdgrvavypfdDhnpptleLleeivedvdkwLkedksnVvavH

CKAGKGRTGLMICCWLMYCGMWKNTEDSLRFYAALRTYNQKGVTIPSQIRYVGYFGRSIRESIKYVPRNVTLKKIVLRPLPKEINLSEVQFNISVGKNCV
|||||||||.|||..|.. |. |.....|..|.  || ..|||||||| ||| || . .. |. |   .. . .| .||  |. .||| ...   |.|  
CkaGkGRtGvmicayLlksgikksadealaiydekRtkdkkGVtiPSQrRYvqYfsklvkssvpyskvslnvceirfsesscvqnlgmvecsisvlhdsa

-FNSKEHNMNVVI
 ....        
tenakpdrlktlp

Phosphatase pten.AA Subfamily.TPIP.PD 83-230 31 2.1e-33 106.6 In-house 3-155 (245) Show / Hide
Range on Protein: 83-230
Range on HMM: 3-155/245
Sequence Identity: 31% (47 aa)

GRVGYYPFDDHNAPQFEMIDAFCRDVDAWMKEDSKNIAVIHCKAGKGRTGLMICCWLMYCGMWKNTEDSLRFYAALRTYNQ-----KGVTIPSQIRYVGY
||     |||| |..| .  |...|. |...| .|. .|||| |||||| ..|..|.. ......|.|| ...  || ..     .||  ||| |||||.
nrvsrimiddhnvPtleelvvftkevkewlakdlenvvaihckGGkgrtGtivcalliaseifltaeesldyfgerrtdkthsnkfqGvetPsqnryvgy

FGRSIRES-IKYVPRNV-TLKKIVLRPLPKEInlSEVQFNISVGKNCVFNSKEHN
   ..    .  || .  .|....  .  ..   ... .. . |. ||.|     
laqvkhlynwnlpprrilfikrfiiysirgdv--cdlkvqvvmekkvvfsstslg

Phosphatase pten.AA Family.DSP.PD 31-233 24 5.3e-30 95.7 In-house 100-292 (387) Show / Hide
Range on Protein: 31-233
Range on HMM: 100-292/387
Sequence Identity: 24% (52 aa)

NIVAMGFPSEKVEGVFRNPMKDVQRFLDQYHKDHFKVYNLCservYDHSKFYG--RVGY--YPFDDHNAPQFEMIdaFCRDVDaWMKE--DSKNIAVIHC
. |. | |||  ....  ...... .    .. . |. ||.    .|...|.    . |  .|.||||||..| .  |....| ...|  |||. ...||
ervengkpseilphlylgsllaaknlewlkelgvtkivnlt----ddkpqftkelgikylripidDhnapplenl--fekaid-fieegndskgvVlVHC

KAGKGRTGLMICCWLMYCGMWKNTeDSLRFYAALRtynqKGVTIPSQIrYVGYFGRSIRESIKYVPRNVTLKKIVLRPLPkeiNLSEVQFNISVGKNCVF
||||||.| .|...||..  ..   ..|....  |    .||..|.|  .. .. .   | .|   . . |...     .   || .|.  .|| |. ..
kaGkgRsgtliiaYlmksegltle-ealdwvrskR----pgvitpnqg-flkqlkdlekeklkvssevmelrfvissivq---nlgsvevsvsvlkkvat

NSKEHNMNV
..   .  .
ekakldrlk

Phosphatase pten.AA Subfamily.Tensin.PD 90-205 34 4.2e-24 76.0 In-house 10-127 (237) Show / Hide
Range on Protein: 90-205
Range on HMM: 10-127/237
Sequence Identity: 34% (41 aa)

FDDHNAPQFEMIDAFCRDVDAWMKEDSKNIAVIHCKAGKGRTGLMICCWLMYCGMWKNTEDSLRFYAALRTYNQKG--VTIPSQIRYVGYFGRSIRESIK
. |. || .| . . |. ...|.| | .|. |.||| ||||.|..|.... |  . . .. .|  .|  | |..|   || ||| ||| ||   . .|||
WPdllaPpleklcsickalesWlkadpqnvvvlhckGgkGrigvvisaymhyskisasadaaldrfalkrfyddkvsgvtqPsqrryveyfsgllsgsik

YVPRNVTLKKIVLRPLPK
   . . |. ..|. .|.
lnssplflhyvilhgipn

Phosphatase pten.AA PTEN_C2 188-405 15 2.9e-22 81.84 Pfam 1-141 (141) Show / Hide
Range on Protein: 188-405
Range on HMM: 1-141/141
Sequence Identity: 15% (37 aa)

YVPRNVTLKKIVL-RPLP--KEINLS-EVQFNISVGKNCVFNSKEHNMNVVISKKKKTVVDKNKKDPKKKLTKENSEKNIDSQQQQQSQSSLSQSQQGQS
. |. ..|..|.. ...|  |  . .   .. |  ....||                                                           
PPPKPLFLHCIIMDHGIPNFKQGGGCWRPYIQIYQNDQKVF-----------------------------------------------------------

SPNMQSLSASGTISSGSNVGTVNGNTLHQLGGSQFSLSDLADGNTIG-NDEYISFEIG-ALSLAGDIRIEFTNKQ--------DDRMFMFWVNTSFVQ--
                                   . ..   ....   .. . |..   . ..||..|.. .|.        .. || || ||.|..  
-----------------------------------YTCKKYWHCKKYKQQKCCIFKFPQPCPVQGDVKIQCYHKGPSDLPWMYEECMFRFWFNTCFIEHN

-QLEIIPKSGLDKAHKDKNHKAFPEDFHVELTFDQ
  . ..||. ||||.|||..| ||.||.||. |. 
NNRLTFPKNELDKAWKDKKWKRFPPDFKVEVVFSE

Phosphatase pten.AA Subfamily.PRL.PD 51-154 28 2.6e-12 37.4 In-house 12-116 (140) Show / Hide
Range on Protein: 51-154
Range on HMM: 12-116/140
Sequence Identity: 28% (30 aa)

KDVQRFLDQYHKDHFKVYNLCSERVYDHSKF---YGRVGYYPFDDHNAPQFEMIDAFCRDVDAWMKEDSKNIAVIHCKAGKGRTGLMICCWLMYCGMwkN
. |..|... .|.. |    . |  || .|.     .|  ..||| ..|  |..| . . . .  ||..|..  .|| || ||. ....  |..||  ..
etvekfieelkkenvkevvrvcepsydaeklkeegievldlafddGavPpkevvdeWlellkekfkeepkstvavhcvaGlGraPvlvalalieaGm--k

TEDSLRF
||.. | 
yedavef

Phosphatase pten.AA Subfamily.PTPDC1.PD 87-178 28 7.7e-12 35.8 In-house 139-223 (229) Show / Hide
Range on Protein: 87-178
Range on HMM: 139-223/229
Sequence Identity: 28% (25 aa)

YYPFDDHNAPQFEMIDAFCRDVDAWMkeDSKNIAvIHCKAGKGRTGLMICCWLMYCGMWKNtEDSLRFyaaLRTYNQKGVTIPSQIRYVGYF
....|....  | |    . ||  .     .|| .|| ||.||||..|.|.|.|    .  |.....   .|    | .   .|.. ||   
nfglkDygvasleriLdivkvvdfal--eegkia-vHCHAGlGRtGvliacylvyakrlta-eeaikl---vrskrpksiqtreqvelveeF

Phosphatase pten.AA Subfamily.CDC14.PD 54-142 26 8e-11 32.7 In-house 137-223 (258) Show / Hide
Range on Protein: 54-142
Range on HMM: 137-223/258
Sequence Identity: 26% (24 aa)

QRFLDQYHKDHFKVYNLCSERVYDHSKFYgRVGY----YPFDDHNAPQFEMIDAFCRdvdawMKEDSKNIAVIHCKAGKGRTGLMICCWLMYC
...|. ..|   .      ...||..||    |.      | |   |. ...  | .     . |...  ...||||| |||| .| |.|.. 
eklleyfrknnvttivrLnkklYdakkft-daGfahlDlffiDGtvPsdailkkfle-----itekaeGaiavhCkaGLGrtgtligcylikh

Phosphatase pten.AA Subfamily.DSP11.PD 73-161 24 2.6e-10 30.9 In-house 32-124 (141) Show / Hide
Range on Protein: 73-161
Range on HMM: 32-124/141
Sequence Identity: 24% (22 aa)

ERVYDHSKFYGR-VGYYPF--DDHNAPQFEMIDAFCRDVDAWM--KEDSKNIAVIHCKAGKGRTGLMICCWLMYCGMWKnTEDSLRFYAALRTY
.| |.....  . | |. .    |. |. |... |.. |. ..  ..|....  .||  |  ||| .|| .|. .  .. .||... .| .   
dryykkkeltdegvkykklncpGhevpekedvkkfkeavkefleknkdndkligvhCthGvnrtGyliCrylidvegys-pedaieafeearGh

Phosphatase pten.AA Family.DSP.PD 258-404 18 5.3e-10 29.8 In-house 225-378 (387) Show / Hide
Range on Protein: 258-404
Range on HMM: 225-378/387
Sequence Identity: 18% (30 aa)

NSEKNIDSQQQqqSQSSLSQSQQGQSSPNMQSLSASGTISSG-SNVGTVNGNT--LHQLGGSQFSLSdlaDGNTIGNDEYISFEI---GALSLAGDIRIE
. ..|  .|.    . |.. .. ..... . .     |||.  |.| |..    |..  ... .|     . ..  ||  .. |   ..| | ||...|.
kRpgvitpnqg--flkqlkdlekeklkvssevmelrfvissivqnlgsvevsvsvlkkvatekakld---rlkiLvideqekvvitikdglplsgDVkve

FTNKQDD-----RMFMFWVNTSFVQQ-LEIIPKSGLDKAHKDKNHKAFPEDFHVELTFD
..|  |      .. .. .|.....    ..|  ||..||.|  . ... ..||. .. 
lfkknldkiirdiilntfFvtnyikdeslvlvkkeldelhkskifdvykdseaveisee

Phosphatase pten.AA Subfamily.PTPMT1.PD 91-157 22 1.1e-09 28.9 In-house 62-125 (146) Show / Hide
Range on Protein: 91-157
Range on HMM: 62-125/146
Sequence Identity: 22% (15 aa)

DDHNAPQFEMIDAFCRDVDAWMKedSKNIAVIHCKAGKGRTGLMICCWLMYCGMWKNtEDSLRFYAA
|  .||..| .    . ..  ..   ..   .|||||..| . .. |.||.   ..  |.. .| ..
Dfteapslekleegvefiekvas--kgssvYvHCkAGrtRsatlvacylmkkkklsp-eeavkflkk

Phosphatase pten.AA Subfamily.RNGTT.PD 94-159 27 1.3e-09 28.6 In-house 56-120 (140) Show / Hide
Range on Protein: 94-159
Range on HMM: 56-120/140
Sequence Identity: 27% (18 aa)

NAPQFEMIDAFCRDVDAWMKEDSKNIAVIHCKAGKGRTGLMICCWLMYCGMWkNTEDSLRFYAALR
.||. | .. | . |. ..|.  ...  .||  |  |||..|...|.    | . |...  .|  |
eaPtkeqtklfiklvkeflkkkPdevigvhCthGfnrtGflivayLvekedw-sveaavalfakar

Phosphatase pten.AA Subfamily.TPIP.PD 354-404 41 1.5e-09 28.5 In-house 193-244 (245) Show / Hide
Range on Protein: 354-404
Range on HMM: 193-244/245
Sequence Identity: 41% (21 aa)

NKQDDRMFMFWVNTSFVQQLE-IIPKSGLDKAHKDKNHKAFPEDFHVELTFD
.  |.  |.||.||||.|.   ..|.. ||. ||.| .| .| .| ||. | 
kyydncpfffwfntsfiqnnrlclprneldnphkqkawkiyppefaveilfg

Phosphatase pten.AA Subfamily.RK.PD 67-161 18 1.7e-09 27.9 In-house 146-241 (267) Show / Hide
Range on Protein: 67-161
Range on HMM: 146-241/267
Sequence Identity: 18% (18 aa)

VYNLCS-ERVYDHSKFYGRVGYYPFDDH-NAPQFE-MIDAFCRDVDAWMKEDSKNIAVIHCKAGKGRTGLMICCWLMyCGMWKNtEDSLRFYAALRTY
.....   | ..  .   .. .  . .. . |. .  . .. | |... .|...   |.|| || ||.|  | .  . . | .. |. .  . |.|  
ifrveklargqeeirevrqfqflgWpeyrdvPvskrsllklirrvkksqeeeeeGrivvhClaGaGrsGtfiaidiv-lemier-egvvdvfnavktl

Phosphatase pten.AA Subfamily.DSP23.PD 90-140 30 1.5e-08 25.5 In-house 41-89 (128) Show / Hide
Range on Protein: 90-140
Range on HMM: 41-89/128
Sequence Identity: 30% (15 aa)

FDDHNAPQFEMIDAFCRDVDAWMKedSKNIAVIHCKAGKGRTGLMICCWLM
.|.  |  | .. . | |.   |  ...   .||  | |||| .. |.|. 
ipdfcPPaleqvarlvriveeaek--keeavgvhcalGlGrtGtllacylv

Phosphatase pten.AA Subfamily.N20.PD 73-149 28 5.2e-08 23.5 In-house 147-221 (257) Show / Hide
Range on Protein: 73-149
Range on HMM: 147-221/257
Sequence Identity: 28% (21 aa)

ERVYDHSKFYGRVGYYPFDDHNAPQfeMIDAFCRDVDAWMKEDSKNIAVIHCKAGKGRTGLMICCWLMYCGMWKNTE
|.    |.   .. .  . || .|     |.| . .    |       |.|| || ||||...|  ...| . ||  
ekstgtshsvkqlqftkwpdhgtpa--sadsfikyiryarkshltgpmvvhcsagigrtgvflcvdvvfcaivkncs

Phosphatase pten.AA Subfamily.RB.PD 60-137 25 5.4e-08 23.2 In-house 135-213 (261) Show / Hide
Range on Protein: 60-137
Range on HMM: 135-213/261
Sequence Identity: 25% (20 aa)

YHKDHFKVYNLCSERvYDHSKFYGRVGYYPFDDHNAPQF-EMIDAFCRDVDAWMKED-SKNIAVIHCKAGKGRTGLMICC
..|.. . ..  |.  ....   .. .  . ||. |.  . . .|.| |. ..... ||.  |.|| || ||||  |   
keldewvirefkiek-gkekrkvrqyhftsWpdhgvPektktlldfvrtvreaiekkaskkPivvHCsaGvGRtGtfial

Phosphatase pten.AA Subfamily.PTEN.PD 341-404 30 1.3e-07 21.9 In-house 227-304 (305) Show / Hide
Range on Protein: 341-404
Range on HMM: 227-304/305
Sequence Identity: 30% (24 aa)

ALSLAGDIRIEFTNKQDDRMF-MFWVNTSFVQQ-------------LEIIPKSGLDKAHKDKNHKAFPEDFHVELTFD
.. ..||...|.|.|  |..   ||.|| ||..             .  . || .|  ||| .|| | |.|.. . |.
sipvsgdvkfeltkkspdkiichfwlntffvrnyspcesdgtvnkyihtlskseiddvhkdsehkrfseefkisivfe

Phosphatase pten.AA Subfamily.R_Anemone_2.PD 88-140 30 3e-07 20.9 In-house 164-217 (262) Show / Hide
Range on Protein: 88-140
Range on HMM: 164-217/262
Sequence Identity: 30% (16 aa)

YPFDDHNAPQF--EMIDaFCRDVDAWMKEDSKNIAVIHCKAGKGRTGLMICCWLM
. |...|.   ...| . |.|... .| .... |.|| || ||||  |    .  
tsWpdegvpesgaslld-lvrqvekaqqesgagpivvhcsaGvGrtGvfiavdil

Phosphatase pten.AA Subfamily.N5_RR.PD 58-140 21 3.4e-07 20.6 In-house 135-220 (265) Show / Hide
Range on Protein: 58-140
Range on HMM: 135-220/265
Sequence Identity: 21% (18 aa)

DQYHKDHFKVYNLCSERVYDHSKFYGRVGYYPFDDHNAPQ-FEMIDAFCRDVDAWMKEDSKN--IAVIHCKAGKGRTGLMICCWLM
.  ......| .|  . . . ..      |  . ||..|.  . .  ....|.   .|....    |.|| || |||| .|.  . 
eiverndysvrklvlkylerversvkhywytdWPdhksPddintlldlvleveesreeenaklaPvvvhcsaGiGrtGcfiaisia

Phosphatase pten.AA Subfamily.N12.PD 61-147 22 5.3e-07 19.7 In-house 144-229 (270) Show / Hide
Range on Protein: 61-147
Range on HMM: 144-229/270
Sequence Identity: 22% (20 aa)

HKDHFKVYNLCSERVyDHSKFYGRVGYYPFDDHNAPQ-FEMIDAFCRDVDAWMKEDSKNIaVIHCKAGKGRTGLMICCWLMYCGMWKN
.| | .  |  |.  ..|.   .  |  . ||. |.  . . .. ..|    ..... . |.|| || |||| .|   ...  . .. 
vdddflirtLkveaq-kesrkvyqfhytaWPDhgvPssaksllelielvrelqesedaPl-vvhCsaGvGrtGtiiaidyvrellkae

Phosphatase pten.AA Subfamily.R_Sponge_2.PD 69-170 19 6.6e-07 19.7 In-house 145-245 (262) Show / Hide
Range on Protein: 69-170
Range on HMM: 145-245/262
Sequence Identity: 19% (20 aa)

NLCSERVYDHSKFYGRVGYYPFDDHNAPQFE--MIDaFCRDV-DAWMKEDSKNIaVIHCKAGKGRTGLMICCWLMYCGMwkNTEDSLRFYAALRTYNQKG
.|..|.  ....   .  .  . .|. |...  ... . ..|  | .|. .| | ...|..| ||||  |.   .   .  ..|...  .  |.|   | 
klskekssegeadvtqfhfvaWpehevPkdatslle-likrvlraqkksgnkai-tvvCsdgvgrtGtfialdsvlerl--kaeeeidvfevlktlrtkr

VTIPS
. . .
iglvq

Phosphatase pten.AA Subfamily.N_Choan_1.PD 84-136 37 1.6e-06 18.4 In-house 159-212 (262) Show / Hide
Range on Protein: 84-136
Range on HMM: 159-212/262
Sequence Identity: 37% (20 aa)

RVGYYPFDDHNAPQ--FEMIDaFCRDVDAWMKEDSKNIAVIHCKAGKGRTGLMIC
.. |  . || .|.   |... | ..|    |...|   |||| || ||||  | 
qlaytaWPdhGvPattkelle-frkavlkatkkktkaplvihCsaGvGrtGtyia

Phosphatase pten.AA Subfamily.N14.PD 99-149 30 2.4e-06 17.6 In-house 187-239 (275) Show / Hide
Range on Protein: 99-149
Range on HMM: 187-239/275
Sequence Identity: 30% (16 aa)

EMIDAFCRDVDAWMK--EDSKNIAVIHCKAGKGRTGLMICCWLMYCGMWKNTE
|.... .| ..  ..  ..||   ..|| || |||| .|   |.   . .| |
eevqsvrrktnsevesvkeskPPvlvhCsaGvGrtGvlilsdlliatlehnee

Phosphatase pten.AA Subfamily.N_Choan_2.PD 103-175 28 2.4e-06 17.6 In-house 183-257 (266) Show / Hide
Range on Protein: 103-175
Range on HMM: 183-257/266
Sequence Identity: 28% (21 aa)

AFCRDVDAWMKEDSKN-IAVIHCKAGKGRTGLMICCWLMYCGMWKN-TEDSLRFYAALRTYNQKGVTIPSQIRYV
.  |.| .. || .|.   ..|| || ||||..|    . . . ..   | |.  ..|| .  . |  | | ...
kmlravrrvrkeldkaePllvHcsaGvgRtGtliaiDiavrlLeetkkvdvlaiieelRkdRmalvqhpeqyell

Phosphatase pten.AA Subfamily.N13.PD 78-139 29 4.8e-06 16.9 In-house 153-213 (259) Show / Hide
Range on Protein: 78-139
Range on HMM: 153-213/259
Sequence Identity: 29% (18 aa)

HSKFYGRVGYYPFDDHNAPQF--EMIdAFCRDVDAwMKEDSKNIaVIHCKAGKGRTGLMICCWL
.|.   .. .  . ||. |.   |..  | ..|   ...|.  | |.|| || ||.| .|.   
esrevahlnfvkwPdhgvPssaaelv-qfvaevrl-lqtdagPi-vvhcsaGiGrsGvlitidv

Phosphatase pten.AA Subfamily.N3.PD 84-147 24 4.8e-06 16.6 In-house 160-223 (261) Show / Hide
Range on Protein: 84-147
Range on HMM: 160-223/261
Sequence Identity: 24% (16 aa)

RVGYYPFDDHNAPQFE-MIDAFCRDVDAwMKEDSKNIAVIHCKAGKGRTGLMICCWLMYCGMWKN
.. |  . ||. |. .  .  | . | . ... ...  |.|| || ||||..|   .  . . ..
qlqylaWpdhgvPddsadflefvervrk-lrsgkeePvvvhCsaGigrtGvlilletalalieaa

Phosphatase pten.AA Subfamily.Laforin.PD 118-146 39 5.5e-06 16.8 In-house 105-133 (165) Show / Hide
Range on Protein: 118-146
Range on HMM: 105-133/165
Sequence Identity: 39% (11 aa)

NIAVIHCKAGKGRTGLMICCWLMYCGMWK
|  .||.|| ||.  ..| .|.|   |. 
hivyvhcnagvgrstaivcgflqyvlgws

Sequence
Name Sequence Type Origin Length Description Download
pten.AA Protein None 533 None Fasta, JSON
pten.NA RNA None 1602 None Fasta, JSON